{"id":"https://openalex.org/W299957193","doi":null,"title":"In vitro cytotoxicology model of oligo-chitosan and n, o-carboxymethyl chitosan using primary normal human epidermal keratinocyte cultures.","display_name":"In vitro cytotoxicology model of oligo-chitosan and n, o-carboxymethyl chitosan using primary normal human epidermal keratinocyte cultures.","publication_year":2007,"publication_date":"2007-05-01","ids":{"openalex":"https://openalex.org/W299957193","mag":"299957193","pmid":"https://pubmed.ncbi.nlm.nih.gov/20799177"},"language":"en","primary_location":{"id":"pmid:20799177","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20799177","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied biomaterials & biomechanics : JABB","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037859912","display_name":"Chin Keong Lim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139322472","display_name":"Universiti Sains Malaysia","ror":"https://ror.org/02rgb2k63","country_code":"MY","type":"education","lineage":["https://openalex.org/I139322472"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"C K Lim","raw_affiliation_strings":["Reconstructive Sciences Unit, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reconstructive Sciences Unit, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia","institution_ids":["https://openalex.org/I139322472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050007885","display_name":"Ahmad Sukari Halim","orcid":"https://orcid.org/0000-0001-8999-6403","observed_orcids":["https://orcid.org/0000-0001-8999-6403"]},"institutions":[{"id":"https://openalex.org/I139322472","display_name":"Universiti Sains Malaysia","ror":"https://ror.org/02rgb2k63","country_code":"MY","type":"education","lineage":["https://openalex.org/I139322472"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"A S Halim","raw_affiliation_strings":["Reconstructive Sciences Unit, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reconstructive Sciences Unit, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian,","institution_ids":["https://openalex.org/I139322472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025079295","display_name":"Hut Yee Lau","orcid":"https://orcid.org/0000-0002-4824-7921","observed_orcids":["https://orcid.org/0000-0002-4824-7921"]},"institutions":[{"id":"https://openalex.org/I139322472","display_name":"Universiti Sains Malaysia","ror":"https://ror.org/02rgb2k63","country_code":"MY","type":"education","lineage":["https://openalex.org/I139322472"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"H Y Lau","raw_affiliation_strings":["Reconstructive Sciences Unit, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reconstructive Sciences Unit, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian,","institution_ids":["https://openalex.org/I139322472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078906165","display_name":"Zanariah Ujang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I23726118","display_name":"Sirim Berhad","ror":"https://ror.org/008g13a47","country_code":"MY","type":"government","lineage":["https://openalex.org/I23726118"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Z Ujang","raw_affiliation_strings":["SIRIM, Environmental and Bioprocess Technology Centre, Shah Alam, Selangor - Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SIRIM, Environmental and Bioprocess Technology Centre, Shah Alam, Selangor - Malaysia","institution_ids":["https://openalex.org/I23726118"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064079296","display_name":"Ahmad Hazri Abdul Rashid","orcid":"https://orcid.org/0000-0001-8617-7103","observed_orcids":["https://orcid.org/0000-0001-8617-7103"]},"institutions":[{"id":"https://openalex.org/I23726118","display_name":"Sirim Berhad","ror":"https://ror.org/008g13a47","country_code":"MY","type":"government","lineage":["https://openalex.org/I23726118"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"A Hazri","raw_affiliation_strings":["SIRIM, Environmental and Bioprocess Technology Centre, Shah Alam, Selangor - Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SIRIM, Environmental and Bioprocess Technology Centre, Shah Alam, Selangor - Malaysia","institution_ids":["https://openalex.org/I23726118"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5983,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.61590845,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"5","issue":"2","first_page":"82","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10488","display_name":"Nanocomposite Films for Food Packaging","score":0.478300005197525,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10488","display_name":"Nanocomposite Films for Food Packaging","score":0.478300005197525,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.155799999833107,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.10019999742507935,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oligochitosan","display_name":"oligochitosan","score":0.8550000190734863},{"id":"https://openalex.org/keywords/n-o-carboxymethyl-chitosan","display_name":"N,O-carboxymethyl