{"id":"https://openalex.org/W3000560666","doi":"https://doi.org/10.2147/btt.s236433","title":"Biosimilars to Antitumor Necrosis Factor Agents in Inflammatory Bowel Disease","display_name":"Biosimilars to Antitumor Necrosis Factor Agents in Inflammatory Bowel Disease","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3000560666","doi":"https://doi.org/10.2147/btt.s236433","mag":"3000560666","pmid":"https://pubmed.ncbi.nlm.nih.gov/32021084","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6966952"},"language":"en","primary_location":{"id":"doi:10.2147/btt.s236433","doi":"https://doi.org/10.2147/btt.s236433","is_oa":true,"landing_page_url":"https://doi.org/10.2147/btt.s236433","pdf_url":"https://www.dovepress.com/getfile.php?fileID=55328","source":{"id":"https://openalex.org/S177732258","display_name":"Biologics","issn_l":"1177-5475","issn":["1177-5475","1177-5491"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biologics: Targets and Therapy","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=55328","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026283023","display_name":"Eman Al Sulais","orcid":"https://orcid.org/0000-0002-4155-219X","observed_orcids":["https://orcid.org/0000-0002-4155-219X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Eman Al Sulais","raw_affiliation_strings":["Department of Medicine, Royal Commission Hospital, Jubail, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Royal Commission Hospital, Jubail, Saudi Arabia","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030148494","display_name":"Turki AlAmeel","orcid":"https://orcid.org/0000-0003-0147-7540","observed_orcids":["https://orcid.org/0000-0003-0147-7540"]},"institutions":[{"id":"https://openalex.org/I2802282791","display_name":"King Fahad Specialist Hospital","ror":"https://ror.org/01m1gv240","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I2802282791"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Turki AlAmeel","raw_affiliation_strings":["Department of Medicine, King Fahad Specialist Hospital, Dammam, Saudi Arabia"],"raw_orcid":"https://orcid.org/0000-0003-0147-7540","affiliations":[{"raw_affiliation_string":"Department of Medicine, King Fahad Specialist Hospital, Dammam, Saudi Arabia","institution_ids":["https://openalex.org/I2802282791"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5026283023"],"corresponding_institution_ids":[],"apc_list":{"value":2320,"currency":"USD","value_usd":2320},"apc_paid":{"value":2320,"currency":"USD","value_usd":2320},"fwci":0.1663,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.13246377,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"Volume 14","issue":null,"first_page":"1","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.8794000148773193,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.8794000148773193,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.11810000240802765,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11792","display_name":"Pharmaceutical Economics and Policy","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biosimilars","display_name":"biosimilars","score":0.9990000128746033},{"id":"https://openalex.org/keywords/anti-tumor-necrosis-factor-agents","display_name":"anti-tumor necrosis factor agents","score":0.9480000138282776},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.9959999918937683},{"id":"https://openalex.org/keywords/drug-cost-reduction","display_name":"drug cost reduction","score":0.625},{"id":"https://openalex.org/keywords/biosimilar-safety","display_name":"biosimilar safety","score":0.9480000138282776},{"id":"https://openalex.org/keywords/patient-concerns","display_name":"patient concerns","score":0.7409999966621399},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.7440000176429749},{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C59491497","wikidata":"https://www.wikidata.org/wiki/Q864715","display_name":"Biosimilar","level":2,"score":0.938362717628479},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.7987849116325378},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6721314191818237},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5436815619468689},{"id":"https://openalex.org/C2777572184","wikidata":"https://www.wikidata.org/wiki/Q15749161","display_name":"Inflammatory Bowel Diseases","level":4,"score":0.4776816964149475},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.36364734172821045},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28820860385894775},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2400262951850891}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.2147/btt.s236433","doi":"https://doi.org/10.2147/btt.s236433","is_oa":true,"landing_page_url":"https://doi.org/10.2147/btt.s236433","pdf_url":"https://www.dovepress.com/getfile.php?fileID=55328","source":{"id":"https://openalex.org/S177732258","display_name":"Biologics","issn_l":"1177-5475","issn":["1177-5475","1177-5491"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biologics: