{"id":"https://openalex.org/W2999637957","doi":"https://doi.org/10.1016/j.nmni.2020.100651","title":"FadA-positive Fusobacterium nucleatum is prevalent in biopsy specimens of Iranian patients with colorectal cancer","display_name":"FadA-positive Fusobacterium nucleatum is prevalent in biopsy specimens of Iranian patients with colorectal cancer","publication_year":2020,"publication_date":"2020-01-09","ids":{"openalex":"https://openalex.org/W2999637957","doi":"https://doi.org/10.1016/j.nmni.2020.100651","mag":"2999637957","pmid":"https://pubmed.ncbi.nlm.nih.gov/32025313","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6997561"},"language":"en","primary_location":{"id":"doi:10.1016/j.nmni.2020.100651","doi":"https://doi.org/10.1016/j.nmni.2020.100651","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.nmni.2020.100651","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2052297520300032?via%3Dihub","source":{"id":"https://openalex.org/S2765012804","display_name":"New Microbes and New Infections","issn_l":"2052-2975","issn":["2052-2975"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New Microbes and New Infections","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2052297520300032?via%3Dihub","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078350951","display_name":"Negin Kashani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1516879","display_name":"Tarbiat Modares University","ror":"https://ror.org/03mwgfy56","country_code":"IR","type":"education","lineage":["https://openalex.org/I1516879"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"N. Kashani","raw_affiliation_strings":["Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran","institution_ids":["https://openalex.org/I1516879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043704535","display_name":"Amin Talebi Bezmin Abadi","orcid":"https://orcid.org/0000-0001-5209-6436","observed_orcids":["https://orcid.org/0000-0001-5209-6436","https://orcid.org/0000-0002-3979-8975"]},"institutions":[{"id":"https://openalex.org/I1516879","display_name":"Tarbiat Modares University","ror":"https://ror.org/03mwgfy56","country_code":"IR","type":"education","lineage":["https://openalex.org/I1516879"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"A.T. Bezmin Abadi","raw_affiliation_strings":["Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran","institution_ids":["https://openalex.org/I1516879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056746205","display_name":"Farid Rahimi","orcid":"https://orcid.org/0000-0002-0920-8188","observed_orcids":["https://orcid.org/0000-0002-0920-8188"]},"institutions":[{"id":"https://openalex.org/I118347636","display_name":"Australian National University","ror":"https://ror.org/019wvm592","country_code":"AU","type":"education","lineage":["https://openalex.org/I118347636"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"F. Rahimi","raw_affiliation_strings":["Research School of Biology, The Australian National University, Canberra, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research School of Biology, The Australian National University, Canberra, Australia","institution_ids":["https://openalex.org/I118347636"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033711243","display_name":"Mojgan Forootan","orcid":"https://orcid.org/0000-0002-5101-5806","observed_orcids":["https://orcid.org/0000-0002-5101-5806"]},"institutions":[{"id":"https://openalex.org/I4405270669","display_name":"Research Institute for Gastroenterology and Liver Diseases","ror":"https://ror.org/014xcbd14","country_code":"IR","type":"facility","lineage":["https://openalex.org/I4405270669"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"M. Forootan","raw_affiliation_strings":["Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I4405270669","https://openalex.org/I58048189"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5043704535"],"corresponding_institution_ids":["https://openalex.org/I1516879"],"apc_list":{"value":1573,"currency":"USD","value_usd":1573},"apc_paid":{"value":1573,"currency":"USD","value_usd":1573},"fwci":2.4298,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.90549831,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"34","issue":null,"first_page":"100651","last_page":"100651"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.5038999915122986,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.5038999915122986,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.3628000020980835,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.027899999171495438,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fusobacterium-nucleatum","display_name":"Fusobacterium