{"id":"https://openalex.org/W29996649","doi":null,"title":"[A combination of dexmedetomidine with ketamine and opioids results in significant inhibition of hemodynamic changes associated with laparoscopic cholecystectomy and in prolongation of postoperative analgesia].","display_name":"[A combination of dexmedetomidine with ketamine and opioids results in significant inhibition of hemodynamic changes associated with laparoscopic cholecystectomy and in prolongation of postoperative analgesia].","publication_year":2010,"publication_date":"2010-05-01","ids":{"openalex":"https://openalex.org/W29996649","mag":"29996649","pmid":"https://pubmed.ncbi.nlm.nih.gov/20666328"},"language":"cs","primary_location":{"id":"pmid:20666328","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20666328","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti","raw_type":"English Abstract"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022322243","display_name":"Ji\u0159\u00ed M\u00e1lek","orcid":"https://orcid.org/0000-0002-4048-341X","observed_orcids":["https://orcid.org/0000-0002-4048-341X"]},"institutions":[{"id":"https://openalex.org/I4210156160","display_name":"University Hospital Kralovske Vinohrady","ror":"https://ror.org/04sg4ka71","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210156160"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"J M\u00e1lek","raw_affiliation_strings":["Klinika anesteziologie a resuscitace 3. LF UK a FNKV. malekj@fnkv.cz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinika anesteziologie a resuscitace 3. LF UK a FNKV. malekj@fnkv.cz","institution_ids":["https://openalex.org/I4210156160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020760293","display_name":"F Marecek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Marecek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"L Hess","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Hess","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006988160","display_name":"A. Kurzov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Kurzov\u00e1","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082724785","display_name":"M Ocadl\u00edk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Ocadl\u00edk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5089871977","display_name":"Martin Votava","orcid":"https://orcid.org/0009-0009-5592-4722","observed_orcids":["https://orcid.org/0009-0009-5592-4722"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Votava","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4225,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.6767962,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"89","issue":"5","first_page":"275","last_page":"81"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11905","display_name":"Veterinary Pharmacology and Anesthesia","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dexmedetomidine","display_name":"dexmedetomidine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ketamine","display_name":"ketamine","score":0.8849999904632568},{"id":"https://openalex.org/keywords/alpha-2-adrenergic-agonists","display_name":"alpha-2 adrenergic agonists","score":0.7350000143051147},{"id":"https://openalex.org/keywords/premedication","display_name":"premedication","score":0.8880000114440918},{"id":"https://openalex.org/keywords/laparoscopic-cholecystectomy","display_name":"laparoscopic cholecystectomy","score":0.9819999933242798},{"id":"https://openalex.org/keywords/postoperative-analgesia","display_name":"postoperative analgesia","score":0.7360000014305115},{"id":"https://openalex.org/keywords/fentanyl-consumption","display_name":"fentanyl consumption","score":0.6549999713897705},{"id":"https://openalex.org/keywords/alfentanil","display_name":"alfentanil","score":0.8799999952316284},{"id":"https://openalex.org/keywords/meperidine","display_name":"pethidine","score":0.9210000038146973},{"id":"https://openalex.org/keywords/opioid-sparing-effect","display_name":"opioid-sparing effect","score":0.4790000021457672},{"id":"https://openalex.org/keywords/postoperative-nausea-and-vomiting","display_name":"postoperative