{"id":"https://openalex.org/W3000526324","doi":"https://doi.org/10.1016/j.neulet.2020.134763","title":"Early high-frequency spinal cord stimulation treatment inhibited the activation of spinal mitogen-activated protein kinases and ameliorated spared nerve injury-induced neuropathic pain in rats","display_name":"Early high-frequency spinal cord stimulation treatment inhibited the activation of spinal mitogen-activated protein kinases and ameliorated spared nerve injury-induced neuropathic pain in rats","publication_year":2020,"publication_date":"2020-01-16","ids":{"openalex":"https://openalex.org/W3000526324","doi":"https://doi.org/10.1016/j.neulet.2020.134763","mag":"3000526324","pmid":"https://pubmed.ncbi.nlm.nih.gov/31954764"},"language":"en","primary_location":{"id":"doi:10.1016/j.neulet.2020.134763","doi":"https://doi.org/10.1016/j.neulet.2020.134763","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neulet.2020.134763","pdf_url":null,"source":{"id":"https://openalex.org/S203050076","display_name":"Neuroscience Letters","issn_l":"0304-3940","issn":["0304-3940","1872-7972"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043270861","display_name":"Wen-Tzu Liao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210156562","display_name":"Chiayi Chang Gung Memorial Hospital","ror":"https://ror.org/04gy6pv35","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210156562"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wen-Tzu Liao","raw_affiliation_strings":["Department of Anesthesiology, Chia-Yi Chang Gung Memorial Hospital, Chia-Yi, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Chia-Yi Chang Gung Memorial Hospital, Chia-Yi, Taiwan","institution_ids":["https://openalex.org/I3020100970","https://openalex.org/I4210156562"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113563068","display_name":"Chia-Chih Alex Tseng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158999","display_name":"National Cheng Kung University Hospital","ror":"https://ror.org/04zx3rq17","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158999"]},{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chia-Chih Tseng","raw_affiliation_strings":["Department of Anesthesiology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan","institution_ids":["https://openalex.org/I4210158999","https://openalex.org/I91807558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051639002","display_name":"Chih-Hsien Wu","orcid":"https://orcid.org/0000-0002-2075-4200","observed_orcids":["https://orcid.org/0000-0002-2075-4200"]},"institutions":[{"id":"https://openalex.org/I4210158999","display_name":"National Cheng Kung University Hospital","ror":"https://ror.org/04zx3rq17","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158999"]},{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chih-Hsien Wu","raw_affiliation_strings":["Department of Anesthesiology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan","institution_ids":["https://openalex.org/I4210158999","https://openalex.org/I91807558"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035470831","display_name":"Chung\u2010Ren Lin","orcid":"https://orcid.org/0000-0001-6808-0295","observed_orcids":["https://orcid.org/0000-0001-6808-0295"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210093821","display_name":"Kaohsiung Chang Gung Memorial Hospital","ror":"https://ror.org/00k194y12","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210093821"]},{"id":"https://openalex.org/I4210158999","display_name":"National Cheng Kung University Hospital","ror":"https://ror.org/04zx3rq17","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158999"]},{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Chung-Ren Lin","raw_affiliation_strings":["Department of Anesthesiology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Anesthesiology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan. Electronic address: chungren@ntu.edu.tw","Department of Anesthesiology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan","Department of Anesthesiology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Anesthesiology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan. Electronic address: chungren@ntu.edu.tw","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I3020100970","https://openalex.org/I4210093821","https://openalex.org/I4210158999","https://openalex.org/I91807558"]},{"raw_affiliation_string":"Department of Anesthesiology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I4210093821"]},{"raw_affiliation_string":"Department of Anesthesiology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan","institution_ids":["https://openalex.org/I4210158999","https://openalex.org/I91807558"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5035470831"],"corresponding_institution_ids":["https://openalex.org/I173093425","https://openalex.org/I3020100970","https://openalex.org/I4210093821","https://openalex.org/I4210158999","https://openalex.org/I91807558"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":3.1354,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.91178954,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"721","issue":null,"first_page":"134763","last_page":"134763"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11840","display_name":"Pain Management and Treatment","score":0.8901000022888184,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11840","display_name":"Pain Management and Treatment","score":0.8901000022888184,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.10849999636411667,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-frequency-spinal-cord-stimulation","display_name":"high-frequency