{"id":"https://openalex.org/W3000189340","doi":"https://doi.org/10.1080/14756366.2019.1702655","title":"Synthesis and biological evaluation of novel (E)-N'-benzylidene hydrazides as novel c-Met inhibitors through fragment based virtual screening","display_name":"Synthesis and biological evaluation of novel (E)-N'-benzylidene hydrazides as novel c-Met inhibitors through fragment based virtual screening","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3000189340","doi":"https://doi.org/10.1080/14756366.2019.1702655","mag":"3000189340","pmid":"https://pubmed.ncbi.nlm.nih.gov/31902266"},"language":"en","primary_location":{"id":"doi:10.1080/14756366.2019.1702655","doi":"https://doi.org/10.1080/14756366.2019.1702655","is_oa":true,"landing_page_url":"https://doi.org/10.1080/14756366.2019.1702655","pdf_url":null,"source":{"id":"https://openalex.org/S192603849","display_name":"Journal of Enzyme Inhibition and Medicinal Chemistry","issn_l":"1475-6366","issn":["1475-6366","1475-6374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Enzyme Inhibition and Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1080/14756366.2019.1702655","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090029554","display_name":"Jingwei Liang","orcid":"https://orcid.org/0009-0008-0785-6246","observed_orcids":["https://orcid.org/0009-0008-0785-6246","https://orcid.org/0000-0002-4779-5854"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing-wei Liang","raw_affiliation_strings":["School of Pharmacy, China Medical University, Shen Yang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, China Medical University, Shen Yang, China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100725232","display_name":"Shilong Li","orcid":"https://orcid.org/0000-0002-9581-8029","observed_orcids":["https://orcid.org/0000-0002-9581-8029"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shi-long Li","raw_affiliation_strings":["School of Pharmacy, China Medical University, Shen Yang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, China Medical University, Shen Yang, China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100388447","display_name":"Shan Wang","orcid":"https://orcid.org/0000-0002-6912-1949","observed_orcids":["https://orcid.org/0000-0002-6912-1949"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shan Wang","raw_affiliation_strings":["School of Pharmacy, China Medical University, Shen Yang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, China Medical University, Shen Yang, China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101565891","display_name":"Wanqiu Li","orcid":"https://orcid.org/0000-0001-6359-5505","observed_orcids":["https://orcid.org/0000-0001-6359-5505"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wan-qiu Li","raw_affiliation_strings":["School of Pharmacy, China Medical University, Shen Yang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, China Medical University, Shen Yang, China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054340650","display_name":"Fan\u2010hao Meng","orcid":"https://orcid.org/0000-0002-1331-2164","observed_orcids":["https://orcid.org/0000-0002-1331-2164","https://orcid.org/0000-0001-9858-7652"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fan-hao Meng","raw_affiliation_strings":["School of Pharmacy, China Medical University, Shen Yang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, China Medical University, Shen Yang, China","institution_ids":["https://openalex.org/I91656880"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5054340650"],"corresponding_institution_ids":["https://openalex.org/I91656880"],"apc_list":{"value":1880,"currency":"GBP","value_usd":2306},"apc_paid":{"value":1880,"currency":"GBP","value_usd":2306},"fwci":0.9582,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.77139399,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"35","issue":"1","first_page":"468","last_page":"477"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.524399995803833,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.524399995803833,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.3375999927520752,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.07240000367164612,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-met-kinase-inhibitors","display_name":"c-Met inhibitor","score":0.9129999876022339},{"id":"https://openalex.org/keywords/type-ii-kinase-inhibitors","display_name":"type II kinase inhibitors","score":0.7749999761581421},{"id":"https://openalex.org/keywords/fragment-based-virtual-screening","display_name":"fragment-based virtual screening","score":0.8389999866485596},{"id":"https://openalex.org/keywords/vegfr-2-inhibition","display_name":"VEGFR-2 