{"id":"https://openalex.org/W3000477277","doi":"https://doi.org/10.3389/fendo.2019.00866","title":"Evidence in Favor of an Alternative Glucocorticoid Synthesis Pathway During Acute Experimental Chagas Disease","display_name":"Evidence in Favor of an Alternative Glucocorticoid Synthesis Pathway During Acute Experimental Chagas Disease","publication_year":2020,"publication_date":"2020-01-08","ids":{"openalex":"https://openalex.org/W3000477277","doi":"https://doi.org/10.3389/fendo.2019.00866","mag":"3000477277","pmid":"https://pubmed.ncbi.nlm.nih.gov/31998227","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6961479"},"language":"en","primary_location":{"id":"doi:10.3389/fendo.2019.00866","doi":"https://doi.org/10.3389/fendo.2019.00866","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2019.00866","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2019.00866/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fendo.2019.00866/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028801516","display_name":"Esdras da Silva Oliveira Barbosa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I4141589","display_name":"National University of Rosario","ror":"https://ror.org/02tphfq59","country_code":"AR","type":"education","lineage":["https://openalex.org/I4141589"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Esdras da Silva Oliveira Barbosa","raw_affiliation_strings":["Institute of Clinical and Experimental Immunology of Rosario (IDICER-CONICET-UNR), Rosario, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical and Experimental Immunology of Rosario (IDICER-CONICET-UNR), Rosario, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4141589"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088044564","display_name":"Eduardo Roggero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I4141589","display_name":"National University of Rosario","ror":"https://ror.org/02tphfq59","country_code":"AR","type":"education","lineage":["https://openalex.org/I4141589"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Eduardo A. Roggero","raw_affiliation_strings":["Institute of Clinical and Experimental Immunology of Rosario (IDICER-CONICET-UNR), Rosario, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical and Experimental Immunology of Rosario (IDICER-CONICET-UNR), Rosario, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4141589"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062682761","display_name":"Florencia Bel\u00e9n Gonz\u00e1lez","orcid":"https://orcid.org/0000-0003-3828-1963","observed_orcids":["https://orcid.org/0000-0003-3828-1963"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I4141589","display_name":"National University of Rosario","ror":"https://ror.org/02tphfq59","country_code":"AR","type":"education","lineage":["https://openalex.org/I4141589"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Florencia B. Gonz\u00e1lez","raw_affiliation_strings":["Institute of Clinical and Experimental Immunology of Rosario (IDICER-CONICET-UNR), Rosario, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical and Experimental Immunology of Rosario (IDICER-CONICET-UNR), Rosario, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4141589"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071143941","display_name":"Roc\u00edo del Valle Fern\u00e1ndez","orcid":"https://orcid.org/0000-0002-3457-4139","observed_orcids":["https://orcid.org/0000-0002-3457-4139"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I4141589","display_name":"National University of Rosario","ror":"https://ror.org/02tphfq59","country_code":"AR","type":"education","lineage":["https://openalex.org/I4141589"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Roc\u00edo del Valle Fern\u00e1ndez","raw_affiliation_strings":["Institute of Clinical and Experimental Immunology of Rosario (IDICER-CONICET-UNR), Rosario, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical and Experimental Immunology of Rosario (IDICER-CONICET-UNR), Rosario, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4141589"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050213266","display_name":"Vin\u00edcius F. Carvalho","orcid":"https://orcid.org/0000-0003-2136-8958","observed_orcids":["https://orcid.org/0000-0003-2136-8958"]},"institutions":[{"id":"https://openalex.org/I4405271386","display_name":"Instituto Nacional de Ci\u00eancia e Tecnologia em