{"id":"https://openalex.org/W2999314875","doi":"https://doi.org/10.1371/journal.pone.0227215","title":"A pre-clinical validation plan to evaluate analytical sensitivities of molecular diagnostics such as BD MAX MDR-TB, Xpert MTB/Rif Ultra and FluoroType MTB","display_name":"A pre-clinical validation plan to evaluate analytical sensitivities of molecular diagnostics such as BD MAX MDR-TB, Xpert MTB/Rif Ultra and FluoroType MTB","publication_year":2020,"publication_date":"2020-01-07","ids":{"openalex":"https://openalex.org/W2999314875","doi":"https://doi.org/10.1371/journal.pone.0227215","mag":"2999314875","pmid":"https://pubmed.ncbi.nlm.nih.gov/31910223","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6946130"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0227215","doi":"https://doi.org/10.1371/journal.pone.0227215","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0227215","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0227215&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0227215&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036827804","display_name":"Markus Beutler","orcid":"https://orcid.org/0000-0002-4323-462X","observed_orcids":["https://orcid.org/0000-0002-4323-462X"]},"institutions":[{"id":"https://openalex.org/I4210105654","display_name":"World Health Organization","ror":"https://ror.org/01f80g185","country_code":"CH","type":"government","lineage":["https://openalex.org/I4210105654"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Markus Beutler","raw_affiliation_strings":["Institute of Microbiology and Laboratory Medicine, Department IML Red GmbH, WHO-Supranational Reference Laboratory of Tuberculosis, Munich-Gauting, Germany"],"raw_orcid":"https://orcid.org/0000-0002-4323-462X","affiliations":[{"raw_affiliation_string":"Institute of Microbiology and Laboratory Medicine, Department IML Red GmbH, WHO-Supranational Reference Laboratory of Tuberculosis, Munich-Gauting, Germany","institution_ids":["https://openalex.org/I4210105654"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011711684","display_name":"Sara Plesnik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105654","display_name":"World Health Organization","ror":"https://ror.org/01f80g185","country_code":"CH","type":"government","lineage":["https://openalex.org/I4210105654"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Sara Plesnik","raw_affiliation_strings":["Institute of Microbiology and Laboratory Medicine, Department IML Red GmbH, WHO-Supranational Reference Laboratory of Tuberculosis, Munich-Gauting, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microbiology and Laboratory Medicine, Department IML Red GmbH, WHO-Supranational Reference Laboratory of Tuberculosis, Munich-Gauting, Germany","institution_ids":["https://openalex.org/I4210105654"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078293020","display_name":"Marina Mihalic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105654","display_name":"World Health Organization","ror":"https://ror.org/01f80g185","country_code":"CH","type":"government","lineage":["https://openalex.org/I4210105654"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Marina Mihalic","raw_affiliation_strings":["Institute of Microbiology and Laboratory Medicine, Department IML Red GmbH, WHO-Supranational Reference Laboratory of Tuberculosis, Munich-Gauting, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microbiology and Laboratory Medicine, Department IML Red GmbH, WHO-Supranational Reference Laboratory of Tuberculosis, Munich-Gauting, Germany","institution_ids":["https://openalex.org/I4210105654"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051334198","display_name":"Laura Olbrich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018771216","display_name":"LMU Klinikum","ror":"https://ror.org/02jet3w32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I4210115305","display_name":"German Center for Infection Research","ror":"https://ror.org/028s4q594","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210115305","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Laura Olbrich","raw_affiliation_strings":["Division of Infectious Diseases and Tropical Medicine, LMU University Hospital, Munich, Germany","German Centre of Research on Infectious Diseases (DZIF), Partner Site Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases and Tropical Medicine, LMU University Hospital, Munich, Germany","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"raw_affiliation_string":"German