{"id":"https://openalex.org/W2999873377","doi":null,"title":"A new generic platform for PET imaging based on 68Ga-labeled Pept-insTM: from infectious disease to cancer imaging","display_name":"A new generic platform for PET imaging based on 68Ga-labeled Pept-insTM: from infectious disease to cancer imaging","publication_year":2018,"publication_date":"2018-05-01","ids":{"openalex":"https://openalex.org/W2999873377","mag":"2999873377"},"language":"en","primary_location":{"id":"mag:2999873377","doi":null,"is_oa":false,"landing_page_url":"https://jnm.snmjournals.org/content/59/supplement_1/70","pdf_url":null,"source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Nuclear Medicine","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048462496","display_name":"Maxime Siemons","orcid":"https://orcid.org/0000-0001-7736-1582","observed_orcids":["https://orcid.org/0000-0001-7736-1582"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Maxime Siemons","raw_affiliation_strings":["Laboratory for Radiopharmaceutical Research, KU Leuven, Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0001-7736-1582","affiliations":[{"raw_affiliation_string":"Laboratory for Radiopharmaceutical Research, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049354738","display_name":"Ladan Khodaparast","orcid":"https://orcid.org/0000-0001-6373-8019","observed_orcids":["https://orcid.org/0000-0001-6373-8019","https://orcid.org/0009-0006-4845-285X"]},"institutions":[{"id":"https://openalex.org/I4210153928","display_name":"VIB-KU Leuven Center for Brain & Disease Research","ror":"https://ror.org/045c7t348","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950","https://openalex.org/I4210153928","https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Ladan Khodaparast","raw_affiliation_strings":["Switch Laboratory, VIB\u2010KU Leuven Center for Brain & Disease Research KU Leuven Leuven  Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Switch Laboratory, VIB\u2010KU Leuven Center for Brain & Disease Research KU Leuven Leuven  Belgium","institution_ids":["https://openalex.org/I4210153928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101735632","display_name":"Laleh Khodaparast","orcid":"https://orcid.org/0000-0002-5865-7748","observed_orcids":["https://orcid.org/0000-0002-5865-7748","https://orcid.org/0009-0004-9659-4137"]},"institutions":[{"id":"https://openalex.org/I4210153928","display_name":"VIB-KU Leuven Center for Brain & Disease Research","ror":"https://ror.org/045c7t348","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950","https://openalex.org/I4210153928","https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Laleh Khodaparast","raw_affiliation_strings":["Switch Laboratory, VIB\u2010KU Leuven Center for Brain & Disease Research KU Leuven Leuven  Belgium"],"raw_orcid":"https://orcid.org/0009-0004-9659-4137","affiliations":[{"raw_affiliation_string":"Switch Laboratory, VIB\u2010KU Leuven Center for Brain & Disease Research KU Leuven Leuven  Belgium","institution_ids":["https://openalex.org/I4210153928"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Filip Claes","orcid":"https://orcid.org/0000-0002-5705-7572","observed_orcids":["https://orcid.org/0000-0002-5705-7572"]},"institutions":[{"id":"https://openalex.org/I4210153928","display_name":"VIB-KU Leuven Center for Brain & Disease Research","ror":"https://ror.org/045c7t348","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950","https://openalex.org/I4210153928","https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Filip Claes","raw_affiliation_strings":["Switch Laboratory, VIB\u2010KU Leuven Center for Brain & Disease Research KU Leuven Leuven  Belgium"],"raw_orcid":"https://orcid.org/0000-0002-5705-7572","affiliations":[{"raw_affiliation_string":"Switch Laboratory, VIB\u2010KU Leuven Center for Brain & Disease Research KU Leuven Leuven  Belgium","institution_ids":["https://openalex.org/I4210153928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018247276","display_name":"Rodrigo U. Gallardo","orcid":"https://orcid.org/0000-0003-1584-3564","observed_orcids":["https://orcid.org/0000-0003-1584-3564"]},"institutions":[{"id":"https://openalex.org/I4210153928","display_name":"VIB-KU Leuven Center for Brain & Disease Research","ror":"https://ror.org/045c7t348","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950","https://openalex.org/I4210153928","https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Rodrigo Gallardo","raw_affiliation_strings":["Switch Laboratory, VIB\u2010KU Leuven Center for Brain & Disease Research