{"id":"https://openalex.org/W3000208382","doi":"https://doi.org/10.1016/j.ctarc.2020.100164","title":"Emerging treatments for metastatic castration-resistant prostate cancer: Immunotherapy, PARP inhibitors, and PSMA-targeted approaches","display_name":"Emerging treatments for metastatic castration-resistant prostate cancer: Immunotherapy, PARP inhibitors, and PSMA-targeted approaches","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3000208382","doi":"https://doi.org/10.1016/j.ctarc.2020.100164","mag":"3000208382","pmid":"https://pubmed.ncbi.nlm.nih.gov/31978677"},"language":"en","primary_location":{"id":"doi:10.1016/j.ctarc.2020.100164","doi":"https://doi.org/10.1016/j.ctarc.2020.100164","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ctarc.2020.100164","pdf_url":null,"source":{"id":"https://openalex.org/S4210186504","display_name":"Cancer Treatment and Research Communications","issn_l":"2468-2942","issn":["2468-2942"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Treatment and Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.ctarc.2020.100164","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054465612","display_name":"Catherine Handy Marshall","orcid":"https://orcid.org/0000-0002-2653-4110","observed_orcids":["https://orcid.org/0000-0002-2653-4110"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine Handy Marshall","raw_affiliation_strings":["CHM, ESA - The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 201 N. Broadway, Skip Viragh Building, Baltimore, MD 21287, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHM, ESA - The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 201 N. Broadway, Skip Viragh Building, Baltimore, MD 21287, United States","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018645768","display_name":"Emmanuel S. Antonarakis","orcid":"https://orcid.org/0000-0003-0031-9655","observed_orcids":["https://orcid.org/0000-0003-0031-9655","https://orcid.org/0000-0003-3531-3851"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Emmanuel S. Antonarakis","raw_affiliation_strings":["CHM, ESA - The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 201 N. Broadway, Skip Viragh Building, Baltimore, MD 21287, United States. Electronic address: eantona1@jhmi.edu","CHM, ESA \u2013 The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 201 N. Broadway, Skip Viragh Building, Baltimore, MD 21287, United States"],"raw_orcid":"https://orcid.org/0000-0003-0031-9655","affiliations":[{"raw_affiliation_string":"CHM, ESA - The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 201 N. Broadway, Skip Viragh Building, Baltimore, MD 21287, United States. Electronic address: eantona1@jhmi.edu","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]},{"raw_affiliation_string":"CHM, ESA \u2013 The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 201 N. Broadway, Skip Viragh Building, Baltimore, MD 21287, United States","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5018645768"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"],"apc_list":{"value":650,"currency":"USD","value_usd":650},"apc_paid":{"value":650,"currency":"USD","value_usd":650},"fwci":3.7341,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.94982216,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"23","issue":null,"first_page":"100164","last_page":"100164"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastatic-castration-resistant-prostate-cancer","display_name":"metastatic castration-resistant prostate cancer","score":1.0},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.9700000286102295},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.9739999771118164},{"id":"https://openalex.org/keywords/parp-inhibitors","display_name":"PARP inhibitors","score":0.9950000047683716},{"id":"https://openalex.org/keywords/prostate-specific-membrane-antigen","display_name":"prostate-specific membrane antigen","score":0.9279999732971191},{"id":"https://openalex.org/keywords/psma-targeted-therapy","display_name":"PSMA-targeted therapy","score":0.9599999785423279},{"id":"https://openalex.org/keywords/biomarker-selection","display_name":"biomarker selection","score":0.9039999842643738},{"id":"https://openalex.org/keywords/novel-cancer-therapies","display_name":"novel cancer therapies","score":0.3610000014305115}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.8784217834472656},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7562999129295349},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6891019344329834},{"id":"https://openalex.org/C2779138821","wikidata":"https://www.wikidata.org/wiki/Q7118227","display_name":"PARP inhibitor","level":5,"score":0.6211082935333252},{"id":"https://openalex.org/C2779962180","wikidata":"https://www.wikidata.org/wiki/Q7083106","display_name":"Olaparib","level":5,"score":0.5089151859283447},{"id":"https://openalex.org/C2776551883","wikidata":"https://www.wikidata.org/wiki/Q1996756","display_name":"Enzalutamide","level":5,"score":0.4337872862815857},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.42646318674087524},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.424814373254776},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41633540391921997},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.41172075271606445},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.3805687427520752},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3380777835845947},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.1554587185382843},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08860522508621216},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.ctarc.2020.100164","doi":"https://doi.org/10.1016/j.ctarc.2020.100164","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ctarc.2020.100164","pdf_url":null,"source":{"id":"https://openalex.org/S4210186504","display_name":"Cancer Treatment and Research