{"id":"https://openalex.org/W3000445848","doi":"https://doi.org/10.1186/s13578-019-0372-1","title":"The antagonism of 6-shogaol in high-glucose-activated NLRP3 inflammasome and consequent calcification of human artery smooth muscle cells","display_name":"The antagonism of 6-shogaol in high-glucose-activated NLRP3 inflammasome and consequent calcification of human artery smooth muscle cells","publication_year":2020,"publication_date":"2020-01-09","ids":{"openalex":"https://openalex.org/W3000445848","doi":"https://doi.org/10.1186/s13578-019-0372-1","mag":"3000445848","pmid":"https://pubmed.ncbi.nlm.nih.gov/31938471","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6953308"},"language":"en","primary_location":{"id":"doi:10.1186/s13578-019-0372-1","doi":"https://doi.org/10.1186/s13578-019-0372-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13578-019-0372-1","pdf_url":"https://cellandbioscience.biomedcentral.com/track/pdf/10.1186/s13578-019-0372-1","source":{"id":"https://openalex.org/S14303005","display_name":"Cell & Bioscience","issn_l":"2045-3701","issn":["2045-3701"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell &amp; Bioscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://cellandbioscience.biomedcentral.com/track/pdf/10.1186/s13578-019-0372-1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045621067","display_name":"Te\u2010Chuan Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I4210093821","display_name":"Kaohsiung Chang Gung Memorial Hospital","ror":"https://ror.org/00k194y12","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210093821"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Te-Chuan Chen","raw_affiliation_strings":["1Division of Nephrology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan","Division of Nephrology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Division of Nephrology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I4210093821"]},{"raw_affiliation_string":"Division of Nephrology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I4210093821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014534904","display_name":"Chia\u2010Kung Yen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183570559","display_name":"National Chiayi University","ror":"https://ror.org/04gknbs13","country_code":"TW","type":"education","lineage":["https://openalex.org/I183570559"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chia-Kung Yen","raw_affiliation_strings":["2Department of Food Science, National Chiayi University, Chiayi, Taiwan","Department of Food Science, National Chiayi University, Chiayi, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Food Science, National Chiayi University, Chiayi, Taiwan","institution_ids":["https://openalex.org/I183570559"]},{"raw_affiliation_string":"Department of Food Science, National Chiayi University, Chiayi, Taiwan","institution_ids":["https://openalex.org/I183570559"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036993170","display_name":"Ying-Chen Lu","orcid":"https://orcid.org/0000-0002-9987-1898","observed_orcids":["https://orcid.org/0000-0002-9987-1898"]},"institutions":[{"id":"https://openalex.org/I183570559","display_name":"National Chiayi University","ror":"https://ror.org/04gknbs13","country_code":"TW","type":"education","lineage":["https://openalex.org/I183570559"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ying-Chen Lu","raw_affiliation_strings":["2Department of Food Science, National Chiayi University, Chiayi, Taiwan","Department of Food Science, National Chiayi University, Chiayi, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Food Science, National Chiayi University, Chiayi, Taiwan","institution_ids":["https://openalex.org/I183570559"]},{"raw_affiliation_string":"Department of Food Science, National Chiayi University, Chiayi, Taiwan","institution_ids":["https://openalex.org/I183570559"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053487335","display_name":"Chung\u2010Sheng Shi","orcid":"https://orcid.org/0000-0002-5548-7675","observed_orcids":["https://orcid.org/0000-0002-5548-7675"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210156562","display_name":"Chiayi Chang Gung Memorial Hospital","ror":"https://ror.org/04gy6pv35","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210156562"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chung-Sheng Shi","raw_affiliation_strings":["3Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang-Gung University, Taoyuan, Taiwan","4Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan","Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang-Gung