nausea and vomiting","score":0.7620000243186951},{"id":"https://openalex.org/keywords/sedation","display_name":"sedation","score":0.4580000042915344},{"id":"https://openalex.org/keywords/intubation-response","display_name":"intubation response","score":0.5329999923706055},{"id":"https://openalex.org/keywords/alpha2-adrenoceptor-antagonists","display_name":"alpha2-adrenoceptor antagonists","score":0.5619999766349792}],"concepts":[{"id":"https://openalex.org/C2781302539","wikidata":"https://www.wikidata.org/wiki/Q412133","display_name":"Dexmedetomidine","level":3,"score":0.8739229440689087},{"id":"https://openalex.org/C2778300832","wikidata":"https://www.wikidata.org/wiki/Q1589604","display_name":"Premedication","level":2,"score":0.8627927303314209},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8399820327758789},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.8150438070297241},{"id":"https://openalex.org/C2780795376","wikidata":"https://www.wikidata.org/wiki/Q243547","display_name":"Ketamine","level":2,"score":0.6504234671592712},{"id":"https://openalex.org/C2781072394","wikidata":"https://www.wikidata.org/wiki/Q407541","display_name":"Fentanyl","level":2,"score":0.644748866558075},{"id":"https://openalex.org/C2781168792","wikidata":"https://www.wikidata.org/wiki/Q55434","display_name":"Pethidine","level":3,"score":0.6308050751686096},{"id":"https://openalex.org/C2776814716","wikidata":"https://www.wikidata.org/wiki/Q574801","display_name":"Sedation","level":2,"score":0.5421382784843445},{"id":"https://openalex.org/C2775859210","wikidata":"https://www.wikidata.org/wiki/Q26272","display_name":"Atropine","level":2,"score":0.479495108127594},{"id":"https://openalex.org/C31174226","wikidata":"https://www.wikidata.org/wiki/Q64855140","display_name":"Perioperative","level":2,"score":0.4473702311515808},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.17998361587524414}],"mesh":[{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000762","descriptor_name":"Anesthesia Recovery Period","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000778","descriptor_name":"Anesthetics, Dissociative","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001285","descriptor_name":"Atropine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005283","descriptor_name":"Fentanyl","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006993","descriptor_name":"Hypnotics and Sedatives","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007649","descriptor_name":"Ketamine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008614","descriptor_name":"Meperidine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010149","descriptor_name":"Postoperative Pain","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D017081","descriptor_name":"Cholecystectomy, Laparoscopic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018712","descriptor_name":"Analgesics, Non-Narcotic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019162","descriptor_name":"Anesthetics, Combined","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D020927","descriptor_name":"Dexmedetomidine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:20666328","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20666328","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti","raw_type":"English Abstract"},{"id":"mag:29996649","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20666328","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W2044088883","https://openalex.org/W1999005000","https://openalex.org/W2016318120","https://openalex.org/W2040905261","https://openalex.org/W1573414954","https://openalex.org/W2335659822","https://openalex.org/W2100882466","https://openalex.org/W1998220831","https://openalex.org/W2057725451","https://openalex.org/W2618468622","https://openalex.org/W2141721229","https://openalex.org/W2258625868","https://openalex.org/W2150294514","https://openalex.org/W2763238899","https://openalex.org/W2084745568","https://openalex.org/W2746085539","https://openalex.org/W1999518190","https://openalex.org/W2608064079","