{"id":"https://openalex.org/W3000405276","doi":"https://doi.org/10.1186/s13063-019-4000-5","title":"Dose reduction and withdrawal strategy for TNF-inhibitors in psoriatic arthritis and axial spondyloarthritis: design of a pragmatic open-label, randomised, non-inferiority trial","display_name":"Dose reduction and withdrawal strategy for TNF-inhibitors in psoriatic arthritis and axial spondyloarthritis: design of a pragmatic open-label, randomised, non-inferiority trial","publication_year":2020,"publication_date":"2020-01-15","ids":{"openalex":"https://openalex.org/W3000405276","doi":"https://doi.org/10.1186/s13063-019-4000-5","mag":"3000405276","pmid":"https://pubmed.ncbi.nlm.nih.gov/31941544","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6964104"},"language":"en","primary_location":{"id":"doi:10.1186/s13063-019-4000-5","doi":"https://doi.org/10.1186/s13063-019-4000-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13063-019-4000-5","pdf_url":"https://trialsjournal.biomedcentral.com/track/pdf/10.1186/s13063-019-4000-5","source":{"id":"https://openalex.org/S109512841","display_name":"Trials","issn_l":"1745-6215","issn":["1745-6215"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trials","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://trialsjournal.biomedcentral.com/track/pdf/10.1186/s13063-019-4000-5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076760427","display_name":"Celia A J Michielsens","orcid":"https://orcid.org/0000-0001-8625-034X","observed_orcids":["https://orcid.org/0000-0001-8625-034X"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]},{"id":"https://openalex.org/I4210134551","display_name":"Sint Maartenskliniek","ror":"https://ror.org/0454gfp30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210134551"]},{"id":"https://openalex.org/I4405268322","display_name":"Radboud Institute for Health Sciences","ror":"https://ror.org/00k5r1z23","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4405268322"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Celia A. J. Michielsens","raw_affiliation_strings":["Department of Rheumatic Diseases, Radboud Institute of Health Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands. c.michielsens@maartenskliniek.nl","Department of Rheumatology, Sint Maartenskliniek, Hengstdal 3, 6574 NA, Nijmegen, The Netherlands. c.michielsens@maartenskliniek.nl","Department of Rheumatic Diseases, Radboud Institute of Health Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands","Department of Rheumatology, Sint Maartenskliniek, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatic Diseases, Radboud Institute of Health Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands. c.michielsens@maartenskliniek.nl","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I2802934949","https://openalex.org/I4405268322"]},{"raw_affiliation_string":"Department of Rheumatology, Sint Maartenskliniek, Hengstdal 3, 6574 NA, Nijmegen, The Netherlands. c.michielsens@maartenskliniek.nl","institution_ids":["https://openalex.org/I4210134551"]},{"raw_affiliation_string":"Department of Rheumatic Diseases, Radboud Institute of Health Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I2802934949","https://openalex.org/I4405268322"]},{"raw_affiliation_string":"Department of Rheumatology, Sint Maartenskliniek, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I4210134551"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039728225","display_name":"Nadine Boers","orcid":"https://orcid.org/0000-0002-0873-6405","observed_orcids":["https://orcid.org/0000-0002-0873-6405"]},"institutions":[{"id":"https://openalex.org/I4210134551","display_name":"Sint Maartenskliniek","ror":"https://ror.org/0454gfp30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210134551"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Nadine Boers","raw_affiliation_strings":["Department of Rheumatology, Sint Maartenskliniek, Hengstdal 3, 6574 NA, Nijmegen, The Netherlands","Department of Rheumatology, Sint Maartenskliniek, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Sint Maartenskliniek, Hengstdal 3, 6574 NA, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I4210134551"]},{"raw_affiliation_string":"Department of Rheumatology, Sint Maartenskliniek, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I4210134551"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090181676","display_name":"Nathan den Broeder","orcid":"https://orcid.org/0000-0001-7126-2209","observed_orcids":["https://orcid.org/0000-0001-7126-2209"]},"institutions":[{"id":"https://openalex.org/I4210134551","display_name":"Sint