{"id":"https://openalex.org/W3000444766","doi":"https://doi.org/10.1210/endocr/bqaa003","title":"Myeloid-Derived Growth Factor Promotes Intestinal Glucagon-Like Peptide-1 Production in Male Mice With Type 2 Diabetes","display_name":"Myeloid-Derived Growth Factor Promotes Intestinal Glucagon-Like Peptide-1 Production in Male Mice With Type 2 Diabetes","publication_year":2020,"publication_date":"2020-01-08","ids":{"openalex":"https://openalex.org/W3000444766","doi":"https://doi.org/10.1210/endocr/bqaa003","mag":"3000444766","pmid":"https://pubmed.ncbi.nlm.nih.gov/31913472"},"language":"en","primary_location":{"id":"doi:10.1210/endocr/bqaa003","doi":"https://doi.org/10.1210/endocr/bqaa003","is_oa":true,"landing_page_url":"https://doi.org/10.1210/endocr/bqaa003","pdf_url":"https://academic.oup.com/endo/article-pdf/161/2/bqaa003/32518996/bqaa003.pdf","source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/endo/article-pdf/161/2/bqaa003/32518996/bqaa003.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Li Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4401726912","display_name":"General Hospital of Central Theater Command","ror":"https://ror.org/030ev1m28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4401726912"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Wang","raw_affiliation_strings":["Department of Endocrinology, General Hospital of Central Theater Command, Wuhan, Hubei Province, China","The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, General Hospital of Central Theater Command, Wuhan, Hubei Province, China","institution_ids":["https://openalex.org/I4401726912"]},{"raw_affiliation_string":"The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong Province, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119697676","display_name":"Yixiang Li","orcid":"https://orcid.org/0000-0003-0640-149X","observed_orcids":["https://orcid.org/0000-0003-0640-149X"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yixiang Li","raw_affiliation_strings":["Department of Hematology and Medical Oncology, School of Medicine, Emory University, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, School of Medicine, Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bei Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4401726912","display_name":"General Hospital of Central Theater Command","ror":"https://ror.org/030ev1m28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4401726912"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bei Guo","raw_affiliation_strings":["Department of Endocrinology, General Hospital of Central Theater Command, Wuhan, Hubei Province, China","The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, General Hospital of Central Theater Command, Wuhan, Hubei Province, China","institution_ids":["https://openalex.org/I4401726912"]},{"raw_affiliation_string":"The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong Province, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100417650","display_name":"Jiajia Zhang","orcid":"https://orcid.org/0000-0003-4623-6134","observed_orcids":["https://orcid.org/0000-0003-4623-6134"]},"institutions":[{"id":"https://openalex.org/I4401726912","display_name":"General Hospital of Central Theater Command","ror":"https://ror.org/030ev1m28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4401726912"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiajia Zhang","raw_affiliation_strings":["Department of Endocrinology, General Hospital of Central Theater Command, Wuhan, Hubei Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, General Hospital of Central Theater Command, Wuhan, Hubei Province, China","institution_ids":["https://openalex.org/I4401726912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009494524","display_name":"Biao Zhu","orcid":"https://orcid.org/0000-0003-3794-1499","observed_orcids":["https://orcid.org/0000-0003-3794-1499"]},"institutions":[{"id":"https://openalex.org/I4401726912","display_name":"General Hospital of Central Theater Command","ror":"https://ror.org/030ev1m28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4401726912"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Biao Zhu","raw_affiliation_strings":["Department of Endocrinology, General Hospital of Central Theater Command, Wuhan, Hubei Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, General Hospital of Central Theater Command, Wuhan, Hubei Province, China","institution_ids":["https://openalex.org/I4401726912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100319209","display_name":"Huan Li","orcid":"https://orcid.org/0000-0001-5125-069X","observed_orcids":["https://orcid.org/0000-0001-5125-069X","https://orcid.org/0000-0003-4471-9327"]},"institutions":[{"id":"https://openalex.org/I4401726912","display_name":"General Hospital of Central Theater Command","ror":"https://ror.org/030ev1m28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4401726912"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huan Li","raw_affiliation_strings":["Department of Endocrinology, General Hospital of Central Theater Command, Wuhan, Hubei Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, General Hospital of Central Theater Command, Wuhan, Hubei Province, China","institution_ids":["https://openalex.org/I4401726912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009893382","display_name":"Yan Ding","orcid":"https://orcid.org/0000-0002-9522-1097","observed_orcids":["https://orcid.org/0000-0002-9522-1097"]},"institutions":[{"id":"https://openalex.org/I4401726912","display_name":"General