{"id":"https://openalex.org/W3000311912","doi":"https://doi.org/10.1016/j.jalz.2018.06.1433","title":"P3\u2010077: ALZHEIMER'S DISEASE (AD) POLYGENIC RISK SCORE (PRS) AS A PREDICTOR OF CONVERSION FROM MILD COGNITIVE IMPAIRMENT (MCI)","display_name":"P3\u2010077: ALZHEIMER'S DISEASE (AD) POLYGENIC RISK SCORE (PRS) AS A PREDICTOR OF CONVERSION FROM MILD COGNITIVE IMPAIRMENT (MCI)","publication_year":2018,"publication_date":"2018-07-01","ids":{"openalex":"https://openalex.org/W3000311912","doi":"https://doi.org/10.1016/j.jalz.2018.06.1433","mag":"3000311912"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2018.06.1433","doi":"https://doi.org/10.1016/j.jalz.2018.06.1433","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2018.06.1433","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059367620","display_name":"Sultan Raja Chaudhury","orcid":"https://orcid.org/0009-0004-8914-1316","observed_orcids":["https://orcid.org/0009-0004-8914-1316"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Sultan Raja Chaudhury","raw_affiliation_strings":["University of Nottingham, Nottingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nottingham, Nottingham, United Kingdom","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042523801","display_name":"Tulsi Patel","orcid":"https://orcid.org/0000-0002-2797-1443","observed_orcids":["https://orcid.org/0000-0002-2797-1443"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tulsi Patel","raw_affiliation_strings":["University of Nottingham, Nottingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nottingham, Nottingham, United Kingdom","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034178390","display_name":"Abigail Fallows","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Abigail Fallows","raw_affiliation_strings":["University of Nottingham, Nottingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nottingham, Nottingham, United Kingdom","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076142860","display_name":"Keeley J. Brookes","orcid":"https://orcid.org/0000-0003-2427-2513","observed_orcids":["https://orcid.org/0000-0003-2427-2513"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Keeley J. Brookes","raw_affiliation_strings":["University of Nottingham, Nottingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nottingham, Nottingham, United Kingdom","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064741088","display_name":"Tamar Guetta\u2010Baranes","orcid":"https://orcid.org/0000-0001-5178-0252","observed_orcids":["https://orcid.org/0000-0001-5178-0252"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tamar Guetta-Baranes","raw_affiliation_strings":["University of Nottingham, Nottingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nottingham, Nottingham, United Kingdom","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011954398","display_name":"James C. Turton","orcid":"https://orcid.org/0000-0003-2681-0477","observed_orcids":["https://orcid.org/0000-0003-2681-0477"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James Turton","raw_affiliation_strings":["University of Nottingham, Nottingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nottingham, Nottingham, United Kingdom","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108115792","display_name":"Rebecca Sussams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rebecca Sussams","raw_affiliation_strings":["University of Southampton, Southampton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Southampton, Southampton, United Kingdom","institution_ids":["https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002376486","display_name":"Rita Jo\u00e3o Guerreiro","orcid":"https://orcid.org/0000-0001-5879-3486","observed_orcids":["https://orcid.org/0000-0001-5879-3486"]},"institutions":[{"id":"https://openalex.org/I4210126463","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210126463"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rita Guerreiro","raw_affiliation_strings":["UK Dementia Research Institute at UCL, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UK Dementia Research Institute at UCL, London, United Kingdom","institution_ids":["https://openalex.org/I4210126463","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074083478","display_name":"Jos\u00e9 Br\u00e1s","orcid":"https://orcid.org/0000-0001-8186-0333","observed_orcids":["https://orcid.org/0000-0001-8186-0333"]},"institutions":[{"id":"https://openalex.org/I4210126463","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210126463"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jose T. Bras","raw_affiliation_strings":["UK Dementia Research Institute at UCL, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UK Dementia Research Institute at UCL, London, United Kingdom","institution_ids":["https://openalex.org/I4210126463","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020514779","display_name":"John Hardy","orcid":"https://orcid.org/0000-0002-3122-0423","observed_orcids":["https://orcid.org/0000-0002-3122-0423"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John Hardy","raw_affiliation_strings":["University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051635855","display_name":"Paul T. Francis","orcid":"https://orcid.org/0000-0001-8159-4469","observed_orcids":["https://orcid.org/0000-0001-8159-4469"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul T. Francis","raw_affiliation_strings":["King's College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King's College London, London, United Kingdom","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064532444","display_name":"Clive Holmes","orcid":"https://orcid.org/0000-0003-1999-6912","observed_orcids":["https://orcid.org/0000-0003-1999-6912"]},"institutions":[{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Clive Holmes","raw_affiliation_strings":["University of Southampton, Southampton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Southampton, Southampton, United