{"id":"https://openalex.org/W3000326382","doi":"https://doi.org/10.1093/jnen/nlz123","title":"From the Entorhinal Region via the Prosubiculum to the Dentate Fascia: Alzheimer Disease-Related Neurofibrillary Changes in the Temporal Allocortex","display_name":"From the Entorhinal Region via the Prosubiculum to the Dentate Fascia: Alzheimer Disease-Related Neurofibrillary Changes in the Temporal Allocortex","publication_year":2020,"publication_date":"2020-01-08","ids":{"openalex":"https://openalex.org/W3000326382","doi":"https://doi.org/10.1093/jnen/nlz123","mag":"3000326382","pmid":"https://pubmed.ncbi.nlm.nih.gov/31913466","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6970449"},"language":"en","primary_location":{"id":"doi:10.1093/jnen/nlz123","doi":"https://doi.org/10.1093/jnen/nlz123","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jnen/nlz123","pdf_url":"https://academic.oup.com/jnen/article-pdf/79/2/163/31888272/nlz123.pdf","source":{"id":"https://openalex.org/S38023437","display_name":"Journal of Neuropathology & Experimental Neurology","issn_l":"0022-3069","issn":["0022-3069","1554-6578"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuropathology &amp; Experimental Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/jnen/article-pdf/79/2/163/31888272/nlz123.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016965073","display_name":"Heiko Braak","orcid":"https://orcid.org/0000-0002-6776-1045","observed_orcids":["https://orcid.org/0000-0002-6776-1045"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Heiko Braak","raw_affiliation_strings":["Department of Neurology, Clinical Neuroanatomy, Center for Biomedical Research, University of Ulm From the , Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Clinical Neuroanatomy, Center for Biomedical Research, University of Ulm From the , Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049320398","display_name":"Kelly Del Tredici","orcid":"https://orcid.org/0000-0002-9130-7838","observed_orcids":["https://orcid.org/0000-0002-9130-7838"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kelly Del Tredici","raw_affiliation_strings":["Department of Neurology, Clinical Neuroanatomy, Center for Biomedical Research, University of Ulm From the , Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Clinical Neuroanatomy, Center for Biomedical Research, University of Ulm From the , Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5016965073"],"corresponding_institution_ids":["https://openalex.org/I196349391"],"apc_list":{"value":5036,"currency":"USD","value_usd":5036},"apc_paid":{"value":5036,"currency":"USD","value_usd":5036},"fwci":1.8985,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.84483533,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"79","issue":"2","first_page":"163","last_page":"175"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neurofibrillary-tangles","display_name":"neurofibrillary tangles","score":0.8640000224113464},{"id":"https://openalex.org/keywords/tau-pathology","display_name":"tau pathology","score":0.8360000252723694},{"id":"https://openalex.org/keywords/dentate-gyrus","display_name":"dentate gyrus","score":0.8320000171661377},{"id":"https://openalex.org/keywords/ca1","display_name":"CA1","score":0.5580000281333923},{"id":"https://openalex.org/keywords/mossy-cells","display_name":"mossy cells","score":0.9549999833106995},{"id":"https://openalex.org/keywords/dentate-granule-cells","display_name":"dentate gyrus granule cells","score":0.8690000176429749},{"id":"https://openalex.org/keywords/projection-neurons","display_name":"projection neurons","score":0.49399998784065247}],"concepts":[{"id":"https://openalex.org/C2781134066","wikidata":"https://www.wikidata.org/wiki/Q5436626","display_name":"Fascia dentata","level":4,"score":0.8880354166030884},{"id":"https://openalex.org/C2780715579","wikidata":"https://www.wikidata.org/wiki/Q2603645","display_name":"Entorhinal cortex","level":3,"score":0.7938882112503052},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6478719711303711},{"id":"https://openalex.org/C2776464000","wikidata":"https://www.wikidata.org/wiki/Q545787","display_name":"Dentate