Hospital of Central Theater Command","ror":"https://ror.org/030ev1m28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4401726912"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Ding","raw_affiliation_strings":["Department of Endocrinology, General Hospital of Central Theater Command, Wuhan, Hubei Province, China","The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, General Hospital of Central Theater Command, Wuhan, Hubei Province, China","institution_ids":["https://openalex.org/I4401726912"]},{"raw_affiliation_string":"The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong Province, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014807050","display_name":"Biying Meng","orcid":"https://orcid.org/0000-0002-6244-0904","observed_orcids":["https://orcid.org/0000-0002-6244-0904"]},"institutions":[{"id":"https://openalex.org/I4401726912","display_name":"General Hospital of Central Theater Command","ror":"https://ror.org/030ev1m28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4401726912"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Biying Meng","raw_affiliation_strings":["Department of Endocrinology, General Hospital of Central Theater Command, Wuhan, Hubei Province, China","The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, General Hospital of Central Theater Command, Wuhan, Hubei Province, China","institution_ids":["https://openalex.org/I4401726912"]},{"raw_affiliation_string":"The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong Province, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017312003","display_name":"Hui Zhao","orcid":"https://orcid.org/0000-0003-2220-2458","observed_orcids":["https://orcid.org/0000-0003-2220-2458"]},"institutions":[{"id":"https://openalex.org/I4401726912","display_name":"General Hospital of Central Theater Command","ror":"https://ror.org/030ev1m28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4401726912"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Zhao","raw_affiliation_strings":["Department of Endocrinology, General Hospital of Central Theater Command, Wuhan, Hubei Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, General Hospital of Central Theater Command, Wuhan, Hubei Province, China","institution_ids":["https://openalex.org/I4401726912"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lin Xiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4401726912","display_name":"General Hospital of Central Theater Command","ror":"https://ror.org/030ev1m28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4401726912"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Xiang","raw_affiliation_strings":["Department of Endocrinology, General Hospital of Central Theater Command, Wuhan, Hubei Province, China","ICF, 3 Corporate Square NE, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, General Hospital of Central Theater Command, Wuhan, Hubei Province, China","institution_ids":["https://openalex.org/I4401726912"]},{"raw_affiliation_string":"ICF, 3 Corporate Square NE, Atlanta, GA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115590238","display_name":"Jing Dong","orcid":"https://orcid.org/0000-0002-3684-2432","observed_orcids":["https://orcid.org/0000-0002-3684-2432"]},"institutions":[{"id":"https://openalex.org/I4401726912","display_name":"General Hospital of Central Theater Command","ror":"https://ror.org/030ev1m28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4401726912"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Dong","raw_affiliation_strings":["Department of Endocrinology, General Hospital of Central Theater Command, Wuhan, Hubei Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, General Hospital of Central Theater Command, Wuhan, Hubei Province, China","institution_ids":["https://openalex.org/I4401726912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100343907","display_name":"Min Liu","orcid":"https://orcid.org/0000-0002-5486-7051","observed_orcids":["https://orcid.org/0000-0002-5486-7051"]},"institutions":[{"id":"https://openalex.org/I4401726912","display_name":"General Hospital of Central Theater Command","ror":"https://ror.org/030ev1m28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4401726912"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Liu","raw_affiliation_strings":["Department of Endocrinology, General Hospital of Central Theater Command, Wuhan, Hubei Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, General Hospital of Central Theater Command, Wuhan, Hubei Province, China","institution_ids":["https://openalex.org/I4401726912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018122772","display_name":"Junxia Zhang","orcid":"https://orcid.org/0000-0002-8753-1650","observed_orcids":["https://orcid.org/0000-0002-8753-1650"]},"institutions":[{"id":"https://openalex.org/I4401726912","display_name":"General Hospital of Central Theater Command","ror":"https://ror.org/030ev1m28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4401726912"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Junxia Zhang","raw_affiliation_strings":["Department of Endocrinology, General Hospital of Central Theater Command, Wuhan, Hubei Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, General Hospital of Central Theater Command, Wuhan, Hubei Province, China","institution_ids":["https://openalex.org/I4401726912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073116242","display_name":"Lingwei