{"id":"https://openalex.org/W2999558384","doi":"https://doi.org/10.1080/23808993.2020.1707077","title":"Challenges and advances in translating gene therapy for hearing disorders","display_name":"Challenges and advances in translating gene therapy for hearing disorders","publication_year":2020,"publication_date":"2020-01-02","ids":{"openalex":"https://openalex.org/W2999558384","doi":"https://doi.org/10.1080/23808993.2020.1707077","mag":"2999558384"},"language":"en","primary_location":{"id":"doi:10.1080/23808993.2020.1707077","doi":"https://doi.org/10.1080/23808993.2020.1707077","is_oa":false,"landing_page_url":"https://doi.org/10.1080/23808993.2020.1707077","pdf_url":null,"source":{"id":"https://openalex.org/S4210210132","display_name":"Expert Review of Precision Medicine and Drug Development","issn_l":"2380-8993","issn":["2380-8993"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","norway-1","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Precision Medicine and Drug Development","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064539315","display_name":"Hildegard B\u00fcning","orcid":"https://orcid.org/0000-0002-3365-6933","observed_orcids":["https://orcid.org/0000-0002-3365-6933"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]},{"id":"https://openalex.org/I4210115305","display_name":"German Center for Infection Research","ror":"https://ror.org/028s4q594","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210115305","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4405271840","display_name":"Research Center for Translational Regenerative Medicine","ror":"https://ror.org/03526v062","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4405271840"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hildegard B\u00fcning","raw_affiliation_strings":["German Center for Infection Research, Braunschweig, Germany","Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany","REBIRTH Cluster of Excellence, Hannover Medical School, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Center for Infection Research, Braunschweig, Germany","institution_ids":["https://openalex.org/I4210115305"]},{"raw_affiliation_string":"Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]},{"raw_affiliation_string":"REBIRTH Cluster of Excellence, Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795","https://openalex.org/I4405271840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054362291","display_name":"Axel Schambach","orcid":"https://orcid.org/0000-0003-2743-0070","observed_orcids":["https://orcid.org/0000-0003-2743-0070"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]},{"id":"https://openalex.org/I4405271840","display_name":"Research Center for Translational Regenerative Medicine","ror":"https://ror.org/03526v062","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4405271840"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Axel Schambach","raw_affiliation_strings":["Division of Hematology/Oncology, Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA, USA","Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany","REBIRTH Cluster of Excellence, Hannover Medical School, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]},{"raw_affiliation_string":"REBIRTH Cluster of Excellence, Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795","https://openalex.org/I4405271840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111927421","display_name":"Michael Alexander Morgan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]},{"id":"https://openalex.org/I4405271840","display_name":"Research Center for Translational Regenerative Medicine","ror":"https://ror.org/03526v062","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4405271840"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Morgan","raw_affiliation_strings":["Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany","REBIRTH Cluster of Excellence, Hannover Medical School, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]},{"raw_affiliation_string":"REBIRTH Cluster of Excellence, Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795","https://openalex.org/I4405271840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042172277","display_name":"Axel Rossi","orcid":"https://orcid.org/0000-0003-0312-3965","observed_orcids":["https://orcid.org/0000-0003-0312-3965"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Axel Rossi","raw_affiliation_strings":["Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047368249","display_name":"Helena Wichova","orcid":"https://orcid.org/0000-0002-3707-6469","observed_orcids":["https://orcid.org/0000-0002-3707-6469","https://orcid.org/0000-0003-3334-5163"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Helena Wichova","raw_affiliation_strings":["Department of Otolaryngology Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, USA","institution_ids":["https://openalex.org/I146416000","https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027202219","display_name":"Hinrich Staecker","orcid":"https://orcid.org/0000-0002-0348-3015","observed_orcids":["https://orcid.org/0000-0002-0348-3015"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hinrich Staecker","raw_affiliation_strings":["Department of