{"id":"https://openalex.org/W3000398809","doi":"https://doi.org/10.1016/j.annonc.2019.10.008","title":"Adverse event profile for immunotherapy agents compared with chemotherapy in solid organ tumors: a systematic review and meta-analysis of randomized clinical trials","display_name":"Adverse event profile for immunotherapy agents compared with chemotherapy in solid organ tumors: a systematic review and meta-analysis of randomized clinical trials","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3000398809","doi":"https://doi.org/10.1016/j.annonc.2019.10.008","mag":"3000398809","pmid":"https://pubmed.ncbi.nlm.nih.gov/31912796"},"language":"en","primary_location":{"id":"doi:10.1016/j.annonc.2019.10.008","doi":"https://doi.org/10.1016/j.annonc.2019.10.008","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.annonc.2019.10.008","pdf_url":null,"source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.annonc.2019.10.008","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045696014","display_name":"Diana Magee","orcid":"https://orcid.org/0000-0002-3948-2057","observed_orcids":["https://orcid.org/0000-0002-3948-2057"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"D.E. Magee","raw_affiliation_strings":["Division of Urology, Department of Surgery, University of Toronto, Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Urology, Department of Surgery, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079367283","display_name":"Amanda Elizabeth Hird","orcid":"https://orcid.org/0000-0002-2549-6079","observed_orcids":["https://orcid.org/0000-0002-2549-6079"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"A.E. Hird","raw_affiliation_strings":["Division of Urology, Department of Surgery, University of Toronto, Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Urology, Department of Surgery, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084068381","display_name":"Zachary William Abraham Klaassen","orcid":"https://orcid.org/0000-0001-7392-8916","observed_orcids":["https://orcid.org/0000-0001-7392-8916"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Z. Klaassen","raw_affiliation_strings":["Division of Urology, Department of Surgery, Medical College of Georgia-Augusta University, Augusta, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Urology, Department of Surgery, Medical College of Georgia-Augusta University, Augusta, USA","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044972820","display_name":"Srikala S. Sridhar","orcid":"https://orcid.org/0000-0002-6994-1285","observed_orcids":["https://orcid.org/0000-0002-6994-1285"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"S.S. Sridhar","raw_affiliation_strings":["Division of Medical Oncology, Department of Internal Medicine, University Health Network, University of Toronto, Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Department of Internal Medicine, University Health Network, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113881350","display_name":"R. K. Nam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1323843004","display_name":"Sunnybrook Health Science Centre","ror":"https://ror.org/03wefcv03","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"R.K. Nam","raw_affiliation_strings":["Division of Urology, Department of Surgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Urology, Department of Surgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I1323843004","https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090167552","display_name":"Christopher J. D. Wallis","orcid":"https://orcid.org/0000-0002-5990-4026","observed_orcids":["https://orcid.org/0000-0002-5990-4026"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"C.J.D. Wallis","raw_affiliation_strings":["Division of Urology, Department of Surgery, University of Toronto, Toronto, Canada; Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, USA","Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, USA","Division of Urology, Department of Surgery, University of Toronto, Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Urology, Department of Surgery, University of Toronto, Toronto, Canada; Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, USA","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, USA","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Division of Urology, Department of Surgery, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018908850","display_name":"Girish S. Kulkarni","orcid":"https://orcid.org/0000-0002-6929-6124","observed_orcids":["https://orcid.org/0000-0002-6929-6124"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"G.S. Kulkarni","raw_affiliation_strings":["Division of Urology, Department of Surgery, University Health Network, University of Toronto, Toronto, Canada. Electronic address: Girish.Kulkarni@uhn.ca","Division of Urology, Department of Surgery, University Health Network, University of Toronto, Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Urology, Department of Surgery, University Health Network, University of Toronto, Toronto, Canada. Electronic address: Girish.Kulkarni@uhn.ca","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750"]},{"raw_affiliation_string":"Division of Urology, Department of Surgery, University Health Network, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5018908850"],"corresponding_institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750"],"apc_list":{"value":2528,"currency":"USD","value_usd":2528},"apc_paid":null,"fwci":3.1156,"has_fulltext":false,"cited_by_count":175,"citation_normalized_percentile":{"value":0.94568817,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"31","issue":"1","first_page":"50","last_page":"60"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.8650000095367432},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.8040000200271606},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.7770000100135803},{"id":"https://openalex.org/keywords/solid-organ-tumors","display_name":"solid