KU Leuven Leuven  Belgium"],"raw_orcid":"https://orcid.org/0000-0003-1584-3564","affiliations":[{"raw_affiliation_string":"Switch Laboratory, VIB\u2010KU Leuven Center for Brain & Disease Research KU Leuven Leuven  Belgium","institution_ids":["https://openalex.org/I4210153928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026197000","display_name":"Meine Ramakers","orcid":"https://orcid.org/0000-0002-9417-4196","observed_orcids":["https://orcid.org/0000-0002-9417-4196"]},"institutions":[{"id":"https://openalex.org/I4210153928","display_name":"VIB-KU Leuven Center for Brain & Disease Research","ror":"https://ror.org/045c7t348","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950","https://openalex.org/I4210153928","https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Meine Ramakers","raw_affiliation_strings":["Switch Laboratory, VIB\u2010KU Leuven Center for Brain & Disease Research KU Leuven Leuven  Belgium"],"raw_orcid":"https://orcid.org/0000-0002-9417-4196","affiliations":[{"raw_affiliation_string":"Switch Laboratory, VIB\u2010KU Leuven Center for Brain & Disease Research KU Leuven Leuven  Belgium","institution_ids":["https://openalex.org/I4210153928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008256216","display_name":"Fr\u00e9d\u00e9ric Rousseau","orcid":"https://orcid.org/0000-0002-9189-7399","observed_orcids":["https://orcid.org/0000-0002-9189-7399"]},"institutions":[{"id":"https://openalex.org/I4210153928","display_name":"VIB-KU Leuven Center for Brain & Disease Research","ror":"https://ror.org/045c7t348","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950","https://openalex.org/I4210153928","https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Fr\u00e9d\u00e9ric Rousseau","raw_affiliation_strings":["Switch Laboratory, VIB\u2010KU Leuven Center for Brain & Disease Research KU Leuven Leuven  Belgium"],"raw_orcid":"https://orcid.org/0000-0002-9189-7399","affiliations":[{"raw_affiliation_string":"Switch Laboratory, VIB\u2010KU Leuven Center for Brain & Disease Research KU Leuven Leuven  Belgium","institution_ids":["https://openalex.org/I4210153928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031589452","display_name":"Joost W. H. Schymkowitz","orcid":"https://orcid.org/0000-0003-2020-0168","observed_orcids":["https://orcid.org/0000-0003-2020-0168"]},"institutions":[{"id":"https://openalex.org/I4210153928","display_name":"VIB-KU Leuven Center for Brain & Disease Research","ror":"https://ror.org/045c7t348","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950","https://openalex.org/I4210153928","https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Joost Schymkowitz","raw_affiliation_strings":["Switch Laboratory, VIB\u2010KU Leuven Center for Brain & Disease Research KU Leuven Leuven  Belgium"],"raw_orcid":"https://orcid.org/0000-0003-2020-0168","affiliations":[{"raw_affiliation_string":"Switch Laboratory, VIB\u2010KU Leuven Center for Brain & Disease Research KU Leuven Leuven  Belgium","institution_ids":["https://openalex.org/I4210153928"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072600244","display_name":"Guy M Bormans","orcid":"https://orcid.org/0000-0002-0335-7190","observed_orcids":["https://orcid.org/0000-0002-0335-7190"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Guy Bormans","raw_affiliation_strings":["Laboratory for Radiopharmaceutical Research, KU Leuven, Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-0335-7190","affiliations":[{"raw_affiliation_string":"Laboratory for Radiopharmaceutical Research, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.26822687,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"59","issue":null,"first_page":"70","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyloidogenic-peptides","display_name":"amyloidogenic peptides","score":0.8130000233650208},{"id":"https://openalex.org/keywords/beta-sheet-aggregation","display_name":"\u03b2-sheet aggregation","score":0.8159999847412109},{"id":"https://openalex.org/keywords/positron-emission-tomography","display_name":"positron emission tomography","score":0.6029999852180481},{"id":"https://openalex.org/keywords/vegfr2","display_name":"VEGFR2","score":0.8009999990463257},{"id":"https://openalex.org/keywords/escherichia-coli-infection","display_name":"Escherichia coli infection","score":0.6600000262260437},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.7049999833106995},{"id":"https://openalex.org/keywords/radiolabeled-peptides","display_name":"radiolabeled