{"id":"https://openalex.org/W3000221494","doi":"https://doi.org/10.1158/1078-0432.ccr-19-2184","title":"Surfactant Expression Defines an Inflamed Subtype of Lung Adenocarcinoma Brain Metastases that Correlates with Prolonged Survival","display_name":"Surfactant Expression Defines an Inflamed Subtype of Lung Adenocarcinoma Brain Metastases that Correlates with Prolonged Survival","publication_year":2020,"publication_date":"2020-01-17","ids":{"openalex":"https://openalex.org/W3000221494","doi":"https://doi.org/10.1158/1078-0432.ccr-19-2184","mag":"3000221494","pmid":"https://pubmed.ncbi.nlm.nih.gov/31953311"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-19-2184","doi":"https://doi.org/10.1158/1078-0432.ccr-19-2184","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-19-2184","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045140301","display_name":"Kolja Pocha","orcid":"https://orcid.org/0009-0002-7386-1357","observed_orcids":["https://orcid.org/0009-0002-7386-1357"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kolja Pocha","raw_affiliation_strings":["1Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069790818","display_name":"Andreas M\u00f6ck","orcid":"https://orcid.org/0000-0002-3332-9166","observed_orcids":["https://orcid.org/0000-0002-3332-9166"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4210111460","display_name":"National Center for Tumor Diseases","ror":"https://ror.org/01txwsw02","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210111460"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Mock","raw_affiliation_strings":["1Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany","2Department of Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg University Hospital, Heidelberg, Germany","3Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg, German Cancer Research Center (DKFZ), Heidelberg, Germany","4German Cancer Consortium (DKTK), Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]},{"raw_affiliation_string":"2Department of Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg University Hospital, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210111460"]},{"raw_affiliation_string":"3Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg, German Cancer Research Center (DKFZ), Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I4210111460"]},{"raw_affiliation_string":"4German Cancer Consortium (DKTK), Heidelberg, Germany","institution_ids":["https://openalex.org/I4391767962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034274607","display_name":"Carmen Rapp","orcid":"https://orcid.org/0009-0001-5935-5127","observed_orcids":["https://orcid.org/0009-0001-5935-5127"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Carmen Rapp","raw_affiliation_strings":["1Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033389304","display_name":"Steffen Dettling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Steffen Dettling","raw_affiliation_strings":["1Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014216255","display_name":"Rolf Warta","orcid":"https://orcid.org/0000-0003-2821-4361","observed_orcids":["https://orcid.org/0000-0003-2821-4361"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rolf Warta","raw_affiliation_strings":["1Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany","4German Cancer Consortium (DKTK), Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]},{"raw_affiliation_string":"4German Cancer Consortium (DKTK), Heidelberg, Germany","institution_ids":["https://openalex.org/I4391767962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071462400","display_name":"Christoph Geisenberger","orcid":"https://orcid.org/0000-0002-5846-7127","observed_orcids":["https://orcid.org/0000-0002-5846-7127"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christoph Geisenberger","raw_affiliation_strings":["1Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080916428","display_name":"Christine Jungk","orcid":"https://orcid.org/0009-0004-7911-0268","observed_orcids":["https://orcid.org/0009-0004-7911-0268"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christine Jungk","raw_affiliation_strings":["1Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005841369","display_name":"Leila R. Martins","orcid":"https://orcid.org/0000-0002-5887-4734","observed_orcids":["https://orcid.org/0000-0002-5887-4734"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Leila R. Martins","raw_affiliation_strings":["5Division of Applied Functional Genomics, German Cancer Research Center (DKFZ) Heidelberg, Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-5887-4734","affiliations":[{"raw_affiliation_string":"5Division