Centre of Research on Infectious Diseases (DZIF), Partner Site Munich, Germany","institution_ids":["https://openalex.org/I4210115305"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081968121","display_name":"Norbert Heinrich","orcid":"https://orcid.org/0000-0001-9252-7106","observed_orcids":["https://orcid.org/0000-0001-9252-7106"]},"institutions":[{"id":"https://openalex.org/I3018771216","display_name":"LMU Klinikum","ror":"https://ror.org/02jet3w32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I4210115305","display_name":"German Center for Infection Research","ror":"https://ror.org/028s4q594","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210115305","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Norbert Heinrich","raw_affiliation_strings":["Division of Infectious Diseases and Tropical Medicine, LMU University Hospital, Munich, Germany","German Centre of Research on Infectious Diseases (DZIF), Partner Site Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases and Tropical Medicine, LMU University Hospital, Munich, Germany","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"raw_affiliation_string":"German Centre of Research on Infectious Diseases (DZIF), Partner Site Munich, Germany","institution_ids":["https://openalex.org/I4210115305"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034689350","display_name":"Samuel G. Schumacher","orcid":"https://orcid.org/0000-0002-6136-206X","observed_orcids":["https://orcid.org/0000-0002-6136-206X"]},"institutions":[{"id":"https://openalex.org/I1281389954","display_name":"FIND","ror":"https://ror.org/05tcsqz68","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I1281389954"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Samuel Schumacher","raw_affiliation_strings":["Foundation for Innovative New Diagnostics, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Foundation for Innovative New Diagnostics, Geneva, Switzerland","institution_ids":["https://openalex.org/I1281389954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034569250","display_name":"Michael Lindner","orcid":"https://orcid.org/0000-0002-2106-0286","observed_orcids":["https://orcid.org/0000-0002-2106-0286"]},"institutions":[{"id":"https://openalex.org/I4210125421","display_name":"Asklepios Fachkliniken M\u00fcnchen-Gauting","ror":"https://ror.org/02v4fpg03","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125421"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Lindner","raw_affiliation_strings":["Asklepios Fachkliniken M\u00fcnchen-Gauting, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Asklepios Fachkliniken M\u00fcnchen-Gauting, Munich, Germany","institution_ids":["https://openalex.org/I4210125421"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063526989","display_name":"Ina Koch","orcid":"https://orcid.org/0000-0002-8766-017X","observed_orcids":["https://orcid.org/0000-0002-8766-017X"]},"institutions":[{"id":"https://openalex.org/I4210125421","display_name":"Asklepios Fachkliniken M\u00fcnchen-Gauting","ror":"https://ror.org/02v4fpg03","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125421"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ina Koch","raw_affiliation_strings":["Asklepios Fachkliniken M\u00fcnchen-Gauting, Munich, Germany"],"raw_orcid":"https://orcid.org/0000-0002-8766-017X","affiliations":[{"raw_affiliation_string":"Asklepios Fachkliniken M\u00fcnchen-Gauting, Munich, Germany","institution_ids":["https://openalex.org/I4210125421"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037881629","display_name":"Wolfgang Grasse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102981","display_name":"Zumtobel Group (Austria)","ror":"https://ror.org/018pwv131","country_code":"AT","type":"company","lineage":["https://openalex.org/I4210102981"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Wolfgang Grasse","raw_affiliation_strings":["gerbion GmbH & Co. KG, Kornwestheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"gerbion GmbH & Co. KG, Kornwestheim, Germany","institution_ids":["https://openalex.org/I4210102981"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079331455","display_name":"Christoph Metzger-Boddien","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102981","display_name":"Zumtobel Group (Austria)","ror":"https://ror.org/018pwv131","country_code":"AT","type":"company","lineage":["https://openalex.org/I4210102981"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Christoph