{"id":"https://openalex.org/W3000299205","doi":"https://doi.org/10.1080/07391102.2019.1709546","title":"Investigating into the molecular interactions of flavonoids targeting NS2B-NS3 protease from ZIKA virus through in-silico approaches","display_name":"Investigating into the molecular interactions of flavonoids targeting NS2B-NS3 protease from ZIKA virus through in-silico approaches","publication_year":2020,"publication_date":"2020-01-10","ids":{"openalex":"https://openalex.org/W3000299205","doi":"https://doi.org/10.1080/07391102.2019.1709546","mag":"3000299205","pmid":"https://pubmed.ncbi.nlm.nih.gov/31920173"},"language":"en","primary_location":{"id":"doi:10.1080/07391102.2019.1709546","doi":"https://doi.org/10.1080/07391102.2019.1709546","is_oa":false,"landing_page_url":"https://doi.org/10.1080/07391102.2019.1709546","pdf_url":null,"source":{"id":"https://openalex.org/S178711970","display_name":"Journal of Biomolecular Structure and Dynamics","issn_l":"0739-1102","issn":["0739-1102","1538-0254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomolecular Structure and Dynamics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075643135","display_name":"Rakhi Yadav","orcid":"https://orcid.org/0000-0002-3913-4669","observed_orcids":["https://orcid.org/0000-0002-3913-4669"]},"institutions":[{"id":"https://openalex.org/I9579091","display_name":"Indian Institute of Technology Mandi","ror":"https://ror.org/05r9r2f34","country_code":"IN","type":"education","lineage":["https://openalex.org/I9579091"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rakhi Yadav","raw_affiliation_strings":["School of Basic Science, Indian Institute of Technology Mandi, Mandi, India;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Science, Indian Institute of Technology Mandi, Mandi, India;","institution_ids":["https://openalex.org/I9579091"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016686816","display_name":"Chandrabose Selvaraj","orcid":"https://orcid.org/0000-0002-8115-0486","observed_orcids":["https://orcid.org/0000-0002-8115-0486"]},"institutions":[{"id":"https://openalex.org/I131155284","display_name":"Alagappa University","ror":"https://ror.org/04ec9cc06","country_code":"IN","type":"education","lineage":["https://openalex.org/I131155284"]},{"id":"https://openalex.org/I9579091","display_name":"Indian Institute of Technology Mandi","ror":"https://ror.org/05r9r2f34","country_code":"IN","type":"education","lineage":["https://openalex.org/I9579091"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Chandrabose Selvaraj","raw_affiliation_strings":["Department of Bioinformatics, Computer Aided Drug Design and Molecular Modeling Lab, Alagappa University, Karaikudi, India","School of Basic Science, Indian Institute of Technology Mandi, Mandi, India;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Computer Aided Drug Design and Molecular Modeling Lab, Alagappa University, Karaikudi, India","institution_ids":["https://openalex.org/I131155284"]},{"raw_affiliation_string":"School of Basic Science, Indian Institute of Technology Mandi, Mandi, India;","institution_ids":["https://openalex.org/I9579091"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049721522","display_name":"Murali Aarthy","orcid":"https://orcid.org/0000-0002-8777-9998","observed_orcids":["https://orcid.org/0000-0002-8777-9998"]},"institutions":[{"id":"https://openalex.org/I131155284","display_name":"Alagappa University","ror":"https://ror.org/04ec9cc06","country_code":"IN","type":"education","lineage":["https://openalex.org/I131155284"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Murali Aarthy","raw_affiliation_strings":["Department of Bioinformatics, Computer Aided Drug Design and Molecular Modeling Lab, Alagappa University, Karaikudi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Computer Aided Drug Design and Molecular Modeling Lab, Alagappa University, Karaikudi, India","institution_ids":["https://openalex.org/I131155284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011017617","display_name":"Prateek Kumar","orcid":"https://orcid.org/0000-0001-7392-5045","observed_orcids":["https://orcid.org/0000-0001-7392-5045"]},"institutions":[{"id":"https://openalex.org/I9579091","display_name":"Indian