{"id":"https://openalex.org/W3000352784","doi":"https://doi.org/10.1016/j.jalz.2018.06.2184","title":"IC\u2010P\u2010118: TAU PATHOLOGY AND STRUCTURAL BRAIN CHANGES IN AGING","display_name":"IC\u2010P\u2010118: TAU PATHOLOGY AND STRUCTURAL BRAIN CHANGES IN AGING","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W3000352784","doi":"https://doi.org/10.1016/j.jalz.2018.06.2184","mag":"3000352784"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2018.06.2184","doi":"https://doi.org/10.1016/j.jalz.2018.06.2184","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2018.06.2184","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020383216","display_name":"Leonardino A. Digma","orcid":"https://orcid.org/0000-0003-0854-6609","observed_orcids":["https://orcid.org/0000-0003-0854-6609"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Leonardino A. Digma","raw_affiliation_strings":["University of California, San Diego, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109406992","display_name":"Barbara E. Spencer","orcid":"https://orcid.org/0000-0002-1685-2967","observed_orcids":["https://orcid.org/0000-0002-1685-2967"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara E. Spencer","raw_affiliation_strings":["University of California, San Diego, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076826262","display_name":"Hauke Bartsch","orcid":"https://orcid.org/0000-0003-1486-4128","observed_orcids":["https://orcid.org/0000-0003-1486-4128"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hauke Bartsch","raw_affiliation_strings":["University of California, San Diego, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017692684","display_name":"Dominic Holland","orcid":"https://orcid.org/0000-0002-0565-5298","observed_orcids":["https://orcid.org/0000-0002-0565-5298"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dominic Holland","raw_affiliation_strings":["University of California, San Diego, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087626511","display_name":"Anders Martin Dale","orcid":"https://orcid.org/0000-0002-6126-2966","observed_orcids":["https://orcid.org/0000-0002-6126-2966"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anders M. Dale","raw_affiliation_strings":["University of California, San Diego, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107908519","display_name":"James B. Brewer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James B. Brewer","raw_affiliation_strings":["University of California San Diego, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5020383216"],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.32135164,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"7S_Part_2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8906000256538391,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8906000256538391,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.10679999738931656,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tau-pathology","display_name":"tau pathology","score":0.9869999885559082}],"concepts":[{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.607890248298645},{"id":"https://openalex.org/C2780715579","wikidata":"https://www.wikidata.org/wiki/Q2603645","display_name":"Entorhinal cortex","level":3,"score":0.5885086059570312},{"id":"https://openalex.org/C54170458","wikidata":"https://www.wikidata.org/wiki/Q663554","display_name":"Voxel","level":2,"score":0.5720304250717163},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.5610405206680298},{"id":"https://openalex.org/C3017833866","wikidata":"https://www.wikidata.org/wiki/Q2397106","display_name":"Tau pathology","level":4,"score":0.5247355103492737},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.437956839799881},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3949083387851715},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.36550337076187134},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2793594300746918},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.24812030792236328},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.24212777614593506},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.22243034839630127},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.1392461061477661},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2018.06.2184","doi":"https://doi.org/10.1016/j.jalz.2018.06.2184","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2018.06.2184","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2897338019","https://openalex.org/W2533666394","https://openalex.org/W4234193659","https://openalex.org/W2896639749","https://openalex.org/W3000467265","https://openalex.org/W2765356700","https://openalex.org/W2765097167","https://openalex.org/W2617162028","https://openalex.org/W4241787318","https://openalex.org/W2971871890"],"abstract_inverted_index":{"There":[0],"is":[1,8,291,449,478],"ample":[2],"evidence":[3,443],"that":[4,72,103,312,330,447,455,480,491],"suggests":[5],"tau":[6,23,437,448],"pathology":[7,24,115],"spatially":[9],"and":[10,29,61,107,130,164,186,196,214,235,272,338,376,404,438,454,469,493],"temporally":[11],"tied":[12,451],"to":[13,78,125,