{"id":"https://openalex.org/W3000277650","doi":null,"title":"Autism-associated mutations interfere with the function of the Shank3 N-terminus in postsynaptic signaling pathways","display_name":"Autism-associated mutations interfere with the function of the Shank3 N-terminus in postsynaptic signaling pathways","publication_year":2019,"publication_date":"2019-05-24","ids":{"openalex":"https://openalex.org/W3000277650","mag":"3000277650"},"language":"en","primary_location":{"id":"mag:3000277650","doi":null,"is_oa":false,"landing_page_url":"https://ediss.sub.uni-hamburg.de/volltexte/2019/9745/pdf/Dissertation.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004972465","display_name":"Fatemeh Hassani Nia","orcid":"https://orcid.org/0000-0002-5036-0317","observed_orcids":["https://orcid.org/0000-0002-5036-0317"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Fatemeh Hassani Nia","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5036-0317","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5004972465"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1750214,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.9297000169754028,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.9297000169754028,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.04039999842643738,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.02590000070631504,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/shank3","display_name":"SHANK3","score":0.9890000224113464},{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":0.9900000095367432},{"id":"https://openalex.org/keywords/postsynaptic-signaling","display_name":"postsynaptic signaling","score":0.9810000061988831},{"id":"https://openalex.org/keywords/synaptic-function","display_name":"synaptic function","score":0.800000011920929},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.6449999809265137},{"id":"https://openalex.org/keywords/synaptic-proteins","display_name":"synaptic proteins","score":0.48100000619888306}],"concepts":[{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.7198929786682129},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.6805123686790466},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.520121693611145},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5184771418571472},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4878220856189728},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45117300748825073},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4474770426750183},{"id":"https://openalex.org/C187541742","wikidata":"https://www.wikidata.org/wiki/Q4374336","display_name":"Postsynaptic density","level":4,"score":0.42917540669441223},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.34135520458221436},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20862874388694763},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.20692971348762512},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.103597491979599}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3000277650","doi":null,"is_oa":false,"landing_page_url":"https://ediss.sub.uni-hamburg.de/volltexte/2019/9745/pdf/Dissertation.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2887375278","https://openalex.org/W4319744477","https://openalex.org/W2739292121","https://openalex.org/W2978298001","https://openalex.org/W4390658391","https://openalex.org/W3097512380","https://openalex.org/W7095678577","https://openalex.org/W2609341206","https://openalex.org/W2051155897","https://openalex.org/W2493420810"],"abstract_inverted_index":{"This":[0],"study":[1],"represents":[2],"an":[3],"attempt":[4],"to":[5,19,39],"clarify":[6],"the":[7,10,14,21,25,29,40],"role":[8],"of":[9,16,28,42],"Shank3":[11,30],"N-terminus":[12,31],"in":[13,23,35],"functioning":[15],"synapses":[17],"and":[18,32],"determine":[20],"mechanisms":[22],"which":[24],"molecular":[26],"interactions":[27],"ASD-associated":[33],"mutations":[34],"this":[36],"part":[37],"contribute":[38],"development":[41],"autism.":[43]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2020-01-23T00:00:00"}