Maartenskliniek","ror":"https://ror.org/0454gfp30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210134551"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Nathan den Broeder","raw_affiliation_strings":["Department of Rheumatology, Sint Maartenskliniek, Hengstdal 3, 6574 NA, Nijmegen, The Netherlands","Department of Rheumatology, Sint Maartenskliniek, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Sint Maartenskliniek, Hengstdal 3, 6574 NA, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I4210134551"]},{"raw_affiliation_string":"Department of Rheumatology, Sint Maartenskliniek, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I4210134551"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039757915","display_name":"Mark H. Wenink","orcid":"https://orcid.org/0000-0002-0088-4155","observed_orcids":["https://orcid.org/0000-0002-0088-4155"]},"institutions":[{"id":"https://openalex.org/I4210134551","display_name":"Sint Maartenskliniek","ror":"https://ror.org/0454gfp30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210134551"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Mark H. Wenink","raw_affiliation_strings":["Department of Rheumatology, Sint Maartenskliniek, Hengstdal 3, 6574 NA, Nijmegen, The Netherlands","Department of Rheumatology, Sint Maartenskliniek, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Sint Maartenskliniek, Hengstdal 3, 6574 NA, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I4210134551"]},{"raw_affiliation_string":"Department of Rheumatology, Sint Maartenskliniek, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I4210134551"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066283044","display_name":"Aatke van der Maas","orcid":"https://orcid.org/0000-0002-3855-6763","observed_orcids":["https://orcid.org/0000-0002-3855-6763"]},"institutions":[{"id":"https://openalex.org/I4210134551","display_name":"Sint Maartenskliniek","ror":"https://ror.org/0454gfp30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210134551"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Aatke van der Maas","raw_affiliation_strings":["Department of Rheumatology, Sint Maartenskliniek, Hengstdal 3, 6574 NA, Nijmegen, The Netherlands","Department of Rheumatology, Sint Maartenskliniek, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Sint Maartenskliniek, Hengstdal 3, 6574 NA, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I4210134551"]},{"raw_affiliation_string":"Department of Rheumatology, Sint Maartenskliniek, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I4210134551"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074553278","display_name":"Elien A. M. Mahler","orcid":"https://orcid.org/0000-0002-6833-3157","observed_orcids":["https://orcid.org/0000-0002-6833-3157"]},"institutions":[{"id":"https://openalex.org/I4210134551","display_name":"Sint Maartenskliniek","ror":"https://ror.org/0454gfp30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210134551"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Elien A. M. Mahler","raw_affiliation_strings":["Department of Rheumatology, Sint Maartenskliniek, Hengstdal 3, 6574 NA, Nijmegen, The Netherlands","Department of Rheumatology, Sint Maartenskliniek, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Sint Maartenskliniek, Hengstdal 3, 6574 NA, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I4210134551"]},{"raw_affiliation_string":"Department of Rheumatology, Sint Maartenskliniek, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I4210134551"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027558065","display_name":"Michelle L M Mulder","orcid":"https://orcid.org/0000-0001-5320-5702","observed_orcids":["https://orcid.org/0000-0001-5320-5702"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]},{"id":"https://openalex.org/I4210134551","display_name":"Sint Maartenskliniek","ror":"https://ror.org/0454gfp30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210134551"]},{"id":"https://openalex.org/I4405268322","display_name":"Radboud Institute for Health Sciences","ror":"https://ror.org/00k5r1z23","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4405268322"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Michelle L. M. Mulder","raw_affiliation_strings":["Department of Rheumatic Diseases, Radboud Institute of Health Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands","Department of Rheumatology, Sint Maartenskliniek, Hengstdal 3, 6574 NA, Nijmegen, The Netherlands","Department of Rheumatology, Sint Maartenskliniek, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatic Diseases, Radboud Institute of