University, Taoyuan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang-Gung University, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425"]},{"raw_affiliation_string":"4Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan","institution_ids":["https://openalex.org/I3020100970","https://openalex.org/I4210156562"]},{"raw_affiliation_string":"Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang-Gung University, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006762012","display_name":"Rong\u2010Ze Hsieh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210156562","display_name":"Chiayi Chang Gung Memorial Hospital","ror":"https://ror.org/04gy6pv35","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210156562"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Rong-Ze Hsieh","raw_affiliation_strings":["3Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang-Gung University, Taoyuan, Taiwan","5Department of Medical Research and Development, Chang Gung Memorial Hospital, Chiayi, Taiwan","Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang-Gung University, Taoyuan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang-Gung University, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425"]},{"raw_affiliation_string":"5Department of Medical Research and Development, Chang Gung Memorial Hospital, Chiayi, Taiwan","institution_ids":["https://openalex.org/I3020100970","https://openalex.org/I4210156562"]},{"raw_affiliation_string":"Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang-Gung University, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048415604","display_name":"Shun\u2010Fu Chang","orcid":"https://orcid.org/0000-0002-2276-7785","observed_orcids":["https://orcid.org/0000-0002-2276-7785"]},"institutions":[{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210156562","display_name":"Chiayi Chang Gung Memorial Hospital","ror":"https://ror.org/04gy6pv35","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210156562"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Shun-Fu Chang","raw_affiliation_strings":["5Department of Medical Research and Development, Chang Gung Memorial Hospital, Chiayi, Taiwan","Department of Medical Research and Development, Chang Gung Memorial Hospital, Chiayi, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Department of Medical Research and Development, Chang Gung Memorial Hospital, Chiayi, Taiwan","institution_ids":["https://openalex.org/I3020100970","https://openalex.org/I4210156562"]},{"raw_affiliation_string":"Department of Medical Research and Development, Chang Gung Memorial Hospital, Chiayi, Taiwan","institution_ids":["https://openalex.org/I3020100970","https://openalex.org/I4210156562"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000319201","display_name":"Cheng\u2010Nan Chen","orcid":"https://orcid.org/0000-0002-1417-7734","observed_orcids":["https://orcid.org/0000-0002-1417-7734"]},"institutions":[{"id":"https://openalex.org/I183570559","display_name":"National Chiayi University","ror":"https://ror.org/04gknbs13","country_code":"TW","type":"education","lineage":["https://openalex.org/I183570559"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Cheng-Nan Chen","raw_affiliation_strings":["6Department of Biochemical Science and Technology, National Chiayi University, Chiayi, 600 Taiwan","Department of Biochemical Science and Technology, National Chiayi University, Chiayi, 600, Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-1417-7734","affiliations":[{"raw_affiliation_string":"6Department of Biochemical Science and Technology, National Chiayi University, Chiayi, 600 Taiwan","institution_ids":["https://openalex.org/I183570559"]},{"raw_affiliation_string":"Department of Biochemical Science and Technology, National Chiayi University, Chiayi, 600, Taiwan","institution_ids":["https://openalex.org/I183570559"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5000319201","https://openalex.org/A5048415604"],"corresponding_institution_ids":["https://openalex.org/I183570559","https://openalex.org/I3020100970","https://openalex.org/I4210156562"],"apc_list":{"value":2145,"currency":"USD","value_usd":2145},"apc_paid":{"value":2145,"currency":"USD","value_usd":2145},"fwci":2.144,"has_fulltext":true,"cited_by_count":49,"citation_normalized_percentile":{"value":0.88560977,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"10","issue":"1","first_page":"5","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.9063000082969666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.9063000082969666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.022099999710917473,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12924","display_name":"Dermatological