{"id":"https://openalex.org/W3000477354","doi":null,"title":"Assessment and Optimisation of Hermes Amyloid BRASS as a Quantitative Diagnostic Tool in Reporting 18F-florbetapir (Amyvid) Investigations","display_name":"Assessment and Optimisation of Hermes Amyloid BRASS as a Quantitative Diagnostic Tool in Reporting 18F-florbetapir (Amyvid) Investigations","publication_year":2018,"publication_date":"2018-05-01","ids":{"openalex":"https://openalex.org/W3000477354","mag":"3000477354"},"language":"en","primary_location":{"id":"mag:3000477354","doi":null,"is_oa":false,"landing_page_url":"http://jnm.snmjournals.org/content/59/supplement_1/1011.short","pdf_url":null,"source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Nuclear Medicine","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044823136","display_name":"Neva Patel","orcid":"https://orcid.org/0000-0001-8954-7958","observed_orcids":["https://orcid.org/0000-0001-8954-7958"]},"institutions":[{"id":"https://openalex.org/I153355300","display_name":"Imperial College Healthcare NHS Trust","ror":"https://ror.org/056ffv270","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Neva Patel","raw_affiliation_strings":["+Imperial College Healthcare NHS Trust, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-8954-7958","affiliations":[{"raw_affiliation_string":"+Imperial College Healthcare NHS Trust, London, United Kingdom","institution_ids":["https://openalex.org/I153355300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033798196","display_name":"Daniel Fakhry-Darian","orcid":"https://orcid.org/0000-0002-8838-746X","observed_orcids":["https://orcid.org/0000-0002-8838-746X"]},"institutions":[{"id":"https://openalex.org/I153355300","display_name":"Imperial College Healthcare NHS Trust","ror":"https://ror.org/056ffv270","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Daniel Fakhry-Darian","raw_affiliation_strings":["+Imperial College Healthcare NHS Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"+Imperial College Healthcare NHS Trust, London, United Kingdom","institution_ids":["https://openalex.org/I153355300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052995669","display_name":"Kuldip S. Nijran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153355300","display_name":"Imperial College Healthcare NHS Trust","ror":"https://ror.org/056ffv270","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"K. S. Nijran","raw_affiliation_strings":["+Imperial College Healthcare NHS Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"+Imperial College Healthcare NHS Trust, London, United Kingdom","institution_ids":["https://openalex.org/I153355300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107051126","display_name":"Sairah R. Khan","orcid":"https://orcid.org/0009-0007-8440-2216","observed_orcids":["https://orcid.org/0009-0007-8440-2216"]},"institutions":[{"id":"https://openalex.org/I153355300","display_name":"Imperial College Healthcare NHS Trust","ror":"https://ror.org/056ffv270","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sairah R. Khan","raw_affiliation_strings":["+Imperial College Healthcare NHS Trust, London, United Kingdom"],"raw_orcid":"https://orcid.org/0009-0007-8440-2216","affiliations":[{"raw_affiliation_string":"+Imperial College Healthcare NHS Trust, London, United Kingdom","institution_ids":["https://openalex.org/I153355300"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110781190","display_name":"Zarni Win","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153355300","display_name":"Imperial College Healthcare NHS Trust","ror":"https://ror.org/056ffv270","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Zarni Win","raw_affiliation_strings":["+Imperial College Healthcare NHS Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"+Imperial College Healthcare NHS Trust, London, United Kingdom","institution_ids":["https://openalex.org/I153355300"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I153355300"],"apc_list":null,"apc_paid":null,"fwci":0.3575,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.59657135,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"59","issue":null,"first_page":"1011","last_page":"1011"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9272000193595886,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9272000193595886,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.04450000077486038,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.019099999219179153,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.8169999718666077},{"id":"https://openalex.org/keywords/reader-agreement","display_name":"reader