https://openalex.org/W2787452999","https://openalex.org/W2062074008","https://openalex.org/W2609020416","https://openalex.org/W2587631365","https://openalex.org/W1784814409","https://openalex.org/W1850737816","https://openalex.org/W2140095309","https://openalex.org/W4230164597","https://openalex.org/W2108633440"],"related_works":["https://openalex.org/W2529338041","https://openalex.org/W2498446095","https://openalex.org/W3107703108","https://openalex.org/W2033427705","https://openalex.org/W4411311710","https://openalex.org/W3035722903","https://openalex.org/W4387264301","https://openalex.org/W7218780832","https://openalex.org/W3008475867","https://openalex.org/W2949693804"],"abstract_inverted_index":{"THE":[0,3],"AIM":[1],"OF":[2],"STUDY:":[4],"Recently,":[5],"alpha2":[6,31],"sympathoadrenergic":[7,32],"drugs":[8],"are":[9],"used":[10],"in":[11,46,122,132,198,205,210,216,222,293,299,312],"premedication":[12,27],"to":[13,24,113,155,164,266,309],"improve":[14],"the":[15,165,267],"perioperative":[16],"course.":[17],"The":[18,178,218],"aim":[19],"of":[20,52,142,146,314,318],"our":[21],"study":[22],"was":[23,111,130,190],"compare":[25],"a":[26,29,47,114,133],"with":[28,207],"new":[30],"drug":[33],"and":[34,42,157,171,174,184,200,202,228,251,264,326],"standard":[35,134],"premedication.":[36],"METHODS:":[37],"After":[38],"ethic":[39],"committee":[40],"approval":[41],"written":[43],"patient":[44],"consent,":[45],"randomised,":[48],"double-blinded":[49],"study,":[50],"combination":[51,306,311],"dexmedetomidine":[53,76],"1.0":[54,66,77,101],"microg":[55,67,78,90,243],"x":[56,62,68,79,85,91,103],"kg(-1)":[57,63,69,80,86,92,104],"+":[58,64,70,81,87,93,105],"ketamine":[59,82],"0.5":[60,72,83,95,107],"mg":[61,73,84,96,102,108],"fentanyl":[65,159,239],"atropine":[71,94,106],"(group":[74,97,109],"FNT),":[75],"alfentanil":[88],"5.0":[89],"ALFNT),":[98],"or":[99],"pethidine":[100],"Dolsin)":[110],"administered":[112],"deltoid":[115],"muscle":[116],"15":[117,203],"min.":[118],"before":[119,151],"anaesthesia":[120],"(GA)":[121],"patients":[123,197,204],"elicited":[124],"for":[125,168,213,297,322],"laparoscopic":[126],"cholecystectomy":[127],"(LCHE).":[128],"GA":[129,325],"performed":[131],"way,":[135],"ECG,":[136],"NIBP,":[137],"respiration":[138],"rate,":[139],"SpO2,":[140],"onset":[141],"effect,":[143],"Observers":[144],"Assessment":[145],"Alertness":[147],"Sedation":[148],"Score":[149],"(OAASS)":[150],"GA,":[152,162],"circulatory":[153],"reaction":[154],"intubation":[156],"capnoperitoneum,":[158,319],"consumption":[160],"during":[161,224,324],"time":[163],"first":[166,268],"request":[167,265],"post-operative":[169],"analgesia":[170,323],"postoperative":[172,328],"nausea":[173],"vomiting":[175],"were":[176,180,195,221,290],"measured.":[177],"data":[179],"processed":[181],"by":[182],"Kruskal-Wallis":[183],"Fisher":[185],"tests.":[186],"P-value":[187],"<":[188,236,249,256,262,280,287,302],"0.05":[189,257,281],"considered":[191],"significant.":[192],"RESULTS:":[193],"There":[194,289],"16":[196],"FNT":[199,227,241,272],"Dolsin":[201,245,276],"ALFNT":[206,230,252,283,300],"no":[208,291],"differences":[209,220,292],"demography":[211],"except":[212,296],"younger":[214],"age":[215],"ALFNT.":[217],"main":[219],"hypertension":[223],"capnoperitoneum:":[225],"0/16":[226],"1/15":[229],"vs.":[231,244,259,275,282],"11/16":[232],"Dolsin,":[233,260],"both":[234],"p":[235,248,255,261,279,286],"0.001,":[237],"per-operative":[238],"consumption:":[240],"31.5":[242],"165.0":[246],"microg,":[247,254],"0.001":[250],"50.0":[253],"(ALFNT":[258],"0.01)":[263],"analgesic":[269],"post":[270],"surgery:":[271],"1.3":[273],"h.":[274],"0.45":[277],"h.,":[278,285],"0.8":[284],"0.01.":[288],"side":[294],"effects":[295,317],"bradycardia":[298],"(p":[301],"0.05).":[303],"CONCLUSIONS:":[304],"Dexmedetomidine-ketamine-fentanyl-atropine":[305],"is":[307],"superior":[308],"pethidine-atropine":[310],"suppressing":[313],"adverse":[315],"hemodynamic":[316],"decreased":[320],"need":[321],"prolonged":[327],"analgesia.":[329]},"counts_by_year":[{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}