and Skeletal Disorders","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/6-shogaol","display_name":"6-shogaol","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.9129999876022339},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8090000152587891},{"id":"https://openalex.org/keywords/vascular-calcification","display_name":"vascular calcification","score":0.8560000061988831},{"id":"https://openalex.org/keywords/high-glucose","display_name":"high glucose","score":0.6859999895095825},{"id":"https://openalex.org/keywords/caspase-1","display_name":"caspase-1","score":0.8700000047683716},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.8759999871253967},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":1.0},{"id":"https://openalex.org/keywords/bone-matrix-proteins","display_name":"bone matrix proteins","score":0.6510000228881836},{"id":"https://openalex.org/keywords/diabetes-complications","display_name":"diabetes complications","score":0.6620000004768372}],"concepts":[{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.9078424572944641},{"id":"https://openalex.org/C2780309369","wikidata":"https://www.wikidata.org/wiki/Q933382","display_name":"Calcification","level":2,"score":0.8225141763687134},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.6526609659194946},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.49677449464797974},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4772781729698181},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.45955169200897217},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4555448889732361},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4018457531929016},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3880600929260254},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.26568859815597534},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23993444442749023},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.22777366638183594}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/s13578-019-0372-1","doi":"https://doi.org/10.1186/s13578-019-0372-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13578-019-0372-1","pdf_url":"https://cellandbioscience.biomedcentral.com/track/pdf/10.1186/s13578-019-0372-1","source":{"id":"https://openalex.org/S14303005","display_name":"Cell & Bioscience","issn_l":"2045-3701","issn":["2045-3701"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell &amp; Bioscience","raw_type":"journal-article"},{"id":"pmid:31938471","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31938471","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell & bioscience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6953308","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6953308/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Biosci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:7b9bf037bdca450f98f6a08dcbe51808","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/7b9bf037bdca450f98f6a08dcbe51808","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell & Bioscience, Vol 10, Iss 1, Pp 1-10 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13578-019-0372-1","doi":"https://doi.org/10.1186/s13578-019-0372-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13578-019-0372-1","pdf_url":"https://cellandbioscience.biomedcentral.com/track/pdf/10.1186/s13578-019-0372-1","source":{"id":"https://openalex.org/S14303005","display_name":"Cell & Bioscience","issn_l":"2045-3701","issn":["2045-3701"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell &amp; Bioscience","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1627710989","display_name":null,"funder_award_id":"CMRPG8G1201","funder_id":"https://openalex.org/F4320335753","funder_display_name":"Kaohsiung Chang Gung Memorial Hospital"},{"id":"https://openalex.org/G2013073497","display_name":null,"funder_award_id":"CMRPG8B0611","funder_id":"https://openalex.org/F4320335753","funder_display_name":"Kaohsiung Chang Gung Memorial Hospital"},{"id":"https://openalex.org/G6263319757","display_name":null,"funder_award_id":"CMRPG8B0612","funder_id":"https://openalex.org/F4320335753","funder_display_name":"Kaohsiung Chang Gung Memorial Hospital"},{"id":"https://openalex.org/G8956314284","display_name":null,"funder_award_id":"CMRPG8F1271","funder_id":"https://openalex.org/F4320335753","funder_display_name":"Kaohsiung Chang Gung Memorial Hospital"}],"funders":[{"id":"https://openalex.org/F4320322767","display_name":"Chang Gung Medical Foundation","ror":"https://ror.org/02verss31"},{"id":"https://openalex.org/F4320335753","display_name":"Kaohsiung Chang Gung Memorial Hospital","ror":"https://ror.org/00k194y12"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3000445848.pdf","grobid_xml":"https://content.openalex.org/works/W3000445848.