Targets and Therapy","raw_type":"journal-article"},{"id":"pmid:32021084","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32021084","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biologics : targets & therapy","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6966952","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6966952/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biologics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:8b0f7337174e4d028df9e7df5dafc9aa","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8b0f7337174e4d028df9e7df5dafc9aa","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biologics: Targets & Therapy, Vol Volume 14, Pp 1-11 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.2147/btt.s236433","doi":"https://doi.org/10.2147/btt.s236433","is_oa":true,"landing_page_url":"https://doi.org/10.2147/btt.s236433","pdf_url":"https://www.dovepress.com/getfile.php?fileID=55328","source":{"id":"https://openalex.org/S177732258","display_name":"Biologics","issn_l":"1177-5475","issn":["1177-5475","1177-5491"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biologics: Targets and Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3000560666.pdf","grobid_xml":"https://content.openalex.org/works/W3000560666.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W1547943993","https://openalex.org/W1997063318","https://openalex.org/W2020859458","https://openalex.org/W2023193839","https://openalex.org/W2030491651","https://openalex.org/W2052724916","https://openalex.org/W2072640801","https://openalex.org/W2097892010","https://openalex.org/W2113674146","https://openalex.org/W2121050884","https://openalex.org/W2122527047","https://openalex.org/W2148487286","https://openalex.org/W2162768160","https://openalex.org/W2167582510","https://openalex.org/W2169467558","https://openalex.org/W2171720233","https://openalex.org/W2288929578","https://openalex.org/W2293590090","https://openalex.org/W2310558709","https://openalex.org/W2321453230","https://openalex.org/W2341548813","https://openalex.org/W2411052913","https://openalex.org/W2502393457","https://openalex.org/W2531216194","https://openalex.org/W2545293585","https://openalex.org/W2546839065","https://openalex.org/W2548000951","https://openalex.org/W2560455300","https://openalex.org/W2589454171","https://openalex.org/W2613299853","https://openalex.org/W2673376286","https://openalex.org/W2750911325","https://openalex.org/W2753860164","https://openalex.org/W2759307758","https://openalex.org/W2765952171","https://openalex.org/W2766046358","https://openalex.org/W2766388803","https://openalex.org/W2770190609","https://openalex.org/W2784409714","https://openalex.org/W2790246629","https://openalex.org/W2795103548","https://openalex.org/W2809293243","https://openalex.org/W2885292041","https://openalex.org/W2885617448","https://openalex.org/W2891340572","https://openalex.org/W2891439022","https://openalex.org/W2891495287","https://openalex.org/W2894977001","https://openalex.org/W2897263984","https://openalex.org/W2899941886","https://openalex.org/W2904014975","https://openalex.org/W2906711878","https://openalex.org/W2913878532","https://openalex.org/W2915543214","https://openalex.org/W2919081348","https://openalex.org/W2923675504","https://openalex.org/W2925276402","https://openalex.org/W2926897045","https://openalex.org/W2930414230","https://openalex.org/W2945792041","https://openalex.org/W2957460692","https://openalex.org/W4211138554","https://openalex.org/W4235359424"],"related_works":["https://openalex.org/W4400963255","https://openalex.org/W4229082874","https://openalex.org/W2033039826","https://openalex.org/W1560551965","https://openalex.org/W2534979621","https://openalex.org/W3097733214","https://openalex.org/W2577886726","https://openalex.org/W2586756950","https://openalex.org/W3179577515","https://openalex.org/W3191857774"],"abstract_inverted_index":{"Anti-":[0],"tumor":[1],"Necrosis":[2],"Factor":[3],"(anti-TNF)":[4],"agents":[5,26,38],"are":[6],"the":[7,21,28,43,53,58,70,75],"backbone":[8],"treatment":[9],"of":[10,15,20,24,33,52,62],"moderate":[11],"to":[12,36,41,49,84],"severe":[13],"cases":[14],"inflammatory":[16],"bowel":[17],"disease.":[18],"One":[19],"main":[22],"drawbacks":[23],"these":[25],"is":[27,39],"high":[29],"cost.":[30,44],"The":[31],"introduction":[32],"biosimilar":[34,77],"products":[35],"anti-TNF":[37],"expected":[40],"lower":[42],"Health":[45],"care":[46],"providers":[47],"ought":[48],"be":[50],"aware":[51],"available":[54,76],"data":[55,73],"that":[56],"addresses":[57],"safety":[59],"and":[60,82],"efficacy":[61,81],"biosimilars":[63],"in":[64],"IBD":[65],"patients.":[66],"This":[67],"article":[68],"outlines":[69],"current":[71],"evidence-based":[72],"regarding":[74],"products,":[78],"their":[79],"safety,":[80],"how":[83],"deal":[85],"with":[86],"patients'":[87],"concerns.":[88]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-01-23T00:00:00"}