Otolaryngology Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, USA","institution_ids":["https://openalex.org/I146416000","https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041712482","display_name":"Athanasia Warnecke","orcid":"https://orcid.org/0000-0001-9652-1035","observed_orcids":["https://orcid.org/0000-0001-9652-1035"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Athanasia Warnecke","raw_affiliation_strings":["Department of Otolaryngology, Hannover Medical School, 30625 Hannover, Germany","Hearing4all Cluster of Excellence, Hannover Medical School, Hannover, Germany"],"raw_orcid":"https://orcid.org/0000-0001-9652-1035","affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Hannover Medical School, 30625 Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]},{"raw_affiliation_string":"Hearing4all Cluster of Excellence, Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071800169","display_name":"Thomas Lenarz","orcid":"https://orcid.org/0000-0002-9307-5989","observed_orcids":["https://orcid.org/0000-0002-9307-5989"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Lenarz","raw_affiliation_strings":["Department of Otolaryngology, Hannover Medical School, 30625 Hannover, Germany","Hearing4all Cluster of Excellence, Hannover Medical School, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Hannover Medical School, 30625 Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]},{"raw_affiliation_string":"Hearing4all Cluster of Excellence, Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5041712482"],"corresponding_institution_ids":["https://openalex.org/I34809795"],"apc_list":null,"apc_paid":null,"fwci":0.2642,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.50361795,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"5","issue":"1","first_page":"23","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.03189999982714653,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.9890000224113464},{"id":"https://openalex.org/keywords/sensorineural-hearing-loss","display_name":"sensorineural hearing loss","score":0.9890000224113464},{"id":"https://openalex.org/keywords/inner-ear","display_name":"inner ear","score":0.8930000066757202},{"id":"https://openalex.org/keywords/gene-delivery-systems","display_name":"gene delivery systems","score":0.7080000042915344},{"id":"https://openalex.org/keywords/clinical-translation","display_name":"clinical translation","score":0.5419999957084656},{"id":"https://openalex.org/keywords/hearing-loss","display_name":"hearing loss","score":0.375},{"id":"https://openalex.org/keywords/gene-therapy-clinical-trials","display_name":"gene therapy clinical trials","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C2780607864","wikidata":"https://www.wikidata.org/wiki/Q928697","display_name":"Sensorineural hearing loss","level":3,"score":0.6541451215744019},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6316275596618652},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5858198404312134},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.5741259455680847},{"id":"https://openalex.org/C2780493683","wikidata":"https://www.wikidata.org/wiki/Q16035842","display_name":"Hearing loss","level":2,"score":0.5653842687606812},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5057687759399414},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.4983940124511719},{"id":"https://openalex.org/C3020580240","wikidata":"https://www.wikidata.org/wiki/Q663272","display_name":"Expert opinion","level":2,"score":0.471303790807724},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4661112427711487},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3654724061489105},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.322634756565094},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2523948550224304},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.23247483372688293},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2088308334350586},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16999727487564087},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1362188756465912},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.10942035913467407},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08856934309005737},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1080/23808993.2020.1707077","doi":"https://doi.org/10.1080/23808993.2020.1707077","is_oa":false,"landing_page_url":"https://doi.org/10.1080/23808993.2020.1707077","pdf_url":null,"source":{"id":"https://openalex.org/S4210210132","display_name":"Expert Review of Precision Medicine and Drug Development","issn_l":"2380-8993","issn":["2380-8993"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","norway-1","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Precision Medicine and Drug