{"id":"https://openalex.org/W3000401679","doi":"https://doi.org/10.3390/cancers12010229","title":"RASSF1A Tumour Suppressor: Target the Network for Effective Cancer Therapy","display_name":"RASSF1A Tumour Suppressor: Target the Network for Effective Cancer Therapy","publication_year":2020,"publication_date":"2020-01-17","ids":{"openalex":"https://openalex.org/W3000401679","doi":"https://doi.org/10.3390/cancers12010229","mag":"3000401679","pmid":"https://pubmed.ncbi.nlm.nih.gov/31963420","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7017281"},"language":"en","primary_location":{"id":"doi:10.3390/cancers12010229","doi":"https://doi.org/10.3390/cancers12010229","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/cancers12010229","pdf_url":"https://www.mdpi.com/2072-6694/12/1/229/pdf?version=1579246354","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6694/12/1/229/pdf?version=1579246354","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088061809","display_name":"Lucia Garc\u00eda-Guti\u00e9rrez","orcid":"https://orcid.org/0000-0003-4396-4814","observed_orcids":["https://orcid.org/0000-0003-4396-4814"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Luc\u00eda Garc\u00eda-Guti\u00e9rrez","raw_affiliation_strings":["Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland"],"raw_orcid":"https://orcid.org/0000-0003-4396-4814","affiliations":[{"raw_affiliation_string":"Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011831209","display_name":"Stephanie McKenna","orcid":"https://orcid.org/0000-0002-9627-1416","observed_orcids":["https://orcid.org/0000-0002-9627-1416"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Stephanie McKenna","raw_affiliation_strings":["Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland"],"raw_orcid":"https://orcid.org/0000-0002-9627-1416","affiliations":[{"raw_affiliation_string":"Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036674933","display_name":"Walter K\u00f6lch","orcid":"https://orcid.org/0000-0001-5777-5016","observed_orcids":["https://orcid.org/0000-0001-5777-5016"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Walter Kolch","raw_affiliation_strings":["Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland","School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland","Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland"],"raw_orcid":"https://orcid.org/0000-0001-5777-5016","affiliations":[{"raw_affiliation_string":"Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland","institution_ids":["https://openalex.org/I100930933"]},{"raw_affiliation_string":"School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland","institution_ids":["https://openalex.org/I100930933"]},{"raw_affiliation_string":"Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091893851","display_name":"David Matallanas","orcid":"https://orcid.org/0000-0002-2360-3141","observed_orcids":["https://orcid.org/0000-0002-2360-3141"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"David Matallanas","raw_affiliation_strings":["School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland","Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland"],"raw_orcid":"https://orcid.org/0000-0002-2360-3141","affiliations":[{"raw_affiliation_string":"School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland","institution_ids":["https://openalex.org/I100930933"]},{"raw_affiliation_string":"Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland","institution_ids":["https://openalex.org/I100930933"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5091893851"],"corresponding_institution_ids":["https://openalex.org/I100930933"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2324},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2324},"fwci":0.8318,"has_fulltext":true,"cited_by_count":65,"citation_normalized_percentile":{"value":0.63621859,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"12","issue":"1","first_page":"229","last_page":"229"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.8759999871253967,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.8759999871253967,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.08110000193119049,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rassf1a","display_name":"RASSF1A","score":1.0},{"id":"https://openalex.org/keywords/tumour-suppressor","display_name":"tumour