{"id":"https://openalex.org/W2999080067","doi":"https://doi.org/10.3389/fbioe.2019.00451","title":"Assessment of the Angiogenic Potential of 2-Deoxy-D-Ribose Using a Novel in vitro 3D Dynamic Model in Comparison With Established in vitro Assays","display_name":"Assessment of the Angiogenic Potential of 2-Deoxy-D-Ribose Using a Novel in vitro 3D Dynamic Model in Comparison With Established in vitro Assays","publication_year":2020,"publication_date":"2020-01-17","ids":{"openalex":"https://openalex.org/W2999080067","doi":"https://doi.org/10.3389/fbioe.2019.00451","mag":"2999080067","pmid":"https://pubmed.ncbi.nlm.nih.gov/32010677","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6978624"},"language":"en","primary_location":{"id":"doi:10.3389/fbioe.2019.00451","doi":"https://doi.org/10.3389/fbioe.2019.00451","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbioe.2019.00451","pdf_url":"https://www.frontiersin.org/articles/10.3389/fbioe.2019.00451/pdf","source":{"id":"https://openalex.org/S2595131146","display_name":"Frontiers in Bioengineering and Biotechnology","issn_l":"2296-4185","issn":["2296-4185"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioengineering and Biotechnology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fbioe.2019.00451/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061117501","display_name":"Serkan D\u0131k\u0131c\u0131","orcid":"https://orcid.org/0000-0001-9933-5254","observed_orcids":["https://orcid.org/0000-0001-9933-5254"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]},{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Serkan Dikici","raw_affiliation_strings":["Department of Materials Science and Engineering, Kroto Research Institute, University of Sheffield, Sheffield, United Kingdom","Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, United States","Department of Materials Science and Engineering, Kroto Research Institute, University of Sheffield, United Kingdom","Institute for Medical Engineering and Science, Massachusetts Institute of Technology, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials Science and Engineering, Kroto Research Institute, University of Sheffield, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, United States","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Materials Science and Engineering, Kroto Research Institute, University of Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Institute for Medical Engineering and Science, Massachusetts Institute of Technology, United States","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020388446","display_name":"Bet\u00fcl Aldemir Dikici","orcid":"https://orcid.org/0000-0002-5516-469X","observed_orcids":["https://orcid.org/0000-0002-5516-469X"]},"institutions":[{"id":"https://openalex.org/I4210147861","display_name":"Insigneo","ror":"https://ror.org/04ve58z79","country_code":"GB","type":"education","lineage":["https://openalex.org/I4210147861"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]},{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Bet\u00fcl Aldemir Dikici","raw_affiliation_strings":["Department of Materials Science and Engineering, INSIGNEO Institute for In Silico Medicine, University of Sheffield, Sheffield, United Kingdom","Department of Materials Science and Engineering, Kroto Research Institute, University of Sheffield, Sheffield, United Kingdom","Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, United States","Department of Materials Science and Engineering, INSIGNEO Institute for In Silico Medicine, University of Sheffield, United Kingdom","Department of Materials Science and Engineering, Kroto Research Institute, University of Sheffield, United Kingdom","Institute for Medical Engineering and Science, Massachusetts Institute of Technology, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials Science and Engineering, INSIGNEO Institute for In Silico Medicine, University of Sheffield, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I4210147861","https://openalex.org/I91136226"]},{"raw_affiliation_string":"Department of Materials Science and Engineering, Kroto Research Institute, University of Sheffield, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, United States","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Materials Science and Engineering, INSIGNEO Institute for In Silico Medicine, University of Sheffield, United Kingdom","institution_ids":["https://openalex.org/I4210147861","https://openalex.org/I91136226"]},{"raw_affiliation_string":"Department of Materials Science and Engineering, Kroto Research Institute, University of Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Institute for Medical Engineering and Science, Massachusetts