{"id":"https://openalex.org/W3000412185","doi":"https://doi.org/10.1093/abbs/gmz144","title":"Downregulating integrin subunit alpha 7 (ITGA7) promotes proliferation, invasion, and migration of papillary thyroid carcinoma cells through regulating epithelial-to-mesenchymal transition","display_name":"Downregulating integrin subunit alpha 7 (ITGA7) promotes proliferation, invasion, and migration of papillary thyroid carcinoma cells through regulating epithelial-to-mesenchymal transition","publication_year":2019,"publication_date":"2019-11-19","ids":{"openalex":"https://openalex.org/W3000412185","doi":"https://doi.org/10.1093/abbs/gmz144","mag":"3000412185","pmid":"https://pubmed.ncbi.nlm.nih.gov/31942970"},"language":"en","primary_location":{"id":"doi:10.1093/abbs/gmz144","doi":"https://doi.org/10.1093/abbs/gmz144","is_oa":true,"landing_page_url":"https://doi.org/10.1093/abbs/gmz144","pdf_url":"https://academic.oup.com/abbs/article-pdf/52/2/116/32762868/gmz144.pdf","source":{"id":"https://openalex.org/S145090216","display_name":"Acta Biochimica et Biophysica Sinica","issn_l":"1672-9145","issn":["1672-9145","1745-7270"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Biochimica et Biophysica Sinica","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/abbs/article-pdf/52/2/116/32762868/gmz144.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110850203","display_name":"Yaoyao Guan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaoyao Guan","raw_affiliation_strings":["Department of Thyroid & Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thyroid & Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China","institution_ids":["https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052611964","display_name":"Adheesh Bhandari","orcid":"https://orcid.org/0000-0002-0406-2685","observed_orcids":["https://orcid.org/0000-0002-0406-2685"]},"institutions":[{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Adheesh Bhandari","raw_affiliation_strings":["Department of Thyroid & Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thyroid & Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China","institution_ids":["https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070275317","display_name":"Erjie Xia","orcid":"https://orcid.org/0000-0003-0036-0703","observed_orcids":["https://orcid.org/0000-0003-0036-0703"]},"institutions":[{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Erjie Xia","raw_affiliation_strings":["Department of Thyroid & Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thyroid & Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China","institution_ids":["https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071357939","display_name":"Lingguo Kong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingguo Kong","raw_affiliation_strings":["Department of Thyroid & Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thyroid & Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China","institution_ids":["https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100445798","display_name":"Xiaohua Zhang","orcid":"https://orcid.org/0009-0002-1707-6346","observed_orcids":["https://orcid.org/0009-0002-1707-6346"]},"institutions":[{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaohua Zhang","raw_affiliation_strings":["Department of Thyroid & Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thyroid & Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China","institution_ids":["https://openalex.org/I2801769982"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041509753","display_name":"Ouchen Wang","orcid":"https://orcid.org/0000-0001-5230-379X","observed_orcids":["https://orcid.org/0000-0001-5230-379X"]},"institutions":[{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ouchen Wang","raw_affiliation_strings":["Department of Thyroid & Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thyroid & Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China","institution_ids":["https://openalex.org/I2801769982"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5041509753","https://openalex.org/A5100445798"],"corresponding_institution_ids":["https://openalex.org/I2801769982"],"apc_list":null,"apc_paid":null,"fwci":1.4201,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.83529572,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"52","issue":"2","first_page":"116","last_page":"124"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/itga7","display_name":"ITGA7","score":0.9980000257492065},{"id":"https://openalex.org/keywords/papillary-thyroid-carcinoma","display_name":"papillary