suppressor","score":0.9879999756813049},{"id":"https://openalex.org/keywords/signaling-networks","display_name":"signaling networks","score":0.6869999766349792},{"id":"https://openalex.org/keywords/ras-signaling","display_name":"Ras signaling","score":0.6449999809265137},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9440000057220459},{"id":"https://openalex.org/keywords/death-receptor-signaling","display_name":"death receptor signaling","score":0.8690000176429749},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.875},{"id":"https://openalex.org/keywords/promoter-methylation","display_name":"promoter methylation","score":0.8370000123977661},{"id":"https://openalex.org/keywords/epigenetic-silencing","display_name":"epigenetic silencing","score":0.8650000095367432},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.7379999756813049}],"concepts":[{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.6818041801452637},{"id":"https://openalex.org/C10679952","wikidata":"https://www.wikidata.org/wiki/Q5308937","display_name":"Druggability","level":3,"score":0.6708226799964905},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.6473298072814941},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.592247724533081},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.55026775598526},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5096375942230225},{"id":"https://openalex.org/C39743133","wikidata":"https://www.wikidata.org/wiki/Q3262595","display_name":"Signalling","level":2,"score":0.5005877017974854},{"id":"https://openalex.org/C172512520","wikidata":"https://www.wikidata.org/wiki/Q5768379","display_name":"Hippo signaling pathway","level":3,"score":0.49915051460266113},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49309536814689636},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46575766801834106},{"id":"https://openalex.org/C53645450","wikidata":"https://www.wikidata.org/wiki/Q907093","display_name":"Scaffold protein","level":3,"score":0.44109290838241577},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.42773282527923584},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4012943506240845},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3410959839820862},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.339731365442276},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21244019269943237},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.20612534880638123},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1257973611354828}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3390/cancers12010229","doi":"https://doi.org/10.3390/cancers12010229","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/cancers12010229","pdf_url":"https://www.mdpi.com/2072-6694/12/1/229/pdf?version=1579246354","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},{"id":"pmid:31963420","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31963420","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7017281","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7017281/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers (Basel)","raw_type":"Text"},{"id":"pmh:oai:repositorio.unican.es:10902/39342","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10902/39342","pdf_url":null,"source":{"id":"https://openalex.org/S4306400398","display_name":"UCrea (University of Cantabria)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I13134134","host_organization_name":"Universidad de Cantabria","host_organization_lineage":["https://openalex.org/I13134134"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers, 12(1), 229","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:researchrepository.ucd.ie:10197/11883","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10197/11883","pdf_url":"http://hdl.handle.net/10197/11883","source":{"id":"https://openalex.org/S4306402280","display_name":"Research Repository UCD (University College Dublin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I100930933","host_organization_name":"University College Dublin","host_organization_lineage":["https://openalex.org/I100930933"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:http://www.rian.ie/193312/","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10197/11883","pdf_url":null,"source":{"id":"https://openalex.org/S4306400033","display_name":"Arrow@dit (Dublin Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210144925","host_organization_name":"Technological