inhibition","score":0.8500000238418579},{"id":"https://openalex.org/keywords/multikinase-inhibitor","display_name":"multikinase inhibitor","score":0.8569999933242798},{"id":"https://openalex.org/keywords/dfg-out-conformation","display_name":"DFG-out conformation","score":0.8090000152587891},{"id":"https://openalex.org/keywords/anticancer-drug-discovery","display_name":"anticancer drug discovery","score":0.7239999771118164}],"concepts":[{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.7325378656387329},{"id":"https://openalex.org/C2776235265","wikidata":"https://www.wikidata.org/wiki/Q18392052","display_name":"Fragment (logic)","level":2,"score":0.7298310995101929},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.7005047798156738},{"id":"https://openalex.org/C103697762","wikidata":"https://www.wikidata.org/wiki/Q4112105","display_name":"Virtual screening","level":3,"score":0.6733326315879822},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6330780386924744},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.540849506855011},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5282860398292542},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5160303115844727},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.4794965386390686},{"id":"https://openalex.org/C2780467284","wikidata":"https://www.wikidata.org/wiki/Q5005897","display_name":"C-Met","level":4,"score":0.46354907751083374},{"id":"https://openalex.org/C193042331","wikidata":"https://www.wikidata.org/wiki/Q1772003","display_name":"Structure\u2013activity relationship","level":3,"score":0.4248831272125244},{"id":"https://openalex.org/C2777752112","wikidata":"https://www.wikidata.org/wiki/Q903238","display_name":"Lead compound","level":3,"score":0.41452455520629883},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3542816638946533},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.32815802097320557},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3242778182029724},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.15803304314613342},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15705958008766174},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.06732240319252014},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C2776996007","wikidata":"https://www.wikidata.org/wiki/Q2399112","display_name":"Hepatocyte growth factor","level":3,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001597","descriptor_name":"Benzylidene Compounds","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D001597","descriptor_name":"Benzylidene Compounds","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D001597","descriptor_name":"Benzylidene Compounds","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D001597","descriptor_name":"Benzylidene Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001597","descriptor_name":"Benzylidene Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001597","descriptor_name":"Benzylidene Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001597","descriptor_name":"Benzylidene Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001597","descriptor_name":"Benzylidene Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001597","descriptor_name":"Benzylidene Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019859","descriptor_name":"Proto-Oncogene Proteins c-met","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019859","descriptor_name":"Proto-Oncogene Proteins c-met","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019859","descriptor_name":"Proto-Oncogene Proteins c-met","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040301","descriptor_name":"Vascular Endothelial Growth Factor Receptor-2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D040301","descriptor_name":"Vascular Endothelial Growth Factor Receptor-2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D040301","descriptor_name":"Vascular Endothelial Growth Factor Receptor-2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1080/14756366.2019.1702655","doi":"https://doi.org/10.1080/14756366.2019.1702655","is_oa":true,"landing_page_url":"https://doi.org/10.1080/14756366.2019.1702655","pdf_url":null,"source":{"id":"https://openalex.org/S192603849","display_name":"Journal of Enzyme Inhibition and Medicinal Chemistry","issn_l":"1475-6366","issn":["1475-6366","1475-6374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Enzyme Inhibition and Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:31902266","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31902266","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of enzyme inhibition and medicinal chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6968643","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6968643","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Enzyme