{"id":"https://openalex.org/W2999566","doi":"https://doi.org/10.1096/fasebj.26.1_supplement.lb770","title":"Involvement of NADPH oxidase in serotonin\u2010induced angiogenesis","display_name":"Involvement of NADPH oxidase in serotonin\u2010induced angiogenesis","publication_year":2012,"publication_date":"2012-04-01","ids":{"openalex":"https://openalex.org/W2999566","doi":"https://doi.org/10.1096/fasebj.26.1_supplement.lb770","mag":"2999566"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.26.1_supplement.lb770","doi":"https://doi.org/10.1096/fasebj.26.1_supplement.lb770","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.26.1_supplement.lb770","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100739941","display_name":"Hyun\u2010Young Kim","orcid":"https://orcid.org/0000-0003-0106-9969","observed_orcids":["https://orcid.org/0000-0003-0106-9969"]},"institutions":[{"id":"https://openalex.org/I55240360","display_name":"Yeungnam University","ror":"https://ror.org/05yc6p159","country_code":"KR","type":"education","lineage":["https://openalex.org/I55240360"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyun-Young Kim","raw_affiliation_strings":["Dept. of Pharmacy Yeungnam University Gyeongsan Korea, Republic of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Pharmacy Yeungnam University Gyeongsan Korea, Republic of","institution_ids":["https://openalex.org/I55240360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030084766","display_name":"Ganesh Prasad Neupane","orcid":"https://orcid.org/0000-0002-9099-5456","observed_orcids":["https://orcid.org/0000-0002-9099-5456"]},"institutions":[{"id":"https://openalex.org/I55240360","display_name":"Yeungnam University","ror":"https://ror.org/05yc6p159","country_code":"KR","type":"education","lineage":["https://openalex.org/I55240360"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ganesh Prasad Neupane","raw_affiliation_strings":["Dept. of Pharmacy Yeungnam University Gyeongsan Korea, Republic of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Pharmacy Yeungnam University Gyeongsan Korea, Republic of","institution_ids":["https://openalex.org/I55240360"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101774713","display_name":"Jung\u2010Ae Kim","orcid":"https://orcid.org/0000-0002-0824-8532","observed_orcids":["https://orcid.org/0000-0002-0824-8532"]},"institutions":[{"id":"https://openalex.org/I55240360","display_name":"Yeungnam University","ror":"https://ror.org/05yc6p159","country_code":"KR","type":"education","lineage":["https://openalex.org/I55240360"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jung-Ae Kim","raw_affiliation_strings":["Dept. of Pharmacy Yeungnam University Gyeongsan Korea, Republic of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Pharmacy Yeungnam University Gyeongsan Korea, Republic of","institution_ids":["https://openalex.org/I55240360"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I55240360"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0002554,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.5512999892234802,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.5512999892234802,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.4092000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.021199999377131462,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.9739999771118164},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9860000014305115},{"id":"https://openalex.org/keywords/nadph-oxidase","display_name":"NADPH oxidase","score":1.0},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9959999918937683},{"id":"https://openalex.org/keywords/5-ht1a-receptor","display_name":"5-HT1A receptor","score":0.9330000281333923},{"id":"https://openalex.org/keywords/5-ht2a-receptor","display_name":"5-HT2A receptor","score":1.0},{"id":"https://openalex.org/keywords/human-umbilical-vein-endothelial-cells","display_name":"human umbilical vein endothelial cells","score":0.8859999775886536},{"id":"https://openalex.org/keywords/endothelial-cell-migration-and-invasion","display_name":"endothelial cell migration and invasion","score":0.7440000176429749},{"id":"https://openalex.org/keywords/tube-formation","display_name":"tube formation","score":0.7829999923706055},{"id":"https://openalex.org/keywords/apocynin","display_name":"apocynin","score":0.8399999737739563}],"concepts":[{"id":"https://openalex.org/C2777209548","wikidata":"https://www.wikidata.org/wiki/Q414754","display_name":"Apocynin","level":4,"score":0.9052435159683228},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.8496677875518799},{"id":"https://openalex.org/C2779719074","wikidata":"https://www.wikidata.org/wiki/Q2038057","display_name":"NADPH oxidase","level":3,"score":0.8032752275466919},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4900416135787964},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38106009364128113},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37632787227630615},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35956770181655884},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.3532394766807556},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.1653113067150116}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.26.1_supplement.lb770","doi":"https://doi.org/10.1096/fasebj.26.1_supplement.lb770","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.26.1_supplement.lb770","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2102771571","https://openalex.org/W2131525005","https://openalex.org/W7097399606","https://openalex.org/W2110539420","https://openalex.org/W1986948325","https://openalex.org/W2731600307","https://openalex.org/W3176600301","https://openalex.org/W2207420855","https://openalex.org/W2044754928","https://openalex.org/W2110234428"],"abstract_inverted_index":{"Serotonin":[0,111],"(5\u2010Hydroxytrytamine,":[1],"5\u2010HT),":[2],"a":[3,18,28,163,164],"gastrointestinal":[4],"paracrine":[5],"hormone,":[6],"has":[7],"been":[8],"shown":[9],"to":[10,159],"induce":[11],"angiogenesis.":[12,60],"Reactive":[13],"oxygen":[14],"species":[15],"(ROS)":[16],"play":[17],"role":[19],"in":[20,58,66,154],"vascular":[21,34],"endothelial":[22,44,80],"growth":[23],"factor":[24],"(VEGF)\u2010induced":[25],"angiogenesis":[26,62,75,143],"as":[27,162],"receptor":[29,99,104,165],"downstream":[30,166],"signaling":[31,167],"molecule.":[32,168],"In":[33,47,73,140],"endothelium,":[35],"multi\u2010subunit":[36],"NADPH":[37,54,108,125,157],"oxidase":[38,55,109,126,133,158],"is":[39,56,144],"the":[40,48],"predominant":[41],"contributor":[42],"of":[43],"superoxide":[45],"generation.":[46],"present":[49],"study,":[50],"we":[51],"investigated":[52],"whether":[53],"involved":[57],"serotonin\u2010induced":[59,142],"Seroton\u2010ininduced\u2010":[61],"was":[63,93,117],"confirmed":[64],"by":[65,95,119,130],"vivo":[67],"chick":[68],"chorioallantoic":[69],"membrane":[70],"(CAM)":[71],"assay.":[72],"vitro":[74],"using":[76],"human":[77],"umbilical":[78],"vein":[79],"cells":[81],"(HUVEC),":[82],"serotonin":[83],"enhanced":[84],"cell":[85],"migration,":[86],"invasion":[87],"and":[88,106,114,121,135,149],"tube":[89],"formation.":[90],"Such":[91],"serotonin\u2010induced\u2010angiogenesis":[92],"inhibited":[94,118],"cyanopindolol,":[96],"5\u2010HT":[97,102,147,150],"1A":[98,148],"antagonist,":[100,105],"cinanserin,":[101],"2A":[103,151],"apocynin,":[107],"inhibitor.":[110],"produced":[112],"ROS,":[113],"such":[115],"ROS":[116,161],"apocynin":[120],"diphenyl":[122],"iodonium":[123],"(DPI),":[124],"inhibitors,":[127],"but":[128],"not":[129],"allopurinol":[131],"(Xantine":[132],"inhibitor)":[134],"anitmycin":[136],"A":[137],"(mitochondrial":[138],"inhibitor).":[139],"conclusion,":[141],"mediated":[145],"through":[146],"receptor,":[152],"which,":[153],"turn,":[155],"activates":[156],"generate":[160]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}