{"id":"https://openalex.org/W3000230186","doi":null,"title":"Micro RNA-19a suppresses interleukin-10 in peripheral B cells of patients with diabetic retinopathy.","display_name":"Micro RNA-19a suppresses interleukin-10 in peripheral B cells of patients with diabetic retinopathy.","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W3000230186","mag":"3000230186","pmid":"https://pubmed.ncbi.nlm.nih.gov/28386366","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5376031"},"language":"en","primary_location":{"id":"pmid:28386366","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28386366","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5376031/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Cong Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294606314","display_name":"Beijing Tongren Hospital","ror":"https://ror.org/013e4n276","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294606314"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cong Wang","raw_affiliation_strings":["Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University; Beijing Ophthalmol and Vis Sci Key Lab Beijing 100730, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University; Beijing Ophthalmol and Vis Sci Key Lab Beijing 100730, China","institution_ids":["https://openalex.org/I1294606314","https://openalex.org/I183519381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001586304","display_name":"Qi Sheng You","orcid":"https://orcid.org/0000-0003-0743-7320","observed_orcids":["https://orcid.org/0000-0003-0743-7320"]},"institutions":[{"id":"https://openalex.org/I1294606314","display_name":"Beijing Tongren Hospital","ror":"https://ror.org/013e4n276","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294606314"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qisheng You","raw_affiliation_strings":["Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Ophthalmology & Visual Sciences Key Lab Beijing 100730, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Ophthalmology & Visual Sciences Key Lab Beijing 100730, China","institution_ids":["https://openalex.org/I1294606314","https://openalex.org/I183519381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114232297","display_name":"Xusheng Cao","orcid":"https://orcid.org/0000-0002-4885-4537","observed_orcids":["https://orcid.org/0000-0002-4885-4537"]},"institutions":[{"id":"https://openalex.org/I1294606314","display_name":"Beijing Tongren Hospital","ror":"https://ror.org/013e4n276","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294606314"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xusheng Cao","raw_affiliation_strings":["Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University; Beijing Ophthalmol and Vis Sci Key Lab Beijing 100730, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University; Beijing Ophthalmol and Vis Sci Key Lab Beijing 100730, China","institution_ids":["https://openalex.org/I1294606314","https://openalex.org/I183519381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100694538","display_name":"Huiling Guo","orcid":"https://orcid.org/0009-0009-2774-5866","observed_orcids":["https://orcid.org/0009-0009-2774-5866"]},"institutions":[{"id":"https://openalex.org/I4210107698","display_name":"PLA 306 Hospital","ror":"https://ror.org/01k0q5v34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210107698"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huiling Guo","raw_affiliation_strings":["Department of Ophthalmology, 306th Hospital of PLA Beijing 100101, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, 306th Hospital of PLA Beijing 100101, China","institution_ids":["https://openalex.org/I4210107698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042846805","display_name":"Xinxiao Gao","orcid":"https://orcid.org/0000-0002-3203-1544","observed_orcids":["https://orcid.org/0000-0002-3203-1544"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210119028","display_name":"Beijing Anzhen Hospital","ror":"https://ror.org/02h2j1586","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119028"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinxiao Gao","raw_affiliation_strings":["Department of Ophthalmology, Beijing Anzhen Hospital, Capital Medical University Beijing 100029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Beijing Anzhen Hospital, Capital Medical University Beijing 100029, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210119028"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100747554","display_name":"Xiaoyan Peng","orcid":"https://orcid.org/0000-0002-4275-6856","observed_orcids":["https://orcid.org/0000-0002-4275-6856"]},"institutions":[{"id":"https://openalex.org/I1294606314","display_name":"Beijing Tongren Hospital","ror":"https://ror.org/013e4n276","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294606314"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyan Peng","raw_affiliation_strings":["Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Ophthalmology & Visual Sciences Key Lab Beijing 100730, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Ophthalmology & Visual Sciences Key Lab Beijing 100730, China","institution_ids":["https://openalex.org/I1294606314","https://openalex.org/I183519381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7393,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.62461139,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"9","issue":"3","first_page":"1410","last_page":"1417"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.8564000129699707,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.8564000129699707,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.09179999679327011,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.014499999582767487,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-retinopathy","display_name":"diabetic