organ cancer","score":0.8180000185966492},{"id":"https://openalex.org/keywords/ctla-4-inhibitors","display_name":"CTLA-4 inhibitors","score":0.921999990940094},{"id":"https://openalex.org/keywords/pd-1-inhibitors","display_name":"PD-1 inhibitors","score":0.9819999933242798},{"id":"https://openalex.org/keywords/pd-l1-inhibitors","display_name":"PD-L1 inhibitors","score":0.9850000143051147},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.6489999890327454},{"id":"https://openalex.org/keywords/treatment-discontinuation","display_name":"treatment discontinuation","score":0.6919999718666077},{"id":"https://openalex.org/keywords/immune-related-adverse-events","display_name":"immune-related adverse events","score":0.7269999980926514},{"id":"https://openalex.org/keywords/pneumonitis","display_name":"pneumonitis","score":0.7360000014305115},{"id":"https://openalex.org/keywords/colitis","display_name":"colitis","score":0.9700000286102295},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.8059999942779541},{"id":"https://openalex.org/keywords/hypothyroidism","display_name":"hypothyroidism","score":0.8759999871253967},{"id":"https://openalex.org/keywords/fatigue","display_name":"fatigue","score":0.8399999737739563},{"id":"https://openalex.org/keywords/diarrhea","display_name":"diarrhea","score":0.9639999866485596},{"id":"https://openalex.org/keywords/advanced-cancer","display_name":"advanced cancer","score":0.42899999022483826},{"id":"https://openalex.org/keywords/treatment-safety-comparison","display_name":"treatment safety comparison","score":0.4909999966621399},{"id":"https://openalex.org/keywords/immunotherapy-versus-chemotherapy","display_name":"immunotherapy versus chemotherapy","score":0.3089999854564667}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9430129528045654},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7283744812011719},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6008340120315552},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5176251530647278},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.4599124789237976},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.4443260133266449},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.4233753979206085},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.41841238737106323},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.415530800819397},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3922322392463684},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.19937589764595032},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12989464402198792},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.annonc.2019.10.008","doi":"https://doi.org/10.1016/j.annonc.2019.10.008","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.annonc.2019.10.008","pdf_url":null,"source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},{"id":"pmid:31912796","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31912796","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of oncology : official journal of the European Society for Medical Oncology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.annonc.2019.10.008","doi":"https://doi.org/10.1016/j.annonc.2019.10.008","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.annonc.2019.10.008","pdf_url":null,"source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1809627231","https://openalex.org/W1810964460","https://openalex.org/W2044389879","https://openalex.org/W2082158071","https://openalex.org/W2092018061","https://openalex.org/W2098923148","https://openalex.org/W2104347254","https://openalex.org/W2112121482","https://openalex.org/W2128035403","https://openalex.org/W2134047636","https://openalex.org/W2136746908","https://openalex.org/W2156353875","https://openalex.org/W2198093519","https://openalex.org/W2265285917","https://openalex.org/W2293531514","https://openalex.org/W2468996569","https://openalex.org/W2527905628","https://openalex.org/W2529484692","https://openalex.org/W2554828182","https://openalex.org/W2567564314","https://openalex.org/W2588916311","https://openalex.org/W2598424499","https://openalex.org/W2605367713","https://openalex.org/W2625652544","https://openalex.org/W2635951006","https://openalex.org/W2736166064","https://openalex.org/W2765432649","https://openalex.org/W2777192533","https://openalex.org/W2797675588","https://openalex.org/W2806614796","https://openalex.org/W2883552436","https://openalex.org/W2893602866","https://openalex.org/W2903493423","https://openalex.org/W2908684819","https://openalex.org/W2908914600","https://openalex.org/W2925446385","https://openalex.org/W2940759533","https://openalex.org/W2991792334"],"related_works":["https://openalex.org/W3005456302","https://openalex.org/W2768499948","https://openalex.org/W3168161180","https://openalex.org/W3153591481","https://openalex.org/W2891948100","https://openalex.org/W2986986359","https://openalex.org/W4391349928","https://openalex.org/W4393006128","https://openalex.org/W4386594839","https://openalex.org/W4240446558"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":15},{"year":2025,"cited_by_count":26},{"year":2024,"cited_by_count":26},{"year":2023,"cited_by_count":28},{"year":2022,"cited_by_count":27},{"year":2021,"cited_by_count":38},{"year":2020,"cited_by_count":15}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-01-23T00:00:00"}