Health Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I2802934949","https://openalex.org/I4405268322"]},{"raw_affiliation_string":"Department of Rheumatology, Sint Maartenskliniek, Hengstdal 3, 6574 NA, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I4210134551"]},{"raw_affiliation_string":"Department of Rheumatology, Sint Maartenskliniek, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I4210134551"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104506506","display_name":"D\u00e9sir\u00e9e M F M van der Heijde","orcid":"https://orcid.org/0000-0002-5781-158X","observed_orcids":["https://orcid.org/0000-0002-5781-158X"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"D\u00e9sir\u00e9e van der Heijde","raw_affiliation_strings":["Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075230176","display_name":"Frank H J van den Hoogen","orcid":"https://orcid.org/0000-0003-1044-015X","observed_orcids":["https://orcid.org/0000-0003-1044-015X"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]},{"id":"https://openalex.org/I4210134551","display_name":"Sint Maartenskliniek","ror":"https://ror.org/0454gfp30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210134551"]},{"id":"https://openalex.org/I4405268322","display_name":"Radboud Institute for Health Sciences","ror":"https://ror.org/00k5r1z23","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4405268322"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Frank H. J. van den Hoogen","raw_affiliation_strings":["Department of Rheumatic Diseases, Radboud Institute of Health Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands","Department of Rheumatology, Sint Maartenskliniek, Hengstdal 3, 6574 NA, Nijmegen, The Netherlands","Department of Rheumatology, Sint Maartenskliniek, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatic Diseases, Radboud Institute of Health Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I2802934949","https://openalex.org/I4405268322"]},{"raw_affiliation_string":"Department of Rheumatology, Sint Maartenskliniek, Hengstdal 3, 6574 NA, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I4210134551"]},{"raw_affiliation_string":"Department of Rheumatology, Sint Maartenskliniek, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I4210134551"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057545573","display_name":"Lise M Verhoef","orcid":"https://orcid.org/0000-0002-9740-5607","observed_orcids":["https://orcid.org/0000-0002-9740-5607"]},"institutions":[{"id":"https://openalex.org/I4210134551","display_name":"Sint Maartenskliniek","ror":"https://ror.org/0454gfp30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210134551"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Lise M. Verhoef","raw_affiliation_strings":["Department of Rheumatology, Sint Maartenskliniek, Hengstdal 3, 6574 NA, Nijmegen, The Netherlands","Department of Rheumatology, Sint Maartenskliniek, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Sint Maartenskliniek, Hengstdal 3, 6574 NA, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I4210134551"]},{"raw_affiliation_string":"Department of Rheumatology, Sint Maartenskliniek, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I4210134551"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030365370","display_name":"Alfons A den Broeder","orcid":"https://orcid.org/0000-0002-9012-4079","observed_orcids":["https://orcid.org/0000-0002-9012-4079"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]},{"id":"https://openalex.org/I4210134551","display_name":"Sint Maartenskliniek","ror":"https://ror.org/0454gfp30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210134551"]},{"id":"https://openalex.org/I4405268322","display_name":"Radboud Institute for Health Sciences","ror":"https://ror.org/00k5r1z23","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4405268322"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Alfons A. den Broeder","raw_affiliation_strings":["Department of Rheumatic Diseases, Radboud Institute of Health Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands","Department of Rheumatology, Sint Maartenskliniek, Hengstdal 3, 6574 NA, Nijmegen, The Netherlands","Department of Rheumatology, Sint Maartenskliniek, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatic Diseases, Radboud Institute of Health Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I2802934949","https://openalex.org/I4405268322"]},{"raw_affiliation_string":"Department of Rheumatology, Sint Maartenskliniek, Hengstdal 3, 6574 NA, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I4210134551"]},{"raw_affiliation_string":"Department of