{"id":"https://openalex.org/W3000480166","doi":"https://doi.org/10.5483/bmbrep.2020.53.1.309","title":"Peripheral inflammatory biomarkers in Alzheimer\u2019s disease: a brief review","display_name":"Peripheral inflammatory biomarkers in Alzheimer\u2019s disease: a brief review","publication_year":2020,"publication_date":"2020-01-31","ids":{"openalex":"https://openalex.org/W3000480166","doi":"https://doi.org/10.5483/bmbrep.2020.53.1.309","mag":"3000480166","pmid":"https://pubmed.ncbi.nlm.nih.gov/31865964","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6999828"},"language":"en","primary_location":{"id":"doi:10.5483/bmbrep.2020.53.1.309","doi":"https://doi.org/10.5483/bmbrep.2020.53.1.309","is_oa":true,"landing_page_url":"https://doi.org/10.5483/bmbrep.2020.53.1.309","pdf_url":"https://www.bmbreports.org/journal/download_pdf.php?doi=10.5483/BMBRep.2020.53.1.309","source":{"id":"https://openalex.org/S58514918","display_name":"BMB Reports","issn_l":"1976-6696","issn":["1976-6696","1976-670X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","kci-registered","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319427","host_organization_name":"Korean Society for Biochemistry and Molecular Biology","host_organization_lineage":["https://openalex.org/P4310319427"],"host_organization_lineage_names":["Korean Society for Biochemistry and Molecular Biology"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMB Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.bmbreports.org/journal/download_pdf.php?doi=10.5483/BMBRep.2020.53.1.309","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100721989","display_name":"Jong\u2010Chan Park","orcid":"https://orcid.org/0000-0001-7516-7292","observed_orcids":["https://orcid.org/0000-0001-7516-7292","https://orcid.org/0000-0003-3766-7274"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jong-Chan Park","raw_affiliation_strings":["Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul 03080, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul 03080, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111939423","display_name":"Sun-Ho Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sun-Ho Han","raw_affiliation_strings":["Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul 03080, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul 03080, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029374567","display_name":"Inhee Mook\u2010Jung","orcid":"https://orcid.org/0000-0001-7085-4085","observed_orcids":["https://orcid.org/0000-0001-7085-4085"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Inhee Mook-Jung","raw_affiliation_strings":["Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul 03080, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul 03080, Korea","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I139264467"],"apc_list":{"value":550,"currency":"USD","value_usd":550},"apc_paid":{"value":550,"currency":"USD","value_usd":550},"fwci":11.8654,"has_fulltext":true,"cited_by_count":206,"citation_normalized_percentile":{"value":0.99447904,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"53","issue":"1","first_page":"10","last_page":"19"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.586899995803833,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.586899995803833,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.24819999933242798,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.15219999849796295,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":1.0},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9459999799728394},{"id":"https://openalex.org/keywords/early-diagnosis","display_name":"early diagnosis","score":0.6840000152587891},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.777999997138977},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.8949999809265137},{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":0.9800000190734863},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.7829999923706055},{"id":"https://openalex.org/keywords/neurofibrillary-tangles","display_name":"neurofibrillary tangles","score":0.9539999961853027},{"id":"https://openalex.org/keywords/noninvasive-biomarkers","display_name":"non-invasive biomarkers","score":0.7020000219345093},{"id":"https://openalex.org/keywords/molecular-diagnosis","display_name":"molecular diagnosis","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6535230875015259},{"id":"https://openalex.org/C3017910909","wikidata":"https://www.wikidata.org/wiki/Q618363","display_name":"Peripheral blood","level":2,"score":0.6438356637954712},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.6400951147079468},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6180521845817566},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.6116384267807007},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5556723475456238},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5524340867996216},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5371658802032471},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4334106743335724},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.41305190324783325},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2595073878765106},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15820926427841187},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15132135152816772},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.5483/bmbrep.2020.53.1.309","doi":"https://doi.org/10.5483/bmbrep.2020.53.1.309","is_oa":true,"landing_page_url":"https://doi.org/10.5483/bmbrep.2020.53.1.309","pdf_url":"https://www.bmbreports.org/journal/download_pdf.php?doi=10.5483/BMBRep.2020.53.1.309","source":{"id":"https://openalex.org/S58514918","display_name":"BMB