agreement","score":0.39100000262260437},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.47200000286102295},{"id":"https://openalex.org/keywords/receiver-operating-characteristic","display_name":"receiver operating characteristic","score":0.47099998593330383},{"id":"https://openalex.org/keywords/false-positive-reduction","display_name":"false positive reduction","score":0.40799999237060547}],"concepts":[{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.543651282787323},{"id":"https://openalex.org/C2780033417","wikidata":"https://www.wikidata.org/wiki/Q39782","display_name":"Brass","level":3,"score":0.46962669491767883},{"id":"https://openalex.org/C3017724952","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Pet imaging","level":3,"score":0.4693143367767334},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.45903491973876953},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41973692178726196},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3638898730278015},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.34976956248283386},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3234636187553406},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2189132273197174},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.1848137378692627},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C544778455","wikidata":"https://www.wikidata.org/wiki/Q753","display_name":"Copper","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3000477354","doi":null,"is_oa":false,"landing_page_url":"http://jnm.snmjournals.org/content/59/supplement_1/1011.short","pdf_url":null,"source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Nuclear Medicine","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2940885106","https://openalex.org/W7163884628","https://openalex.org/W565346185","https://openalex.org/W4243800263","https://openalex.org/W2169388901","https://openalex.org/W2232560068","https://openalex.org/W2025027931","https://openalex.org/W2545072337","https://openalex.org/W2213225786","https://openalex.org/W2772609666"],"abstract_inverted_index":{"1011":[0],"Purpose:":[2],"Amyloid":[6,43],"PET/CT":[7],"plays":[8],"an":[9],"important":[10],"role":[11],"in":[12,159,207,235,382,394,413],"investigation":[13],"of":[14,31,41,114,119,227,482,488,511,531,547,558,561,569,595],"patients":[15,70],"with":[16,23,74,428,462,585],"cognitive":[17],"impairment":[18],"and":[19,25,37,49,57,77,94,138,151,172,190,204,224,263,298,304,322,341,372,445,494,513,528,534,572,576,593],"dementia,":[20],"especially":[21],"those":[22],"atypical":[24],"mixed":[26],"clinical":[27,99,164],"presentations.":[28],"The":[29,145,349],"aim":[30],"this":[32,173,363,399,414,556],"work":[33],"was":[34,88,157,174,315],"to":[35,46,108,142,242,259,275,284,291,337,357,367,375,393,441,451,460,474,476,480,507,603],"assess":[36],"optimise":[38,292],"the":[39,97,121,160,177,181,231,236,243,260,309,353,368,425,544,596],"ability":[40],"Hermes":[42,91],"BRASS":[44,55,92,209,237,290,318,339,369],"software":[45,597],"identify":[47],"positive":[48,137,252,294,300],"negative":[50,139],"amyloid":[51,215],"scans":[52,122,140,183,437,478,564,601],"using":[53,90,424],"default":[54,317,340],"values":[56,222,273,377,568],"published":[58,383],"literature":[59],"values.":[60,279],"Materials":[61],"and\n":[62],"Methods:":[64],"Data":[67],"from":[68,230,448],"100":[69,182,195],"(41-88":[71],"years)":[72],"injected":[73],"370MBq":[75],"18F-florbetapir,":[76],"imaged":[78],"for":[79,135,154,251,255,265,269,289,308,312,359,396,598],"20":[80],"minutes":[81,113],"following":[82],"a":[83,501,522,550,607],"40":[84],"minute":[85],"uptake":[86,216],"period,":[87],"evaluated":[89,206],"software,":[93],"compared":[95,602],"against":[96],"final":[98],"report.":[100],"Frames":[101],"that":[102,455],"included":[103],"excessive":[104],"motion":[105,492],"were":[106,123,185,197,239,249,282],"removed":[107],"create":[109],"at":[110],"least":[111],"10