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1945441451","https://openalex.org/W1963885748","https://openalex.org/W1970882491","https://openalex.org/W1980413669","https://openalex.org/W2000305089","https://openalex.org/W2004673584","https://openalex.org/W2018607502","https://openalex.org/W2027334114","https://openalex.org/W2048211245","https://openalex.org/W2050449334","https://openalex.org/W2056564326","https://openalex.org/W2056696616","https://openalex.org/W2058980569","https://openalex.org/W2084588383","https://openalex.org/W2084961987","https://openalex.org/W2096742261","https://openalex.org/W2103890875","https://openalex.org/W2107383248","https://openalex.org/W2108116509","https://openalex.org/W2114426847","https://openalex.org/W2123531059","https://openalex.org/W2124848390","https://openalex.org/W2147834547","https://openalex.org/W2148597002","https://openalex.org/W2149504543","https://openalex.org/W2150702412","https://openalex.org/W2150762378","https://openalex.org/W2156002770","https://openalex.org/W2157224349","https://openalex.org/W2170893247","https://openalex.org/W2222010873","https://openalex.org/W2302447233","https://openalex.org/W2337454357","https://openalex.org/W2410143679","https://openalex.org/W2522054313","https://openalex.org/W2767187722","https://openalex.org/W2770704239","https://openalex.org/W2783618610","https://openalex.org/W2784856289","https://openalex.org/W2922360615","https://openalex.org/W2925935237","https://openalex.org/W4211217520","https://openalex.org/W4240175730"],"related_works":["https://openalex.org/W2027334114","https://openalex.org/W2012429849","https://openalex.org/W2066486686","https://openalex.org/W4308252459","https://openalex.org/W7165170922","https://openalex.org/W1169931174","https://openalex.org/W2488959094","https://openalex.org/W4386977121","https://openalex.org/W2166496184","https://openalex.org/W4390534468"],"abstract_inverted_index":{"BACKGROUND:":[0],"Vascular":[1],"calcification":[2,56,91,189,204],"is":[3],"the":[4,50,61,80,129,140,167,183],"major":[5,67],"reason":[6],"for":[7,13,76],"high":[8,43],"mortality":[9],"of":[10,45,82,92,142,186,200,206],"cardiovascular":[11],"complications":[12],"diabetes.":[14,207],"Interleukin":[15],"(IL)-1\u03b2":[16],"has":[17,70],"been":[18,32,71],"implicated":[19],"in":[20,89,104,202],"this":[21,36,83,105],"pathogenesis,":[22],"but":[23],"its":[24,73],"precise":[25],"role":[26,75,199],"and":[27,60,111,118,134,146,157,170,174,194],"clinical":[28],"evidence":[29],"have":[30],"not":[31],"clearly":[33],"identified.":[34],"Hence,":[35],"study":[37,84,181],"was":[38,152],"aimed":[39],"to":[40,138],"investigate":[41],"whether":[42],"concentration":[44],"glucose":[46],"(HG),":[47],"which":[48],"mimics":[49],"hyperglycemia":[51],"environment,":[52],"could":[53,127,165],"initiate":[54],"vascular":[55,90,203],"through":[57,190],"NLRP3/IL-1\u03b2":[58],"inflammasome":[59,173,193],"underlying":[62],"mechanism.":[63],"Recently,":[64],"6-shogaol,":[65],"a":[66,196],"ginger":[68],"derivate,":[69],"elucidated":[72],"pharmaceutic":[74],"various":[77],"diseases.":[78],"Therefore,":[79],"aims":[81],"also":[85],"determined":[86],"6-shogaol":[87,164,201],"effect":[88],"HG":[93,119,126],"initiation.":[94],"RESULT:":[95],"Human":[96],"artery":[97],"smooth":[98],"muscle":[99],"cells":[100],"(HASMCs)":[101],"were":[102,114],"used":[103],"study.":[106],"Glucose":[107],"concentrations":[108],"at":[109],"5":[110],"25":[112],"mM":[113],"defined":[115],"as":[116],"normal":[117],"status,":[120],"respectively.":[121],"The":[122],"results":[123],"showed":[124],"that":[125],"increase":[128],"NLRP3,":[130],"cleaved":[131],"caspase":[132],"1,":[133],"pro/mature":[135],"IL-1\u03b2":[136],"levels":[137],"induce":[139],"expressions":[141],"bone-related":[143],"matrix":[144],"proteins":[145],"subsequent":[147],"HASMC":[148,177,188],"calcification.":[149,178],"This":[150,180],"process":[151],"regulated":[153],"by":[154],"Akt":[155],"activation":[156],"reactive":[158],"oxygen":[159],"species":[160],"(ROS)":[161],"production.":[162],"Moreover,":[163],"inhibit":[166],"Akt/ROS":[168],"signaling":[169],"NLRP3/caspase":[171,191],"1/IL-1\u03b2":[172,192],"hence":[175],"attenuated":[176],"CONCLUSIONS:":[179],"elucidates":[182],"detailed":[184],"mechanism":[185],"HG-initiated":[187],"indicates":[195],"potential":[197],"therapeutic":[198],"complication":[205]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-01-23T00:00:00"}