137,178,263,267,336,413,425,452],"neurodegeneration.":[14],"In":[15,297,306],"this":[16,501],"study,":[17],"we":[18,66,310],"assessed":[19],"the":[20,55,68,79,126,141,157,180,247,264,287,307,325,331,362,434,445,474],"relationship":[21,181,399,435],"between":[22,90,109,182,400,436],"(as":[25,32],"measured":[26,33],"by":[27,34,135,152],"AV1451-PET)":[28],"longitudinal":[30,83,187,494],"atrophy":[31,188],"serial":[35,58],"structural":[36,458],"MRI).":[37],"We":[38],"examined":[39],"61":[40],"cognitively":[41],"normal":[42],"older":[43],"adults":[44],"(age":[45],"=":[46,52,92],"73.8\u00b15.9":[47],"years,":[48],"N=32":[49],"females,":[50],"MMSE":[51],"29.1\u00b11.0)":[53],"from":[54,156,384],"ADNI":[56],"with":[57,97,223,318,421,431],"MRI":[59,70,87,128,218,266,495],"data":[60,212],"an":[62,269,303,397],"AV1451-PET":[63,120,492],"scan.":[64],"First,":[65],"identified":[67],"two":[69,86,110],"scans":[71,88,121,219],"were":[73,95,122,133,200,316,334,359],"acquired":[74],"closest":[75,127,265],"in":[76,140,174,250,361,392,433,463,499],"proximity":[77],"AV1451-PET.":[80],"To":[81],"measure":[82],"atrophy,":[84],"these":[85],"(delay":[89],"MRIs":[91],"1.8\u00b10.6":[93],"years)":[94],"processed":[96],"Quarc,":[98],"a":[99,146,274,300,422],"nonlinear":[100],"registration":[101],"method":[102],"estimates":[104,226],"voxel-level":[105,227],"expansions":[106],"shrinkages":[108],"timepoints":[111],"(Figure":[112,168,344],"1a).":[113],"Tau":[114],"was":[116,150,176],"estimated":[117],"as":[118,233,240,466],"follows.":[119],"first":[123],"registered":[124,222],"scan":[129],"SUVr":[131,154,270],"images":[132,260],"generated":[134,383],"normalizing":[136],"mean":[138],"uptake":[139],"cerebellar":[142],"grey":[143],"matter.":[144],"Then,":[145],"summary":[147,183,294,401],"AV1451":[148,184,276,295,314,402,410],"score":[149,185,403,411],"derived":[151],"averaging":[153],"values":[155,230,237,395],"amygdala,":[158],"entorhinal,":[159],"parahippocampal,":[160],"fusiform,":[161],"inferior":[162,337,368,378],"temporal,":[163,369,372,375],"middle":[165,371],"temporal":[166,342],"regions":[167],"1b).":[169],"Surface-based":[170],"GLM":[171,255],"analysis":[172],"(implemented":[173],"FreeSurfer)":[175],"performed":[177],"assess":[179,426],"at":[189],"each":[190,284,298],"vertex,":[191],"while":[192],"correcting":[193],"for":[194,202,211,252,348,444,482],"age":[195],"sex.":[197],"These":[198,440],"analyses":[199],"corrected":[201],"multiple":[203,349],"comparisons":[204],"using":[205],"Monte":[206],"Carlo":[207],"simulation":[208],"methods.":[209],"Schematic":[210],"processing":[213],"analysis,":[215,309],"a)":[216],"Two":[217],"are":[220,231,238,244,261,391,419],"nonlinearly":[221],"QUARC,":[224],"which":[225],"deformation.":[228],"Negative":[229,394],"interpreted":[232,239],"shrinkage":[234],"positive":[236],"expansion.":[241],"Deformation":[242],"maps":[243,328,382,418],"projected":[245],"onto":[246,293],"cortical":[248],"surface":[249,253,327,381,417],"preparation":[251],"vertex-level":[254,405],"analysis.":[256,282,389],"b)":[257],"Preprocessed":[258],"PET":[259],"coregistered":[262],"generate":[268],"image,":[271],"subsequently":[273],"\u201csummary":[275],"score\u201d,":[277],"c)":[278],"Visualization":[279],"of":[280,324,341],"statistical":[281,326],"At":[283],"vertex":[285],"on":[286],"surface,":[288],"Quarc":[289,406],"deformation":[290,407],"regressed":[292],"score.":[296],"plot,":[299],"point":[301],"denotes":[302],"individual":[304],"subject.":[305],"surface-based":[308],"observed":[311],"higher":[313,409],"scores":[315],"associated":[317],"more":[319,414],"severe":[320],"atrophy.":[321,439],"Visual":[322],"inspection":[323],"revealed":[329],"strongest":[332],"effects":[333],"localized":[335],"lateral":[339],"portions":[340],"cortex":[343],"2).":[345],"After":[346],"correction":[347],"comparisons,":[350],"significant":[351,428],"clusters":[352,429],"(vertex-wise":[353],"threshold":[354,424],"p<0.0001,":[355],"cluster-wise":[356],"threshold,":[357],"p<0.05)":[358],"found":[360],"following":[363],"FreeSurfer":[364],"defined":[365],"regions:":[366],"bilateral":[367],"left":[370,373,377],"superior":[374],"parietal.":[379],"Statistical":[380],"vertex-wise":[385],"general":[386],"linear":[387],"model":[388],"Values":[390],"-log(p)scale.":[393],"indicate":[396],"inverse":[398],"(i.e.":[408],"related":[412],"atrophy).":[415],"Uncorrected":[416],"displayed":[420],"liberal":[423],"both":[427],"along":[430],"trends":[432],"findings":[441],"provide":[442],"hypothesis":[446],"closely":[450],"neurodegeneration":[453],"discernable,":[456],"AD-related":[457],"changes":[459],"predate":[460],"cognitive":[461],"impairment":[462],"AD.":[464],"Further,":[465],"basic":[467],"research":[468],"clinical":[470],"trials":[471],"move":[472],"into":[473],"preclinical":[475],"space,":[476],"it":[477],"imperative":[479],"markers":[481],"imminent":[483],"neurodegenerative":[484],"disease":[485],"become":[486],"available.":[487],"Our":[488],"study":[489],"indicates":[490],"could":[496],"have":[497],"utility":[498],"filling":[500],"need.":[502]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-01-23T00:00:00"}