Metzger-Boddien","raw_affiliation_strings":["gerbion GmbH & Co. KG, Kornwestheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"gerbion GmbH & Co. KG, Kornwestheim, Germany","institution_ids":["https://openalex.org/I4210102981"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042126916","display_name":"Sabine Hofmann-Thiel","orcid":"https://orcid.org/0000-0002-3592-5818","observed_orcids":["https://orcid.org/0000-0002-3592-5818"]},"institutions":[{"id":"https://openalex.org/I4210105654","display_name":"World Health Organization","ror":"https://ror.org/01f80g185","country_code":"CH","type":"government","lineage":["https://openalex.org/I4210105654"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Sabine Hofmann-Thiel","raw_affiliation_strings":["Institute of Microbiology and Laboratory Medicine, Department IML Red GmbH, WHO-Supranational Reference Laboratory of Tuberculosis, Munich-Gauting, Germany","SYNLAB Gauting, SYNLAB Human Genetics Munich, Munich-Gauting, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microbiology and Laboratory Medicine, Department IML Red GmbH, WHO-Supranational Reference Laboratory of Tuberculosis, Munich-Gauting, Germany","institution_ids":["https://openalex.org/I4210105654"]},{"raw_affiliation_string":"SYNLAB Gauting, SYNLAB Human Genetics Munich, Munich-Gauting, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084704104","display_name":"Harald Hoffmann","orcid":"https://orcid.org/0000-0003-4886-5022","observed_orcids":["https://orcid.org/0000-0003-4886-5022"]},"institutions":[{"id":"https://openalex.org/I4210105654","display_name":"World Health Organization","ror":"https://ror.org/01f80g185","country_code":"CH","type":"government","lineage":["https://openalex.org/I4210105654"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Harald Hoffmann","raw_affiliation_strings":["Institute of Microbiology and Laboratory Medicine, Department IML Red GmbH, WHO-Supranational Reference Laboratory of Tuberculosis, Munich-Gauting, Germany","SYNLAB Gauting, SYNLAB Human Genetics Munich, Munich-Gauting, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microbiology and Laboratory Medicine, Department IML Red GmbH, WHO-Supranational Reference Laboratory of Tuberculosis, Munich-Gauting, Germany","institution_ids":["https://openalex.org/I4210105654"]},{"raw_affiliation_string":"SYNLAB Gauting, SYNLAB Human Genetics Munich, Munich-Gauting, Germany","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5036827804"],"corresponding_institution_ids":["https://openalex.org/I4210105654"],"apc_list":{"value":1695,"currency":"USD","value_usd":1695},"apc_paid":{"value":1695,"currency":"USD","value_usd":1695},"fwci":0.4764,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.79053839,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"15","issue":"1","first_page":"e0227215","last_page":"e0227215"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12167","display_name":"Bacterial Identification and Susceptibility Testing","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tuberculosis","display_name":"tuberculosis","score":0.621999979019165},{"id":"https://openalex.org/keywords/molecular-diagnosis","display_name":"molecular diagnosis","score":0.7110000252723694},{"id":"https://openalex.org/keywords/analytical-sensitivity","display_name":"analytical sensitivity","score":0.8450000286102295},{"id":"https://openalex.org/keywords/detection-limit","display_name":"detection limit","score":0.8939999938011169},{"id":"https://openalex.org/keywords/xpert-mtb-rif-ultra","display_name":"Xpert MTB/RIF Ultra","score":0.921999990940094},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.8759999871253967},{"id":"https://openalex.org/keywords/rifampicin-resistance","display_name":"rifampicin resistance","score":0.9129999876022339},{"id":"https://openalex.org/keywords/isoniazid-resistance","display_name":"isoniazid resistance","score":0.9990000128746033},{"id":"https://openalex.org/keywords/preclinical-validation","display_name":"preclinical