Institute of Technology, United States","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049502688","display_name":"Shirin Issa Bhaloo","orcid":"https://orcid.org/0000-0001-9765-8711","observed_orcids":["https://orcid.org/0000-0001-9765-8711"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shirin Issa Bhaloo","raw_affiliation_strings":["Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, United States","Institute for Medical Engineering and Science, Massachusetts Institute of Technology, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, United States","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Institute for Medical Engineering and Science, Massachusetts Institute of Technology, United States","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066978972","display_name":"Mercedes Balcells","orcid":"https://orcid.org/0000-0002-2532-0516","observed_orcids":["https://orcid.org/0000-0002-2532-0516"]},"institutions":[{"id":"https://openalex.org/I4210150658","display_name":"Institut Qu\u00edmic de Sarri\u00e0","ror":"https://ror.org/04y3yya25","country_code":"ES","type":"education","lineage":["https://openalex.org/I4210150658","https://openalex.org/I5593406"]},{"id":"https://openalex.org/I5593406","display_name":"Universitat Ramon Llull","ror":"https://ror.org/04p9k2z50","country_code":"ES","type":"education","lineage":["https://openalex.org/I5593406"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["ES","US"],"is_corresponding":false,"raw_author_name":"Mercedes Balcells","raw_affiliation_strings":["Bioengineering Department, Institut Quimic de Sarria, Ramon Llull University, Barcelona, Spain","Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, United States","Bioengineering Department, Institut Quimic de Sarria, Ramon Llull University, Spain","Institute for Medical Engineering and Science, Massachusetts Institute of Technology, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioengineering Department, Institut Quimic de Sarria, Ramon Llull University, Barcelona, Spain","institution_ids":["https://openalex.org/I4210150658","https://openalex.org/I5593406"]},{"raw_affiliation_string":"Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, United States","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Bioengineering Department, Institut Quimic de Sarria, Ramon Llull University, Spain","institution_ids":["https://openalex.org/I4210150658","https://openalex.org/I5593406"]},{"raw_affiliation_string":"Institute for Medical Engineering and Science, Massachusetts Institute of Technology, United States","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005931821","display_name":"Elazer Reuven Edelman","orcid":"https://orcid.org/0000-0002-7832-7156","observed_orcids":["https://orcid.org/0000-0002-7832-7156"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elazer R. Edelman","raw_affiliation_strings":["Division of Cardiovascular Medicine, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, United States","Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, United States","Division of Cardiovascular Medicine, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, United States","Institute for Medical Engineering and Science, Massachusetts Institute of Technology, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Medicine, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, United States","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Division of Cardiovascular Medicine, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Institute for Medical Engineering and Science, Massachusetts Institute of Technology, United States","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049275138","display_name":"Sheila MacNeil","orcid":"https://orcid.org/0000-0002-9188-5769","observed_orcids":["https://orcid.org/0000-0002-9188-5769"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sheila MacNeil","raw_affiliation_strings":["Department of Materials Science and Engineering, Kroto Research Institute, University of Sheffield, Sheffield, United Kingdom","Department of Materials Science and Engineering, Kroto Research Institute, University of Sheffield, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials Science and Engineering, Kroto Research Institute, University of Sheffield, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Department of Materials Science and Engineering, Kroto Research Institute, University of Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105979536","display_name":"Gwendolen Clair Reilly","orcid":"https://orcid.org/0000-0003-1456-1071","observed_orcids":["https://orcid.org/0000-0003-1456-1071"]},"institutions":[{"id":"https://openalex.org/I4210147861","display_name":"Insigneo","ror":"https://ror.org/04ve58z79","country_code":"GB","type":"education","lineage":["https://openalex.org/I4210147861"]},{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gwendolen