{"id":"https://openalex.org/W3000227413","doi":"https://doi.org/10.1002/cbic.201900723","title":"Characterization of a Tryptophan 6\u2010Halogenase from Streptomyces albus and Its Regioselectivity Determinants","display_name":"Characterization of a Tryptophan 6\u2010Halogenase from Streptomyces albus and Its Regioselectivity Determinants","publication_year":2020,"publication_date":"2020-01-08","ids":{"openalex":"https://openalex.org/W3000227413","doi":"https://doi.org/10.1002/cbic.201900723","mag":"3000227413","pmid":"https://pubmed.ncbi.nlm.nih.gov/31916339"},"language":"en","primary_location":{"id":"doi:10.1002/cbic.201900723","doi":"https://doi.org/10.1002/cbic.201900723","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cbic.201900723","pdf_url":null,"source":{"id":"https://openalex.org/S154285657","display_name":"ChemBioChem","issn_l":"1439-4227","issn":["1439-4227","1439-7633"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemBioChem","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088704520","display_name":"Jeongchan Lee","orcid":"https://orcid.org/0000-0002-8528-1897","observed_orcids":["https://orcid.org/0000-0002-8528-1897"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jeongchan Lee","raw_affiliation_strings":["Institute of Molecular Biology and Genetics, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul, 08826 Republic of Korea","School of Chemical and Biological Engineering, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul, 08826 Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-8528-1897","affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology and Genetics, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul, 08826 Republic of Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"School of Chemical and Biological Engineering, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul, 08826 Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103096536","display_name":"Joonwon Kim","orcid":"https://orcid.org/0000-0001-9964-0777","observed_orcids":["https://orcid.org/0000-0001-9964-0777"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4405269631","display_name":"Institute of Engineering Research","ror":"https://ror.org/04scsat82","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405269631"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Joonwon Kim","raw_affiliation_strings":["Institute of Engineering Research, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul, 08826 Republic of Korea","Institute of Molecular Biology and Genetics, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul, 08826 Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Engineering Research, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul, 08826 Republic of Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4405269631"]},{"raw_affiliation_string":"Institute of Molecular Biology and Genetics, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul, 08826 Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100371178","display_name":"Hyun Kim","orcid":"https://orcid.org/0000-0002-5997-186X","observed_orcids":["https://orcid.org/0000-0002-5997-186X"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyun Kim","raw_affiliation_strings":["Institute of Molecular Biology and Genetics, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul, 08826 Republic of Korea","School of Chemical and Biological Engineering, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul, 08826 Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-5997-186X","affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology and Genetics, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul, 08826 Republic of Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"School of Chemical and Biological Engineering, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul, 08826 Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100354955","display_name":"Eun Jung Kim","orcid":"https://orcid.org/0000-0003-2352-5267","observed_orcids":["https://orcid.org/0000-0003-2352-5267"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eun\u2010Jung Kim","raw_affiliation_strings":["Institute of Molecular Biology and Genetics, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul, 08826 Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology and Genetics, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul, 08826 Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052728964","display_name":"Hee\u2010Jin Jeong","orcid":"https://orcid.org/0000-0001-5897-1756","observed_orcids":["https://orcid.org/0000-0001-5897-1756","https://orcid.org/0009-0004-6501-8460"]},"institutions":[{"id":"https://openalex.org/I94588446","display_name":"Hongik University","ror":"https://ror.org/00egdv862","country_code":"KR","type":"education","lineage":["https://openalex.org/I94588446"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hee\u2010Jin Jeong","raw_affiliation_strings":["Department of Biological and Chemical Engineering, Hongik University, Sejong-ro 2639, Jochiwon-eup, Sejong, 30016 Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological and Chemical Engineering, Hongik University, Sejong-ro 2639, Jochiwon-eup, Sejong, 30016 Republic of Korea","institution_ids":["https://openalex.org/I94588446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033647207","display_name":"Kwon\u2010Young