thyroid carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9929999709129333},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.9449999928474426},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9160000085830688},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.7900000214576721},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9990000128746033},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6240000128746033},{"id":"https://openalex.org/keywords/n-cadherin","display_name":"N-cadherin","score":0.8870000243186951},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.8989999890327454},{"id":"https://openalex.org/keywords/vimentin","display_name":"vimentin","score":0.972000002861023},{"id":"https://openalex.org/keywords/gene-knockdown","display_name":"gene knockdown","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7126914858818054},{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.6764861345291138},{"id":"https://openalex.org/C147447768","wikidata":"https://www.wikidata.org/wiki/Q411624","display_name":"Vimentin","level":3,"score":0.6743096113204956},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.6735390424728394},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.575652539730072},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47740569710731506},{"id":"https://openalex.org/C2993294228","wikidata":"https://www.wikidata.org/wiki/Q13632630","display_name":"Thyroid carcinoma","level":3,"score":0.45699259638786316},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.4126729965209961},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.38032934069633484},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.3763148784637451},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.248782217502594},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.23957061767578125},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.20042118430137634},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.19644084572792053},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.1959332823753357},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14240676164627075},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.10358381271362305},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05634027719497681}],"mesh":[{"descriptor_ui":"D000077273","descriptor_name":"Thyroid Cancer, Papillary","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D000077273","descriptor_name":"Thyroid Cancer, Papillary","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D039001","descriptor_name":"Integrin alpha Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D039001","descriptor_name":"Integrin alpha Chains","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/abbs/gmz144","doi":"https://doi.org/10.1093/abbs/gmz144","is_oa":true,"landing_page_url":"https://doi.org/10.1093/abbs/gmz144","pdf_url":"https://academic.oup.com/abbs/article-pdf/52/2/116/32762868/gmz144.pdf","source":{"id":"https://openalex.org/S145090216","display_name":"Acta Biochimica et Biophysica Sinica","issn_l":"1672-9145","issn":["1672-9145","1745-7270"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Biochimica et Biophysica Sinica","raw_type":"journal-article"},{"id":"pmid:31942970","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31942970","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta biochimica et biophysica Sinica","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/abbs/gmz144","doi":"https://doi.org/10.1093/abbs/gmz144","is_oa":true,"landing_page_url":"https://doi.org/10.1093/abbs/gmz144","pdf_url":"https://academic.oup.com/abbs/article-pdf/52/2/116/32762868/gmz144.pdf","source":{"id":"https://openalex.org/S145090216","display_name":"Acta Biochimica et Biophysica Sinica","issn_l":"1672-9145","issn":["1672-9145","1745-7270"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Biochimica et Biophysica Sinica","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1374291085","display_name":null,"funder_award_id":"LY18H160053","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"},{"id":"https://openalex.org/G5588635380","display_name":null,"funder_award_id":"LGF18H160032","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"},{"id":"https://openalex.org/G7715614555","display_name":null,"funder_award_id":"LGF18H160031","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"}],"funders":[{"id":"https://openalex.org/F4320338464","display_name":"Natural Science Foundation of Zhejiang Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3000412185.pdf","grobid_xml":"https://content.openalex.org/works/W3000412185.