gyrus","level":3,"score":0.5620807409286499},{"id":"https://openalex.org/C2778499278","wikidata":"https://www.wikidata.org/wiki/Q1499420","display_name":"Subiculum","level":4,"score":0.5054922103881836},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.47306859493255615},{"id":"https://openalex.org/C2778888523","wikidata":"https://www.wikidata.org/wiki/Q1777753","display_name":"Granule cell","level":4,"score":0.44791823625564575},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.440043181180954},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.38966426253318787},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16644427180290222}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003712","descriptor_name":"Dendrites","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013702","descriptor_name":"Temporal Lobe","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016874","descriptor_name":"Neurofibrillary Tangles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018728","descriptor_name":"Entorhinal Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018891","descriptor_name":"Dentate Gyrus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/jnen/nlz123","doi":"https://doi.org/10.1093/jnen/nlz123","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jnen/nlz123","pdf_url":"https://academic.oup.com/jnen/article-pdf/79/2/163/31888272/nlz123.pdf","source":{"id":"https://openalex.org/S38023437","display_name":"Journal of Neuropathology & Experimental Neurology","issn_l":"0022-3069","issn":["0022-3069","1554-6578"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuropathology &amp; Experimental Neurology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5924919","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6970449","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6970449","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6970449","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neuropathol Exp Neurol","raw_type":"Text"},{"id":"pmid:31913466","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31913466","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuropathology and experimental neurology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/jnen/nlz123","doi":"https://doi.org/10.1093/jnen/nlz123","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jnen/nlz123","pdf_url":"https://academic.oup.com/jnen/article-pdf/79/2/163/31888272/nlz123.pdf","source":{"id":"https://openalex.org/S38023437","display_name":"Journal of Neuropathology & Experimental Neurology","issn_l":"0022-3069","issn":["0022-3069","1554-6578"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuropathology &amp; Experimental Neurology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320325530","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3000326382.pdf","grobid_xml":"https://content.openalex.org/works/W3000326382.grobid-xml"},"referenced_works_count":93,"referenced_works":["https://openalex.org/W4406892","https://openalex.org/W128037027","https://openalex.org/W160745650","https://openalex.org/W248039357","https://openalex.org/W334027006","https://openalex.org/W581945075","https://openalex.org/W610927360","https://openalex.org/W644076287","https://openalex.org/W1492103690","https://openalex.org/W1496738545","https://openalex.org/W1505548944","https://openalex.org/W1586007354","https://openalex.org/W1595133323","https://openalex.org/W1931319403","https://openalex.org/W1965201584","https://openalex.org/W1967069915","https://openalex.org/W1967823816","https://openalex.org/W1975008037","https://openalex.org/W1983611639","https://openalex.org/W1984827962","https://openalex.org/W1986414879","https://openalex.org/W1987477983","https://openalex.org/W1993023011","https://openalex.org/W1993940897","https://openalex.org/W1997363820","https://openalex.org/W1999627180","https://openalex.org/W2002654771","https://openalex.org/W2002899749","https://openalex.org/W2004347786","https://openalex.org/W2006905953","https://openalex.org/W2009166384","https://openalex.org/W2015563160","https://openalex.org/W2015860144","https://openalex.org/W2022532556","https://openalex.org/W2029978572","https://openalex.org/W2032221178","https://openalex.org/W2035339855","https://openalex.org/W2036362108","https://openalex.org/W2036433997","https://openalex.org/W2044964176","https://openalex.org/W2050665230","https://openalex.org/W2051218719","https://openalex.org/W2053082937","https://openalex.org/W2064029647","https://