Institute of Technology Mandi","ror":"https://ror.org/05r9r2f34","country_code":"IN","type":"education","lineage":["https://openalex.org/I9579091"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Prateek Kumar","raw_affiliation_strings":["School of Basic Science, Indian Institute of Technology Mandi, Mandi, India;"],"raw_orcid":"https://orcid.org/0000-0001-7392-5045","affiliations":[{"raw_affiliation_string":"School of Basic Science, Indian Institute of Technology Mandi, Mandi, India;","institution_ids":["https://openalex.org/I9579091"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029687882","display_name":"Ankur Kumar","orcid":"https://orcid.org/0000-0002-4535-5783","observed_orcids":["https://orcid.org/0000-0002-4535-5783","https://orcid.org/0000-0001-5733-8334"]},"institutions":[{"id":"https://openalex.org/I9579091","display_name":"Indian Institute of Technology Mandi","ror":"https://ror.org/05r9r2f34","country_code":"IN","type":"education","lineage":["https://openalex.org/I9579091"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ankur Kumar","raw_affiliation_strings":["School of Basic Science, Indian Institute of Technology Mandi, Mandi, India;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Science, Indian Institute of Technology Mandi, Mandi, India;","institution_ids":["https://openalex.org/I9579091"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054825291","display_name":"Sanjeev Kumar Singh","orcid":"https://orcid.org/0000-0003-4153-6437","observed_orcids":["https://orcid.org/0000-0003-4153-6437","https://orcid.org/0000-0001-8001-3802"]},"institutions":[{"id":"https://openalex.org/I131155284","display_name":"Alagappa University","ror":"https://ror.org/04ec9cc06","country_code":"IN","type":"education","lineage":["https://openalex.org/I131155284"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sanjeev Kumar Singh","raw_affiliation_strings":["Department of Bioinformatics, Computer Aided Drug Design and Molecular Modeling Lab, Alagappa University, Karaikudi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Computer Aided Drug Design and Molecular Modeling Lab, Alagappa University, Karaikudi, India","institution_ids":["https://openalex.org/I131155284"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068982877","display_name":"Rajanish Giri","orcid":"https://orcid.org/0000-0002-2046-836X","observed_orcids":["https://orcid.org/0000-0002-2046-836X"]},"institutions":[{"id":"https://openalex.org/I9579091","display_name":"Indian Institute of Technology Mandi","ror":"https://ror.org/05r9r2f34","country_code":"IN","type":"education","lineage":["https://openalex.org/I9579091"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Rajanish Giri","raw_affiliation_strings":["School of Basic Science, Indian Institute of Technology Mandi, Mandi, India;"],"raw_orcid":"https://orcid.org/0000-0002-2046-836X","affiliations":[{"raw_affiliation_string":"School of Basic Science, Indian Institute of Technology Mandi, Mandi, India;","institution_ids":["https://openalex.org/I9579091"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5068982877"],"corresponding_institution_ids":["https://openalex.org/I9579091"],"apc_list":null,"apc_paid":null,"fwci":1.9282,"has_fulltext":false,"cited_by_count":75,"citation_normalized_percentile":{"value":0.8737017,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"39","issue":"1","first_page":"272","last_page":"284"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.8467000126838684,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.8467000126838684,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.11829999834299088,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zika-virus","display_name":"Zika virus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ns2b-ns3-protease","display_name":"NS2B-NS3 protease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.9139999747276306},{"id":"https://openalex.org/keywords/protease-inhibitors","display_name":"protease inhibitors","score":0.7720000147819519},{"id":"https://openalex.org/keywords/epigallocatechin-gallate","display_name":"epigallocatechin