Xiang","orcid":"https://orcid.org/0000-0002-0361-103X","observed_orcids":["https://orcid.org/0000-0002-0361-103X"]},"institutions":[{"id":"https://openalex.org/I4401726912","display_name":"General Hospital of Central Theater Command","ror":"https://ror.org/030ev1m28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4401726912"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingwei Xiang","raw_affiliation_strings":["Department of Endocrinology, General Hospital of Central Theater Command, Wuhan, Hubei Province, China","ICF, 3 Corporate Square NE, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, General Hospital of Central Theater Command, Wuhan, Hubei Province, China","institution_ids":["https://openalex.org/I4401726912"]},{"raw_affiliation_string":"ICF, 3 Corporate Square NE, Atlanta, GA, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061437036","display_name":"Guangda Xiang","orcid":"https://orcid.org/0000-0002-6044-2308","observed_orcids":["https://orcid.org/0000-0002-6044-2308"]},"institutions":[{"id":"https://openalex.org/I4401726912","display_name":"General Hospital of Central Theater Command","ror":"https://ror.org/030ev1m28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4401726912"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guangda Xiang","raw_affiliation_strings":["Department of Endocrinology, General Hospital of Central Theater Command, Wuhan, Hubei Province, China","The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong Province, China"],"raw_orcid":"https://orcid.org/0000-0002-6044-2308","affiliations":[{"raw_affiliation_string":"Department of Endocrinology, General Hospital of Central Theater Command, Wuhan, Hubei Province, China","institution_ids":["https://openalex.org/I4401726912"]},{"raw_affiliation_string":"The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong Province, China","institution_ids":["https://openalex.org/I58200834"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5018122772","https://openalex.org/A5061437036"],"corresponding_institution_ids":["https://openalex.org/I4401726912","https://openalex.org/I58200834"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":2.641,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.90419882,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"161","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.015399999916553497,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucagon-like-peptide-1","display_name":"glucagon-like peptide-1","score":0.9789999723434448},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9440000057220459},{"id":"https://openalex.org/keywords/incretin-system","display_name":"incretin system","score":0.8299999833106995},{"id":"https://openalex.org/keywords/intestinal-l-cells","display_name":"intestinal L cells","score":0.8460000157356262},{"id":"https://openalex.org/keywords/glucose-homeostasis","display_name":"glucose homeostasis","score":0.9559999704360962},{"id":"https://openalex.org/keywords/glucose-tolerance","display_name":"glucose tolerance","score":0.9629999995231628},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.9860000014305115},{"id":"https://openalex.org/keywords/mek-erk-signaling","display_name":"MEK/ERK signaling","score":0.9350000023841858},{"id":"https://openalex.org/keywords/bone-marrow-derived-cells","display_name":"bone marrow-derived cells","score":0.8709999918937683},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.4690000116825104}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8352952003479004},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8017014265060425},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.5646750330924988},{"id":"https://openalex.org/C2781219945","wikidata":"https://www.wikidata.org/wiki/Q5572288","display_name":"Glucagon-like peptide-2","level":3,"score":0.5630515813827515},{"id":"https://openalex.org/C2780768396","wikidata":"https://www.wikidata.org/wiki/Q66310097","display_name":"Proglucagon","level":5,"score":0.5589969158172607},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.4926472306251526},{"id":"https://openalex.org/C2776398474","wikidata":"https://www.wikidata.org/wiki/Q424611","display_name":"Glucagon-like peptide-1","level":4,"score":0.4706878960132599},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4517214000225067},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.43017399311065674},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.39165088534355164},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38017967343330383},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.3114941716194153},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.19860565662384033},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07788366079330444},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07756316661834717}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D054795","descriptor_name":"Incretins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1210/endocr/bqaa003","doi":"https://doi.org/10.1210/endocr/bqaa003","is_oa":true,"landing_page_url":"https://doi.org/10.1210/endocr/bqaa003","pdf_url":"https://academic.oup.com/endo/article-pdf/161/2/bqaa003/32518996/bqaa003.pdf","source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:31913472","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31913472","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1210/endocr/bqaa003","doi":"https://doi.org/10.1210/endocr/bqaa003","is_oa":true,"landing_page_url":"https://doi.org/10.1210/endocr/bqaa003","pdf_url":"https://academic.oup.com/endo/article-pdf/161/2/bqaa003/32518996/bqaa003.pdf","source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4566375601","display_name":null,"funder_award_id":"81370896","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4839520244","display_name":null,"funder_award_id":"2016YFC1305601","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G5219703288","display_name":null,"funder_award_id":"81870573","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6082654464","display_name":null,"funder_award_id":"WJ2017H0031","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7908086967","display_name":null,"funder_award_id":"2016YFC1305601","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8226705388","display_name":null,"funder_award_id":"81570730","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320317798","display_name":"Health