Rheumatology, Sint Maartenskliniek, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I4210134551"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5076760427"],"corresponding_institution_ids":["https://openalex.org/I145872427","https://openalex.org/I2802934949","https://openalex.org/I4210134551","https://openalex.org/I4405268322"],"apc_list":{"value":2190,"currency":"USD","value_usd":2190},"apc_paid":{"value":2190,"currency":"USD","value_usd":2190},"fwci":3.7644,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.94077292,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"21","issue":"1","first_page":"90","last_page":"90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-necrosis-factor-inhibitors","display_name":"tumor necrosis factor inhibitors","score":0.9269999861717224},{"id":"https://openalex.org/keywords/dose-reduction","display_name":"dose reduction","score":0.7160000205039978},{"id":"https://openalex.org/keywords/drug-withdrawal","display_name":"drug withdrawal","score":0.7919999957084656},{"id":"https://openalex.org/keywords/psoriatic-arthritis","display_name":"psoriatic arthritis","score":0.9089999794960022},{"id":"https://openalex.org/keywords/axial-spondyloarthritis","display_name":"axial spondyloarthritis","score":1.0},{"id":"https://openalex.org/keywords/spondyloarthritis","display_name":"spondyloarthritis","score":0.9399999976158142},{"id":"https://openalex.org/keywords/low-disease-activity","display_name":"low disease activity","score":0.9290000200271606},{"id":"https://openalex.org/keywords/treat-to-target","display_name":"treat-to-target","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9460527896881104},{"id":"https://openalex.org/C2776260265","wikidata":"https://www.wikidata.org/wiki/Q511097","display_name":"Psoriatic arthritis","level":3,"score":0.7587528228759766},{"id":"https://openalex.org/C2776213234","wikidata":"https://www.wikidata.org/wiki/Q28867094","display_name":"Axial spondyloarthritis","level":4,"score":0.6525132656097412},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.5909230709075928},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5367928743362427},{"id":"https://openalex.org/C2780564577","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Psoriasis","level":2,"score":0.5201625823974609},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.49942994117736816},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4663587808609009},{"id":"https://openalex.org/C2778975655","wikidata":"https://www.wikidata.org/wiki/Q420305","display_name":"Ustekinumab","level":4,"score":0.4580456614494324},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.43881431221961975},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.40357327461242676},{"id":"https://openalex.org/C2777402515","wikidata":"https://www.wikidata.org/wiki/Q52849","display_name":"Ankylosing spondylitis","level":2,"score":0.39145752787590027},{"id":"https://openalex.org/C2780132546","wikidata":"https://www.wikidata.org/wiki/Q348260","display_name":"Adalimumab","level":3,"score":0.37366557121276855},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.12131094932556152},{"id":"https://openalex.org/C2778579456","wikidata":"https://www.wikidata.org/wiki/Q2213687","display_name":"Sacroiliitis","level":3,"score":0.10856696963310242}],"mesh":[{"descriptor_ui":"D000068800","descriptor_name":"Etanercept","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000068800","descriptor_name":"Etanercept","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D000068800","descriptor_name":"Etanercept","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000068879","descriptor_name":"Adalimumab","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000068879","descriptor_name":"Adalimumab","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D000068879","descriptor_name":"Adalimumab","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000069285","descriptor_name":"Infliximab","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000069285","descriptor_name":"Infliximab","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D000069285","descriptor_name":"Infliximab","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000074099","descriptor_name":"Equivalence Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000079424","descriptor_name":"Tumor Necrosis Factor Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000079424","descriptor_name":"Tumor Necrosis Factor Inhibitors","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D000079424","descriptor_name":"Tumor Necrosis