Inhib Med Chem","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:9836e3cd13414540b69bd3d4f0257da7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9836e3cd13414540b69bd3d4f0257da7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 468-477 (2020)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/11522259","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Synthesis_and_biological_evaluation_of_novel_i_E_i_-_i_N_i_-benzylidene_hydrazides_as_novel_c-Met_inhibitors_through_fragment_based_virtual_screening/11522259","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"doi:10.6084/m9.figshare.11522259.v1","doi":"https://doi.org/10.6084/m9.figshare.11522259.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.11522259.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1080/14756366.2019.1702655","doi":"https://doi.org/10.1080/14756366.2019.1702655","is_oa":true,"landing_page_url":"https://doi.org/10.1080/14756366.2019.1702655","pdf_url":null,"source":{"id":"https://openalex.org/S192603849","display_name":"Journal of Enzyme Inhibition and Medicinal Chemistry","issn_l":"1475-6366","issn":["1475-6366","1475-6374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Enzyme Inhibition and Medicinal Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2925929823","display_name":null,"funder_award_id":"81274182","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G293111913","display_name":"\u57fa\u4e8eHsp90\u7684\u4e4c\u5934\u4e8c\u841c\u751f\u7269\u78b1\u6784\u6548\u5173\u7cfb\u4e0e\u9776\u5411\u6297\u80bf\u7624\u6bd2\u6548\u673a\u5236\u7814\u7a76","funder_award_id":"81573687","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6774338142","display_name":null,"funder_award_id":"81274182,81573687","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1426393029","https://openalex.org/W1506923787","https://openalex.org/W1826786205","https://openalex.org/W1837139339","https://openalex.org/W1989168998","https://openalex.org/W2011138678","https://openalex.org/W2018431694","https://openalex.org/W2020914780","https://openalex.org/W2039013742","https://openalex.org/W2067710527","https://openalex.org/W2084630618","https://openalex.org/W2087385582","https://openalex.org/W2099565829","https://openalex.org/W2103850766","https://openalex.org/W2130921495","https://openalex.org/W2170048458","https://openalex.org/W2221511591","https://openalex.org/W2314041260","https://openalex.org/W2329029777","https://openalex.org/W2329789195","https://openalex.org/W2728176075","https://openalex.org/W2785928288","https://openalex.org/W2901806147","https://openalex.org/W2907987643","https://openalex.org/W2909285126","https://openalex.org/W2939564294","https://openalex.org/W3018827483"],"related_works":["https://openalex.org/W2797908443","https://openalex.org/W2155486504","https://openalex.org/W2463644552","https://openalex.org/W2604046749","https://openalex.org/W2054073249","https://openalex.org/W2049431076","https://openalex.org/W2086923589","https://openalex.org/W2018043136","https://openalex.org/W2948979411","https://openalex.org/W2766599093"],"abstract_inverted_index":{"C-Met":[0],"plays":[1],"a":[2,99],"crucial":[3],"role":[4],"in":[5,26,67],"the":[6,18,23,35,49,77,83,120],"development":[7],"and":[8,72],"progression":[9],"of":[10,22,54,122],"neoplastic":[11],"disease.":[12],"Type":[13],"II":[14,102],"c-Met":[15,71,84,94,103],"inhibitors":[16],"recognise":[17],"inactive":[19],"DFG-out":[20],"conformation":[21],"kinase,":[24],"result":[25],"better":[27],"anti-tumour":[28],"effects":[29],"due":[30],"to":[31,39],"synergistic":[32],"effect":[33],"against":[34,70,82,109,113],"other":[36],"kinases.":[37],"According":[38],"our":[40],"previous":[41],"works,":[42],"an":[43],"(E)-N'-benzylidene":[44,55],"group":[45],"was":[46],"selected":[47],"as":[48,98],"initial":[50],"fragment.":[51],"Two":[52],"series":[53],"hydrazides":[56],"were":[57,66],"designed":[58],"by":[59],"fragment":[60],"growth":[61],"method.":[62],"The":[63,115],"inhibitory":[64,80,96],"activities":[65],"vitro":[68],"investigated":[69],"VEGFR-2.":[73],"Compound":[74,90],"10b":[75],"exhibited":[76,92],"most":[78],"potent":[79],"activity":[81,97],"inhibitor":[85,104],"(IC50":[86,105],"=":[87,106],"0.37":[88],"nM).":[89],"11b":[91],"multi-target":[93],"kinase":[95],"potential":[100],"type":[101],"3.41":[107],"nM":[108,112],"c-Met;":[110],"25.34":[111],"VEGFR-2).":[114],"two":[116],"compounds":[117],"also":[118],"demonstrate":[119],"feasibility":[121],"fragment-based":[123],"virtual":[124],"screening":[125],"method":[126],"for":[127],"drug":[128],"discovery.":[129]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2}],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2020-01-23T00:00:00"}