Development","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":96,"referenced_works":["https://openalex.org/W241491381","https://openalex.org/W644209773","https://openalex.org/W1520391127","https://openalex.org/W1575834180","https://openalex.org/W1602618928","https://openalex.org/W1846455627","https://openalex.org/W1965873234","https://openalex.org/W1971757408","https://openalex.org/W1972200274","https://openalex.org/W1977108818","https://openalex.org/W1987156959","https://openalex.org/W1989377502","https://openalex.org/W1992657531","https://openalex.org/W1997474957","https://openalex.org/W1997478044","https://openalex.org/W2003930589","https://openalex.org/W2006402322","https://openalex.org/W2007736041","https://openalex.org/W2009133456","https://openalex.org/W2009608640","https://openalex.org/W2010303814","https://openalex.org/W2013935392","https://openalex.org/W2014110756","https://openalex.org/W2014222020","https://openalex.org/W2017802232","https://openalex.org/W2018514799","https://openalex.org/W2020352076","https://openalex.org/W2021088854","https://openalex.org/W2023266954","https://openalex.org/W2034060287","https://openalex.org/W2036867468","https://openalex.org/W2050870581","https://openalex.org/W2056408540","https://openalex.org/W2059108053","https://openalex.org/W2059424037","https://openalex.org/W2060516472","https://openalex.org/W2063311068","https://openalex.org/W2063997093","https://openalex.org/W2064437660","https://openalex.org/W2065280914","https://openalex.org/W2070021689","https://openalex.org/W2070049465","https://openalex.org/W2070969914","https://openalex.org/W2080177691","https://openalex.org/W2081728846","https://openalex.org/W2085546054","https://openalex.org/W2089319449","https://openalex.org/W2089603629","https://openalex.org/W2091020339","https://openalex.org/W2095394899","https://openalex.org/W2100306212","https://openalex.org/W2105056822","https://openalex.org/W2105493567","https://openalex.org/W2107046588","https://openalex.org/W2110710127","https://openalex.org/W2141570423","https://openalex.org/W2173709025","https://openalex.org/W2176417291","https://openalex.org/W2293547542","https://openalex.org/W2293733321","https://openalex.org/W2365931658","https://openalex.org/W2414040529","https://openalex.org/W2442559364","https://openalex.org/W2494602139","https://openalex.org/W2502831104","https://openalex.org/W2527020896","https://openalex.org/W2544781001","https://openalex.org/W2570201053","https://openalex.org/W2586762515","https://openalex.org/W2587791423","https://openalex.org/W2605246466","https://openalex.org/W2611295260","https://openalex.org/W2635865277","https://openalex.org/W2745114912","https://openalex.org/W2745542146","https://openalex.org/W2747322472","https://openalex.org/W2761092054","https://openalex.org/W2778806019","https://openalex.org/W2789176073","https://openalex.org/W2807140244","https://openalex.org/W2889424788","https://openalex.org/W2889863283","https://openalex.org/W2892006929","https://openalex.org/W2902016625","https://openalex.org/W2909513851","https://openalex.org/W2912684492","https://openalex.org/W2913533437","https://openalex.org/W2915061779","https://openalex.org/W2916730093","https://openalex.org/W2919471085","https://openalex.org/W2945064781","https://openalex.org/W2949441841","https://openalex.org/W3016009494","https://openalex.org/W4230358558","https://openalex.org/W4241142387","https://openalex.org/W6776397254"],"related_works":["https://openalex.org/W2806504837","https://openalex.org/W2746861376","https://openalex.org/W2951464551","https://openalex.org/W2132086110","https://openalex.org/W3133696946","https://openalex.org/W4404940997","https://openalex.org/W4376286859","https://openalex.org/W2959029580","https://openalex.org/W4410139668","https://openalex.org/W2317520310"],"abstract_inverted_index":{"Introduction:":[0],"Although":[1],"sensorineural":[2],"hearing":[3,31],"loss":[4,32],"(SNHL)":[5],"is":[6,51,67,75,131],"the":[7,45,76,88,93,97,103,116,119,136,148],"most":[8],"common":[9],"neurodegenerative":[10],"disease":[11,130],"in":[12,115],"humans,":[13],"no":[14],"approved":[15],"pharmaceutical":[16],"interventions":[17],"are":[18],"currently":[19],"available.":[20],"The":[21,48],"progression":[22],"of":[23,30,44,78,82,90,101,144],"inherited":[24],"as":[25,27],"well":[26],"acquired":[28],"forms":[29],"can":[33],"be":[34,113],"altered":[35],"by":[36],"transferring":[37],"single":[38],"genes":[39],"to":[40,139],"distinct":[41],"cell":[42,95],"types":[43],"ear":[46,50,129],"inner.":[47],"inner":[49,128],"an":[52,127],"attractive":[53],"target":[54,94],"for":[55,126],"gene":[56,122],"therapy":[57,123],"given":[58],"its":[59],"small":[60],"size":[61],"and":[62],"localized":[63],"anatomic":[64],"nature,":[65],"which":[66,111],"accessible":[68],"through":[69],"routine":[70],"surgical":[71],"approaches.Areas":[72],"covered:":[73],"SNHL":[74],"symptom":[77],"a":[79,141],"diverse":[80],"group":[81],"disorders":[83],"with":[84],"specific":[85],"requirements":[86],"regarding":[87],"timing":[89],"therapeutic":[91,104,145],"intervention,":[92],"population,":[96],"delivery":[98],"system":[99],"and,":[100],"course,":[102],"active":[105],"\u201csubstance\u2019.Expert":[106],"opinion:":[107],"Despite":[108],"these":[109],"challenges,":[110],"will":[112],"discussed":[114],"following":[117],"paper,":[118],"first":[120],"human":[121],"clinical":[124,151],"trial":[125],"already":[132],"initiated,":[133],"making":[134],"this":[135],"perfect":[137],"time":[138],"translate":[140],"great":[142],"variety":[143],"approaches":[146],"from":[147],"laboratory":[149],"into":[150],"routine.":[152]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2020-01-23T00:00:00"}