Neuroimunomodula\u00e7\u00e3o","ror":"https://ror.org/02c687y03","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4405271386"]},{"id":"https://openalex.org/I4405286966","display_name":"Instituto Oswaldo Cruz","ror":"https://ror.org/03pww0c55","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4405286966","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Vinicius Frias Carvalho","raw_affiliation_strings":["Laboratory of Inflammation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil","National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Inflammation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I4405286966","https://openalex.org/I52325"]},{"raw_affiliation_string":"National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I4405271386"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030080152","display_name":"Oscar Adelmo Bottasso","orcid":"https://orcid.org/0000-0003-2526-7281","observed_orcids":["https://orcid.org/0000-0003-2526-7281"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I4141589","display_name":"National University of Rosario","ror":"https://ror.org/02tphfq59","country_code":"AR","type":"education","lineage":["https://openalex.org/I4141589"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Oscar A. Bottasso","raw_affiliation_strings":["Institute of Clinical and Experimental Immunology of Rosario (IDICER-CONICET-UNR), Rosario, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical and Experimental Immunology of Rosario (IDICER-CONICET-UNR), Rosario, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4141589"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024312874","display_name":"Ana Rosa P\u00e9rez","orcid":"https://orcid.org/0000-0002-1636-7523","observed_orcids":["https://orcid.org/0000-0002-1636-7523"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I4141589","display_name":"National University of Rosario","ror":"https://ror.org/02tphfq59","country_code":"AR","type":"education","lineage":["https://openalex.org/I4141589"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Ana R. P\u00e9rez","raw_affiliation_strings":["Center for Research and Production of Biological Reagents (CIPREB), Faculty of Medical Sciences, National University of Rosario, Rosario, Argentina","Institute of Clinical and Experimental Immunology of Rosario (IDICER-CONICET-UNR), Rosario, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research and Production of Biological Reagents (CIPREB), Faculty of Medical Sciences, National University of Rosario, Rosario, Argentina","institution_ids":["https://openalex.org/I4141589"]},{"raw_affiliation_string":"Institute of Clinical and Experimental Immunology of Rosario (IDICER-CONICET-UNR), Rosario, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4141589"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103409933","display_name":"Silvina Raquel Villar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I4141589","display_name":"National University of Rosario","ror":"https://ror.org/02tphfq59","country_code":"AR","type":"education","lineage":["https://openalex.org/I4141589"]}],"countries":["AR"],"is_corresponding":true,"raw_author_name":"Silvina R. Villar","raw_affiliation_strings":["Center for Research and Production of Biological Reagents (CIPREB), Faculty of Medical Sciences, National University of Rosario, Rosario, Argentina","Institute of Clinical and Experimental Immunology of Rosario (IDICER-CONICET-UNR), Rosario, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research and Production of Biological Reagents (CIPREB), Faculty of Medical Sciences, National University of Rosario, Rosario, Argentina","institution_ids":["https://openalex.org/I4141589"]},{"raw_affiliation_string":"Institute of Clinical and Experimental Immunology of Rosario (IDICER-CONICET-UNR), Rosario, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4141589"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5103409933"],"corresponding_institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4141589"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.1349,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.38157895,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"10","issue":null,"first_page":"866","last_page":"866"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.37549999356269836,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.37549999356269836,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.35519999265670776,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.17180000245571136,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chagas-disease","display_name":"Chagas