Factor Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003362","descriptor_name":"Cost-Benefit Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009426","descriptor_name":"Netherlands","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015535","descriptor_name":"Arthritis, Psoriatic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015535","descriptor_name":"Arthritis, Psoriatic","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025241","descriptor_name":"Spondylarthritis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D025241","descriptor_name":"Spondylarthritis","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064792","descriptor_name":"Pragmatic Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1186/s13063-019-4000-5","doi":"https://doi.org/10.1186/s13063-019-4000-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13063-019-4000-5","pdf_url":"https://trialsjournal.biomedcentral.com/track/pdf/10.1186/s13063-019-4000-5","source":{"id":"https://openalex.org/S109512841","display_name":"Trials","issn_l":"1745-6215","issn":["1745-6215"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trials","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6964104","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6964104","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trials","raw_type":"Text"},{"id":"pmid:31941544","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31941544","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trials","raw_type":"Journal Article"},{"id":"pmh:oai:alma.31UKB_LEU:9940743183902711","doi":null,"is_oa":true,"landing_page_url":"https://scholarlypublications.universiteitleiden.nl/handle/1887/3182977","pdf_url":"https://scholarlypublications.universiteitleiden.nl/download/1887/3182977/1?col=81522199330002711","source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Trials, No. 1","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:ru:oai:repository.ubn.ru.nl:2066/217334","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2066/217334","pdf_url":"http://hdl.handle.net/2066/217334","source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Trials, 21","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:lumc:oai:scholarlypublications.universiteitleiden.nl:item_3182977","doi":null,"is_oa":true,"landing_page_url":"https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-019-4000-5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Trials, 21(1). BMC","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:57219f3f31494167bd5e7678b9c9b2fc","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/57219f3f31494167bd5e7678b9c9b2fc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Trials, Vol 21, Iss 1, Pp 1-12 (2020)","raw_type":"article"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/217334","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2066/217334","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:scholarlypublications.universiteitleiden.nl:item_3182977","doi":null,"is_oa":true,"landing_page_url":"https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-019-4000-5","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Trials","raw_type":"Article / Letter to editor"}],"best_oa_location":{"id":"doi:10.1186/s13063-019-4000-5","doi":"https://doi.org/10.1186/s13063-019-4000-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13063-019-4000-5","pdf_url":"https://trialsjournal.biomedcentral.com/track/pdf/10.1186/s13063-019-4000-5","source":{"id":"https://openalex.org/S109512841","display_name":"Trials","issn_l":"1745-6215","issn":["1745-6215"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trials","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.6399999856948853,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Study Protocol","id":"https://openalex.org/study-designs/study-protocol"}],"awards":[{"id":"https://openalex.org/G8119091242","display_name":null,"funder_award_id":"17-3-303","funder_id":"https://openalex.org/F4320323768","funder_display_name":"ReumaNederland"}],"funders":[{"id":"https://openalex.org/F4320323768","display_name":"ReumaNederland","ror":"https://ror.org/05dr3r825"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3000405276.pdf","grobid_xml":"https://content.openalex.org/works/W3000405276.