chitosan","score":0.9660000205039978},{"id":"https://openalex.org/keywords/chitosan-derivatives","display_name":"chitosan derivatives","score":0.968999981880188},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9819999933242798},{"id":"https://openalex.org/keywords/biocompatibility","display_name":"biocompatibility","score":0.8299999833106995},{"id":"https://openalex.org/keywords/wound-care","display_name":"wound care","score":0.6200000047683716},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.5609999895095825},{"id":"https://openalex.org/keywords/wound-dressings","display_name":"wound dressings","score":0.4309999942779541}],"concepts":[{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.9657636880874634},{"id":"https://openalex.org/C2781088250","wikidata":"https://www.wikidata.org/wiki/Q161219","display_name":"Chitin","level":3,"score":0.8464674353599548},{"id":"https://openalex.org/C2777230088","wikidata":"https://www.wikidata.org/wiki/Q864426","display_name":"Biocompatibility","level":2,"score":0.7242797017097473},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5936644673347473},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.5384952425956726},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5132691860198975},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.5002443790435791},{"id":"https://openalex.org/C2777074287","wikidata":"https://www.wikidata.org/wiki/Q1473931","display_name":"Keratinocyte","level":3,"score":0.486510694026947},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.485982745885849},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.4636441767215729},{"id":"https://openalex.org/C1318750","wikidata":"https://www.wikidata.org/wiki/Q865663","display_name":"Biocompatible material","level":2,"score":0.4119541049003601},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22364869713783264},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.18367886543273926},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.1414099931716919},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11413916945457458}],"mesh":[],"locations_count":2,"locations":[{"id":"pmid:20799177","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20799177","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied biomaterials & biomechanics : JABB","raw_type":"Journal Article"},{"id":"mag:299957193","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20799177","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2010072794","https://openalex.org/W6990256836","https://openalex.org/W1978754917","https://openalex.org/W2044632115","https://openalex.org/W2793049910","https://openalex.org/W2166620597","https://openalex.org/W7099837039","https://openalex.org/W1996298528","https://openalex.org/W7066138238","https://openalex.org/W2166739729"],"abstract_inverted_index":{"Chitosan":[0],"(beta-1,":[1],"4-D-glucosamine)":[2],"is":[3,124],"a":[4,117,162],"deacetylated":[5],"form":[6],"of":[7,19,36,42,56,68,126,137,161],"chitin":[8],"with":[9,44],"excellent":[10],"biological":[11,54],"properties":[12,18,41,160],"in":[13,31,98,170],"wound":[14],"management.":[15],"The":[16,34,121],"natural":[17],"chitosan":[20,43,59,130],"have":[21],"the":[22,37,53,57,66,127,158],"physical":[23,38],"and":[24,39,71,83,152],"chemical":[25,40],"limitations":[26],"to":[27,166],"be":[28,61],"widely":[29],"used":[30,115],"biomedical":[32],"fields.":[33],"improvement":[35],"some":[45],"additional":[46],"chemicals":[47],"will":[48],"alter":[49],"its":[50],"biocompatibility.":[51],"Therefore,":[52,155],"attribute":[55],"modified":[58],"must":[60],"evaluated.":[62],"In":[63],"this":[64,171],"study,":[65],"cytotoxicity":[67],"oligo-chitosan":[69,156],"(OC)":[70],"N,":[72,167],"O-":[73,168],"carboxymethyl-chitosan":[74,169],"(NO-CMC)":[75],"derivatives":[76,131],"(O-C":[77],"1%,":[78],"O-C":[79,122,148],"5%,":[80,149],"NO-CMC":[81,84,150,153],"1%":[82,123],"5%)":[85],"was":[86,114,145],"evaluated":[87],"using":[88],"primary":[89],"normal":[90],"human":[91],"epidermal":[92],"keratinocyte":[93],"(pNHEK)":[94],"cultures":[95],"as":[96,116],"an":[97],"vitro":[99],"toxicology":[100],"model":[101],"at":[102],"standardized":[103],"cell":[104,118],"passages":[105],"(fourth":[106],"passages).":[107],"3-[4,":[108],"5-dimethyl-2-thiazolyl]-2,":[109],"5-diphenyl":[110],"tetrazolium":[111],"bromide":[112],"(MTT)":[113],"viability":[119],"assay.":[120],"one":[125],"most":[128],"compatible":[129],"because":[132],"it":[133],"steadily":[134],"sustained":[135],">70%":[136],"viable":[138],"cells":[139],"until":[140],"72":[141],"hr":[142],"post-treatment.":[143],"This":[144],"followed":[146],"by":[147],"5%":[151],"1%.":[154],"had":[157],"ideal":[159],"biocompatible":[163],"material":[164],"compared":[165],"study.":[172]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