of Applied Functional Genomics, German Cancer Research Center (DKFZ) Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039930487","display_name":"Niels Grabe","orcid":"https://orcid.org/0000-0003-1732-3706","observed_orcids":["https://orcid.org/0000-0003-1732-3706"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Niels Grabe","raw_affiliation_strings":["6Hamamatsu Tissue Imaging and Analysis Center (TIGA), BIOQUANT, University of Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Hamamatsu Tissue Imaging and Analysis Center (TIGA), BIOQUANT, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056148870","display_name":"David Reu\u00df","orcid":"https://orcid.org/0000-0002-4573-6033","observed_orcids":["https://orcid.org/0000-0002-4573-6033"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"David Reuss","raw_affiliation_strings":["7Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany","8Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]},{"raw_affiliation_string":"8Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I2802164966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078003238","display_name":"J\u00fcrgen Debus","orcid":"https://orcid.org/0000-0002-6411-4811","observed_orcids":["https://orcid.org/0000-0002-6411-4811"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Juergen Debus","raw_affiliation_strings":["4German Cancer Consortium (DKTK), Heidelberg, Germany","9Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4German Cancer Consortium (DKTK), Heidelberg, Germany","institution_ids":["https://openalex.org/I4391767962"]},{"raw_affiliation_string":"9Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052657395","display_name":"Andreas von Deimling","orcid":"https://orcid.org/0000-0002-5863-540X","observed_orcids":["https://orcid.org/0000-0002-5863-540X"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas von Deimling","raw_affiliation_strings":["4German Cancer Consortium (DKTK), Heidelberg, Germany","7Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany","8Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4German Cancer Consortium (DKTK), Heidelberg, Germany","institution_ids":["https://openalex.org/I4391767962"]},{"raw_affiliation_string":"7Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]},{"raw_affiliation_string":"8Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I2802164966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075116222","display_name":"Amir Abdollahi","orcid":"https://orcid.org/0000-0002-8016-5897","observed_orcids":["https://orcid.org/0000-0002-8016-5897"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Amir Abdollahi","raw_affiliation_strings":["4German Cancer Consortium (DKTK), Heidelberg, Germany","9Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-8016-5897","affiliations":[{"raw_affiliation_string":"4German Cancer Consortium (DKTK), Heidelberg, Germany","institution_ids":["https://openalex.org/I4391767962"]},{"raw_affiliation_string":"9Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014073957","display_name":"Andreas Wilhelm Unterberg","orcid":"https://orcid.org/0000-0003-3742-3288","observed_orcids":["https://orcid.org/0000-0003-3742-3288"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Unterberg","raw_affiliation_strings":["1Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025477516","display_name":"Christel C. Herold\u2010Mende","orcid":"https://orcid.org/0000-0002-1915-745X","observed_orcids":["https://orcid.org/0000-0002-1915-745X"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christel C. Herold-Mende","raw_affiliation_strings":["1Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany","4German Cancer Consortium (DKTK), Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]},{"raw_affiliation_string":"4German Cancer Consortium (DKTK), Heidelberg, Germany","institution_ids":["https://openalex.org/I4391767962"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.6277,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.91802078,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"26","issue":"9","first_page":"2231","last_page":"2243"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.5259000062942505,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.5259000062942505,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.413100004196167,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12992","display_name":"Metastasis and carcinoma case