C. Reilly","raw_affiliation_strings":["Department of Materials Science and Engineering, INSIGNEO Institute for In Silico Medicine, University of Sheffield, Sheffield, United Kingdom","Department of Materials Science and Engineering, Kroto Research Institute, University of Sheffield, Sheffield, United Kingdom","Department of Materials Science and Engineering, INSIGNEO Institute for In Silico Medicine, University of Sheffield, United Kingdom","Department of Materials Science and Engineering, Kroto Research Institute, University of Sheffield, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials Science and Engineering, INSIGNEO Institute for In Silico Medicine, University of Sheffield, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I4210147861","https://openalex.org/I91136226"]},{"raw_affiliation_string":"Department of Materials Science and Engineering, Kroto Research Institute, University of Sheffield, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Department of Materials Science and Engineering, INSIGNEO Institute for In Silico Medicine, University of Sheffield, United Kingdom","institution_ids":["https://openalex.org/I4210147861","https://openalex.org/I91136226"]},{"raw_affiliation_string":"Department of Materials Science and Engineering, Kroto Research Institute, University of Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008223800","display_name":"Colin Sherborne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Colin Sherborne","raw_affiliation_strings":["Department of Materials Science and Engineering, Kroto Research Institute, University of Sheffield, Sheffield, United Kingdom","Department of Materials Science and Engineering, Kroto Research Institute, University of Sheffield, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials Science and Engineering, Kroto Research Institute, University of Sheffield, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Department of Materials Science and Engineering, Kroto Research Institute, University of Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087716394","display_name":"Frederik Claeyssens","orcid":"https://orcid.org/0000-0002-1030-939X","observed_orcids":["https://orcid.org/0000-0002-1030-939X"]},"institutions":[{"id":"https://openalex.org/I4210147861","display_name":"Insigneo","ror":"https://ror.org/04ve58z79","country_code":"GB","type":"education","lineage":["https://openalex.org/I4210147861"]},{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Frederik Claeyssens","raw_affiliation_strings":["Department of Materials Science and Engineering, INSIGNEO Institute for In Silico Medicine, University of Sheffield, Sheffield, United Kingdom","Department of Materials Science and Engineering, Kroto Research Institute, University of Sheffield, Sheffield, United Kingdom","Department of Materials Science and Engineering, INSIGNEO Institute for In Silico Medicine, University of Sheffield, United Kingdom","Department of Materials Science and Engineering, Kroto Research Institute, University of Sheffield, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials Science and Engineering, INSIGNEO Institute for In Silico Medicine, University of Sheffield, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I4210147861","https://openalex.org/I91136226"]},{"raw_affiliation_string":"Department of Materials Science and Engineering, Kroto Research Institute, University of Sheffield, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"Department of Materials Science and Engineering, INSIGNEO Institute for In Silico Medicine, University of Sheffield, United Kingdom","institution_ids":["https://openalex.org/I4210147861","https://openalex.org/I91136226"]},{"raw_affiliation_string":"Department of Materials Science and Engineering, Kroto Research Institute, University of Sheffield, United Kingdom","institution_ids":["https://openalex.org/I91136226"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5087716394"],"corresponding_institution_ids":["https://openalex.org/I4210147861","https://openalex.org/I91136226"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":2.0363,"has_fulltext":true,"cited_by_count":45,"citation_normalized_percentile":{"value":0.87639438,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"7","issue":null,"first_page":"451","last_page":"451"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/2-deoxyribose","display_name":"2-deoxy-D-ribose","score":0.9559999704360962},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9369999766349792},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.8600000143051147},{"id":"https://openalex.org/keywords/human-aortic-endothelial-cells","display_name":"human