disease","score":0.9810000061988831},{"id":"https://openalex.org/keywords/trypanosoma-cruzi","display_name":"Trypanosoma cruzi","score":0.9670000076293945},{"id":"https://openalex.org/keywords/glucocorticoid-synthesis","display_name":"glucocorticoid synthesis","score":0.9739999771118164},{"id":"https://openalex.org/keywords/epac2","display_name":"Epac2","score":0.7929999828338623},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.9359999895095825},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8389999866485596},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.656000018119812},{"id":"https://openalex.org/keywords/pka-signaling","display_name":"PKA signaling","score":0.7379999756813049},{"id":"https://openalex.org/keywords/acth-receptor","display_name":"ACTH receptor","score":0.7300000190734863},{"id":"https://openalex.org/keywords/adrenal-gland","display_name":"adrenal gland","score":0.7570000290870667},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.9079999923706055},{"id":"https://openalex.org/keywords/parasitic-infection","display_name":"parasitic infection","score":0.6439999938011169},{"id":"https://openalex.org/keywords/acute-infection","display_name":"acute infection","score":0.375}],"concepts":[{"id":"https://openalex.org/C2780546910","wikidata":"https://www.wikidata.org/wiki/Q185690","display_name":"Adrenocorticotropic hormone","level":3,"score":0.6596679091453552},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5435911417007446},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5411286950111389},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5195856094360352},{"id":"https://openalex.org/C177865409","wikidata":"https://www.wikidata.org/wiki/Q410784","display_name":"ACTH receptor","level":4,"score":0.42481905221939087},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35774940252304077},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3444554805755615},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34366950392723083},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.2103387713432312},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.19472509622573853}],"mesh":[],"locations_count":11,"locations":[{"id":"doi:10.3389/fendo.2019.00866","doi":"https://doi.org/10.3389/fendo.2019.00866","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2019.00866","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2019.00866/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},{"id":"pmid:31998227","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31998227","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6961479","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6961479/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Endocrinol (Lausanne)","raw_type":"Text"},{"id":"pmh:oai:www.arca.fiocruz.br:icict/41453","doi":null,"is_oa":true,"landing_page_url":"https://www.arca.fiocruz.br/handle/icict/41453","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da FIOCRUZ (ARCA)","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:americanae.aecid.es:2577816","doi":null,"is_oa":true,"landing_page_url":"https://www.arca.fiocruz.br/handle/icict/41453","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da FIOCRUZ (ARCA)","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:arca.fiocruz.br:icict/41453","doi":null,"is_oa":true,"landing_page_url":"https://arca.fiocruz.br/handle/icict/41453","pdf_url":null,"source":{"id":"https://openalex.org/S7407055450","display_name":"Arca - Reposit\u00f3rio Institucional da Fiocruz","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:doaj.org/article:1c91d4d6dc9a4d779440b3f2878fe0c3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1c91d4d6dc9a4d779440b3f2878fe0c3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Endocrinology, Vol 10 (2020)","raw_type":"article"},{"id":"pmh:oai:ri.conicet.gov.ar:11336/145674","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11336/145674","pdf_url":null,"source":{"id":"https://openalex.org/S4306401400","display_name":"Conicet","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210104196","host_organization_name":"Centro Cient\u00edfico Tecnol\u00f3gico - Nordeste","host_organization_lineage":["https://openalex.org/I4210104196"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:ri.conicet.gov.ar:11336/149467","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11336/149467","pdf_url":null,"source":{"id":"https://openalex.org/S4306402455","display_name":"CONICET Digital (CONICET)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210148385","host_organization_name":"Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society","host_organization_lineage":["https://openalex.org/I4210148385"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.60692/m31wm-86q72","doi":"https://doi.org/10.60692/m31wm-86q72","is_oa":true,"landing_page_url":"https://doi.org/10.60692/m31wm-86q72","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/rd2gd-f3z31","doi":"https://doi.org/10.60692/rd2gd-f3z31","is_oa":true,"landing_page_url":"https://doi.org/10.60692/rd2gd-f3z31","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.3389/fendo.2019.00866","doi":"https://doi.org/10.3389/fendo.2019.00866","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2019.00866","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2019.00866/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1074796101","display_name":"MODULACION INMUNO-ENDOCRINA Y METABOLICA EN LA INFECCION POR TRYPANOSOMA CRUZI.","funder_award_id":"PICT-2013-1892","funder_id":"https://openalex.org/F4320334832","funder_display_name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica"},{"id":"https://openalex.org/G167783662","display_name":null,"funder_award_id":"PICT 2013","funder_id":"https://openalex.org/F4320334832","funder_display_name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica"},{"id":"https://openalex.org/G350075096","display_name":null,"funder_award_id":"PICT-2015","funder_id":"https://openalex.org/F4320334832","funder_display_name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica"},{"id":"https://openalex.org/G4294862531","display_name":null,"funder_award_id":"PICT 2013","funder_id":"https://openalex.org/F4320321594","funder_display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas"},{"id":"https://openalex.org/G7378882120","display_name":null,"funder_award_id":"CONICET","funder_id":"https://openalex.org/F4320334832","funder_display_name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica"},{"id":"https://openalex.org/G8162427987","display_name":"Estudio acerca de las potenciales influencias de mediadores inmunol\u00f3gicos sobre el eje HPA en un modelo de infecci\u00f3n aguda por T. cruzi.","funder_award_id":"PICT-2015-3777","funder_id":"https://openalex.org/F4320334832","funder_display_name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica"}],"funders":[{"id":"https://openalex.org/F4320321594","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59"},{"id":"https://openalex.org/F4320334832","display_name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","ror":"https://ror.org/03stxzb56"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3000477277.pdf","grobid_xml":"https://content.openalex.org/works/W3000477277.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1574219214","https://openalex.org/W1775749144","https://openalex.org/W1965732784","https://openalex.org/W1966907779","https://openalex.org/W1977527496","https://openalex.org/W1977688800","https://openalex.org/W1981078229","https://openalex.org/W1986609722","https://openalex.org/W1986905299","https://openalex.org/W1987059501","https://openalex.org/W2006934020","https://openalex.org/W2011798264","https://openalex.org/W2021394845","https://openalex.org/W2024166804","https://openalex.org/W2033550124","https://openalex.org/W2034222431","https://openalex.org/W2034784902","https://openalex.org/W2038189360","https://openalex.org/W2038641544","https://openalex.org/W2043369249","https://openalex.org/W2043908137","https://openalex.org/W2052943470","https://openalex.org/W2056100207","https://openalex.org/W2061246349","https://openalex.org/W2066564803","https://openalex.org/W2068682884","https://openalex.org/W2070441623","https://openalex.org/W2076333673","https://openalex.org/W2079053528","https://openalex.org/W2084655958","https://openalex.org/W2084810687","https://openalex.org/W2088330531","https://openalex.org/W2090556647","https://openalex.org/W2092807846","https://openalex.org/W2101984138","https://openalex.org/W2119027567","https://openalex.org/W2129968987","https://openalex.org/W2132539548","https://openalex.org/W2135185562","https