validation","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C2776301714","wikidata":"https://www.wikidata.org/wiki/Q259346","display_name":"Sputum","level":3,"score":0.6398426294326782},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.637479841709137},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.544529139995575},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5214663743972778},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4623575806617737},{"id":"https://openalex.org/C2778607973","wikidata":"https://www.wikidata.org/wiki/Q422652","display_name":"Rifampicin","level":3,"score":0.4315844178199768},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3591468334197998},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19328460097312927},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11940008401870728}],"mesh":[{"descriptor_ui":"D000904","descriptor_name":"Antibiotics, Antitubercular","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000904","descriptor_name":"Antibiotics, Antitubercular","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011786","descriptor_name":"Quality Control","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011933","descriptor_name":"Reagent Kits, Diagnostic","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D013183","descriptor_name":"Sputum","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D014397","descriptor_name":"Tuberculosis, Pulmonary","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D014397","descriptor_name":"Tuberculosis, Pulmonary","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D014397","descriptor_name":"Tuberculosis, Pulmonary","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D018088","descriptor_name":"Tuberculosis, Multidrug-Resistant","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018088","descriptor_name":"Tuberculosis, Multidrug-Resistant","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D018088","descriptor_name":"Tuberculosis, Multidrug-Resistant","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D024901","descriptor_name":"Drug Resistance, Multiple, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025202","descriptor_name":"Molecular Diagnostic Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D025202","descriptor_name":"Molecular Diagnostic Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025202","descriptor_name":"Molecular Diagnostic Techniques","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D057230","descriptor_name":"Limit of Detection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0227215","doi":"https://doi.org/10.1371/journal.pone.0227215","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0227215","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0227215&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5916712","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6946130","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:31910223","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31910223","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:6946130","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6946130/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:f076607e98f14880afc9b7b055383d6c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f076607e98f14880afc9b7b055383d6c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 15, Iss 1, p e0227215 (2020)","raw_type":"article"},{"id":"pmh:oai:epub.ub.uni-muenchen.de:87206","doi":null,"is_oa":true,"landing_page_url":"https://epub.ub.uni-muenchen.de/87206/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401845","display_name":"Open access LMU (Ludwid Maxmilian's Universitat Munchen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I8204097","host_organization_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","host_organization_lineage":["https://openalex.org/I8204097"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS One","raw_type":"doc-type:article"},{"id":"pmh:oai:figshare.com:article/11539338","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/A_pre-clinical_validation_plan_to_evaluate_analytical_sensitivities_of_molecular_diagnostics_such_as_BD_MAX_MDR-TB_Xpert_MTB_Rif_Ultra_and_FluoroType_MTB/11539338","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0227215","doi":"https://doi.org/10.1371/journal.pone.0227215","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0227215","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0227215&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G619328018","display_name":null,"funder_award_id":"16GW0153K","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G7267075891","display_name":"Verbundprojekt: Multiplex Analytik von Mycobacterium tuberculosis (MTB) auf Basis von funktionalen Einwegkartuschen (TB-Tube) - Teilvorhaben: Probenpr\u00e4paration und Evaluierung der zu erforschenden Nachweissysteme f\u00fcr den Einsatz in der mykobakteriologischen Diagnostik","funder_award_id":"13N13460","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"}],"funders":[{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2999314875.pdf","grobid_xml":"https://content.openalex.org/works/W2999314875.