aortic endothelial cells","score":0.9919999837875366},{"id":"https://openalex.org/keywords/endothelial-cell-proliferation","display_name":"endothelial cell proliferation","score":0.9380000233650208},{"id":"https://openalex.org/keywords/endothelial-cell-migration","display_name":"endothelial cell migration","score":0.9779999852180481},{"id":"https://openalex.org/keywords/tube-formation","display_name":"tube formation","score":0.9459999799728394},{"id":"https://openalex.org/keywords/neovascularization","display_name":"neovascularization","score":0.8769999742507935},{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"tissue engineering","score":0.7549999952316284},{"id":"https://openalex.org/keywords/in-vitro-angiogenesis-assay","display_name":"in vitro angiogenesis assay","score":0.7459999918937683}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.930450975894928},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.6949111819267273},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6602110862731934},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6586467623710632},{"id":"https://openalex.org/C33618052","wikidata":"https://www.wikidata.org/wiki/Q6013136","display_name":"In vitro toxicology","level":3,"score":0.44182446599006653},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.43981266021728516},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43865087628364563},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4263148307800293},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.42466944456100464},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36124351620674133},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.31892499327659607},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18689823150634766},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1753261387348175},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.08829635381698608},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07728391885757446}],"mesh":[],"locations_count":9,"locations":[{"id":"doi:10.3389/fbioe.2019.00451","doi":"https://doi.org/10.3389/fbioe.2019.00451","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbioe.2019.00451","pdf_url":"https://www.frontiersin.org/articles/10.3389/fbioe.2019.00451/pdf","source":{"id":"https://openalex.org/S2595131146","display_name":"Frontiers in Bioengineering and Biotechnology","issn_l":"2296-4185","issn":["2296-4185"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioengineering and Biotechnology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5941763","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6978624","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6978624","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6978624","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Bioeng Biotechnol","raw_type":"Text"},{"id":"pmid:32010677","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32010677","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in bioengineering and biotechnology","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.whiterose.ac.uk:156357","doi":null,"is_oa":false,"landing_page_url":"http://eprints.whiterose.ac.uk/156357/1/fbioe-07-00451.pdf","pdf_url":"http://eprints.whiterose.ac.uk/156357/1/fbioe-07-00451.pdf","source":{"id":"https://openalex.org/S4306400854","display_name":"White Rose Research Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:dspace.mit.edu:1721.1/125320","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1721.1/125320","pdf_url":"https://dspace.mit.edu/bitstreams/e925404e-628b-4b2b-b5a4-44b3c14bff56/download","source":{"id":"https://openalex.org/S4306400425","display_name":"DSpace@MIT (Massachusetts Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I63966007","host_organization_name":"Massachusetts Institute of Technology","host_organization_lineage":["https://openalex.org/I63966007"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:2ba15d288e2742fc92d0303c01a57786","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/2ba15d288e2742fc92d0303c01a57786","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Bioengineering and Biotechnology, Vol 7 (2020)","raw_type":"article"},{"id":"pmh:oai:recercat.cat:2072/450149","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2072/450149","pdf_url":null,"source":{"id":"https://openalex.org/S4306402147","display_name":"RECERCAT (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"RECERCAT (Dip\u00f2sit de la Recerca de Catalunya)","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:3041040708","doi":null,"is_oa":false,"landing_page_url":"https://dspace.mit.edu/handle/1721.1/125320","pdf_url":null,"source":{"id":"https://openalex.org/S4210203252","display_name":"Frontiers