{"id":"https://openalex.org/W3000254361","doi":"https://doi.org/10.1016/j.toxlet.2020.01.011","title":"Reactive oxygen species production by BP-1,6-quinone and its effects on the endothelial dysfunction: Involvement of the mitochondria","display_name":"Reactive oxygen species production by BP-1,6-quinone and its effects on the endothelial dysfunction: Involvement of the mitochondria","publication_year":2020,"publication_date":"2020-01-14","ids":{"openalex":"https://openalex.org/W3000254361","doi":"https://doi.org/10.1016/j.toxlet.2020.01.011","mag":"3000254361","pmid":"https://pubmed.ncbi.nlm.nih.gov/31953210"},"language":"en","primary_location":{"id":"doi:10.1016/j.toxlet.2020.01.011","doi":"https://doi.org/10.1016/j.toxlet.2020.01.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.toxlet.2020.01.011","pdf_url":null,"source":{"id":"https://openalex.org/S205878144","display_name":"Toxicology Letters","issn_l":"0378-4274","issn":["0378-4274","1879-3169"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041760208","display_name":"Halley Shukla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169335092","display_name":"University of North Carolina at Greensboro","ror":"https://ror.org/04fnxsj42","country_code":"US","type":"education","lineage":["https://openalex.org/I169335092"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Halley Shukla","raw_affiliation_strings":["Department of Biology, University of North Carolina at Greensboro, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of North Carolina at Greensboro, NC, United States","institution_ids":["https://openalex.org/I169335092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058457816","display_name":"Rojin Chitrakar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169335092","display_name":"University of North Carolina at Greensboro","ror":"https://ror.org/04fnxsj42","country_code":"US","type":"education","lineage":["https://openalex.org/I169335092"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rojin Chitrakar","raw_affiliation_strings":["Department of Biology, University of North Carolina at Greensboro, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of North Carolina at Greensboro, NC, United States","institution_ids":["https://openalex.org/I169335092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114133554","display_name":"Humaira A. Bibi","orcid":"https://orcid.org/0009-0003-7025-5367","observed_orcids":["https://orcid.org/0009-0003-7025-5367"]},"institutions":[{"id":"https://openalex.org/I169335092","display_name":"University of North Carolina at Greensboro","ror":"https://ror.org/04fnxsj42","country_code":"US","type":"education","lineage":["https://openalex.org/I169335092"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Humaira A. Bibi","raw_affiliation_strings":["Department of Biology, University of North Carolina at Greensboro, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of North Carolina at Greensboro, NC, United States","institution_ids":["https://openalex.org/I169335092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005490443","display_name":"Gabriella Gaje","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169335092","display_name":"University of North Carolina at Greensboro","ror":"https://ror.org/04fnxsj42","country_code":"US","type":"education","lineage":["https://openalex.org/I169335092"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabriella Gaje","raw_affiliation_strings":["Department of Biology, University of North Carolina at Greensboro, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of North Carolina at Greensboro, NC, United States","institution_ids":["https://openalex.org/I169335092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036355340","display_name":"Ashkon Koucheki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169335092","display_name":"University of North Carolina at Greensboro","ror":"https://ror.org/04fnxsj42","country_code":"US","type":"education","lineage":["https://openalex.org/I169335092"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashkon Koucheki","raw_affiliation_strings":["Department of Biology, University of North Carolina at Greensboro, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of North Carolina at Greensboro, NC, United States","institution_ids":["https://openalex.org/I169335092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111924381","display_name":"Michael A. Trush","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A Trush","raw_affiliation_strings":["Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, United States","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055905669","display_name":"Hong Zhu","orcid":"https://orcid.org/0000-0001-9445-9565","observed_orcids":["https://orcid.org/0000-0001-9445-9565"]},"institutions":[{"id":"https://openalex.org/I132446568","display_name":"Campbell University","ror":"https://ror.org/00dv9q566","country_code":"US","type":"education","lineage":["https://openalex.org/I132446568"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong Zhu","raw_affiliation_strings":["Campbell University School of Osteopathic Medicine, Buies Creek, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Campbell University School of Osteopathic Medicine, Buies Creek, NC, United States","institution_ids":["https://openalex.org/I132446568"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Y. Robert Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132446568","display_name":"Campbell University","ror":"https://ror.org/00dv9q566","country_code":"US","type":"education","lineage":["https://openalex.org/I132446568"]},{"id":"https://openalex.org/I169335092","display_name":"University of North Carolina at Greensboro","ror":"https://ror.org/04fnxsj42","country_code":"US","type":"education","lineage":["https://openalex.org/I169335092"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Y. Robert Li","raw_affiliation_strings":["Department of Biology, University of North Carolina at Greensboro, NC, United States; Campbell University School of Osteopathic Medicine, Buies Creek, NC, United States. Electronic address: yli@campbell.edu","Campbell University School of Osteopathic Medicine, Buies Creek, NC, United States","Department of Biology, University of North Carolina at Greensboro, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of North Carolina at Greensboro, NC, United States; Campbell University School of Osteopathic Medicine, Buies Creek, NC, United States. Electronic address: yli@campbell.edu","institution_ids":["https://openalex.org/I132446568","https://openalex.org/I169335092"]},{"raw_affiliation_string":"Campbell University School of Osteopathic Medicine, Buies Creek, NC, United States","institution_ids":["https://openalex.org/I132446568"]},{"raw_affiliation_string":"Department of Biology, University of North Carolina at Greensboro, NC, United States","institution_ids":["https://openalex.org/I169335092"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016835731","display_name":"Zhenquan Jia","orcid":"https://orcid.org/0000-0002-5187-1549","observed_orcids":["https://orcid.org/0000-0002-5187-1549"]},"institutions":[{"id":"https://openalex.org/I169335092","display_name":"University of North Carolina at Greensboro","ror":"https://ror.org/04fnxsj42","country_code":"US","type":"education","lineage":["https://openalex.org/I169335092"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zhenquan Jia","raw_affiliation_strings":["Department of Biology, University of North Carolina at Greensboro, NC, United States. Electronic address: z_jia@uncg.edu","Department of Biology, University of North Carolina at Greensboro, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of North Carolina at Greensboro, NC, United States. Electronic address: z_jia@uncg.edu","institution_ids":["https://openalex.org/I169335092"]},{"raw_affiliation_string":"Department of Biology, University of North Carolina at Greensboro, NC, United States","institution_ids":["https://openalex.org/I169335092"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5016835731"],"corresponding_institution_ids":["https://openalex.org/I132446568","https://openalex.org/I169335092"],"apc_list":{"value":3200,"currency":"USD","value_usd":3200},"apc_paid":null,"fwci":1.958,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.83882518,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"322","issue":null,"first_page":"120","last_page":"130"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.43070000410079956,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.43070000410079956,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10190","display_name":"Air Quality and Health Impacts","score":0.1599999964237213,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.08030000329017639,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9399999976158142},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.8389999866485596},{"id":"https://openalex.org/keywords/mitochondrial-electron-transport-chain","display_name":"mitochondrial electron transport chain","score":0.9490000009536743},{"id":"https://openalex.org/keywords/air-pollution","display_name":"air pollution","score":0.6869999766349792},{"id":"https://openalex.org/keywords/particulate-matter","display_name":"particulate matter","score":0.9129999876022339},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.921999990940094},{"id":"https://openalex.org/keywords/monocyte-adhesion","display_name":"monocyte adhesion","score":0.7940000295639038},{"id":"https://openalex.org/keywords/vcam-1","display_name":"VCAM-1","score":0.9810000061988831},{"id":"https://openalex.org/keywords/ea-hy926-cells","display_name":"EA.hy926 cells","score":0.9179999828338623},{"id":"https://openalex.org/keywords/rotenone","display_name":"rotenone","score":0.8939999938011169},{"id":"https://openalex.org/keywords/antimycin-a","display_name":"antimycin