Communications","issn_l":"2468-2942","issn":["2468-2942"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Treatment and Research Communications","raw_type":"journal-article"},{"id":"pmid:31978677","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31978677","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer treatment and research communications","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:e290a396bdb940258abda6035db24c35","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e290a396bdb940258abda6035db24c35","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Treatment and Research Communications, Vol 23, Iss , Pp 100164- (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.ctarc.2020.100164","doi":"https://doi.org/10.1016/j.ctarc.2020.100164","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ctarc.2020.100164","pdf_url":null,"source":{"id":"https://openalex.org/S4210186504","display_name":"Cancer Treatment and Research Communications","issn_l":"2468-2942","issn":["2468-2942"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Treatment and Research Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W1578291413","https://openalex.org/W1940241680","https://openalex.org/W1979811833","https://openalex.org/W1981214901","https://openalex.org/W1999671728","https://openalex.org/W2010121426","https://openalex.org/W2045292016","https://openalex.org/W2088438005","https://openalex.org/W2097995306","https://openalex.org/W2103959341","https://openalex.org/W2127132803","https://openalex.org/W2143772132","https://openalex.org/W2160834915","https://openalex.org/W2222086386","https://openalex.org/W2235405584","https://openalex.org/W2372842761","https://openalex.org/W2462985846","https://openalex.org/W2466387665","https://openalex.org/W2467018059","https://openalex.org/W2515436849","https://openalex.org/W2531934133","https://openalex.org/W2589585076","https://openalex.org/W2591709377","https://openalex.org/W2597062310","https://openalex.org/W2622499649","https://openalex.org/W2788746158","https://openalex.org/W2789900707","https://openalex.org/W2790416057","https://openalex.org/W2792588868","https://openalex.org/W2808021061","https://openalex.org/W2809493795","https://openalex.org/W2809814605","https://openalex.org/W2810280645","https://openalex.org/W2838357484","https://openalex.org/W2883285168","https://openalex.org/W2891475975","https://openalex.org/W2891654637","https://openalex.org/W2896844652","https://openalex.org/W2902077831","https://openalex.org/W2908503672","https://openalex.org/W2911188335","https://openalex.org/W2915732659","https://openalex.org/W2915944698","https://openalex.org/W2921027623","https://openalex.org/W2921281835","https://openalex.org/W2921611058","https://openalex.org/W2921644952","https://openalex.org/W2922348865","https://openalex.org/W2937409539","https://openalex.org/W2941516488","https://openalex.org/W2944320012","https://openalex.org/W2947722113","https://openalex.org/W2947985252","https://openalex.org/W2962675576","https://openalex.org/W2977716713","https://openalex.org/W2977776206","https://openalex.org/W2978095728","https://openalex.org/W2982317905","https://openalex.org/W2989894179","https://openalex.org/W2990771207","https://openalex.org/W4234319381","https://openalex.org/W4239963361","https://openalex.org/W4246514338","https://openalex.org/W4249931646","https://openalex.org/W6768033661","https://openalex.org/W6768896714","https://openalex.org/W6770751402","https://openalex.org/W7074041926"],"related_works":["https://openalex.org/W4381988917","https://openalex.org/W3095574415","https://openalex.org/W4308768653","https://openalex.org/W3036764657","https://openalex.org/W3098718205","https://openalex.org/W4319163650","https://openalex.org/W7154481598","https://openalex.org/W7141165881","https://openalex.org/W3217027632","https://openalex.org/W4413094001"],"abstract_inverted_index":{"Recently":[0],"there":[1],"has":[2],"been":[3],"an":[4],"explosion":[5],"of":[6,14,41,52,92,107,115,128,134,138,159],"new":[7,20,27,30],"agents":[8,130,144],"being":[9,87],"investigated":[10],"for":[11,89,100,131,148],"the":[12,45,50,59,90,112,126,132,136,151,157],"treatment":[13,42,91,133],"prostate":[15,55,101],"cancer.":[16,102],"These":[17],"modalities":[18],"represent":[19],"therapies":[21,28,83],"aimed":[22],"at":[23],"old":[24],"targets,":[25],"and":[26,38,68,81,141],"addressing":[29],"targets.":[31],"This":[32,117],"review":[33,118],"will":[34,119,154],"highlight":[35],"three":[36,105],"novel":[37],"emerging":[39],"areas":[40,137],"that":[43],"have":[44],"potential":[46],"to":[47,162,170,172],"significantly":[48],"impact":[49],"management":[51],"metastatic":[53],"castration-resistant":[54],"cancer":[56],"(mCRPC)":[57],"in":[58,150],"near":[60],"future:":[61],"immunotherapy,":[62],"poly":[63],"ADP-ribose":[64],"polymerase":[65],"(PARP)":[66],"inhibitors,":[67,80],"prostate-specific":[69],"membrane":[70],"antigen":[71],"(PSMA)-targeted":[72],"modalities.":[73],"Immunotherapy,":[74],"particularly":[75],"immune":[76],"checkpoint":[77],"blockers,":[78],"PARP":[79],"PSMA-targeted":[82],"are":[84,96,167],"all":[85],"increasingly":[86],"studied":[88],"mCRPC":[93],"although":[94],"none":[95],"currently":[97,123],"FDA-approved":[98],"specifically":[99],"Together":[103],"these":[104,129,143,173],"classes":[106],"treatments":[108],"may":[109,145],"drastically":[110],"change":[111],"future":[113],"landscape":[114],"mCRPC.":[116],"cover":[120],"what":[121],"is":[122],"known":[124],"about":[125],"utility":[127],"mCRPC,":[135],"active":[139],"research,":[140],"how":[142],"be":[146],"useful":[147],"patients":[149,166],"future.":[152],"It":[153],"also":[155],"emphasize":[156],"notion":[158],"biomarker":[160],"selection":[161],"help":[163],"inform":[164],"which":[165],"more":[168],"likely":[169],"respond":[171],"therapies.":[174]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-01-23T00:00:00"}