peptides","score":0.6039999723434448}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7343052625656128},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.6302834153175354},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5092169046401978},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.41670021414756775},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3846694529056549},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3348483443260193},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11044740676879883},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2999873377","doi":null,"is_oa":false,"landing_page_url":"https://jnm.snmjournals.org/content/59/supplement_1/70","pdf_url":null,"source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Nuclear Medicine","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3198681671","https://openalex.org/W2074513503","https://openalex.org/W2055421103","https://openalex.org/W3164689373","https://openalex.org/W4302012188","https://openalex.org/W2278673637","https://openalex.org/W6977862078","https://openalex.org/W2083916521","https://openalex.org/W4309720732","https://openalex.org/W4281766263"],"abstract_inverted_index":{"70":[0],"Objectives:":[2],"The":[4,147],"Pept-in":[5],"technology":[6],"is":[7,183],"based":[8],"on":[9],"a":[10,16,42,67,184,217],"highly":[11],"specific":[12],"beta-sheet":[13,117,186],"aggregation":[14,97,118],"of":[15,98,116,150,158,177,272],"target":[17,38,124,206],"protein,":[18],"induced":[19],"by":[20,56,95,133,175,210],"short":[21],"amyloidogenic":[22,87,136],"peptides":[23],"called":[24,89],"Pept-ins":[25,160],"(7-20":[26],"AA).":[27],"Pept-In":[28],"sequences":[29],"are":[30],"derived":[31],"from":[32],"aggregation-prone":[33,126],"regions":[34,127],"present":[35],"in":[36,61,128,201,216,225,239,253],"the":[37,53,113,129,134,151,155,205,240],"protein.":[39],"They":[40],"provide":[41],"generic":[43],"platform":[44],"for":[45,64,164,173,222,232,260,279],"diagnostics":[46],"similar":[47],"to":[48,76,123,143,161,195],"antibodies":[49,77],"and":[50,66,78,169,179,198,224,247],"derivatives.":[51,79],"However,":[52],"rapid":[54],"production":[55,65,69],"solid-phase":[57],"peptide":[58,88],"synthesis":[59,176],"results":[60],"lower":[62,72],"cost":[63],"higher":[68,277],"throughput":[70],"with":[71,101,256],"batch-to-batch":[73],"variation":[74],"compared":[75],"Gallardo":[80],"et":[81,106],"al.":[82,107],"(2016,":[83],"Science)":[84],"designed":[85],"an":[86,226],"vascin":[90,223,246,261],"that":[91,112],"inhibits":[92],"VEGFR2":[93],"function":[94],"inducing":[96,139],"this":[99],"receptor":[100],"high":[102,257],"specificity.":[103],"Furthermore,":[104],"Khodaparast":[105],"(2018,":[108],"Nature":[109],"Communications)":[110],"showed":[111],"sequence":[114],"specificity":[115,149],"can":[119],"also":[120],"be":[121,162],"exploited":[122],"redundant":[125],"E.":[130,227],"coli":[131,228],"proteome":[132],"Colpeptin1":[135,170,248],"peptide,":[137],"thereby":[138],"proteostatic":[140],"collapse":[141],"leading":[142],"bacterial":[144],"cell":[145],"death.":[146],"observed":[148],"amyloid":[152],"toxicity":[153],"indicates":[154],"large":[156],"potential":[157],"radiolabeled":[159,233],"developed":[163],"PET":[165,254],"imaging.":[166],"Methods:":[167],"Vascin":[168],"were":[171,191,237,275],"modified":[172],"68Ga-labeling":[174],"[68Ga]Ga-NODAGA-PEG4-vascin":[178],"[68Ga]Ga-NODAGA-PEG2-Colpeptin1.":[180],"Since":[181],"proline":[182],"known":[185],"structure":[187],"breaker,":[188],"proline-mutated":[189,281],"variants":[190],"synthesized":[192],"as":[193,269],"controls":[194],"obtain":[196],"[68Ga]Ga-NODAGA-PEG4-vascin(Pro)":[197],"[68Ga]Ga-NODAGA-PEG2-Colpeptin1(Pro).":[199],"Specific":[200],"vivo":[202],"accumulation":[203],"at":[204,283],"site":[207],"was":[208],"evaluated":[209],"dynamic":[211],"3":[212],"hour":[213],"\u00b5PET":[214],"imaging":[215],"mouse":[218,242],"melanoma":[219],"tumor":[220],"model":[221,231],"muscle":[229,268],"infection":[230],"Colpeptin1.":[234],"Biodistribution":[235],"studies":[236],"executed":[238],"same":[241],"models.":[243],"Results:":[244],"Radiolabeled":[245],"provided":[249],"good":[250],"target-to-background":[251],"contrast":[252],"images":[255],"specificity,":[258],"since":[259],"tumor-to-muscle":[262],"SUV":[263],"ratios":[264],"(T/M":[265],"SUVR,":[266],"foreleg":[267],"reference":[270],"tissue":[271],"non-specific":[273],"binding)":[274],"significantly":[276],"than":[278],"its":[280],"variant":[282],"all":[284],"time":[285],"points":[286],"(p":[287]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2020-01-23T00:00:00"}