nucleatum","score":1.0},{"id":"https://openalex.org/keywords/fada","display_name":"FadA","score":0.8169999718666077},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9940000176429749},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.7699999809265137},{"id":"https://openalex.org/keywords/bacterial-colonization","display_name":"bacterial colonization","score":0.8029999732971191},{"id":"https://openalex.org/keywords/tumor-associated-bacteria","display_name":"tumor-associated bacteria","score":0.5400000214576721},{"id":"https://openalex.org/keywords/virulence-factors","display_name":"virulence factors","score":0.6010000109672546},{"id":"https://openalex.org/keywords/iranian-patients","display_name":"Iranian patients","score":0.44699999690055847}],"concepts":[{"id":"https://openalex.org/C2777349128","wikidata":"https://www.wikidata.org/wiki/Q5510311","display_name":"Fusobacterium nucleatum","level":4,"score":0.9724431037902832},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7279480695724487},{"id":"https://openalex.org/C2780960513","wikidata":"https://www.wikidata.org/wiki/Q2720082","display_name":"Fusobacterium","level":4,"score":0.606770396232605},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5582401752471924},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.49127405881881714},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4764290750026703},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43381842970848083},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3871704339981079},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24559232592582703},{"id":"https://openalex.org/C2778168646","wikidata":"https://www.wikidata.org/wiki/Q133186","display_name":"Bacteroides","level":3,"score":0.0739128589630127},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07378518581390381},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.07050788402557373},{"id":"https://openalex.org/C2780183776","wikidata":"https://www.wikidata.org/wiki/Q3214147","display_name":"Porphyromonas gingivalis","level":3,"score":0.0},{"id":"https://openalex.org/C2780385504","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontitis","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1016/j.nmni.2020.100651","doi":"https://doi.org/10.1016/j.nmni.2020.100651","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.nmni.2020.100651","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2052297520300032?via%3Dihub","source":{"id":"https://openalex.org/S2765012804","display_name":"New Microbes and New Infections","issn_l":"2052-2975","issn":["2052-2975"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New Microbes and New Infections","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6997561","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6997561","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New Microbes New Infect","raw_type":"Text"},{"id":"pmid:32025313","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32025313","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New microbes and new infections","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:f2429e3689d2400ab951ae49b8030130","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f2429e3689d2400ab951ae49b8030130","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"New Microbes and New Infections, Vol 34, Iss , Pp - (2020)","raw_type":"article"},{"id":"pmh:oai:openresearch-repository.anu.edu.au:1885/206328","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1885/206328","pdf_url":null,"source":{"id":"https://openalex.org/S4306402539","display_name":"ANU Open Research (Australian National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I118347636","host_organization_name":"Australian National University","host_organization_lineage":["https://openalex.org/I118347636"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"New Microbes and New Infections","raw_type":"Journal article"}],"best_oa_location":{"id":"doi:10.1016/j.nmni.2020.100651","doi":"https://doi.org/10.1016/j.nmni.2020.100651","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.nmni.2020.100651","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2052297520300032?via%3Dihub","source":{"id":"https://openalex.org/S2765012804","display_name":"New Microbes and New Infections","issn_l":"2052-2975","issn":["2052-2975"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New Microbes and New Infections","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320324984","display_name":"Tarbiat Modares University","ror":"https://ror.org/03mwgfy56"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2999637957.pdf","grobid_xml":"https://content.openalex.org/works/W2999637957.