studies","score":0.013100000098347664,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9200000166893005},{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.9869999885559082},{"id":"https://openalex.org/keywords/sftpa1","display_name":"SFTPA1","score":0.9900000095367432},{"id":"https://openalex.org/keywords/surfactant-protein-b","display_name":"surfactant protein B","score":1.0},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.996999979019165},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7419999837875366},{"id":"https://openalex.org/keywords/tumor-microenvironment-inflammation","display_name":"tumor microenvironment inflammation","score":0.6309999823570251},{"id":"https://openalex.org/keywords/alveolar-type-ii-cells","display_name":"alveolar type II cells","score":0.9129999876022339},{"id":"https://openalex.org/keywords/immune-infiltration","display_name":"immune cell infiltration","score":0.6470000147819519},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.3970000147819519}],"concepts":[{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.8085043430328369},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5988845825195312},{"id":"https://openalex.org/C2778164965","wikidata":"https://www.wikidata.org/wiki/Q1620196","display_name":"Brain metastasis","level":4,"score":0.5819363594055176},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5533421635627747},{"id":"https://openalex.org/C2778326572","wikidata":"https://www.wikidata.org/wiki/Q7852668","display_name":"Tumor-infiltrating lymphocytes","level":4,"score":0.5485953092575073},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.4884752333164215},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4850258231163025},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.45914244651794434},{"id":"https://openalex.org/C2779130545","wikidata":"https://www.wikidata.org/wiki/Q233309","display_name":"Brain tumor","level":2,"score":0.44212907552719116},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.44175344705581665},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4226023554801941},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4180793762207031},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41172677278518677},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4112413227558136},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.3457929491996765},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2946944534778595},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2925739884376526},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21642562747001648},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2026297152042389},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16796129941940308},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016246","descriptor_name":"Lymphocytes, Tumor-Infiltrating","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016246","descriptor_name":"Lymphocytes, Tumor-Infiltrating","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016282","descriptor_name":"Aspartic Acid Endopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016282","descriptor_name":"Aspartic Acid Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016827","descriptor_name":"CD8 Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016827","descriptor_name":"CD8 Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017252","descriptor_name":"CD3 Complex","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017252","descriptor_name":"CD3 Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D037662","descriptor_name":"Pulmonary Surfactant-Associated Protein A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D037662","descriptor_name":"Pulmonary Surfactant-Associated Protein A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.ccr-19-2184","doi":"https://doi.org/10.1158/1078-0432.ccr-19-2184","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-19-2184","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:31953311","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31953311","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320881","display_name":"Universit\u00e4t