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W320514574","https://openalex.org/W1509815901","https://openalex.org/W1720744388","https://openalex.org/W1884073707","https://openalex.org/W1968812902","https://openalex.org/W1992728808","https://openalex.org/W2007446347","https://openalex.org/W2010868474","https://openalex.org/W2011212909","https://openalex.org/W2015436472","https://openalex.org/W2019038077","https://openalex.org/W2021808705","https://openalex.org/W2035453768","https://openalex.org/W2047070723","https://openalex.org/W2062491181","https://openalex.org/W2065936889","https://openalex.org/W2069392223","https://openalex.org/W2069792474","https://openalex.org/W2073995368","https://openalex.org/W2074341927","https://openalex.org/W2075637276","https://openalex.org/W2081148836","https://openalex.org/W2086254436","https://openalex.org/W2086333179","https://openalex.org/W2107277218","https://openalex.org/W2118986295","https://openalex.org/W2130134089","https://openalex.org/W2135143152","https://openalex.org/W2141720111","https://openalex.org/W2163188200","https://openalex.org/W2170363825","https://openalex.org/W2272984102","https://openalex.org/W2554356873","https://openalex.org/W2570618306","https://openalex.org/W2596935188","https://openalex.org/W2606491657","https://openalex.org/W2623959190","https://openalex.org/W2753542990","https://openalex.org/W2768538115","https://openalex.org/W2793297320","https://openalex.org/W2802384090","https://openalex.org/W2807247816","https://openalex.org/W2892018916"],"related_works":["https://openalex.org/W7165129138","https://openalex.org/W7048210291","https://openalex.org/W3041545923","https://openalex.org/W2945725973","https://openalex.org/W2094880719","https://openalex.org/W2978615856","https://openalex.org/W3035953298","https://openalex.org/W3166770886","https://openalex.org/W2801297856","https://openalex.org/W4414532690"],"abstract_inverted_index":{"Thyroid":[0],"cancer":[1,17,54,98,110],"is":[2,19,99,192],"one":[3],"of":[4,8,15,30,46,67,94,138,168,197],"the":[5,9,13,27,92,136,166,195],"common":[6],"malignancies":[7],"endocrine":[10],"system":[11],"and":[12,56,70,77,143,152,170,172,183,199],"number":[14],"thyroid":[16,31,53,58,72,88,109,162],"cases":[18],"increasing":[20],"constantly.":[21],"Significant":[22],"work":[23],"has":[24],"focused":[25],"on":[26],"molecular":[28],"mechanisms":[29,35],"cancer,":[32],"but":[33,91,164],"many":[34],"remain":[36],"undiscovered.":[37],"In":[38,185],"this":[39,97],"study,":[40],"we":[41],"employed":[42],"a":[43,62,203],"comprehensive":[44],"analysis":[45],"whole-transcriptome":[47,65],"resequencing":[48,66],"derived":[49],"from":[50],"paired":[51,116],"papillary":[52],"(PTC)":[55],"normal":[57,71],"tissues.":[59],"We":[60,102],"performed":[61],"massive":[63],"parallel":[64],"matched":[68],"PTC":[69,148,198],"tissues":[73,111,119],"in":[74,87,96,108,147,161,194],"19":[75],"patients":[76],"found":[78],"that":[79,105,190],"integrin":[80],"subunit":[81],"alpha":[82],"7":[83],"(ITGA7)":[84],"was":[85,112],"downregulated":[86,113],"tumor":[89,204],"tissues,":[90],"function":[93],"ITGA7":[95,106,155,191],"still":[100],"unclear.":[101],"also":[103],"discovered":[104],"gene":[107],"compared":[114],"to":[115,132],"adjacent":[117],"non-tumor":[118],"by":[120,176],"real-time":[121],"quantitative":[122],"polymerase":[123],"chain":[124],"reaction.":[125],"After":[126],"transfection":[127],"with":[128],"small":[129],"interfering":[130],"RNA":[131],"knock":[133],"down":[134],"ITGA7,":[135],"abilities":[137],"colony":[139],"formation,":[140],"proliferation,":[141],"migration,":[142],"invasion":[144,182],"were":[145],"enhanced":[146],"cell":[149,159],"lines":[150],"(TPC1":[151],"KTC-1).":[153],"Meanwhile,":[154],"knockdown":[156],"decreased":[157,173],"apoptotic":[158],"death":[160],"cells":[163],"promoted":[165],"expressions":[167],"N-cadherin":[169],"vimentin":[171],"E-cadherin":[174],"expression":[175],"epithelial-to-mesenchymal":[177],"transition,":[178],"which":[179],"may":[180],"induce":[181],"migration.":[184],"conclusion,":[186],"these":[187],"results":[188],"indicated":[189],"involved":[193],"progress":[196],"might":[200],"act":[201],"as":[202],"suppressor":[205],"gene.":[206]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-01-23T00:00:00"}