gallate","score":0.8159999847412109},{"id":"https://openalex.org/keywords/isoquercitrin","display_name":"isoquercitrin","score":0.9729999899864197},{"id":"https://openalex.org/keywords/rutin","display_name":"rutin","score":1.0},{"id":"https://openalex.org/keywords/catalytic-triad","display_name":"catalytic triad","score":0.9940000176429749},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.6949999928474426},{"id":"https://openalex.org/keywords/molecular-dynamics-simulation","display_name":"molecular dynamics simulation","score":0.921999990940094},{"id":"https://openalex.org/keywords/antiviral-drug-candidates","display_name":"antiviral drug candidates","score":0.734000027179718},{"id":"https://openalex.org/keywords/flavivirus","display_name":"flavivirus","score":0.9210000038146973}],"concepts":[{"id":"https://openalex.org/C2777053367","wikidata":"https://www.wikidata.org/wiki/Q202864","display_name":"Zika virus","level":3,"score":0.8527958393096924},{"id":"https://openalex.org/C132379496","wikidata":"https://www.wikidata.org/wiki/Q83141645","display_name":"NS3","level":4,"score":0.8340731263160706},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.7123218774795532},{"id":"https://openalex.org/C2780568436","wikidata":"https://www.wikidata.org/wiki/Q1165479","display_name":"Flavivirus","level":3,"score":0.6102715730667114},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6049663424491882},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.578235387802124},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5086761116981506},{"id":"https://openalex.org/C2779635636","wikidata":"https://www.wikidata.org/wiki/Q476209","display_name":"Dengue virus","level":3,"score":0.48889365792274475},{"id":"https://openalex.org/C2777510210","wikidata":"https://www.wikidata.org/wiki/Q1331256","display_name":"Flaviviridae","level":4,"score":0.4255196750164032},{"id":"https://openalex.org/C145770059","wikidata":"https://www.wikidata.org/wiki/Q751908","display_name":"Catalytic triad","level":4,"score":0.4222533702850342},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.38455796241760254},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.24478396773338318},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.2300226390361786},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1761825680732727},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.12015843391418457},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071243","descriptor_name":"Zika Virus Infection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000071244","descriptor_name":"Zika Virus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010447","descriptor_name":"Peptide Hydrolases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011480","descriptor_name":"Protease Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/07391102.2019.1709546","doi":"https://doi.org/10.1080/07391102.2019.1709546","is_oa":false,"landing_page_url":"https://doi.org/10.1080/07391102.2019.1709546","pdf_url":null,"source":{"id":"https://openalex.org/S178711970","display_name":"Journal of Biomolecular Structure and Dynamics","issn_l":"0739-1102","issn":["0739-1102","1538-0254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomolecular Structure and Dynamics","raw_type":"journal-article"},{"id":"pmid:31920173","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31920173","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomolecular structure & dynamics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1909239103","https://openalex.org/W1973494607","https://openalex.org/W1975691556","https://openalex.org/W1978733464","https://openalex.org/W1980627787","https://openalex.org/W1985588649","https://openalex.org/W1997496427","https://openalex.org/W2002869751","https://openalex.org/W2004074614","https://openalex.org/W2021983923","https://openalex.org/W2031102828","https://openalex.org/W2031168104","https://openalex.org/W2046374376","https://openalex.org/W2050953367","https://openalex.org/W2079190340","https://openalex.org/W2084550263","https://openalex.org/W2087541526","https://openalex.org/W2101266541","https://openalex.org/W2102377211","https://openalex.org/W2115683942","https://openalex.org/W2119108696","https://openalex.org/W2134644178","https://openalex