Commission of Hubei Province","ror":null},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3000444766.pdf","grobid_xml":"https://content.openalex.org/works/W3000444766.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W1717133667","https://openalex.org/W1778603900","https://openalex.org/W1933814980","https://openalex.org/W1965692424","https://openalex.org/W1967442749","https://openalex.org/W1980645035","https://openalex.org/W1980740451","https://openalex.org/W1981573464","https://openalex.org/W1983908318","https://openalex.org/W1997801265","https://openalex.org/W2008840975","https://openalex.org/W2021852822","https://openalex.org/W2036703182","https://openalex.org/W2039469443","https://openalex.org/W2044175751","https://openalex.org/W2047708866","https://openalex.org/W2049794912","https://openalex.org/W2063536623","https://openalex.org/W2076511407","https://openalex.org/W2084948079","https://openalex.org/W2089304685","https://openalex.org/W2095915493","https://openalex.org/W2098082048","https://openalex.org/W2100009870","https://openalex.org/W2109728760","https://openalex.org/W2111675794","https://openalex.org/W2120955230","https://openalex.org/W2130189158","https://openalex.org/W2134984662","https://openalex.org/W2145818242","https://openalex.org/W2145824107","https://openalex.org/W2146901093","https://openalex.org/W2149545030","https://openalex.org/W2151847420","https://openalex.org/W2152400573","https://openalex.org/W2152777465","https://openalex.org/W2155353035","https://openalex.org/W2163788293","https://openalex.org/W2215222410","https://openalex.org/W2350973188","https://openalex.org/W2509545560","https://openalex.org/W2530052416","https://openalex.org/W2586983997","https://openalex.org/W2608311306","https://openalex.org/W2609322013","https://openalex.org/W2617757338","https://openalex.org/W2746778308","https://openalex.org/W2762819560","https://openalex.org/W2770497049","https://openalex.org/W2772877608","https://openalex.org/W2789232986","https://openalex.org/W2796399813","https://openalex.org/W2804010377","https://openalex.org/W2808316419","https://openalex.org/W2809799070","https://openalex.org/W2877766970","https://openalex.org/W2884987890","https://openalex.org/W2890783608","https://openalex.org/W2903143648","https://openalex.org/W2903765575","https://openalex.org/W2909534634","https://openalex.org/W2913620013","https://openalex.org/W2944113426","https://openalex.org/W6759185636"],"related_works":["https://openalex.org/W3036043714","https://openalex.org/W6983590462","https://openalex.org/W2082763759","https://openalex.org/W3009177262","https://openalex.org/W3037131005","https://openalex.org/W2136309153","https://openalex.org/W2132956041","https://openalex.org/W7005729533","https://openalex.org/W2900577900","https://openalex.org/W2487474223"],"abstract_inverted_index":{"Myeloid-derived":[0],"growth":[1],"factor":[2],"(MYDGF),":[3],"which":[4],"is":[5,39],"produced":[6],"by":[7,17,55],"bone":[8],"marrow-derived":[9],"cells,":[10],"mediates":[11],"cardiac":[12,19],"repair":[13],"following":[14],"myocardial":[15],"infarction":[16],"inhibiting":[18],"myocyte":[20],"apoptosis":[21],"to":[22,97],"subsequently":[23],"reduce":[24],"the":[25,29,34,77,89,98,125],"infarct":[26],"size.":[27],"However,":[28],"function":[30],"of":[31,37,81,92,100,129],"MYDGF":[32,51,75,93,123],"in":[33,47,83,86,131],"incretin":[35],"system":[36],"diabetes":[38],"still":[40],"unknown.":[41],"Here,":[42],"loss-of-function":[43],"and":[44,61,63,69,79,108,127,134],"gain-of-function":[45],"experiments":[46],"mice":[48],"revealed":[49],"that":[50,64],"maintains":[52],"glucose":[53,67],"homeostasis":[54],"inducing":[56],"glucagon-like":[57],"peptide-1":[58],"(GLP-1)":[59],"production":[60,80,128],"secretion":[62,78,126],"it":[65],"improves":[66],"tolerance":[68],"lipid":[70],"metabolism.":[71],"Treatment":[72],"with":[73],"recombinant":[74],"increased":[76],"GLP-1":[82,130],"STC-1":[84],"cells":[85],"vitro.":[87],"Mechanistically,":[88],"positive":[90],"effects":[91],"are":[94],"potentially":[95,135],"attributable":[96],"activation":[99],"protein":[101,110,115],"kinase":[102,105,111,116],"A/glycogen":[103],"synthase":[104],"3\u03b2/\u03b2-catenin":[106],"(PKA/GSK-3\u03b2/\u03b2-catenin)":[107],"mitogen-activated":[109],"(MAPK)":[112],"kinases/extracellular":[113],"regulated":[114],"(MEK/ERK)":[117],"pathways.":[118],"Based":[119],"on":[120],"these":[121],"findings,":[122],"promotes":[124],"intestinal":[132],"L-cells":[133],"represents":[136],"a":[137],"potential":[138],"therapeutic":[139],"medication":[140],"target":[141],"for":[142],"type":[143],"2":[144],"diabetes.":[145]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2020-01-23T00:00:00"}