Choi","orcid":"https://orcid.org/0000-0001-6856-9728","observed_orcids":["https://orcid.org/0000-0001-6856-9728"]},"institutions":[{"id":"https://openalex.org/I57664883","display_name":"Ajou University","ror":"https://ror.org/03tzb2h73","country_code":"KR","type":"education","lineage":["https://openalex.org/I57664883"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kwon\u2010Young Choi","raw_affiliation_strings":["Department of Environmental Engineering, Ajou University, World cup-ro 206, Yeongtong-gu, Suwon, 16499 Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Engineering, Ajou University, World cup-ro 206, Yeongtong-gu, Suwon, 16499 Republic of Korea","institution_ids":["https://openalex.org/I57664883"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052315121","display_name":"Byung\u2010Gee Kim","orcid":"https://orcid.org/0000-0002-3776-1001","observed_orcids":["https://orcid.org/0000-0002-3776-1001"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4405269631","display_name":"Institute of Engineering Research","ror":"https://ror.org/04scsat82","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405269631"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Byung\u2010Gee Kim","raw_affiliation_strings":["Institute of Bioengineering in Bio-Max, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul, 08826 Republic of Korea","Institute of Engineering Research, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul, 08826 Republic of Korea","Institute of Molecular Biology and Genetics, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul, 08826 Republic of Korea","Interdisciplinary Program of Bioengineering, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul, 08826 Republic of Korea","School of Chemical and Biological Engineering, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul, 08826 Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-3776-1001","affiliations":[{"raw_affiliation_string":"Institute of Bioengineering in Bio-Max, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul, 08826 Republic of Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Institute of Engineering Research, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul, 08826 Republic of Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4405269631"]},{"raw_affiliation_string":"Institute of Molecular Biology and Genetics, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul, 08826 Republic of Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Interdisciplinary Program of Bioengineering, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul, 08826 Republic of Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"School of Chemical and Biological Engineering, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul, 08826 Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5052315121"],"corresponding_institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4405269631"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":1.4487,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.76075458,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"21","issue":"10","first_page":"1446","last_page":"1452"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.3871999979019165,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.3871999979019165,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.17800000309944153,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.10589999705553055,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/streptomyces-albus","display_name":"Streptomyces albus","score":0.968999981880188},{"id":"https://openalex.org/keywords/regioselectivity","display_name":"regioselectivity","score":0.8489999771118164},{"id":"https://openalex.org/keywords/halogenation","display_name":"halogenation","score":0.7329999804496765},{"id":"https://openalex.org/keywords/substrate-specificity","display_name":"substrate specificity","score":0.640999972820282},{"id":"https://openalex.org/keywords/protein-mutagenesis","display_name":"protein mutagenesis","score":0.8379999995231628},{"id":"https://openalex.org/keywords/key-residues","display_name":"key residues","score":0.3529999852180481}],"concepts":[{"id":"https://openalex.org/C59759590","wikidata":"https://www.wikidata.org/wiki/Q2275927","display_name":"Regioselectivity","level":3,"score":0.880112886428833},{"id":"https://openalex.org/C2776706248","wikidata":"https://www.wikidata.org/wiki/Q181003","display_name":"Tryptophan","level":3,"score":0.8680273294448853},{"id":"https://openalex.org/C65973085","wikidata":"https://www.wikidata.org/wiki/Q888529","display_name":"Halogenation","level":2,"score":0.839421272277832},{"id":"https://openalex.org/C2780201653","wikidata":"https://www.wikidata.org/wiki/Q7623378","display_name":"Streptomyces albus","level":4,"score":0.6944842338562012},{"id":"https://openalex.org/C192527728","wikidata":"https://www.wikidata.org/wiki/Q1465700","display_name":"Indole