":[112],"data.":[115],"To":[116],"aid":[117],"reporting":[118,463,529],"examinations":[120],"classified":[124,186],"as":[125,176,187,606],"type":[126,330,360,532,562,599],"A":[127,132,331,361,436,465,533,536,563,600],"(typical":[128],"features)":[129,134],"or":[130,149,484,582],"non-type":[131,464,535],"(atypical":[133],"both":[136,346],"according":[141],"imaging":[143],"characteristics.":[144],"binary":[146],"result":[147],"(positive":[148],"negative)":[150],"sub-group":[152],"classification":[153,247,584],"each":[155],"scan":[156],"identified":[158],"double":[161],"reported":[162],"original":[163],"report":[165],"(independent":[166],"review":[167],"by":[168,200,379,423],"two":[169],"trained":[170],"readers)":[171],"chosen":[175],"reference":[178],"standard.":[179],"Of":[180],"79":[184],"Type":[188],"A,":[189],"21":[191],"non-Type":[192,435],"A.":[193],"All":[194],"studies":[196,333,540],"independently":[198],"reviewed":[199],"three":[201,310],"experienced":[202],"reviewers":[203],"quantitatively":[205],"Amyvid":[208],"(Hermes":[210],"Medical":[211],"Imaging":[212],"Solutions).":[213],"Regional":[214],"ratios":[217],"(SUVr),":[218],"mean":[219],"cortical":[220,468],"SUVr":[221,234,272,278,287,432,588],"(mcSUVr)":[223],"z-score":[225],"(number":[226],"standard":[228],"deviations":[229],"healthy":[232],"control":[233],"template)":[238],"calculated":[240,256],"relative":[241,258,274],"cerebellum.":[244],"Two":[245],"separate":[246],"metrics":[248],"used":[250,283],"scans:":[253],"z>2":[254,264],"mcSUVr":[257,262,325,344,376,386,410,512,580],"template":[261,276,370],"ROI\u22652":[266],"(two-region":[267],"classification)":[268],"individual":[270,514],"ROI":[271,277,431,515,587],"ROC":[280,323,342,354,408,429],"curves":[281],"define":[285],"potential":[286],"thresholds":[288,345],"true":[293],"rate":[295,301],"(TPR,":[296],"sensitivity)":[297],"false":[299],"(FPR,":[302],"1-specificity)":[303],"accuracy.":[305,577],"Results:":[306],"Accuracy":[307],"readers":[311,456],"all":[313,604],"data":[314,605],"90%,":[316],"settings":[319],"yielded":[320,327,347,401],"85%":[321],"optimised":[324,343,430,586],"threshold":[326,400,411],"85%.":[328],"For":[329,434],"only":[332],"reader":[334,438,573],"accuracy":[335,402,417,439,530,594],"increased":[336,490],"96%,":[338],"92%.":[348],"optimum":[350],"point":[351],"on":[352,549,566],"curve":[355],"corresponded":[356],"1.18":[358],"data,":[362],"is":[364,389,505],"approximately":[365],"equal":[366],"mcSUVr+2SD=1.17,":[371],"also":[373,390,420],"equivalent":[374],"derived":[378,409],"other":[380,498],"means":[381],"literature.":[384],"Threshold":[385],"=":[387,403],"1.11":[388],"frequently":[391],"referred":[392],"literature,":[395],"our":[397],"dataset":[398],"87%":[404],"i.e.":[405],"poorer":[406],"than":[407],"found":[412],"study.":[415],"Equivalent":[416],"(92%)":[418],"can":[419],"be":[421,471],"achieved":[422],"two-region":[426,583],"method":[427],"thresholds.":[433],"fell":[440],"70%":[442],"(range":[443],"48-95%)":[444],"agreement":[446,527,571],"ranged":[447],"very":[449],"poor":[450],"poor.":[452],"This":[453,518],"suggests":[454],"require":[457],"further":[458],"support":[459],"assist":[461],"studies.":[466,559],"Mean":[467],"measures":[469],"may":[470],"more":[472,485],"difficult":[473],"apply":[475],"these":[477],"due":[479],"presence":[481],"one":[483],"focal":[486],"regions":[487],"uptake,":[489],"noise,":[491],"artefacts":[493],"ventricular":[495],"atrophy":[496],"amongst":[497],"features.":[499],"Moreover,":[500],"larger":[502],"sample":[503],"size":[504],"necessary":[506],"obtain":[508],"definitive":[509],"optimisation":[510],"SUVr.":[516],"Conclusion:":[517],"study":[519],"has":[520],"shown":[521],"clear":[523],"definition":[524],"between":[525],"inter-reader":[526,570],"florbetapir":[537],"scans.":[538],"Other":[539],"which":[541],"have":[542,553],"investigated":[543],"added":[545],"effect":[546],"quantification":[548],"visual":[551],"read":[552],"not":[554],"considered":[555],"separation":[557],"Separation":[560],"improves":[565,590],"measured":[567],"sensitivity,":[574,591],"specificity":[575,592],"In":[578],"BRASS,":[579],"threshold=1.17,":[581],"thresholds,":[589],"single":[608],"group.":[609]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-01-23T00:00:00"}