retinopathy","score":0.875},{"id":"https://openalex.org/keywords/microrna-19a","display_name":"microRNA-19a","score":0.9200000166893005},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9909999966621399},{"id":"https://openalex.org/keywords/peripheral-blood-b-cells","display_name":"peripheral blood B cells","score":0.8809999823570251},{"id":"https://openalex.org/keywords/mir-17-92-cluster","display_name":"miR-17-92 cluster","score":0.9309999942779541},{"id":"https://openalex.org/keywords/il-17","display_name":"IL-17","score":0.8659999966621399},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5019999742507935},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.8709999918937683}],"concepts":[{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.7968454360961914},{"id":"https://openalex.org/C2779829184","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic retinopathy","level":3,"score":0.6800769567489624},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6248159408569336},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5641570687294006},{"id":"https://openalex.org/C3017910909","wikidata":"https://www.wikidata.org/wiki/Q618363","display_name":"Peripheral blood","level":2,"score":0.5601029992103577},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.5557608604431152},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.5200212001800537},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5026893615722656},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.483679860830307},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4579126238822937},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.4316726326942444},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3936517834663391},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33937400579452515},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3182819187641144},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.2792910933494568},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19202688336372375},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.1448056697845459},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11258399486541748},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06865549087524414},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmid:28386366","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28386366","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5376031","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5376031/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},{"id":"mag:3000230186","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28386366","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5376031","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5376031/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W220518476","https://openalex.org/W1592266520","https://openalex.org/W1788452982","https://openalex.org/W1830827841","https://openalex.org/W1908253056","https://openalex.org/W1935908062","https://openalex.org/W1983981324","https://openalex.org/W1985845937","https://openalex.org/W1987761337","https://openalex.org/W1988613836","https://openalex.org/W1995564674","https://openalex.org/W1997457850","https://openalex.org/W2022625680","https://openalex.org/W2024189251","https://openalex.org/W2052676620","https://openalex.org/W2064902601","https://openalex.org/W2101771134","https://openalex.org/W2152557831","https://openalex.org/W2225985392","https://openalex.org/W2261001830","https://openalex.org/W2298336119","https://openalex.org/W2298784209","https://openalex.org/W2318352544","https://openalex.org/W2332884846","https://openalex.org/W2407273469","https://openalex.org/W4211031298","https://openalex.org/W4240304626"],"related_works":["https://openalex.org/W4200585787","https://openalex.org/W4318815491","https://openalex.org/W3091850392","https://openalex.org/W2609367316","https://openalex.org/W2172316739","https://openalex.org/W2799697055","https://openalex.org/W3032402397","https://openalex.org/W4405988826","https://openalex.org/W4401847434","https://openalex.org/W3212373152"],"abstract_inverted_index":{"A":[0],"number":[1],"of":[2,29,45,76,85,93,107,119,128,132,184],"patients":[3,59,95],"with":[4,42,98,114],"diabetes":[5,46],"suffer":[6],"from":[7,57,67],"retinopathy;":[8],"the":[9,27,43,68,74,115,126,136,152,182],"pathogenesis":[10,44],"is":[11,40],"to":[12,71,123],"be":[13,72,177],"further":[14],"investigated.":[15],"Recent":[16],"reports":[17],"indicate":[18],"that":[19,37,82],"micro":[20],"RNA":[21],"(miR)":[22],"plays":[23],"critical":[24,148],"roles":[25],"in":[26,89,104,135,139,157,168,181],"development":[28],"immune":[30],"inflammation.":[31],"This":[32],"study":[33],"test":[34],"a":[35,147],"hypothesis":[36],"miR-17-92":[38],"cluster":[39],"associated":[41],"retinopathy":[47],"(DR).":[48],"In":[49,150],"this":[50],"study,":[51],"peripheral":[52,90,158],"blood":[53,69],"samples":[54,70],"were":[55,65,87],"collected":[56],"DR":[58,94,108,169],"and":[60,130,165,173],"healthy":[61,99],"subjects.":[62,100],"B":[63,91,105,121,137,159],"cells":[64,92,106,122,160],"isolated":[66],"analyzed":[73],"expression":[75,127,134,156,164],"interleukin":[77],"(IL)-10.":[78],"The":[79,171],"results":[80],"showed":[81],"lower":[83],"levels":[84],"IL-10":[86,116,133,155],"detected":[88],"as":[96],"compared":[97],"miR-19a":[101,129,163,172],"was":[102,111],"increased":[103,125],"patients,":[109],"which":[110,140],"negatively":[112],"correlated":[113],"expression.":[117],"Exposure":[118],"naive":[120],"IL-17":[124,153],"suppression":[131],"cells,":[138],"histone":[141],"deacetylase":[142],"11":[143,175],"(HDAC":[144],"11)":[145],"played":[146],"role.":[149],"conclusion,":[151],"suppresses":[154],"via":[161],"enhancing":[162],"HDAC":[166,174],"activity":[167],"patients.":[170],"may":[176],"novel":[178],"therapeutic":[179],"targets":[180],"treatment":[183],"DR.":[185]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-01-23T00:00:00"}