test","level":2,"score":0.6466164588928223},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5996509194374084},{"id":"https://openalex.org/C2779920670","wikidata":"https://www.wikidata.org/wiki/Q1144013","display_name":"Streptomyces","level":3,"score":0.4696243107318878},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.46082934737205505},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30959805846214294},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.23989272117614746},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.23109173774719238},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2221713364124298},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.1199955940246582},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.06368348002433777},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013302","descriptor_name":"Streptomyces","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017385","descriptor_name":"Sequence Homology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054879","descriptor_name":"Halogenation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/cbic.201900723","doi":"https://doi.org/10.1002/cbic.201900723","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cbic.201900723","pdf_url":null,"source":{"id":"https://openalex.org/S154285657","display_name":"ChemBioChem","issn_l":"1439-4227","issn":["1439-4227","1439-7633"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemBioChem","raw_type":"journal-article"},{"id":"pmid:31916339","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31916339","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chembiochem : a European journal of chemical biology","raw_type":"Journal Article"},{"id":"pmh:oai:s-space.snu.ac.kr:10371/232288","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10371/232288","pdf_url":null,"source":{"id":"https://openalex.org/S4306401345","display_name":"Seoul National University Open Repository (Seoul National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139264467","host_organization_name":"Seoul National University","host_organization_lineage":["https://openalex.org/I139264467"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1957883987","display_name":null,"funder_award_id":"NRF-2016S1A5A2A03926786","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G5448016398","display_name":null,"funder_award_id":"MSIT-2018R1C1B5044988","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G5452325733","display_name":null,"funder_award_id":"NRF\u20102017R1E1A1A01073523","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W2059107251","https://openalex.org/W2090199399","https://openalex.org/W2097186155","https://openalex.org/W2105594174","https://openalex.org/W2111967267","https://openalex.org/W2116137883","https://openalex.org/W2125663031","https://openalex.org/W2132629607","https://openalex.org/W2134967712","https://openalex.org/W2139205312","https://openalex.org/W2152207030","https://openalex.org/W2175390955","https://openalex.org/W2255435815","https://openalex.org/W2306610073","https://openalex.org/W2313164598","https://openalex.org/W2515630092","https://openalex.org/W2578925273","https://openalex.org/W2610507331","https://openalex.org/W2750791471","https://openalex.org/W2804822363","https://openalex.org/W2903851210","https://openalex.org/W2986564978"],"related_works":["https://openalex.org/W3027580104","https://openalex.org/W2255435815","https://openalex.org/W2903851210","https://openalex.org/W1988205409","https://openalex.org/W1970840711","https://openalex.org/W2151772329","https://openalex.org/W2986564978","https://openalex.org/W2003035278","https://openalex.org/W4410627529","https://openalex.org/W2139205312"],"abstract_inverted_index":{"Tryptophan":[0],"halogenases":[1,82],"are":[2,24,107],"found":[3],"in":[4,16,47,74,83,101,105,110],"diverse":[5],"organisms":[6],"and":[7,27,56,103,117],"catalyze":[8],"regiospecific":[9,61],"halogenation.":[10],"They":[11],"play":[12],"an":[13,140],"important":[14],"role":[15],"the":[17,64,84,111,120,126,132,143,148],"biosynthesis":[18],"of":[19,28,66,78,128,134,142,150],"halogenated":[20],"indole":[21],"alkaloids,":[22],"which":[23],"biologically":[25],"active":[26],"therapeutic":[29],"importance.":[30],"Here,":[31],"a":[32,43],"tryptophan":[33,81,115,151],"6-halogenase":[34],"(SatH)":[35],"from":[36],"Streptomyces":[37],"albus":[38],"was":[39],"characterized":[40],"by":[41,130],"using":[42],"whole-cell":[44,85],"reaction":[45,86],"system":[46],"Escherichia":[48],"coli.":[49],"SatH":[50,70,102,129],"showed":[51],"substrate":[52],"specificity":[53],"for":[54],"chloride":[55],"bromide":[57],"ions,":[58],"leading":[59],"to":[60,139],"halogenation":[62],"at":[63],"C6-position":[65],"l-tryptophan.":[67],"In":[68],"addition,":[69],"exhibited":[71],"higher":[72],"performance":[73],"bromination":[75],"than":[76],"that":[77,96,146],"previously":[79],"reported":[80],"system.":[87],"Through":[88],"structure-based":[89],"protein":[90],"mutagenesis,":[91],"it":[92],"has":[93],"been":[94],"revealed":[95],"two":[97],"consecutive":[98],"residues,":[99],"A78/V79":[100],"G77/I78":[104],"PyrH,":[106],"key":[108,144],"determinants":[109],"regioselectivity":[112,127,149],"difference":[113],"between":[114],"6-":[116],"5-halogenases.":[118],"Substituting":[119],"AV":[121],"with":[122],"GI":[123],"residues":[124,145],"switched":[125],"moving":[131],"orientation":[133],"tryptophan.":[135],"These":[136],"data":[137],"contribute":[138],"understanding":[141],"determine":[147],"halogenases.":[152]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-01-23T00:00:00"}
