{"id":"https://openalex.org/W2999385161","doi":"https://doi.org/10.17863/cam.47595","title":"Exploring the neurobiology of OCD: clinical implications","display_name":"Exploring the neurobiology of OCD: clinical implications","publication_year":2020,"publication_date":"2020-01-07","ids":{"openalex":"https://openalex.org/W2999385161","doi":"https://doi.org/10.17863/cam.47595","mag":"2999385161","pmid":"https://pubmed.ncbi.nlm.nih.gov/32624642","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7334048"},"language":"en","primary_location":{"id":"pmid:32624642","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32624642","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Psychiatric times","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7334048/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012235859","display_name":"Jon Edgar Grant","orcid":"https://orcid.org/0000-0001-7784-7021","observed_orcids":["https://orcid.org/0000-0001-7784-7021","https://orcid.org/0000-0001-7014-8121","https://orcid.org/0000-0002-7785-6443"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chamberlain, Samuel","raw_affiliation_strings":["Department of Psychiatry & Behavioral Neuroscience, University of Chicago, Chicago, IL, USA"],"raw_orcid":"https://orcid.org/0000-0001-7014-8121","affiliations":[{"raw_affiliation_string":"Department of Psychiatry & Behavioral Neuroscience, University of Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5160685110","display_name":"Jon Grant","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210144468","display_name":"Cambridgeshire and Peterborough NHS Foundation Trust","ror":"https://ror.org/040ch0e11","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210144468"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Grant, Jon","raw_affiliation_strings":["Department of Psychiatry, University of Cambridge; & Cambridgeshire and Peterborough NHS, Foundation Trust (CPFT), UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Cambridge; & Cambridgeshire and Peterborough NHS, Foundation Trust (CPFT), UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210144468"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4646,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.73799856,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":97},"biblio":{"volume":"2020","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11132","display_name":"Psychoanalysis and Psychopathology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obsessive-compulsive-disorder","display_name":"obsessive-compulsive disorder","score":1.0},{"id":"https://openalex.org/keywords/neurobiology","display_name":"neurobiology","score":0.699999988079071},{"id":"https://openalex.org/keywords/compulsivity","display_name":"compulsivity","score":0.9879999756813049},{"id":"https://openalex.org/keywords/compulsive-disorders","display_name":"compulsive disorders","score":0.75},{"id":"https://openalex.org/keywords/disease-models","display_name":"disease models","score":0.8730000257492065},{"id":"https://openalex.org/keywords/contamination-obsessions","display_name":"contamination obsessions","score":0.6299999952316284},{"id":"https://openalex.org/keywords/hoarding-disorder","display_name":"hoarding disorder","score":0.8169999718666077},{"id":"https://openalex.org/keywords/body-dysmorphic-disorder","display_name":"body dysmorphic disorder","score":0.9190000295639038},{"id":"https://openalex.org/keywords/trichotillomania","display_name":"trichotillomania","score":0.9959999918937683},{"id":"https://openalex.org/keywords/skin-picking-disorder","display_name":"skin picking disorder","score":0.9900000095367432},{"id":"https://openalex.org/keywords/tourette-syndrome","display_name":"Tourette syndrome","score":0.7519999742507935},{"id":"https://openalex.org/keywords/clinical-implications","display_name":"clinical implications","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C2781009140","wikidata":"https://www.wikidata.org/wiki/Q7170389","display_name":"Persistence (discontinuity)","level":2,"score":0.6733540296554565},{"id":"https://openalex.org/C95713431","wikidata":"https://www.wikidata.org/wiki/Q631425","display_name":"Vulnerability (computing)","level":2,"score":0.6328305602073669},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5819739699363708},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5720691680908203},{"id":"https://openalex.org/C2781089630","wikidata":"https://www.wikidata.org/wiki/Q21856745","display_name":"Realization (probability)","level":2,"score":0.4515780210494995},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.3246973752975464},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.07385030388832092},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0},{"id":"https://openalex.org/C187320778","wikidata":"https://www.wikidata.org/wiki/Q1349130","display_name":"Geotechnical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmid:32624642","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32624642","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Psychiatric times","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7334048","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7334048/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Psychiatr Times","raw_type":"Text"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/300521","doi":null,"is_oa":false,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/300521","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"doi:10.17863/cam.47595","doi":"https://doi.org/10.17863/cam.47595","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.47595","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7334048","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7334048/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Psychiatr Times","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4258145431","display_name":null,"funder_award_id":"110,049/Z/15/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W2053022831","https://openalex.org/W2098915263","https://openalex.org/W2099652807","https://openalex.org/W2149340384","https://openalex.org/W2197119601","https://openalex.org/W2401696118","https://openalex.org/W2420109333","https://openalex.org/W2463095253","https://openalex.org/W2516231809","https://openalex.org/W2517818012","https://openalex.org/W2606104089","https://openalex.org/W2625337450","https://openalex.org/W2756509241","https://openalex.org/W2773792486","https://openalex.org/W2788732613","https://openalex.org/W2792826282","https://openalex.org/W2886773765","https://openalex.org/W2902990194","https://openalex.org/W2906471327","https://openalex.org/W2920914681","https://openalex.org/W2935509564","https://openalex.org/W2941851893","https://openalex.org/W2981068578","https://openalex.org/W3092023810"],"related_works":["https://openalex.org/W7046855735","https://openalex.org/W1963912757","https://openalex.org/W6922300200","https://openalex.org/W2469376092","https://openalex.org/W4251909064","https://openalex.org/W157223313","https://openalex.org/W2104041690","https://openalex.org/W2502225480","https://openalex.org/W3022678663","https://openalex.org/W2551524886"],"abstract_inverted_index":{"Introduction":[0],"Obsessive-compulsive":[1],"disorder":[2,63],"(OCD)":[3],"is":[4,41,58],"a":[5,67,74,77],"common":[6,45],"neuropsychiatric":[7],"condition,":[8],"affecting":[9],"1-2%":[10],"of":[11,33,64,97,103,117,147,153,160],"the":[12,19,61,100,145,150,158],"population":[13],"globally.":[14],"Despite":[15],"considerable":[16],"heterogeneity":[17],"in":[18,143,157],"precise":[20],"symptoms":[21],"experienced":[22],"across":[23],"different":[24],"patients":[25,28],"(e.g.,":[26],"some":[27],"are":[29],"preoccupied":[30],"with":[31,81],"worries":[32],"contamination,":[34],"whereas":[35],"others":[36],"obsess":[37],"about":[38],"symmetry),":[39],"there":[40],"growing":[42],"realization":[43],"that":[44,73],"neurobiological":[46],"processes":[47],"may":[48],"contribute":[49],"to":[50,79],"vulnerability":[51],"towards":[52,69],"OCD":[53,57,120],"and":[54,109,121,135,149],"its":[55],"persistence.":[56],"regarded":[59],"as":[60,89,125],"archetypal":[62],"compulsivity":[65,104,118],"(i.e.":[66],"tendency":[68],"repetitive":[70],"habitual":[71],"actions":[72],"person":[75],"feels":[76],"need":[78],"perform,":[80],"these":[82],"tendencies":[83],"having":[84],"untoward":[85],"functional":[86],"consequences,":[87],"such":[88,124,154],"detracting":[90],"from":[91],"overall":[92],"life":[93],"goals,":[94],"or":[95],"quality":[96],"life).":[98],"Although":[99],"optimal":[101],"definition":[102],"likely":[105],"depends":[106],"upon":[107],"perspective":[108],"context1,":[110],"within":[111],"this":[112],"broad":[113],"clinical":[114,151],"framework,":[115],"disorders":[116,123],"include":[119],"related":[122],"hoarding":[126],"disorder,":[127,130,134],"body":[128],"dysmorphic":[129],"trichotillomania,":[131],"skin":[132],"picking":[133],"Tourette\u2019s2.":[136],"Here":[137],"we":[138],"focus":[139],"on":[140],"recent":[141],"advances":[142],"understanding":[144],"neurobiology":[146],"OCD,":[148],"implications":[152],"knowledge":[155],"viewed":[156],"context":[159],"prevailing":[161],"disease":[162],"models.":[163]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-01-23T00:00:00"}