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1568216332","https://openalex.org/W1896348045","https://openalex.org/W1965907230","https://openalex.org/W1971000774","https://openalex.org/W2026515672","https://openalex.org/W2030121633","https://openalex.org/W2047717400","https://openalex.org/W2052951312","https://openalex.org/W2076159367","https://openalex.org/W2091564291","https://openalex.org/W2095269215","https://openalex.org/W2107898260","https://openalex.org/W2109020166","https://openalex.org/W2113969771","https://openalex.org/W2116695221","https://openalex.org/W2140679462","https://openalex.org/W2168694247","https://openalex.org/W2220733632","https://openalex.org/W2293741136","https://openalex.org/W2298181742","https://openalex.org/W2302003756","https://openalex.org/W2344989148","https://openalex.org/W2497721881","https://openalex.org/W2579357550","https://openalex.org/W2769629043","https://openalex.org/W2889646458","https://openalex.org/W2903344530","https://openalex.org/W2904988746","https://openalex.org/W2954746300","https://openalex.org/W2972102107","https://openalex.org/W4292528167","https://openalex.org/W4297875023"],"related_works":["https://openalex.org/W4405345988","https://openalex.org/W3180673819","https://openalex.org/W3165264517","https://openalex.org/W4416228791","https://openalex.org/W4220989625","https://openalex.org/W3173353855","https://openalex.org/W2789721957","https://openalex.org/W2978395615","https://openalex.org/W4402498949","https://openalex.org/W3195477951"],"abstract_inverted_index":{"Fusobacterium":[0],"nucleatum":[1,46,61,130,144,166,192,216,232],"has":[2],"been":[3,30],"increasingly":[4],"implicated":[5],"as":[6,14,169],"a":[7,90,184],"causative":[8],"agent":[9],"of":[10,22,44,108,133,190,212,230,238,241],"various":[11],"diseases,":[12],"such":[13],"inflammatory":[15],"bowel":[16],"disease.":[17],"Moreover,":[18],"the":[19,42,109,117,150,188,213],"gastrointestinal":[20],"tracts":[21],"patients":[23,52,67,79,157,175,198,239],"with":[24,158,163],"colorectal":[25],"cancer":[26],"(CRC)":[27],"also":[28],"have":[29],"shown":[31],"to":[32,40,54,69,99,121,227,245],"be":[33],"colonized":[34,162],"by":[35,89,128],"this":[36],"bacterium.":[37],"We":[38,182],"aimed":[39],"determine":[41],"prevalence":[43],"F.":[45,60,129,143,165,191,215,231],"among":[47],"CRC":[48,64,102,170,197,222],"and":[49,53,62,84,86,116,124,131,194],"non-CRC":[50,154],"Iranian":[51,221],"investigate":[55],"potential":[56],"associations":[57],"between":[58,82,187],"fadA-positive":[59,142,164,214],"diagnosed":[63,88,168],"cases.":[65],"Eighty":[66],"admitted":[68],"two":[70,101],"main":[71],"hospitals":[72],"in":[73,148],"Tehran,":[74],"Iran,":[75],"were":[76,80,87,139,161,167,176],"enrolled.":[77],"The":[78,141],"aged":[81],"20":[83],"75":[85],"gastroenterologist.":[91],"A":[92],"trained":[93],"surgeon":[94],"used":[95,112],"standard":[96],"surgical":[97],"protocols":[98],"collect":[100],"biopsy":[103],"samples":[104,110],"per":[105],"patient.":[106],"One":[107],"was":[111,119,146],"for":[113,178,235],"pathologic":[114],"examination,":[115],"other":[118],"subjected":[120],"DNA":[122],"extraction":[123],"PCR.":[125],"Lesion":[126],"colonization":[127,193,211],"expression":[132],"its":[134],"major":[135],"virulence":[136],"factor,":[137],"fadA,":[138],"investigated.":[140],"strain":[145],"absent":[147],"all":[149],"lesions":[151,159,195,218],"obtained":[152],"from":[153,196,219],"patients.":[155,223],"All":[156],"that":[160],"(p":[171,199],"<":[172],"0.05);":[173],"selected":[174],"sent":[177],"further":[179],"intensive":[180],"treatment.":[181],"found":[183],"significant":[185],"association":[186],"presence":[189],"0.0001;":[200],"odds":[201],"ratio,":[202],"6.74;":[203],"95%":[204],"confidence":[205],"interval,":[206],"2.5\u201318.07).":[207],"Our":[208],"study":[209],"confirmed":[210],"on":[217],"80":[220],"New":[224],"therapeutic":[225],"strategies":[226],"achieve":[228],"eradication":[229],"are":[233],"necessary":[234],"clinical":[236],"management":[237],"suspected":[240],"having":[242],"or":[243],"prone":[244],"developing":[246],"CRC.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-01-23T00:00:00"}