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1575047457","https://openalex.org/W1606105143","https://openalex.org/W1963803001","https://openalex.org/W1970654452","https://openalex.org/W1987635146","https://openalex.org/W1988127920","https://openalex.org/W1995651433","https://openalex.org/W2041590978","https://openalex.org/W2055434618","https://openalex.org/W2087779533","https://openalex.org/W2090542083","https://openalex.org/W2105010248","https://openalex.org/W2121543526","https://openalex.org/W2125289247","https://openalex.org/W2127258416","https://openalex.org/W2131782505","https://openalex.org/W2134732639","https://openalex.org/W2135226086","https://openalex.org/W2154326381","https://openalex.org/W2315920371","https://openalex.org/W2472138188","https://openalex.org/W2530419011","https://openalex.org/W2567852564","https://openalex.org/W2753668595","https://openalex.org/W2779510789","https://openalex.org/W2903229299","https://openalex.org/W2939542519","https://openalex.org/W2944607007","https://openalex.org/W2982824428"],"related_works":["https://openalex.org/W4317425750","https://openalex.org/W2923290090","https://openalex.org/W7143537724","https://openalex.org/W7171983130","https://openalex.org/W4395098299","https://openalex.org/W4402642737","https://openalex.org/W2753668595","https://openalex.org/W3042607872","https://openalex.org/W4368373667","https://openalex.org/W4414043640"],"abstract_inverted_index":{"Rapid":[0],"diagnosis":[1],"of":[2,18,24,64,79,126,143,160,179,227],"tuberculosis":[3,110],"(TB)":[4],"and":[5,14,52,72,100,114,120,135,152,159,169,192,197],"antibiotic":[6],"resistances":[7],"are":[8],"imperative":[9],"to":[10,15,46,86,184,189,203,221],"initiate":[11],"effective":[12],"treatment":[13],"stop":[16],"transmission":[17],"the":[19,44,80,87],"disease.":[20],"A":[21],"new":[22,81],"generation":[23],"more":[25,38],"sensitive,":[26],"automated":[27],"molecular":[28],"TB":[29,231],"diagnostic":[30],"tests":[31],"has":[32],"been":[33],"recently":[34],"launched":[35],"giving":[36],"microbiologists":[37],"choice":[39],"between":[40],"several":[41],"assays":[42,229],"with":[43,108],"potential":[45],"detect":[47],"resistance":[48,180],"markers":[49,181],"for":[50,67,224,230],"rifampicin":[51],"isoniazid.":[53],"In":[54],"this":[55],"study,":[56],"we":[57,122],"determined":[58],"analytical":[59,200],"sensitivities":[60],"as":[61,76],"95%":[62],"limits":[63],"detection":[65],"(LoD95)":[66],"Xpert":[68],"MTB/Rif":[69],"Ultra":[70],"(XP-Ultra)":[71],"BD-MAX":[73,191],"MDR-TB":[74],"(BD-MAX)":[75],"two":[77],"representatives":[78],"test":[82],"generation,":[83],"in":[84,111,140,157,174],"comparison":[85],"conventional":[88,204],"FluoroType":[89],"MTB":[90],"(FT-MTB).":[91],"Test":[92],"matrices":[93],"used":[94],"were":[95,182],"physiological":[96],"saline":[97,175],"solution,":[98,176],"human":[99,141,208],"a":[101],"mucin-based":[102],"artificial":[103],"sputum":[104],"(MUCAS)":[105],"each":[106],"spiked":[107],"Mycobacterium":[109],"declining":[112],"culture-":[113],"qPCR-controlled":[115],"concentrations.":[116],"With":[117],"BD-MAX,":[118],"XP-Ultra,":[119],"FT-MTB,":[121],"measured":[123],"LoD95TB":[124],"values":[125],"2.1":[127],"cfu/ml":[128,132,137,145,149,154,162,166,171],"(CI95%:":[129,133,138,146,150,155,163,167,172],"0.9-23.3),":[130],"3.1":[131],"1.2-88.9),":[134],"52.1":[136],"16.7-664.4)":[139],"sputum;":[142],"6.3":[144],"2.9-31.8),":[147],"1.5":[148],"0.7-5.0),":[151],"30.4":[153],"17.4-60.7)":[156],"MUCAS;":[158],"2.3":[161],"1.1-12.0),":[164],"11.5":[165],"5.6-47.3),":[168],"129.1":[170],"82.8-273.8)":[173],"respectively.":[177],"LoD95":[178],"9":[183],"48":[185],"times":[186],"higher":[187],"compared":[188,202],"LoD95TB.":[190],"XP-Ultra":[193],"have":[194],"an":[195],"equal":[196],"significantly":[198,213],"increased":[199],"sensitivity":[201],"tests.":[205],"MUCAS":[206,219],"resembled":[207],"sputum,":[209],"while":[210],"both":[211],"yielded":[212],"different":[214],"results":[215],"than":[216],"normal":[217],"saline.":[218],"proved":[220],"be":[222],"suitable":[223],"quality":[225],"control":[226],"PCR":[228],"diagnostics.":[232]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-01-23T00:00:00"}