openalex.org/W2064941657","https://openalex.org/W2066011396","https://openalex.org/W2070455103","https://openalex.org/W2074157272","https://openalex.org/W2077422298","https://openalex.org/W2082429191","https://openalex.org/W2090075805","https://openalex.org/W2091354315","https://openalex.org/W2091856304","https://openalex.org/W2093650784","https://openalex.org/W2095963715","https://openalex.org/W2098666649","https://openalex.org/W2104132043","https://openalex.org/W2107960095","https://openalex.org/W2118267556","https://openalex.org/W2121418448","https://openalex.org/W2126128897","https://openalex.org/W2131478918","https://openalex.org/W2136936410","https://openalex.org/W2137140827","https://openalex.org/W2141532872","https://openalex.org/W2143461767","https://openalex.org/W2145935269","https://openalex.org/W2146714497","https://openalex.org/W2157325548","https://openalex.org/W2160683996","https://openalex.org/W2165589151","https://openalex.org/W2219014187","https://openalex.org/W2265209254","https://openalex.org/W2312387752","https://openalex.org/W2556852663","https://openalex.org/W2761829250","https://openalex.org/W2774235975","https://openalex.org/W2779322228","https://openalex.org/W2799729840","https://openalex.org/W2801191590","https://openalex.org/W2805223445","https://openalex.org/W2810078757","https://openalex.org/W2894216346","https://openalex.org/W2898429141","https://openalex.org/W2913454426","https://openalex.org/W2913909521","https://openalex.org/W2937551627","https://openalex.org/W2946976245","https://openalex.org/W2953558218","https://openalex.org/W2955665659","https://openalex.org/W3022734613","https://openalex.org/W4233622592","https://openalex.org/W6674633644"],"related_works":["https://openalex.org/W3008513830","https://openalex.org/W2810078757","https://openalex.org/W4410695682","https://openalex.org/W2004347786","https://openalex.org/W1976452134","https://openalex.org/W7128449951","https://openalex.org/W2048682879","https://openalex.org/W2149005510","https://openalex.org/W2088079659","https://openalex.org/W2149120283"],"abstract_inverted_index":{"The":[0,187],"pathological":[1],"process":[2],"underlying":[3],"Alzheimer":[4],"disease":[5],"(AD)":[6],"unfolds":[7],"predominantly":[8],"in":[9,59,75,91,107,159],"the":[10,14,28,38,60,82,92,97,108,128,151,160,193],"cerebral":[11],"cortex":[12],"with":[13,116],"gradual":[15],"appearance":[16],"and":[17,31,94,101,112,162,174],"regional":[18],"progression":[19,55,135],"of":[20,37,56,78,81,120,127,140,143],"abnormal":[21,57,64,87,144],"tau.":[22],"Intraneuronal":[23],"tau":[24,58,65,74,145],"pathology":[25],"progresses":[26],"from":[27,146,165,179,192],"temporal":[29,39,61],"transentorhinal":[30],"entorhinal":[32],"regions":[33],"into":[34,96],"neocortical":[35],"fields/areas":[36],"allocortex.":[40,62],"Here,":[41],"based":[42],"on":[43],"95":[44],"cases":[45],"staged":[46],"for":[47],"AD-related":[48],"neurofibrillary":[49],"changes,":[50],"we":[51],"propose":[52],"an":[53],"ordered":[54],"Initially,":[63],"was":[66],"limited":[67],"to":[68,150,156,170,183],"distal":[69,88,157],"dendritic":[70],"segments":[71],"followed":[72],"by":[73],"cell":[76],"bodies":[77],"projection":[79,148],"neurons":[80],"transentorhinal/entorhinal":[83],"layer":[84],"pre-\u03b1.":[85],"Next,":[86],"dendrites":[89,105,158],"accumulated":[90],"prosubiculum":[93,161],"extended":[95],"CA1":[98,166],"stratum":[99,110,113],"oriens":[100,111],"lacunosum.":[102],"Subsequently,":[103],"altered":[104],"developed":[106],"CA2/CA3":[109],"lacunosum-moleculare,":[114],"combined":[115],"tau-positive":[117],"thorny":[118],"excrescences":[119],"CA3/CA4":[121,175],"mossy":[122,176,181],"cells.":[123,186],"Finally,":[124],"granule":[125,185],"cells":[126,155,173,182],"dentate":[129,184],"fascia":[130],"became":[131],"involved.":[132],"Such":[133],"a":[134,138],"might":[136],"recapitulate":[137],"sequence":[139],"transsynaptic":[141],"spreading":[142],"1":[147],"neuron":[149],"next:":[152],"From":[153],"pre-\u03b1":[154],"CA1;":[163],"then,":[164],"or":[167],"prosubicular":[168],"pyramids":[169],"CA2":[171],"principal":[172],"cells;":[177],"finally,":[178],"CA4":[180],"lesions":[188],"are":[189],"additive:":[190],"Those":[191],"previous":[194],"steps":[195],"persist.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-01-23T00:00:00"}