A Journal of Women Studies","issn_l":"0160-9009","issn":["0160-9009","1536-0334"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","erih-plus","norway-1","poland-40"],"host_organization":"https://openalex.org/P4310320162","host_organization_name":"University of Nebraska Press","host_organization_lineage":["https://openalex.org/P4310320162"],"host_organization_lineage_names":["University of Nebraska Press"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Frontiers A Journal of Women Studies","raw_type":null}],"best_oa_location":{"id":"doi:10.3389/fbioe.2019.00451","doi":"https://doi.org/10.3389/fbioe.2019.00451","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbioe.2019.00451","pdf_url":"https://www.frontiersin.org/articles/10.3389/fbioe.2019.00451/pdf","source":{"id":"https://openalex.org/S2595131146","display_name":"Frontiers in Bioengineering and Biotechnology","issn_l":"2296-4185","issn":["2296-4185"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioengineering and Biotechnology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1720459405","display_name":"Scaffolds for Neural Tissue Engineering","funder_award_id":"EP/I007695/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G2366285341","display_name":null,"funder_award_id":"EP/I007695/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G3075507695","display_name":"MICA: Open-access biomaterials microfabrication and non-invasive imaging facilities for Regenerative Medicine.","funder_award_id":"MR/L012669/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G710445366","display_name":null,"funder_award_id":"I007695/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G8189073192","display_name":null,"funder_award_id":"MR/L012669/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320306250","display_name":"Battelle","ror":"https://ror.org/01h5tnr73"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2999080067.pdf","grobid_xml":"https://content.openalex.org/works/W2999080067.grobid-xml"},"referenced_works_count":97,"referenced_works":["https://openalex.org/W107313812","https://openalex.org/W175416543","https://openalex.org/W182566489","https://openalex.org/W211121651","https://openalex.org/W568938955","https://openalex.org/W1516603921","https://openalex.org/W1551620887","https://openalex.org/W1562759933","https://openalex.org/W1586102570","https://openalex.org/W1591852023","https://openalex.org/W1655483869","https://openalex.org/W1679229092","https://openalex.org/W1762724222","https://openalex.org/W1783580437","https://openalex.org/W1818943734","https://openalex.org/W1889070148","https://openalex.org/W1969339220","https://openalex.org/W1971839302","https://openalex.org/W1974242642","https://openalex.org/W1974798445","https://openalex.org/W1976506339","https://openalex.org/W1978347107","https://openalex.org/W1980716346","https://openalex.org/W1981805090","https://openalex.org/W1985801265","https://openalex.org/W1993298115","https://openalex.org/W1994935582","https://openalex.org/W1996747774","https://openalex.org/W1996945091","https://openalex.org/W1999358438","https://openalex.org/W2002596243","https://openalex.org/W2003649034","https://openalex.org/W2006431507","https://openalex.org/W2009855429","https://openalex.org/W2025434419","https://openalex.org/W2026632078","https://openalex.org/W2030537668","https://openalex.org/W2033474014","https://openalex.org/W2049503675","https://openalex.org/W2050935277","https://openalex.org/W2051750498","https://openalex.org/W2055218751","https://openalex.org/W2056229778","https://openalex.org/W2057486637","https://openalex.org/W2058177351","https://openalex.org/W2058618487","https://openalex.org/W2059993923","https://openalex.org/W2064109857","https://openalex.org/W2077354973","https://openalex.org/W2081065930","https://openalex.org/W2081843874","https://openalex.org/W2085447070","https://openalex.org/W2090052318","https://openalex.org/W2091774189","https://openalex.org/W2094556528","https://openalex.org/W2094810573","https://openalex.org/W2098533150","https://openalex.org/W2108278446","https://openalex.org/W2112911107","https://openalex.org/W2117228071","https://openalex.org/W2117497670","https://openalex.org/W2126336984","https://openalex.org/W2126725396","https://openalex.org/W2129574021","https://openalex.org/W2131779214","https://openalex.org/W2139731074","https://openalex.org/W2143260418","https://openalex.org/W2151283844","https://openalex.org/W2152265045","https://openalex.org/W2153688789","https://openalex.org/W2156713309","https://openalex.org/W2156992502","https://openalex.org/W2168056522","https://openalex.org