University Dublin","host_organization_lineage":["https://openalex.org/I4210144925"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal article"}],"best_oa_location":{"id":"doi:10.3390/cancers12010229","doi":"https://doi.org/10.3390/cancers12010229","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/cancers12010229","pdf_url":"https://www.mdpi.com/2072-6694/12/1/229/pdf?version=1579246354","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6036999821662903,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G707061355","display_name":"Deciphering the role of the tumour suppressor LATS1 in melanoma","funder_award_id":"15/CDA/3495","funder_id":"https://openalex.org/F4320320847","funder_display_name":"Science Foundation Ireland"},{"id":"https://openalex.org/G7696909983","display_name":"Overcoming Drug Resistance in Metastatic Malignant Melanoma by Personalizing Treatment","funder_award_id":"14/IA/2395","funder_id":"https://openalex.org/F4320320847","funder_display_name":"Science Foundation Ireland"}],"funders":[{"id":"https://openalex.org/F4320320847","display_name":"Science Foundation Ireland","ror":"https://ror.org/0271asj38"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3000401679.pdf","grobid_xml":"https://content.openalex.org/works/W3000401679.grobid-xml"},"referenced_works_count":148,"referenced_works":["https://openalex.org/W834352309","https://openalex.org/W1216130577","https://openalex.org/W1505937832","https://openalex.org/W1522146999","https://openalex.org/W1603787733","https://openalex.org/W1900913687","https://openalex.org/W1908943485","https://openalex.org/W1963822977","https://openalex.org/W1968910405","https://openalex.org/W1971943164","https://openalex.org/W1973300115","https://openalex.org/W1974894964","https://openalex.org/W1975607775","https://openalex.org/W1977328779","https://openalex.org/W1978173004","https://openalex.org/W1982580402","https://openalex.org/W1986627407","https://openalex.org/W1988314411","https://openalex.org/W1988594157","https://openalex.org/W1989823885","https://openalex.org/W1991982333","https://openalex.org/W1995223671","https://openalex.org/W1997141458","https://openalex.org/W1997719641","https://openalex.org/W2002451376","https://openalex.org/W2006400527","https://openalex.org/W2009376532","https://openalex.org/W2010050096","https://openalex.org/W2010735936","https://openalex.org/W2015151766","https://openalex.org/W2017394727","https://openalex.org/W2021527895","https://openalex.org/W2027928327","https://openalex.org/W2030911097","https://openalex.org/W2030929478","https://openalex.org/W2034059681","https://openalex.org/W2035714616","https://openalex.org/W2036540085","https://openalex.org/W2053741567","https://openalex.org/W2054699746","https://openalex.org/W2056400898","https://openalex.org/W2058795586","https://openalex.org/W2059584939","https://openalex.org/W2064149487","https://openalex.org/W2065402899","https://openalex.org/W2069852571","https://openalex.org/W2071525523","https://openalex.org/W2074127106","https://openalex.org/W2074332692","https://openalex.org/W2076931029","https://openalex.org/W2080701453","https://openalex.org/W2080719056","https://openalex.org/W2085628515","https://openalex.org/W2088985926","https://openalex.org/W2092965322","https://openalex.org/W2093497966","https://openalex.org/W2095169768","https://openalex.org/W2096217287","https://openalex.org/W2097749880","https://openalex.org/W2098045211","https://openalex.org/W2102424174","https://openalex.org/W2103007980","https://openalex.org/W2103986437","https://openalex.org/W2106401943","https://openalex.org/W2109050076","https://openalex.org/W2110657916","https://openalex.org/W2111836054","https://openalex.org/W2116117209","https://openalex.org/W2116168071","https://openalex.org/W2116739152","https://openalex.org/W2117904693","https://openalex.org/W2118055059","https://openalex.org/W2121447815","https://openalex.org/W2123027753","https://openalex.org/W2124769674","https://openalex.org/W2126666661","https://openalex.org/W2129627831","https://openalex.org/W2139180993","https://openalex.org/W2139526606","https://openalex.org/W2143929604","https://openalex.org/W2145272757","https://openalex.org/W2145658721","https://openalex.org/W2152651939","https://openalex.org/W2154557203","https://openalex.org/W2160232849","https://openalex.org/W2160857438","https://openalex.org/W2161881624","https://openalex.org/W2168713302","https://openalex.org/W2221752800","https://openalex.org/W2222507697","https://openalex.org/W2227031353","https://openalex.org/W2238390617","https://openalex.org/W2239634118","https://openalex.org/W2239775794","https://openalex.org/W2303102647","https://openalex.org/W2334008446","https://openalex.org/W2409603723","https://openalex.org/W2409811112","https://openalex.org/W2415120689","https://openalex.org/W2417387999","https://openalex.org/W2443568108","https://openalex.org/W2508495626","https://openalex.org/W2514724187","https://openalex.org/W2548080267","https://openalex.org/W2559766398","https://openalex.org/W2560067501","https://openalex.org/W2588146665","https://openalex.org/W2620042166","https://openalex.org/W2621361823","https://openalex.org/W2724458594","https://openalex.org/W2745668487","https://openalex.org/W2755649371","https://openalex.org/W2765578024","https://openalex.org/W2765662194","https://openalex.org/W2770149957","https://openalex.org/W2771031544","https://openalex.org/W2775382512","https://openalex.org/W2777367508","https://openalex.org/W2780724631","https://openalex.org/W2785326673","https://openalex.org/W2787611996","https://openalex.org/W2794426141","https://openalex.org/W2799514453","https://openalex.org/W2803877870","https://openalex.org/W2884071522","https://openalex.org/W2895543470","https://openalex.org/W2896097189","https://openalex.org/W2897219865","https://openalex.org/W2897811394","https://openalex.org/W2898104208","https://openalex.org/W2901916819","https://openalex.org/W2911022816","https://openalex.org/W2912286418","https://openalex.org/W2935846858","https://openalex.org/W2944218049","https://openalex.org/W2944702181","https://openalex.org/W2946328073","https://openalex.org/W2946473529","https://openalex.org/W2960418263","https://openalex.org/W2969893943","https://openalex.org/W2970349558","https://openalex.org/W2972575765","https://openalex.org/W2977339607","https://openalex.org/W2981267455","https://openalex.org/W2981986375","https://openalex.org/W2982525163","https://openalex.org/W6631381145","https://openalex.org/W6664575405"],"related_works":["https://openalex.org/W2367336861","https://openalex.org/W2139526606","https://openalex.org/W2088985926","https://openalex.org/W2149432374","https://openalex.org/W2050474151","https://openalex.org/W2960418263","https://openalex.org/W2301486587","https://openalex.org/W2007103582","https://openalex.org/W4414334447","https://openalex.org/W4412392944"],"abstract_inverted_index":{"The":[0,45],"RASSF1A":[1,50,74,103,128,148],"tumour":[2,93],"suppressor":[3],"is":[4,9,51,62,86],"a":[5,25,87,152],"scaffold":[6],"protein":[7,19],"that":[8,17,126,143],"involved":[10],"in":[11,58,115,159],"cell":[12],"signalling.":[13],"Increasing":[14],"evidence":[15,108],"shows":[16],"this":[18,160],"sits":[20],"at":[21],"the":[22,54,98,102,107,110,123,132],"crossroad":[23],"of":[24,33,47,49,53,73,78,81,101,112],"complex":[26,83],"signalling":[27,84,104,136],"network,":[28,85],"which":[29],"includes":[30],"key":[31],"regulators":[32],"cellular":[34],"homeostasis,":[35],"such":[36],"as":[37],"Ras,":[38],"MST2/Hippo,":[39],"p53,":[40],"and":[41,61,106,131,134,150],"death":[42],"receptor":[43],"pathways.":[44],"loss":[46],"expression":[48],"one":[52],"most":[55],"common":[56],"events":[57],"solid":[59],"tumours":[60],"usually":[63],"caused":[64],"by":[65],"gene":[66],"silencing":[67],"through":[68],"DNA":[69],"methylation.":[70],"Thus,":[71],"re-expression":[72],"or":[75],"therapeutic":[76],"targeting":[77],"effector":[79],"modules":[80,100],"its":[82],"promising":[88],"avenue":[89],"for":[90,109,146],"treating":[91],"several":[92],"types.":[94,118],"Here,":[95],"we":[96,121,139],"review":[97],"main":[99],"network":[105,113,161],"effects":[111],"deregulation":[114],"different":[116,141],"cancer":[117,166],"In":[119],"particular,":[120],"summarise":[122],"epigenetic":[124],"mechanism":[125],"mediates":[127],"promoter":[129],"methylation":[130],"Hippo":[133],"RAF1":[135],"modules.":[137],"Finally,":[138],"discuss":[140],"strategies":[142],"are":[144],"described":[145],"re-establishing":[147],"function":[149],"how":[151],"multitargeting":[153],"pathway":[154],"approach":[155],"selecting":[156],"druggable":[157],"nodes":[158],"could":[162],"lead":[163],"to":[164],"new":[165],"treatments.":[167]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2020-01-23T00:00:00"}