Reports","issn_l":"1976-6696","issn":["1976-6696","1976-670X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","kci-registered","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319427","host_organization_name":"Korean Society for Biochemistry and Molecular Biology","host_organization_lineage":["https://openalex.org/P4310319427"],"host_organization_lineage_names":["Korean Society for Biochemistry and Molecular Biology"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMB Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5960504","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6999828","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6999828","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6999828","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMB Rep","raw_type":"Text"},{"id":"pmid:31865964","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31865964","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMB reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.5483/bmbrep.2020.53.1.309","doi":"https://doi.org/10.5483/bmbrep.2020.53.1.309","is_oa":true,"landing_page_url":"https://doi.org/10.5483/bmbrep.2020.53.1.309","pdf_url":"https://www.bmbreports.org/journal/download_pdf.php?doi=10.5483/BMBRep.2020.53.1.309","source":{"id":"https://openalex.org/S58514918","display_name":"BMB Reports","issn_l":"1976-6696","issn":["1976-6696","1976-670X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","kci-registered","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319427","host_organization_name":"Korean Society for Biochemistry and Molecular Biology","host_organization_lineage":["https://openalex.org/P4310319427"],"host_organization_lineage_names":["Korean Society for Biochemistry and Molecular Biology"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMB Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2688661165","display_name":null,"funder_award_id":"HI18C0630","funder_id":"https://openalex.org/F4320322034","funder_display_name":"Ministry of Health and Welfare"},{"id":"https://openalex.org/G3181920851","display_name":null,"funder_award_id":"HI19C1132","funder_id":"https://openalex.org/F4320322107","funder_display_name":"Korea Health Industry Development Institute"},{"id":"https://openalex.org/G4019877092","display_name":null,"funder_award_id":"NRF-2019R1I1A1A01063525","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G6112057995","display_name":null,"funder_award_id":"HI18C0630","funder_id":"https://openalex.org/F4320322107","funder_display_name":"Korea Health Industry Development Institute"},{"id":"https://openalex.org/G6830175118","display_name":null,"funder_award_id":"HI19C1132","funder_id":"https://openalex.org/F4320322034","funder_display_name":"Ministry of Health and Welfare"}],"funders":[{"id":"https://openalex.org/F4320322034","display_name":"Ministry of Health and Welfare","ror":"https://ror.org/00vxgjw72"},{"id":"https://openalex.org/F4320322107","display_name":"Korea Health Industry Development Institute","ror":"https://ror.org/00fdzyk40"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3000480166.pdf","grobid_xml":"https://content.openalex.org/works/W3000480166.grobid-xml"},"referenced_works_count":124,"referenced_works":["https://openalex.org/W55108809","https://openalex.org/W157966126","https://openalex.org/W231832547","https://openalex.org/W1494417700","https://openalex.org/W1534709281","https://openalex.org/W1593472999","https://openalex.org/W1606617874","https://openalex.org/W1752389919","https://openalex.org/W1847890422","https://openalex.org/W1911139940","https://openalex.org/W1963687105","https://openalex.org/W1965841865","https://openalex.org/W1967176607","https://openalex.org/W1968155895","https://openalex.org/W1970567538","https://openalex.org/W1970606114","https://openalex.org/W1970891635","https://openalex.org/W1972380966","https://openalex.org/W1972693293","https://openalex.org/W1973216353","https://openalex.org/W1976354184","https://openalex.org/W1976845082","https://openalex.org/W1977964374","https://openalex.org/W1978525572","https://openalex.org/W1978567629","https://openalex.org/W1978853688","https://openalex.org/W1979150324","https://openalex.org/W1979341891","https://openalex.org/W1986300349","https://openalex.org/W1991026693","https://openalex.org/W1993057071","https://openalex.org/W1995570133","https://openalex.org/W1997460269","https://openalex.org/W2000525834","https://openalex.org/W2001259634","https://openalex.org/W2008128503","https://openalex.org/W2008423159","https://openalex.org/W2009170813","https://openalex.org/W2014473727","https://openalex.org/W2015186493","https://openalex.org/W2015372700","https://openalex.org/W2015759485","https://openalex.org/W2017512075","https://openalex.org/W2021461507","https://openalex.org/W2023485487","https://openalex.org/W2023641365","https://openalex.org/W2026292908","https://openalex.org/W2028262213","https