/W2169932958","https://openalex.org/W2170047031","https://openalex.org/W2171852683","https://openalex.org/W2264590316","https://openalex.org/W2310033666","https://openalex.org/W2332237703","https://openalex.org/W2399480166","https://openalex.org/W2403779027","https://openalex.org/W2417375737","https://openalex.org/W2417539658","https://openalex.org/W2499418920","https://openalex.org/W2518596275","https://openalex.org/W2612574275","https://openalex.org/W2744365083","https://openalex.org/W2766821282","https://openalex.org/W2803038140","https://openalex.org/W2803499602","https://openalex.org/W2917138587","https://openalex.org/W2944151023","https://openalex.org/W2946688570","https://openalex.org/W2947856563","https://openalex.org/W2955566817","https://openalex.org/W2962603095","https://openalex.org/W2969581489"],"related_works":["https://openalex.org/W3037811313","https://openalex.org/W3083443311","https://openalex.org/W2414511610","https://openalex.org/W3208240334","https://openalex.org/W2917138587","https://openalex.org/W2060075925","https://openalex.org/W2275776660","https://openalex.org/W2051553844","https://openalex.org/W2526432519","https://openalex.org/W6940796966"],"abstract_inverted_index":{"Angiogenesis":[0],"is":[1,36,56,99,166],"a":[2,57,167,259],"highly":[3],"ordered":[4],"physiological":[5,162],"process":[6],"regulated":[7],"by":[8],"the":[9,29,37,51,69,94,100,103,111,144,159,170,178,207,263,272,281,296,304,309],"interaction":[10],"of":[11,18,28,40,53,63,89,102,142,146,151,161,172,180,210,252,266,283,298,306],"endothelial":[12,217,255],"cells":[13,256],"with":[14,96,215],"an":[15,173],"extensive":[16],"variety":[17],"growth":[19,218],"factors,":[20],"extracellular":[21],"matrix":[22],"components":[23],"and":[24,81,114,122,135,153,204,229,249,286,300,308],"mechanical":[25],"stimuli.":[26],"One":[27],"most":[30,104,112],"important":[31],"challenges":[32],"in":[33,77,82,128,193,199,213,224,232,240,258,276],"tissue":[34],"engineering":[35],"rapid":[38],"neovascularization":[39],"constructs":[41],"to":[42],"ensure":[43],"their":[44],"survival":[45],"after":[46],"transplantation.":[47],"To":[48],"achieve":[49],"this,":[50],"use":[52],"pro-angiogenic":[54,92],"agents":[55],"widely":[58],"accepted":[59],"approach.":[60],"The":[61],"study":[62,145,179],"angiogenesis":[64,84,98,174,181,202],"has":[65],"gained":[66],"momentum":[67],"over":[68],"last":[70],"two":[71],"decades.":[72],"Although":[73],"there":[74,165],"are":[75,110,119,131,139],"various":[76],"vitro,":[78],"ex":[79],"vivo":[80,83,108],"models":[85],"that":[86,176,244,295],"enable":[87],"testing":[88],"newly":[90,222,273],"discovered":[91],"agents,":[93],"problem":[95],"researching":[97],"choice":[101],"appropriate":[105],"assay.":[106],"In":[107],"assays":[109,130,242],"representative":[113],"reliable":[115],"models,":[116],"but":[117,137],"they":[118,138,154],"expensive,":[120],"time-consuming":[121],"can":[123],"cause":[124],"ethical":[125,190],"concerns":[126],"whereas":[127],"vitro":[129,200,225,233,241,277],"relatively":[132],"inexpensive,":[133],"practical":[134],"reproducible,":[136],"usually":[140],"lack":[141],"enabling":[143],"more":[147,184],"than":[148],"one":[149],"aspect":[150],"angiogenesis,":[152],"do":[155],"not":[156],"fully":[157],"represent":[158],"complexity":[160],"angiogenesis.":[163],"Therefore,":[164],"need":[168],"for":[169],"development":[171],"model":[175,228],"allows":[177],"under":[182,289,312],"physiologically":[183],"relevant,":[185],"dynamic":[186,201,227,290,316],"conditions":[187],"without":[188],"causing":[189],"concerns.":[191],"Accordingly,":[192],"this":[194],"study,":[195],"we":[196,205],"developed":[197,223,274],"3D":[198,226,275],"model,":[203,278],"tested":[206],"angiogenic":[208,264],"potential":[209],"2-deoxy-D-ribose":[211],"(2dDR)":[212],"comparison":[214],"vascular":[216],"factor":[219],"(VEGF)":[220],"using":[221,238,271],"well":[230],"established":[231],"models.":[234],"Our":[235,292],"results":[236,293],"obtained":[237],"conventional":[239],"demonstrated":[243],"2dDR":[245,267,299],"promoted":[246],"proliferation,":[247],"migration":[248],"tube":[250],"formation":[251],"human":[253],"aortic":[254],"(HAECs)":[257],"dose-dependent":[260],"manner.":[261],"Then,":[262],"activity":[265],"was":[268],"further":[269],"assessed":[270],"which":[279],"enabled":[280],"monitoring":[282],"cell":[284],"proliferation":[285],"infiltration":[287],"simultaneously":[288],"conditions.":[291,317],"showed":[294],"administration":[297],"VEGF":[301],"significantly":[302],"enhanced":[303],"outgrowth":[305],"HAECs":[307],"cellular":[310],"density":[311],"either":[313],"static":[314],"or":[315]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-01-23T00:00:00"}