A","score":0.8399999737739563}],"concepts":[{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.7746831178665161},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.7584548592567444},{"id":"https://openalex.org/C2778175917","wikidata":"https://www.wikidata.org/wiki/Q17125553","display_name":"Mitochondrial ROS","level":3,"score":0.6324344873428345},{"id":"https://openalex.org/C14471203","wikidata":"https://www.wikidata.org/wiki/Q412832","display_name":"Coenzyme Q \u2013 cytochrome c reductase","level":4,"score":0.6156986355781555},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5119775533676147},{"id":"https://openalex.org/C2779965811","wikidata":"https://www.wikidata.org/wiki/Q104708365","display_name":"Antimycin A","level":3,"score":0.4721786081790924},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4694247841835022},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.41606637835502625},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3798743188381195},{"id":"https://openalex.org/C29311851","wikidata":"https://www.wikidata.org/wiki/Q408223","display_name":"Cytochrome c","level":3,"score":0.10145565867424011}],"mesh":[{"descriptor_ui":"D001580","descriptor_name":"Benzopyrenes","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019010","descriptor_name":"Vascular Cell Adhesion Molecule-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019010","descriptor_name":"Vascular Cell Adhesion Molecule-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D045222","descriptor_name":"Electron Transport Chain Complex Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.toxlet.2020.01.011","doi":"https://doi.org/10.1016/j.toxlet.2020.01.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.toxlet.2020.01.011","pdf_url":null,"source":{"id":"https://openalex.org/S205878144","display_name":"Toxicology Letters","issn_l":"0378-4274","issn":["0378-4274","1879-3169"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology Letters","raw_type":"journal-article"},{"id":"pmid:31953210","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31953210","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320333244","display_name":"University of North Carolina at Greensboro","ror":"https://ror.org/04fnxsj42"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W20515147","https://openalex.org/W1480951384","https://openalex.org/W1578041684","https://openalex.org/W1976616659","https://openalex.org/W1980339513","https://openalex.org/W1985581245","https://openalex.org/W2012486917","https://openalex.org/W2013032389","https://openalex.org/W2016004296","https://openalex.org/W2019732735","https://openalex.org/W2024751894","https://openalex.org/W2027191021","https://openalex.org/W2037586146","https://openalex.org/W2037775191","https://openalex.org/W2043155515","https://openalex.org/W2044107583","https://openalex.org/W2044308191","https://openalex.org/W2045169475","https://openalex.org/W2054856305","https://openalex.org/W2059350161","https://openalex.org/W2059571803","https://openalex.org/W2059710697","https://openalex.org/W2062502442","https://openalex.org/W2069584266","https://openalex.org/W2073783162","https://openalex.org/W2076598575","https://openalex.org/W2078364748","https://openalex.org/W2078593792","https://openalex.org/W2080038912","https://openalex.org/W2081658317","https://openalex.org/W2081808451","https://openalex.org/W2083403064","https://openalex.org/W2089006481","https://openalex.org/W2093283930","https://openalex.org/W2100872066","https://openalex.org/W2105385191","https://openalex.org/W2106131101","https://openalex.org/W2107366065","https://openalex.org/W2110676635","https://openalex.org/W2113655677","https://openalex.org/W2125851804","https://openalex.org/W2128839250","https://openalex.org/W2135633069","https://openalex.org/W2139871065","https://openalex.org/W2140282454","https://openalex.org/W2148879071","https://openalex.org/W2153625286","https://openalex.org/W2154229994","https://openalex.org/W2154716740","https://openalex.org/W2156428050","https://openalex.org/W2160099189","https://openalex.org/W2160378405","https://openalex.org/W2173709855","https://openalex.org/W2275204317","https://openalex.org/W2400555275","https://openalex.org/W2405085968","https://openalex.org/W2405402014","https://openalex.org/W2416037044","https://openalex.org/W2417976794","https://openalex.org/W2556361889","https://openalex.org/W2807666749","https://openalex.org/W2957226098","https://openalex.org/W4233619925","https://openalex.org/W4256475235","https://openalex.org/W4285719527","https://openalex.org/W6717041180","https://openalex.org/W6752663144"],"related_works":["https://openalex.org/W2983984387","https://openalex.org/W3045975590","https://openalex.org/W3161302144","https://openalex.org/W7213312268","https://openalex.org/W2593473211","https://openalex.org/W2792724472","https://openalex.org/W2991182564","https://openalex.org/W7219370551","https://openalex.org/W2612672600","https://openalex.org/W1971215002"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-01-23T00:00:00"}
