{"id":"https://openalex.org/W3000478465","doi":null,"title":"Benzethonium chloride suppresses lung cancer tumorigenesis through inducing p38-mediated cyclin D1 degradation.","display_name":"Benzethonium chloride suppresses lung cancer tumorigenesis through inducing p38-mediated cyclin D1 degradation.","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W3000478465","mag":"3000478465","pmid":"https://pubmed.ncbi.nlm.nih.gov/31815042","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6895443"},"language":"en","primary_location":{"id":"pmid:31815042","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31815042","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6895443/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012635924","display_name":"Xiaohui Huang","orcid":"https://orcid.org/0000-0002-4768-9103","observed_orcids":["https://orcid.org/0000-0002-4768-9103"]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Hui Huang","raw_affiliation_strings":["Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University Guangzhou 510632, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University Guangzhou 510632, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060404389","display_name":"Yang Wang","orcid":"https://orcid.org/0000-0001-6440-0204","observed_orcids":["https://orcid.org/0000-0001-6440-0204"]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Wang","raw_affiliation_strings":["Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University Guangzhou 510632, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University Guangzhou 510632, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Pan Hong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pan Hong","raw_affiliation_strings":["Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University Guangzhou 510632, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University Guangzhou 510632, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100404945","display_name":"Jie Yang","orcid":"https://orcid.org/0000-0003-4346-9100","observed_orcids":["https://orcid.org/0000-0003-4346-9100"]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Yang","raw_affiliation_strings":["Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University Guangzhou 510632, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University Guangzhou 510632, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029169241","display_name":"Can\u2010Can Zheng","orcid":"https://orcid.org/0000-0002-1850-0367","observed_orcids":["https://orcid.org/0000-0002-1850-0367"]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Can-Can Zheng","raw_affiliation_strings":["Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University Guangzhou 510632, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University Guangzhou 510632, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109125572","display_name":"Xingfeng Yin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xing-Feng Yin","raw_affiliation_strings":["Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University Guangzhou 510632, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University Guangzhou 510632, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110165738","display_name":"Wenbo Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen-Bo Song","raw_affiliation_strings":["Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University Guangzhou 510632, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University Guangzhou 510632, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wen Wen Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen Wen Xu","raw_affiliation_strings":["Institute of Biomedicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, National Engineering Research Center of Genetic Medicine, Jinan University Guangzhou 510632, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, National Engineering Research Center of Genetic Medicine, Jinan University Guangzhou 510632, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100379778","display_name":"Bin Li","orcid":"https://orcid.org/0000-0002-8979-610X","observed_orcids":["https://orcid.org/0000-0002-8979-610X"]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Li","raw_affiliation_strings":["Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University Guangzhou 510632, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University Guangzhou 510632, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100646656","display_name":"Qing\u2010Yu He","orcid":"https://orcid.org/0000-0003-0503-9492","observed_orcids":["https://orcid.org/0000-0003-0503-9492"]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qing-Yu He","raw_affiliation_strings":["Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University Guangzhou 510632, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University Guangzhou 510632, China","institution_ids":["https://openalex.org/I159948400"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I159948400"],"apc_list":null,"apc_paid":null,"fwci":1.6784,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.84883144,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"9","issue":"11","first_page":"2397","last_page":"2412"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.5303000211715698,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.5303000211715698,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.23019999265670776,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.14650000631809235,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benzethonium-chloride","display_name":"benzethonium chloride","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/cyclin-d1-degradation","display_name":"cyclin D1 degradation","score":0.8140000104904175},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.9089999794960022},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5730000138282776},{"id":"https://openalex.org/keywords/g1-cell-cycle-arrest","display_name":"G1 cell cycle