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1596092785","https://openalex.org/W1967769016","https://openalex.org/W2019159305","https://openalex.org/W2048370747","https://openalex.org/W2065974896","https://openalex.org/W2080638211","https://openalex.org/W2087046046","https://openalex.org/W2089211897","https://openalex.org/W2097209079","https://openalex.org/W2097735143","https://openalex.org/W2099148197","https://openalex.org/W2100274712","https://openalex.org/W2114229314","https://openalex.org/W2117085331","https://openalex.org/W2120232065","https://openalex.org/W2149526570","https://openalex.org/W2152740900","https://openalex.org/W2156996668","https://openalex.org/W2194197257","https://openalex.org/W2203272329","https://openalex.org/W2204687884","https://openalex.org/W2205725453","https://openalex.org/W2275338833","https://openalex.org/W2305878652","https://openalex.org/W2529652362","https://openalex.org/W2559865294","https://openalex.org/W2572897530","https://openalex.org/W2589970663","https://openalex.org/W2592960964","https://openalex.org/W2603931856","https://openalex.org/W2613958818","https://openalex.org/W2724955338","https://openalex.org/W2765884068","https://openalex.org/W2787443244","https://openalex.org/W2788828749","https://openalex.org/W2797152416","https://openalex.org/W2811358573","https://openalex.org/W2888808538","https://openalex.org/W2902140242","https://openalex.org/W2911795323","https://openalex.org/W2953002807","https://openalex.org/W2969598066","https://openalex.org/W3044227846","https://openalex.org/W4210984281","https://openalex.org/W4235489476","https://openalex.org/W4239887421","https://openalex.org/W4308769923"],"related_works":["https://openalex.org/W4282914521","https://openalex.org/W4290997450","https://openalex.org/W4412625374","https://openalex.org/W3096253960","https://openalex.org/W6958486906","https://openalex.org/W3202177818","https://openalex.org/W3208927653","https://openalex.org/W3164374358","https://openalex.org/W2472242299","https://openalex.org/W2322289061"],"abstract_inverted_index":{"BACKGROUND:":[0],"Tumour":[1],"necrosis":[2],"factor":[3],"inhibitors":[4],"(TNFi)":[5],"are":[6,74,123,156],"effective":[7],"in":[8,60,70,109,147,182,185,192],"the":[9,95,143,214],"treatment":[10,200,206],"of":[11,44,97,120,135,145,152,166,189,216,225],"patients":[12,38,47,110,146,191],"with":[13,28,103,111,126,172],"spondyloarthritis":[14,22],"(SpA),":[15],"including":[16],"psoriatic":[17],"arthritis":[18,62],"(PsA)":[19],"and":[20,39,58,72,114,128,163,208,211,233,236],"axial":[21],"(axSpA).":[23],"However,":[24,64],"these":[25],"drugs":[26],"come":[27],"some":[29,224],"disadvantages":[30],"such":[31],"as":[32],"adverse":[33],"events,":[34],"practical":[35],"burden":[36],"for":[37],"high":[40],"costs.":[41],"Dose":[42],"optimisation":[43,69,232],"TNFi":[45,67,230],"after":[46,149],"have":[48,129],"reached":[49],"low":[50,136],"disease":[51,99,137,198],"activity":[52],"(LDA)":[53],"has":[54],"been":[55],"shown":[56],"feasible":[57],"safe":[59],"rheumatoid":[61],"(RA).":[63],"data":[65],"on":[66,177,197,229,246],"dose":[68,231],"PsA":[71],"axSpA":[73,115],"scarce,":[75],"especially":[76],"pragmatic,":[77,86],"randomised":[78],"strategy":[79,102],"studies.":[80],"METHODS:":[81],"We":[82],"developed":[83],"an":[84],"investigator-driven,":[85],"open-label,":[87],"randomised,":[88],"controlled,":[89],"non-inferiority":[90],"trial":[91],"(DRESS-PS)":[92],"to":[93,204],"compare":[94],"effects":[96],"a":[98,106,173,178,186],"activity-guided":[100,199],"treat-to-target":[101],"or":[104],"without":[105],"tapering":[107],"attempt":[108],"SpA":[112],"(PsA":[113],"combined),":[116],"\u2265":[117],"16":[118],"years":[119],"age,":[121],"who":[122],"being":[124],"treated":[125],"TNFi,":[127],"had":[130],"at":[131,158],"least":[132],"6":[133],"months":[134,151,165],"activity.":[138],"The":[139],"primary":[140],"outcome":[141],"is":[142],"percentage":[144],"LDA":[148],"12":[150,164],"follow":[153,167],"up.":[154,168],"Patients":[155],"assessed":[157],"baseline,":[159],"3,":[160],"6,":[161],"9,":[162],"Bayesian":[169],"power":[170],"analyses":[171],"weakened":[174],"prior":[175],"based":[176],"similar":[179],"study":[180],"performed":[181],"RA":[183],"resulted":[184],"sample":[187],"size":[188],"95":[190],"total.":[193],"DISCUSSION:":[194],"More":[195],"knowledge":[196],"algorithms":[201],"would":[202],"contribute":[203],"better":[205],"choices":[207,228],"cost":[209],"savings":[210],"potentially":[212],"decrease":[213],"risk":[215],"side":[217],"effects.":[218],"In":[219],"this":[220],"article":[221],"we":[222],"elucidate":[223],"our":[226],"design":[227],"its":[234],"clinical":[235],"methodological":[237],"consequences.":[238],"TRIAL":[239],"REGISTRATION:":[240],"Dutch":[241],"Trial":[242],"Register,":[243],"NL6771.":[244],"Registered":[245],"27":[247],"November":[248],"2018":[249],"(CMO":[250],"NL66181.091.18,":[251],"23":[252],"October":[253],"2018).":[254]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-01-23T00:00:00"}