://openalex.org/W2029870992","https://openalex.org/W2030105058","https://openalex.org/W2033468757","https://openalex.org/W2034268236","https://openalex.org/W2035072797","https://openalex.org/W2035355245","https://openalex.org/W2037599213","https://openalex.org/W2040756720","https://openalex.org/W2042551037","https://openalex.org/W2051282107","https://openalex.org/W2052696508","https://openalex.org/W2057290284","https://openalex.org/W2060930700","https://openalex.org/W2061136258","https://openalex.org/W2061505846","https://openalex.org/W2061576298","https://openalex.org/W2061671780","https://openalex.org/W2061880413","https://openalex.org/W2062561385","https://openalex.org/W2071695496","https://openalex.org/W2077290313","https://openalex.org/W2077555085","https://openalex.org/W2078701378","https://openalex.org/W2079873627","https://openalex.org/W2081219796","https://openalex.org/W2083283628","https://openalex.org/W2083320551","https://openalex.org/W2084043574","https://openalex.org/W2085558085","https://openalex.org/W2086474013","https://openalex.org/W2087243986","https://openalex.org/W2088041135","https://openalex.org/W2098472276","https://openalex.org/W2108325105","https://openalex.org/W2108405229","https://openalex.org/W2116784956","https://openalex.org/W2131196487","https://openalex.org/W2131732205","https://openalex.org/W2134556872","https://openalex.org/W2145045466","https://openalex.org/W2149954869","https://openalex.org/W2152119060","https://openalex.org/W2152860347","https://openalex.org/W2161996060","https://openalex.org/W2171653890","https://openalex.org/W2198707617","https://openalex.org/W2207268297","https://openalex.org/W2207689373","https://openalex.org/W2277126095","https://openalex.org/W2285257942","https://openalex.org/W2332739634","https://openalex.org/W2399571624","https://openalex.org/W2474716739","https://openalex.org/W2508044717","https://openalex.org/W2518595415","https://openalex.org/W2572551054","https://openalex.org/W2599951549","https://openalex.org/W2615406383","https://openalex.org/W2617126548","https://openalex.org/W2617693460","https://openalex.org/W2769984699","https://openalex.org/W2774947569","https://openalex.org/W2786682365","https://openalex.org/W2892091353","https://openalex.org/W2895288124","https://openalex.org/W2904508814","https://openalex.org/W2909041556","https://openalex.org/W2920516237","https://openalex.org/W2944016326","https://openalex.org/W2945582226","https://openalex.org/W2947364302","https://openalex.org/W2950413420","https://openalex.org/W2954390789","https://openalex.org/W2970148487","https://openalex.org/W3214092816","https://openalex.org/W4292340975"],"related_works":["https://openalex.org/W4280600909","https://openalex.org/W2915893442","https://openalex.org/W3195585427","https://openalex.org/W3185445809","https://openalex.org/W1972693293","https://openalex.org/W2082249109","https://openalex.org/W3117570074","https://openalex.org/W1893288749","https://openalex.org/W1479801731","https://openalex.org/W2056736323"],"abstract_inverted_index":{"Alzheimer's":[0],"disease":[1,7],"(AD)":[2],"is":[3],"a":[4],"chronic":[5,25],"neurodegenerative":[6],"characterized":[8],"by":[9],"the":[10,19,56,81,84,109,129,154],"accumulation":[11],"of":[12,83,102,132,157],"amyloid":[13],"plaques":[14],"and":[15,34,44,61,87,119,139],"neurofibrillary":[16],"tangles":[17],"in":[18,117,136],"brain.":[20],"The":[21],"AD":[22,50,118,158,165],"pathophysiology":[23],"entails":[24],"inflammation":[26,60,79,116,163],"involving":[27],"innate":[28],"immune":[29],"cells":[30],"including":[31],"microglia,":[32],"astrocytes,":[33],"other":[35],"peripheral":[36,90,110],"blood":[37],"cells.":[38],"Inflammatory":[39],"mediators":[40],"such":[41],"as":[42,96],"cytokines":[43],"complements":[45],"are":[46,67],"also":[47,127],"linked":[48],"to":[49,114,162],"pathogenesis.":[51,166],"Despite":[52],"increasing":[53],"evidence":[54],"supporting":[55],"association":[57],"between":[58],"abnormal":[59,78,115],"AD,":[62],"no":[63],"well-established":[64],"inflammatory":[65,91,133],"biomarkers":[66,92,98],"currently":[68],"available":[69,89],"for":[70,99,153],"AD.":[71,103],"Since":[72],"many":[73],"reports":[74],"have":[75],"shown":[76],"that":[77],"precedes":[80],"outbreak":[82],"disease,":[85],"non-invasive":[86],"readily":[88],"should":[93],"be":[94],"considered":[95],"possible":[97,122],"early":[100,155],"diagnosis":[101,156],"In":[104],"this":[105,144],"minireview,":[106],"we":[107,126],"introduce":[108],"biomarker":[111,134,151],"candidates":[112,152],"related":[113],"discuss":[120],"their":[121],"molecular":[123,140],"mechanisms.":[124],"Furthermore,":[125],"summarize":[128],"current":[130],"state":[131],"research":[135],"clinical":[137],"practice":[138],"diagnostics.":[141],"We":[142],"believe":[143],"review":[145],"will":[146],"provide":[147],"new":[148],"insights":[149],"into":[150],"with":[159],"systemic":[160],"relevance":[161],"during":[164],"[BMB":[167],"Reports":[168],"2020;":[169],"53(1):":[170],"10-19].":[171]},"counts_by_year":[{"year":2026,"cited_by_count":20},{"year":2025,"cited_by_count":33},{"year":2024,"cited_by_count":28},{"year":2023,"cited_by_count":34},{"year":2022,"cited_by_count":43},{"year":2021,"cited_by_count":43},{"year":2020,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-01-23T00:00:00"}