arrest","score":0.9549999833106995},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.8199999928474426},{"id":"https://openalex.org/keywords/ki-67-proliferation-index","display_name":"Ki-67 proliferation index","score":0.8880000114440918}],"concepts":[{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.7137580513954163},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6658751964569092},{"id":"https://openalex.org/C199835354","wikidata":"https://www.wikidata.org/wiki/Q15311861","display_name":"Cyclin D1","level":4,"score":0.6529309153556824},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6377026438713074},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.534910261631012},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5333570837974548},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44880348443984985},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.44262921810150146},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.412667453289032},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.314400315284729},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17246907949447632},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09876841306686401}],"mesh":[],"locations_count":3,"locations":[{"id":"pmid:31815042","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31815042","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6895443","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6895443/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},{"id":"mag:3000478465","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31815042","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6895443","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6895443/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9907000064849854}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W29136453","https://openalex.org/W1948333620","https://openalex.org/W1966980496","https://openalex.org/W1976449876","https://openalex.org/W1983409515","https://openalex.org/W2004879613","https://openalex.org/W2013035261","https://openalex.org/W2013955133","https://openalex.org/W2021663476","https://openalex.org/W2025246434","https://openalex.org/W2053736534","https://openalex.org/W2077907123","https://openalex.org/W2086172282","https://openalex.org/W2098953839","https://openalex.org/W2109890375","https://openalex.org/W2126425007","https://openalex.org/W2149873978","https://openalex.org/W2153666475","https://openalex.org/W2160855995","https://openalex.org/W2162370807","https://openalex.org/W2174249243","https://openalex.org/W2411366655","https://openalex.org/W2415721097","https://openalex.org/W2577800379","https://openalex.org/W2586907780","https://openalex.org/W2595251399","https://openalex.org/W2604202456","https://openalex.org/W2626874022","https://openalex.org/W2739258130","https://openalex.org/W2751839060","https://openalex.org/W2766010966","https://openalex.org/W2772508026","https://openalex.org/W2775419658","https://openalex.org/W2789825128","https://openalex.org/W2790038102","https://openalex.org/W2794827677","https://openalex.org/W2794851756","https://openalex.org/W2807967114","https://openalex.org/W2884802886","https://openalex.org/W2885673053","https://openalex.org/W2886763446","https://openalex.org/W2888052891","https://openalex.org/W2889646458","https://openalex.org/W2890399359","https://openalex.org/W2890442986","https://openalex.org/W2895926103","https://openalex.org/W2899973621","https://openalex.org/W2990476997","https://openalex.org/W2995062130","https://openalex.org/W3022216217"],"related_works":["https://openalex.org/W2909528168","https://openalex.org/W2998734087","https://openalex.org/W2789534226","https://openalex.org/W2895542940","https://openalex.org/W1984563910","https://openalex.org/W2002002672","https://openalex.org/W4310383507","https://openalex.org/W2113088945","https://openalex.org/W2082942670","https://openalex.org/W4403965814"],"abstract_inverted_index":{"Lung":[0],"cancer":[1,59,73,84,175],"is":[2,13],"the":[3,69,77,90,111,162],"leading":[4],"cause":[5],"of":[6,33,57,71,92,114,126,156],"cancer-related":[7],"deaths":[8],"worldwide,":[9],"but":[10],"effective":[11],"therapeutics":[12],"limited.":[14],"This":[15],"study":[16],"aims":[17],"to":[18,46,75,110],"identify":[19],"novel":[20],"anticancer":[21],"strategy":[22,80],"from":[23],"a":[24,39,124,169],"Food":[25],"and":[26,50,53,63,101,123,139,153],"Drug":[27],"Administration":[28],"(FDA)-approved":[29],"drug":[30,41],"library":[31],"consisting":[32],"528":[34],"compounds.":[35],"Benzethonium":[36],"Chloride":[37],"(BZN),":[38],"FDA-approved":[40],"for":[42,81],"anti-infective,":[43],"was":[44,141],"found":[45],"markedly":[47],"induce":[48],"apoptosis":[49,100],"inhibit":[51],"proliferation":[52,104],"colony":[54],"formation":[55],"ability":[56],"lung":[58,72,83,174],"cells":[60,74],"in":[61,95,146,173],"dose-":[62],"time-dependent":[64],"manners.":[65],"BZN":[66,87,131,166],"also":[67],"enhanced":[68],"sensitivity":[70],"gefitinib,":[76],"first-line":[78],"treatment":[79],"selected":[82],"patients.":[85],"Furthermore,":[86],"significantly":[88],"delayed":[89],"growth":[91],"tumor":[93],"xenografts":[94],"nude":[96],"mice":[97],"by":[98],"increasing":[99],"decreasing":[102],"Ki-67":[103],"index,":[105],"without":[106],"obvious":[107],"toxic":[108],"effects":[109],"vital":[112],"organs":[113],"animals.":[115],"Mechanistically,":[116],"quantitative":[117],"proteomics":[118],"coupled":[119],"with":[120,143],"bioinformatics":[121],"analyses":[122],"series":[125],"functional":[127],"assays":[128],"demonstrated":[129],"that":[130,165],"induced":[132],"cell":[133],"cycle":[134],"arrest":[135],"at":[136,149],"G1":[137],"phase,":[138],"this":[140],"associated":[142],"an":[144],"increase":[145],"p38-mediated":[147],"phosphorylation":[148],"threonine":[150],"286":[151],"(T286)":[152],"accelerated":[154],"degradation":[155],"cyclin":[157],"D1.":[158],"Our":[159],"findings":[160],"provide":[161],"first":[163],"evidence":[164],"could":[167],"be":[168],"promising":[170],"therapeutic":[171],"agent":[172],"treatment.":[176]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-01-23T00:00:00"}