{"id":"https://openalex.org/W3000229516","doi":"https://doi.org/10.1016/j.joca.2020.01.002","title":"Osteoarthritis year in review 2019: epidemiology and therapy","display_name":"Osteoarthritis year in review 2019: epidemiology and therapy","publication_year":2020,"publication_date":"2020-01-13","ids":{"openalex":"https://openalex.org/W3000229516","doi":"https://doi.org/10.1016/j.joca.2020.01.002","mag":"3000229516","pmid":"https://pubmed.ncbi.nlm.nih.gov/31945457"},"language":"en","primary_location":{"id":"doi:10.1016/j.joca.2020.01.002","doi":"https://doi.org/10.1016/j.joca.2020.01.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.joca.2020.01.002","pdf_url":"http://www.oarsijournal.com/article/S1063458420300078/pdf","source":{"id":"https://openalex.org/S13054843","display_name":"Osteoarthritis and Cartilage","issn_l":"1063-4584","issn":["1063-4584","1522-9653"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osteoarthritis and Cartilage","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.oarsijournal.com/article/S1063458420300078/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104490518","display_name":"M. Kloppenburg","orcid":"https://orcid.org/0000-0002-9294-2307","observed_orcids":["https://orcid.org/0000-0002-9294-2307"]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]},{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"M. Kloppenburg","raw_affiliation_strings":["Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: g.kloppenburg@lumc.nl","LUMC - Leiden University Medical Center (Leids Universitair Medisch Centrum, Universiteit Leiden - 1233 ZA, Leiden - Netherlands)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: g.kloppenburg@lumc.nl","institution_ids":["https://openalex.org/I2800006345"]},{"raw_affiliation_string":"LUMC - Leiden University Medical Center (Leids Universitair Medisch Centrum, Universiteit Leiden - 1233 ZA, Leiden - Netherlands)","institution_ids":["https://openalex.org/I121797337","https://openalex.org/I2800006345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085771274","display_name":"Fran\u00e7is Berenbaum","orcid":"https://orcid.org/0000-0001-8252-7815","observed_orcids":["https://orcid.org/0000-0001-8252-7815"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210102928","display_name":"H\u00f4pital Saint-Antoine","ror":"https://ror.org/01875pg84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]},{"id":"https://openalex.org/I4210134622","display_name":"Centre de Recherche Saint-Antoine","ror":"https://ror.org/03wxndv36","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210097159","https://openalex.org/I4210129850","https://openalex.org/I4210134622"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"F. Berenbaum","raw_affiliation_strings":["Sorbonne Universit\u00e9, INSERM CRSA, Department of Rheumatology, AP-HP Saint-Antoine Hospital, Paris, France","CHU Saint-Antoine [AP-HP] (184, rue du Faubourg Saint-Antoine\r\n 75571 Paris cedex 12 - France)","CRSA - Centre de Recherche Saint-Antoine (B\u00e2timent Kourilsky\r\n34 rue Crozatier\r\n75012 PARIS\r\n\r\nSorbonne Universit\u00e9\r\n27 rue Chaligny\r\n75012 PARIS - France)","SU - Sorbonne Universite\u0301 (21 rue de l\u2019\u00c9cole de m\u00e9decine - 75006 Paris - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sorbonne Universit\u00e9, INSERM CRSA, Department of Rheumatology, AP-HP Saint-Antoine Hospital, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210097159","https://openalex.org/I4210102928"]},{"raw_affiliation_string":"CHU Saint-Antoine [AP-HP] (184, rue du Faubourg Saint-Antoine\r\n 75571 Paris cedex 12 - France)","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]},{"raw_affiliation_string":"CRSA - Centre de Recherche Saint-Antoine (B\u00e2timent Kourilsky\r\n34 rue Crozatier\r\n75012 PARIS\r\n\r\nSorbonne Universit\u00e9\r\n27 rue Chaligny\r\n75012 PARIS - France)","institution_ids":["https://openalex.org/I39804081","https://openalex.org/I4210134622"]},{"raw_affiliation_string":"SU - Sorbonne Universite\u0301 (21 rue de l\u2019\u00c9cole de m\u00e9decine - 75006 Paris - France)","institution_ids":["https://openalex.org/I39804081"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5104490518"],"corresponding_institution_ids":["https://openalex.org/I121797337","https://openalex.org/I2800006345"],"apc_list":{"value":2588,"currency":"USD","value_usd":2588},"apc_paid":{"value":2588,"currency":"USD","value_usd":2588},"fwci":14.542,"has_fulltext":true,"cited_by_count":566,"citation_normalized_percentile":{"value":0.99569661,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"28","issue":"3","first_page":"242","last_page":"248"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10084","display_name":"Musculoskeletal pain and rehabilitation","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/3612","display_name":"Physical Therapy, Sports Therapy and