Heidelberg","ror":"https://ror.org/038t36y30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1584549463","https://openalex.org/W1760562407","https://openalex.org/W1827997917","https://openalex.org/W1859257957","https://openalex.org/W1867691097","https://openalex.org/W1966896924","https://openalex.org/W1981934675","https://openalex.org/W2005312471","https://openalex.org/W2016908822","https://openalex.org/W2020830322","https://openalex.org/W2028426093","https://openalex.org/W2034387476","https://openalex.org/W2043729728","https://openalex.org/W2049491375","https://openalex.org/W2056998032","https://openalex.org/W2071793654","https://openalex.org/W2078439148","https://openalex.org/W2089597174","https://openalex.org/W2097677427","https://openalex.org/W2114701172","https://openalex.org/W2119301589","https://openalex.org/W2124837959","https://openalex.org/W2137119270","https://openalex.org/W2158564443","https://openalex.org/W2158982109","https://openalex.org/W2161643019","https://openalex.org/W2161818848","https://openalex.org/W2169556367","https://openalex.org/W2180481128","https://openalex.org/W2276790712","https://openalex.org/W2321170268","https://openalex.org/W2329413991","https://openalex.org/W2339862396","https://openalex.org/W2412681020","https://openalex.org/W2533301708","https://openalex.org/W2589021658","https://openalex.org/W2737095627","https://openalex.org/W2760098927","https://openalex.org/W2772527484","https://openalex.org/W2785416267","https://openalex.org/W2786452644","https://openalex.org/W2793974615","https://openalex.org/W2796207838","https://openalex.org/W2796442831","https://openalex.org/W2799898070","https://openalex.org/W2803457783","https://openalex.org/W2865352686","https://openalex.org/W2888914413","https://openalex.org/W2900082702","https://openalex.org/W2907564726","https://openalex.org/W2922140624","https://openalex.org/W4233270106"],"related_works":["https://openalex.org/W4414786589","https://openalex.org/W4416141069","https://openalex.org/W2947137333","https://openalex.org/W4386644935","https://openalex.org/W4409216678","https://openalex.org/W2955609209","https://openalex.org/W3177458483","https://openalex.org/W3191232168","https://openalex.org/W4304083982","https://openalex.org/W4221060671"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"To":[2],"provide":[3],"a":[4,54,72,195,206,211,250,254],"better":[5],"understanding":[6],"of":[7,47,59,62,74,130,171,186,214,221,233,242],"the":[8,11,60],"interplay":[9],"between":[10,198],"immune":[12,187],"system":[13],"and":[14,51,99,137,201,227,253],"brain":[15,37,65,81,123,152,166,236],"metastases":[16,38,66,82,167,237],"to":[17,85,247,262],"advance":[18],"therapeutic":[19],"options":[20],"for":[21],"this":[22],"life-threatening":[23],"disease.":[24],"Experimental":[25],"Design:":[26],"Tumor-infiltrating":[27],"lymphocytes":[28],"(TIL)":[29],"were":[30,67,83],"quantified":[31],"by":[32,69,239],"semiautomated":[33],"whole-slide":[34],"analysis":[35],"in":[36,64,71,78,118,151,156,190,244],"from":[39,176],"81":[40],"lung":[41,79,89,121,158,192,234],"adenocarcinomas.":[42],"Multi-color":[43],"staining":[44],"enabled":[45],"phenotyping":[46],"TILs":[48,63,243],"(CD3,":[49],"CD8,":[50],"FOXP3)":[52],"on":[53],"single-cell":[55,100],"resolution.":[56],"Molecular":[57],"determinants":[58],"extent":[61],"analyzed":[68],"transcriptomics":[70,126],"subset":[73],"63":[75],"patients.":[76],"Findings":[77],"adenocarcinoma":[80,90,122,193,235],"related":[84],"published":[86],"multi-omic":[87],"primary":[88,157,191],"The":[91,219],"Cancer":[92],"Genome":[93],"Atlas":[94],"data":[95,103,163],"(n":[96,104],"=":[97,105],"230)":[98],"RNA-sequencing":[101],"(scRNA-seq)":[102],"52,698).":[106],"Results:":[107],"TIL":[108,143],"numbers":[109],"within":[110],"tumor":[111,177,248,255],"islands":[112],"was":[113,139,147],"an":[114,215,230],"independent":[115],"prognostic":[116,150],"marker":[117],"patients":[119],"with":[120,142,161,168,205],"metastases.":[124],"Comparative":[125],"revealed":[127,164],"that":[128,165],"expression":[129,146,170,209,220],"three":[131],"surfactant":[132,172,202,208,222],"metabolism-related":[133,223],"genes":[134,173,224],"(SFTPA1,":[135,225],"SFTPB,":[136,226],"NAPSA)":[138,228],"closely":[140],"associated":[141],"numbers.":[144],"Their":[145],"not":[148],"only":[149],"metastasis":[153],"but":[154],"also":[155],"adenocarcinoma.":[159],"Correlation":[160],"scRNA-seq":[162],"high":[169,207,240],"might":[174,258],"originate":[175],"cells":[178],"resembling":[179],"alveolar":[180],"type":[181],"2":[182],"cells.":[183],"Methylome-based":[184],"estimation":[185],"cell":[188],"fractions":[189],"confirmed":[194],"positive":[196],"association":[197],"lymphocyte":[199],"infiltration":[200],"expression.":[203],"Tumors":[204],"displayed":[210],"transcriptomic":[212],"profile":[213],"inflammatory":[216],"microenvironment.":[217],"Conclusions:":[218],"defines":[229],"inflamed":[231],"subtype":[232],"characterized":[238],"abundance":[241],"close":[245],"vicinity":[246],"cells,":[249],"prolonged":[251],"survival,":[252],"microenvironment":[256],"which":[257],"be":[259],"more":[260],"accessible":[261],"immunotherapeutic":[263],"approaches.":[264]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2020-01-23T00:00:00"}