Kingdom","institution_ids":["https://openalex.org/I43439940"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047373823","display_name":"Kevin Morgan","orcid":"https://orcid.org/0000-0002-8217-2396","observed_orcids":["https://orcid.org/0000-0002-8217-2396"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kevin Morgan","raw_affiliation_strings":["University of Nottingham, Nottingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nottingham, Nottingham, United Kingdom","institution_ids":["https://openalex.org/I142263535"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5059367620"],"corresponding_institution_ids":["https://openalex.org/I142263535"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.31842051,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"7S_Part_20","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.03099999949336052,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9729999899864197},{"id":"https://openalex.org/keywords/mild-cognitive-impairment","display_name":"mild cognitive impairment","score":0.8849999904632568}],"concepts":[{"id":"https://openalex.org/C147021879","wikidata":"https://www.wikidata.org/wiki/Q3027971","display_name":"Decile","level":2,"score":0.6637323498725891},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.5641542673110962},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5623015761375427},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5375217199325562},{"id":"https://openalex.org/C2780292510","wikidata":"https://www.wikidata.org/wiki/Q1140331","display_name":"Prodrome","level":3,"score":0.5111835598945618},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.4717470109462738},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.47078341245651245},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4561213552951813},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.4535263180732727},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.23746007680892944},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.1405661404132843},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1289307177066803},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12536072731018066},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C2779727114","wikidata":"https://www.wikidata.org/wiki/Q170082","display_name":"Psychosis","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2018.06.1433","doi":"https://doi.org/10.1016/j.jalz.2018.06.1433","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2018.06.1433","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2945720997","https://openalex.org/W2765460006","https://openalex.org/W4415583893","https://openalex.org/W2056868456","https://openalex.org/W4312087255","https://openalex.org/W3207398908","https://openalex.org/W4390194717","https://openalex.org/W3113192810","https://openalex.org/W3198441495","https://openalex.org/W2950828186"],"abstract_inverted_index":{"MCI":[0,26,32,72,151,185,266],"occurs":[1],"in":[2,6,220,235],"up":[3],"to":[4,40,52,165,176,200,212,259,270],"one":[5],"five":[7],"individuals":[8,38,58,70,149],"above":[9],"the":[10,14,54,93,103,133,189,221,236,261],"age":[11],"of":[12,21,25,43,57,68,118,135,143,148,264],"65;":[13],"condition":[15],"is":[16],"often":[17],"considered":[18],"a":[19,65,116,272],"prodrome":[20],"dementia":[22],"with":[23,71,150],"10-38%":[24],"diagnoses":[27],"converting;":[28],"most":[29],"retain":[30],"an":[31,161],"diagnosis":[33],"at":[34],"death":[35],"and":[36,61,81,125,158,191,194,203,250,254,267],"some":[37],"revert":[39],"normal":[41],"levels":[42],"cognitive":[44],"ability.":[45],"Polygenic":[46],"risk":[47,56,263],"scores":[48,183],"(PRS)":[49],"were":[50,62,98,130,169,195,252],"calculated":[51,99],"identify":[53,260],"genetic":[55,262],"for":[59,64,111,137,173,184,246,275],"AD":[60,83,174,190,204,213,249],"generated":[63],"target":[66],"dataset":[67,106],"80":[69],"(Southampton":[73],"ICOS":[74],"Study;":[75],"clinically":[76],"diagnosed),":[77],"105":[78],"non-diseased":[79],"controls":[80,177,201,251],"248":[82],"patients":[84,186],"(BDR;":[85],"neuropathology":[86,247],"confirmed).":[87],"All":[88],"genotyping":[89],"was":[90,156],"conducted":[91],"on":[92],"Illumina":[94],"customised":[95],"NeuroChip.":[96],"PRS":[97,136,168,257],"using":[100],"PRSice":[101],"from":[102,115,132],"IGAP":[104],"base":[105],"which":[107,230],"contains":[108],"SNP":[109],"information":[110],"7,055,881":[112],"SNPs":[113],"collated":[114],"meta-analysis":[117],"17,008":[119],"late":[120],"onset":[121],"Alzheimer's":[122],"disease":[123],"cases":[124],"37,154":[126],"controls.":[127],"Decile":[128],"thresholds":[129],"determined":[131],"distribution":[134],"controls,":[138],"forming":[139],"decile":[140],"score":[141,154],"bands":[142],"increasing":[144],"risk.":[145],"The":[146,182,243],"number":[147],"within":[152],"each":[153],"band":[155],"identified,":[157],"this":[159],"permitted":[160],"odds":[162],"ratio":[163],"(OR)":[164],"be":[166,180,271],"determined.":[167],"significantly":[170,196,215],"higher":[171,217],"(P<0.0001)":[172],"compared":[175,199],"as":[178],"would":[179],"expected.":[181],"lay":[187],"between":[188],"control":[192],"groups":[193],"different":[197],"when":[198],"(P=0.0017)":[202],"(P=0.0023).":[205],"On":[206],"further":[207],"analyses":[208],"MCIs":[209,229],"that":[210],"converted":[211],"had":[214],"(P=0.021)":[216],"OR":[218],"(OR=7.4":[219],"highest":[222],"decile;":[223,238],"range":[224,239],"0.3-7.4,":[225],"mean":[226,241],"3.4)":[227],"than":[228],"did":[231],"not":[232],"convert":[233],"(OR=0.5":[234],"lowest":[237],"0.5-6.2,":[240],"1.9).":[242],"corresponding":[244],"ORs":[245],"confirmed":[248],"6.2":[253],"1":[255],"respectively.":[256],"appears":[258],"developing":[265],"might":[268],"prove":[269],"useful":[273],"marker":[274],"predicting":[276],"conversion.":[277]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-01-23T00:00:00"}