Rehabilitation"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11218","display_name":"Hip disorders and treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/osteoarthritis-pain","display_name":"osteoarthritis pain","score":0.8889999985694885},{"id":"https://openalex.org/keywords/drug-therapy","display_name":"pharmacotherapy","score":0.8019999861717224},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.6610000133514404},{"id":"https://openalex.org/keywords/joint-replacement","display_name":"joint replacement","score":0.5789999961853027},{"id":"https://openalex.org/keywords/knee-arthroplasty","display_name":"knee arthroplasty","score":0.5960000157356262},{"id":"https://openalex.org/keywords/treatment-duration","display_name":"treatment duration","score":0.38600000739097595}],"concepts":[{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.7024860382080078},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6779481172561646},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.6449454426765442},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5635107159614563},{"id":"https://openalex.org/C2779903281","wikidata":"https://www.wikidata.org/wiki/Q6888026","display_name":"Modalities","level":2,"score":0.5078907608985901},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.45579278469085693},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.44964584708213806},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.42245322465896606},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.42006632685661316},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.4108017683029175},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.3929741084575653},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1348671019077301},{"id":"https://openalex.org/C36289849","wikidata":"https://www.wikidata.org/wiki/Q34749","display_name":"Social science","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000079424","descriptor_name":"Tumor Necrosis Factor Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000082","descriptor_name":"Acetaminophen","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002211","descriptor_name":"Capsaicin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007136","descriptor_name":"Immunoglobulins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007270","descriptor_name":"Injections, Intra-Articular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007273","descriptor_name":"Injections, Intramuscular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009026","descriptor_name":"Mortality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D014147","descriptor_name":"Tramadol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018689","descriptor_name":"Sensory System Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018712","descriptor_name":"Analgesics, Non-Narcotic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019643","descriptor_name":"Arthroplasty, Replacement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059408","descriptor_name":"Pain Management","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1016/j.joca.2020.01.002","doi":"https://doi.org/10.1016/j.joca.2020.01.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.joca.2020.01.002","pdf_url":"http://www.oarsijournal.com/article/S1063458420300078/pdf","source":{"id":"https://openalex.org/S13054843","display_name":"Osteoarthritis and Cartilage","issn_l":"1063-4584","issn":["1063-4584","1522-9653"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osteoarthritis and Cartilage","raw_type":"journal-article"},{"id":"pmid:31945457","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31945457","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osteoarthritis and cartilage","raw_type":"Journal Article"},{"id":"pmh:oai:alma.31UKB_LEU:9940743189502711","doi":null,"is_oa":true,"landing_page_url":"https://scholarlypublications.universiteitleiden.nl/handle/1887/3182958","pdf_url":"https://scholarlypublications.universiteitleiden.nl/download/1887/3182958/1?col=81522199330002711","source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Osteoarthritis and Cartilage, Vol. 28, no. 3, p. 242-248","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:lumc:oai:scholarlypublications.universiteitleiden.nl:item_3182958","doi":null,"is_oa":true,"landing_page_url":"https://www.sciencedirect.com/science/article/pii/S1063458420300078?via%3Dihub","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Osteoarthritis and Cartilage, 28(3), 242 - 248. ELSEVIER SCI LTD","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-02512282v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.sorbonne-universite.fr/hal-02512282v1/document","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Osteoarthritis and Cartilage, 2020, 28 (3), pp.242-248. ⟨10.1016/j.joca.2020.01.002⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:scholarlypublications.universiteitleiden.nl:item_3182958","doi":null,"is_oa":true,"landing_page_url":"https://www.sciencedirect.com/science/article/pii/S1063458420300078?via%3Dihub","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Osteoarthritis and Cartilage","raw_type":"Article / Letter to editor"}],"best_oa_location":{"id":"doi:10.1016/j.joca.2020.01.002","doi":"https://doi.org/10.1016/j.joca.2020.01.