.org/W2138281535","https://openalex.org/W2147577072","https://openalex.org/W2147733973","https://openalex.org/W2270566630","https://openalex.org/W2311770845","https://openalex.org/W2413824110","https://openalex.org/W2474204065","https://openalex.org/W2546103267","https://openalex.org/W2552154125","https://openalex.org/W2553288939","https://openalex.org/W2580321919","https://openalex.org/W2587582684","https://openalex.org/W2596230237","https://openalex.org/W2598662432","https://openalex.org/W2601484038","https://openalex.org/W2623526848","https://openalex.org/W2674963909","https://openalex.org/W2734554201","https://openalex.org/W2767876239","https://openalex.org/W2792233460","https://openalex.org/W2805880199","https://openalex.org/W2809841748","https://openalex.org/W2887387229","https://openalex.org/W2906329236","https://openalex.org/W2945300448","https://openalex.org/W2952724023","https://openalex.org/W2952766657","https://openalex.org/W2969004961","https://openalex.org/W2972564034","https://openalex.org/W2986147680","https://openalex.org/W2987159150","https://openalex.org/W2990077952","https://openalex.org/W4250728771"],"related_works":["https://openalex.org/W2553288939","https://openalex.org/W4391419763","https://openalex.org/W3009786781","https://openalex.org/W2734554201","https://openalex.org/W2609127248","https://openalex.org/W4313509721","https://openalex.org/W2564044205","https://openalex.org/W4309370615","https://openalex.org/W4407783373","https://openalex.org/W4391174537"],"abstract_inverted_index":{"Zika":[0,52,80,92,229],"virus":[1,53,93,205],"(ZIKV),":[2],"belongs":[3],"to":[4,35,43,125,172],"the":[5,89,116,127,164,176,185,193,196,204,216],"flavivirus":[6],"genus":[7],"and":[8,19,48,103,133,145,151,161,170],"Flaviviridae":[9],"family":[10],"that":[11,182],"associated":[12],"with":[13,156,184],"serious":[14],"diseased":[15],"conditions":[16],"like":[17],"microcephaly":[18],"other":[20],"neurological":[21],"disorders":[22],"(Guillan-Barr\u00e9":[23],"syndrome).":[24],"As":[25],"there":[26,83],"is":[27,39,180],"no":[28],"vaccine":[29],"or":[30],"therapies":[31],"available":[32],"against":[33,51,122],"ZIKV":[34,65],"date.":[36],"Hence,":[37],"it":[38,179],"an":[40,58],"unmet":[41],"need":[42],"find":[44],"potential":[45],"drug":[46],"candidates":[47],"target":[49,60],"sites":[50],"infection.":[54],"NS2B-NS3":[55,94,123,168,224],"protease":[56,95,101,124,169,225],"making":[57],"attractive":[59],"for":[61,214,226],"therapeutic":[62],"intervention":[63],"in":[64,72,192],"infections":[66],"because":[67],"of":[68,74,163,167,195,203,218,220,228],"its":[69,146],"critical":[70],"role":[71,191],"hydrolysis":[73],"a":[75,189,200],"single":[76],"polyprotein":[77],"encoded":[78],"by":[79],"virus.":[81,230],"Recently,":[82],"are":[84],"some":[85],"experimental":[86],"evidence":[87],"about":[88],"flavonoids":[90,120,141],"as":[91,143,199],"inhibitors.":[96],"However,":[97],"molecular":[98,128,131,134],"interaction":[99,129,155,183],"between":[100],"complex":[102],"inhibitors":[104,121],"at":[105],"atomic":[106],"levels":[107],"has":[108],"not":[109],"been":[110],"explored.":[111],"Here,":[112],"we":[113],"have":[114],"taken":[115],"experimentally":[117],"validated":[118],"thirty-eight":[119],"examine":[126],"using":[130],"docking":[132],"dynamics":[135],"simulations.":[136],"We":[137],"found":[138,171],"out":[139],"few":[140],"such":[142],"EGCG":[144],"two":[147],"derivatives,":[148],"isoquercetin,":[149],"rutin":[150],"sanggenon":[152],"O":[153],"showing":[154],"catalytic":[157,186],"triad":[158,187],"(His51,":[159],"Asp75,":[160],"Ser135)":[162],"active":[165],"site":[166],"be":[173,211],"stable":[174],"throughout":[175],"simulation.":[177],"Therefore":[178],"evident":[181],"playing":[188],"vital":[190],"inhibition":[194,202,227],"enzyme":[197],"activity":[198],"result":[201],"propagation.":[206],"However":[207],"these":[208,221],"compounds":[209,222],"can":[210],"explored":[212],"further":[213],"understanding":[215],"mechanism":[217],"action":[219],"targeting":[223]},"counts_by_year":[{"year":2026,"cited_by_count":31},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":10}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-01-23T00:00:00"}