://openalex.org/W2139717699","https://openalex.org/W2150734066","https://openalex.org/W2154183756","https://openalex.org/W2168765205","https://openalex.org/W2171512984","https://openalex.org/W2320050200","https://openalex.org/W2429963365","https://openalex.org/W2502330811","https://openalex.org/W2567481983","https://openalex.org/W2584376012","https://openalex.org/W2593859685","https://openalex.org/W2602917953","https://openalex.org/W2604132026","https://openalex.org/W2622282058","https://openalex.org/W2730083272","https://openalex.org/W2887293104","https://openalex.org/W2893475454","https://openalex.org/W4210980497","https://openalex.org/W4210984474"],"related_works":["https://openalex.org/W2021394845","https://openalex.org/W2050672767","https://openalex.org/W2143724611","https://openalex.org/W2413027686","https://openalex.org/W1986609722","https://openalex.org/W2122224235","https://openalex.org/W2119027567","https://openalex.org/W2416427641","https://openalex.org/W1536907727","https://openalex.org/W2991366087"],"abstract_inverted_index":{"It":[0],"is":[1,26],"well":[2,186],"established":[3],"that":[4,38,54,241,280],"infectious":[5],"stress":[6],"activates":[7],"the":[8,13,61,111,154,161,168,176,202,220,236,259,281,286],"hypothalamus-pituitary-adrenal":[9],"axis":[10],"leading":[11],"to":[12,99,131,270],"production":[14,237,257,268],"of":[15,48,64,70,113,121,136,163,171,182,190,204,238,262,277,283],"pituitary":[16],"adrenocorticotropin":[17],"(ACTH)":[18],"and":[19,151,165,192,196,250],"adrenal":[20,169,188,232],"glucocorticoids":[21],"(GC).":[22],"Usually,":[23],"GC":[24,55,71,137,164,209,245,256,267],"synthesis":[25,56,72,210],"mediated":[27,292],"by":[28,33,225,293],"PKA":[29],"signaling":[30],"pathway":[31,116],"triggered":[32],"ACTH.":[34],"We":[35],"previously":[36],"demonstrated":[37],"acute":[39,155],"murine":[40],"Chagas":[41,127],"disease":[42,125],"courses":[43],"with":[44,50,147,219,273],"a":[45,101,122,226,274],"marked":[46],"increase":[47],"GC,":[49],"some":[51],"data":[52],"suggesting":[53,279],"may":[57,234,290],"be":[58,271,291],"ACTH-dissociated":[59],"in":[60,76,81,103,117,129,208,213,258,285],"late":[62],"phase":[63,156,289],"this":[65,104,140],"parasitic":[66,124],"infection.":[67,264],"Alternative":[68],"pathways":[69,135],"have":[73,108],"been":[74],"reported":[75],"sepsis":[77],"or":[78],"mental":[79],"diseases,":[80],"which":[82],"interleukin":[83],"(IL)-1\u03b2,":[84],"prostaglandin":[85],"E2":[86],"(PGE2)":[87],"and/or":[88],"cAMP":[89],"activated":[90],"guanine":[91],"nucleotide":[92],"exchange":[93],"factor":[94],"2":[95],"(EPAC2)":[96],"are":[97],"likely":[98],"play":[100],"role":[102],"regard.":[105],"Accordingly,":[106],"we":[107],"searched":[109],"for":[110,157,255],"existence":[112,203],"an":[114,118,215],"ACTH-independent":[115,287],"experimental":[119],"model":[120],"mayor":[123],"like":[126,247],"disease,":[128],"addition":[130],"characterizing":[132],"potential":[133],"alternative":[134],"synthesis.":[138],"To":[139],"end,":[141],"C57BL/6":[142],"male":[143],"mice":[144],"were":[145],"infected":[146],"T.":[148],"cruzi":[149],"(Tc),":[150],"evaluated":[152],"throughout":[153],"several":[158],"parameters,":[159],"including":[160],"kinetic":[162],"ACTH":[166],"release,":[167],"level":[170],"MC2R":[172],"(ACTH":[173],"receptor)":[174],"expression,":[175],"p-PKA/PKA":[177],"ratio":[178],"as":[179,185,187,252],"ACTH-dependent":[180,222],"mechanism":[181],"signal":[183],"transduction,":[184],"expression":[189],"IL-1\u03b2":[191],"its":[193],"receptor,":[194],"EPAC2":[195],"PGE2":[197,248],"synthase.":[198],"Our":[199],"results":[200],"reveal":[201],"two":[205],"phases":[206],"involved":[207],"during":[211],"Tc-infection":[212],"mice,":[214],"initial":[216],"one":[217],"dealing":[218],"well-known":[221],"pathway,":[223],"followed":[224],"further":[227],"ACTH-hyporesponsive":[228],"phase.":[229],"Furthermore,":[230],"inflamed":[231],"microenvironment":[233],"tune":[235],"intracellular":[239],"mediators":[240],"also":[242],"operate":[243],"upon":[244],"synthesis,":[246],"synthase":[249],"EPAC2,":[251],"emerging":[253],"driving-forces":[254],"advanced":[260],"course":[261],"Tc":[263],"In":[265],"essence,":[266],"seems":[269],"associated":[272],"biphasic":[275],"action":[276],"PGE2,":[278],"effect":[282],"PGE2/cAMP":[284],"second":[288],"EPAC2.":[294]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-01-23T00:00:00"}