spinal cord stimulation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/spared-nerve-injury","display_name":"spared nerve injury","score":0.8270000219345093},{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":0.9929999709129333},{"id":"https://openalex.org/keywords/mechanical-hyperalgesia","display_name":"mechanical hyperalgesia","score":0.8939999938011169},{"id":"https://openalex.org/keywords/mitogen-activated-protein-kinase","display_name":"mitogen-activated protein kinase","score":0.9660000205039978},{"id":"https://openalex.org/keywords/erk1-2","display_name":"ERK1/2","score":0.8180000185966492},{"id":"https://openalex.org/keywords/jnk","display_name":"JNK","score":0.7889999747276306},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.8989999890327454},{"id":"https://openalex.org/keywords/dorsal-root-ganglia","display_name":"dorsal root ganglia","score":0.9639999866485596},{"id":"https://openalex.org/keywords/spinal-cord-dorsal-horn","display_name":"dorsal horn","score":0.9900000095367432},{"id":"https://openalex.org/keywords/neuromodulation","display_name":"neuromodulation","score":0.7089999914169312},{"id":"https://openalex.org/keywords/sciatic-nerve-injury","display_name":"sciatic nerve injury","score":0.8140000104904175}],"concepts":[{"id":"https://openalex.org/C2777107010","wikidata":"https://www.wikidata.org/wiki/Q2798704","display_name":"Neuropathic pain","level":2,"score":0.8166569471359253},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7506573796272278},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.6072895526885986},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.6017096638679504},{"id":"https://openalex.org/C2778334475","wikidata":"https://www.wikidata.org/wiki/Q1415275","display_name":"Spinal cord injury","level":3,"score":0.5937574505805969},{"id":"https://openalex.org/C2775991916","wikidata":"https://www.wikidata.org/wiki/Q2945973","display_name":"Nerve injury","level":2,"score":0.5427664518356323},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5422090291976929},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5189613699913025},{"id":"https://openalex.org/C132149769","wikidata":"https://www.wikidata.org/wiki/Q899651","display_name":"Mitogen-activated protein kinase","level":3,"score":0.4981400966644287},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4323325455188751},{"id":"https://openalex.org/C2984781990","wikidata":"https://www.wikidata.org/wiki/Q1668448","display_name":"Spinal cord stimulation","level":3,"score":0.4246233105659485},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2781422734260559},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.09835463762283325},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09707465767860413},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006930","descriptor_name":"Hyperalgesia","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006930","descriptor_name":"Hyperalgesia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009437","descriptor_name":"Neuralgia","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009437","descriptor_name":"Neuralgia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020426","descriptor_name":"Sciatic Neuropathy","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D020426","descriptor_name":"Sciatic Neuropathy","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062187","descriptor_name":"Spinal Cord Stimulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.neulet.2020.134763","doi":"https://doi.org/10.1016/j.neulet.2020.134763","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neulet.2020.134763","pdf_url":null,"source":{"id":"https://openalex.org/S203050076","display_name":"Neuroscience Letters","issn_l":"0304-3940","issn":["0304-3940","1872-7972"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience Letters","raw_type":"journal-article"},{"id":"pmid:31954764","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31954764","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3776273014","display_name":null,"funder_award_id":"106-2314-B-182 -029 -MY3","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"}],"funders":[{"id":"https://openalex.org/F4320322795","display_name":"Ministry of Science and Technology, Taiwan","ror":"https://ror.org/02kv4zf79"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1531520808","https://openalex.org/W1841237986","https://openalex.org/W1959104605","https://openalex.org/W1967549103","https://openalex.org/W1968154812","https://openalex.org/W1980016883","https://openalex.org/W2006161356","https://openalex.org/W2014738161","https://openalex.org/W2044224657","https://openalex.org/W2053375242","https://openalex.org/W2059646315","https://openalex.org/W2059841743","https://openalex.org/W2077358692","https://openalex.org/W2080289814","https://openalex.org/W2118098191","https://openalex.org/W2133757306","https://openalex.org/W2138810871","https://openalex.org/W2152447677","https://openalex.org/W2155287559","https://openalex.org/W2346102553","https://openalex.org/W2346640528","https://openalex.org/W2799581454","https://openalex.org/W3130192399","https://openalex.org/W4313634981"],"related_works":["https://openalex.org/W3085413576","https://openalex.org/W7202380258","https://openalex.org/W1959104605","https://openalex.org/W4383814140","https://openalex.org/W2035365866","https://openalex.org/W3013088030","https://openalex.org/W1968154812","https://openalex.org/W2041229911","https://openalex.org/W4390348035","https://openalex.org/W2118098191"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-01-23T00:00:00"}