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.joca.2020.01.002","pdf_url":"http://www.oarsijournal.com/article/S1063458420300078/pdf","source":{"id":"https://openalex.org/S13054843","display_name":"Osteoarthritis and Cartilage","issn_l":"1063-4584","issn":["1063-4584","1522-9653"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osteoarthritis and Cartilage","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3000229516.pdf","grobid_xml":"https://content.openalex.org/works/W3000229516.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1071505693","https://openalex.org/W1599185368","https://openalex.org/W2018004536","https://openalex.org/W2129650714","https://openalex.org/W2151217395","https://openalex.org/W2155048035","https://openalex.org/W2167439117","https://openalex.org/W2299367339","https://openalex.org/W2587979550","https://openalex.org/W2592442606","https://openalex.org/W2616167388","https://openalex.org/W2751884637","https://openalex.org/W2758333171","https://openalex.org/W2779631004","https://openalex.org/W2793466927","https://openalex.org/W2795774212","https://openalex.org/W2799859874","https://openalex.org/W2844450453","https://openalex.org/W2890030095","https://openalex.org/W2892271400","https://openalex.org/W2895008287","https://openalex.org/W2895931359","https://openalex.org/W2898177309","https://openalex.org/W2900351181","https://openalex.org/W2904798486","https://openalex.org/W2905782592","https://openalex.org/W2906508631","https://openalex.org/W2908652588","https://openalex.org/W2912366334","https://openalex.org/W2912654919","https://openalex.org/W2914422470","https://openalex.org/W2916756040","https://openalex.org/W2916794248","https://openalex.org/W2917113195","https://openalex.org/W2921856072","https://openalex.org/W2924867358","https://openalex.org/W2925140760","https://openalex.org/W2937767484","https://openalex.org/W2964756503","https://openalex.org/W4210336301","https://openalex.org/W4245966879","https://openalex.org/W6749696161"],"related_works":["https://openalex.org/W2083812623","https://openalex.org/W2772784997","https://openalex.org/W1965432867","https://openalex.org/W4231182433","https://openalex.org/W2577718098","https://openalex.org/W3119004865","https://openalex.org/W2900550641","https://openalex.org/W2016066326","https://openalex.org/W4225376698","https://openalex.org/W7042922813"],"abstract_inverted_index":{"Over":[0],"the":[1,13,26,39,97,103],"past":[2],"year":[3],"many":[4],"studies":[5,89,111,129],"and":[6,55,112,125],"clinical":[7,60],"trials":[8],"have":[9,95,122,148],"been":[10,123],"published":[11],"in":[12,84],"osteoarthritis":[14],"(OA)":[15],"field.":[16],"This":[17],"review":[18,24],"is":[19,70,142],"based":[20],"on":[21,151],"systematic":[22],"literature":[23],"covering":[25],"period":[27],"May":[28],"1":[29],"st":[30],",":[31,37],"2018":[32],"to":[33,50,99,138],"April":[34],"19":[35],"th":[36],"2019;":[38],"final":[40],"selection":[41],"of":[42,56,80,82,114],"articles":[43,48],"was":[44],"subjective.":[45],"Specifically":[46],"those":[47],"considered":[49],"be":[51,100],"presenting":[52],"novel":[53],"insights":[54],"potential":[57],"importance":[58],"for":[59,134],"practice,":[61],"are":[62,130],"discussed.":[63],"Further":[64],"evidence":[65],"has":[66,86],"emerged":[67],"that":[68],"OA":[69,85],"a":[71],"serious":[72],"disease":[73],"with":[74],"increasing":[75],"impact":[76],"worldwide.":[77],"Our":[78],"understanding":[79],"development":[81],"pain":[83],"increased.":[87],"Detailed":[88],"investigating":[90],"widely":[91],"used":[92,116],"pharmacological":[93,120],"treatments":[94,121],"shown":[96],"benefits":[98],"limited,":[101],"whereas":[102],"risks":[104],"seem":[105],"higher":[106],"than":[107],"expected,":[108],"suggesting":[109],"further":[110],"reconsideration":[113],"currently":[115],"guidelines.":[117],"Promising":[118],"new":[119,135,146],"developed":[124],"published,":[126],"however":[127],"subsequent":[128],"warranted.":[131],"While":[132],"waiting":[133],"treatment":[136],"modalities":[137],"appear":[139],"joint":[140],"replacement":[141],"an":[143],"effective":[144],"alternative;":[145],"data":[147],"become":[149],"available":[150],"how":[152],"long":[153],"they":[154],"might":[155],"last.":[156]},"counts_by_year":[{"year":2026,"cited_by_count":37},{"year":2025,"cited_by_count":53},{"year":2024,"cited_by_count":73},{"year":2023,"cited_by_count":100},{"year":2022,"cited_by_count":131},{"year":2021,"cited_by_count":131},{"year":2020,"cited_by_count":40}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-01-23T00:00:00"}