{"id":"https://openalex.org/W2999059804","doi":"https://doi.org/10.1101/2020.01.17.910091","title":"Morphological profiling of human T and NK lymphocytes identifies actin-mediated control of the immunological synapse","display_name":"Morphological profiling of human T and NK lymphocytes identifies actin-mediated control of the immunological synapse","publication_year":2020,"publication_date":"2020-01-17","ids":{"openalex":"https://openalex.org/W2999059804","doi":"https://doi.org/10.1101/2020.01.17.910091","mag":"2999059804"},"language":"en","primary_location":{"id":"doi:10.1101/2020.01.17.910091","doi":"https://doi.org/10.1101/2020.01.17.910091","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.01.17.910091","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/01/17/2020.01.17.910091.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2020/01/17/2020.01.17.910091.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083386801","display_name":"Yolla German","orcid":"https://orcid.org/0000-0002-3472-6446","observed_orcids":["https://orcid.org/0000-0002-3472-6446"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210113758","display_name":"Centre de Physiopathologie de Toulouse-Purpan","ror":"https://ror.org/02c1tv516","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I134560555","https://openalex.org/I154526488","https://openalex.org/I4210088668","https://openalex.org/I4210096427","https://openalex.org/I4210113758","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4210142115","display_name":"Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases","ror":"https://ror.org/03hgkg910","country_code":"AT","type":"facility","lineage":["https://openalex.org/I2799334681","https://openalex.org/I4210142115"]}],"countries":["AT","FR"],"is_corresponding":false,"raw_author_name":"Yolla German","raw_affiliation_strings":["CNRS, UMR 5282, Toulouse, France","INSERM, UMR1043, Center for Pathophysiology of Toulouse Purpan, Toulouse, France","Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria","Toulouse III Paul-Sabatier University, Toulouse, France","INSERM, UMR043, Center for Pathophysiology of Toulouse Purpan, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS, UMR 5282, Toulouse, France","institution_ids":["https://openalex.org/I1294671590"]},{"raw_affiliation_string":"INSERM, UMR1043, Center for Pathophysiology of Toulouse Purpan, Toulouse, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210113758"]},{"raw_affiliation_string":"Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria","institution_ids":["https://openalex.org/I4210142115"]},{"raw_affiliation_string":"Toulouse III Paul-Sabatier University, Toulouse, France","institution_ids":["https://openalex.org/I134560555"]},{"raw_affiliation_string":"INSERM, UMR043, Center for Pathophysiology of Toulouse Purpan, Toulouse, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210113758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071189271","display_name":"Loan Vulliard","orcid":"https://orcid.org/0000-0002-2260-4935","observed_orcids":["https://orcid.org/0000-0002-2260-4935"]},"institutions":[{"id":"https://openalex.org/I138211613","display_name":"Austrian Academy of Sciences","ror":"https://ror.org/03anc3s24","country_code":"AT","type":"government","lineage":["https://openalex.org/I138211613"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Loan Vulliard","raw_affiliation_strings":["Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria","institution_ids":["https://openalex.org/I138211613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069764165","display_name":"Aude Rubio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210122796","display_name":"Institut de Recherche en Sant\u00e9 Digestive","ror":"https://ror.org/034nb0f30","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I176063091","https://openalex.org/I205747304","https://openalex.org/I4210088668","https://openalex.org/I4210117091","https://openalex.org/I4210122796","https://openalex.org/I4210145734","https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Aude Rubio","raw_affiliation_strings":["INSERM, U1220, Digestive Health Research Institute (IRSD), Toulouse, France","Toulouse III Paul-Sabatier University, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM, U1220, Digestive Health Research Institute (IRSD), Toulouse, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210122796"]},{"raw_affiliation_string":"Toulouse III Paul-Sabatier University, Toulouse, France","institution_ids":["https://openalex.org/I134560555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048616194","display_name":"Kaan Boztu\u01e7","orcid":"https://orcid.org/0000-0001-8387-9185","observed_orcids":["https://orcid.org/0000-0001-8387-9185"]},"institutions":[{"id":"https://openalex.org/I138211613","display_name":"Austrian Academy of Sciences","ror":"https://ror.org/03anc3s24","country_code":"AT","type":"government","lineage":["https://openalex.org/I138211613"]},{"id":"https://openalex.org/I4210123554","display_name":"St Anna Children's Hospital","ror":"https://ror.org/02qb3f692","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210123554"]},{"id":"https://openalex.org/I4210142115","display_name":"Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases","ror":"https://ror.org/03hgkg910","country_code":"AT","type":"facility","lineage":["https://openalex.org/I2799334681","https://openalex.org/I4210142115"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Kaan Boztug","raw_affiliation_strings":["Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria","Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria","Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria","St. Anna Kinderspital and Children\u2019s Cancer Research Institute, Department of Pediatrics, Medical University of Vienna, Vienna, Austria"],"raw_orcid":"https://orcid.org/0000-0001-8387-9185","affiliations":[{"raw_affiliation_string":"Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria","institution_ids":["https://openalex.org/I4210142115"]},{"raw_affiliation_string":"Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria","institution_ids":["https://openalex.org/I138211613"]},{"raw_affiliation_string":"St. Anna Kinderspital and Children\u2019s Cancer Research Institute, Department of Pediatrics, Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I4210123554","https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072787333","display_name":"Audrey Ferrand","orcid":"https://orcid.org/0000-0002-1057-8151","observed_orcids":["https://orcid.org/0000-0002-1057-8151"]},"institutions":[{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210122796","display_name":"Institut de Recherche en Sant\u00e9 Digestive","ror":"https://ror.org/034nb0f30","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I176063091","https://openalex.org/I205747304","https://openalex.org/I4210088668","https://openalex.org/I4210117091","https://openalex.org/I4210122796","https://openalex.org/I4210145734","https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Audrey Ferrand","raw_affiliation_strings":["INSERM, U1220, Digestive Health Research Institute (IRSD), Toulouse, France","Toulouse III Paul-Sabatier University, Toulouse, France"],"raw_orcid":"https://orcid.org/0000-0002-1057-8151","affiliations":[{"raw_affiliation_string":"INSERM, U1220, Digestive Health Research Institute (IRSD), Toulouse, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210122796"]},{"raw_affiliation_string":"Toulouse III Paul-Sabatier University, Toulouse, France","institution_ids":["https://openalex.org/I134560555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025090907","display_name":"J\u00f6rg Menche","orcid":"https://orcid.org/0000-0002-1583-6404","observed_orcids":["https://orcid.org/0000-0002-1583-6404"]},"institutions":[{"id":"https://openalex.org/I138211613","display_name":"Austrian Academy of Sciences","ror":"https://ror.org/03anc3s24","country_code":"AT","type":"government","lineage":["https://openalex.org/I138211613"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"J\u00f6rg Menche","raw_affiliation_strings":["Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria"],"raw_orcid":"https://orcid.org/0000-0002-1583-6404","affiliations":[{"raw_affiliation_string":"Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria","institution_ids":["https://openalex.org/I138211613"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042010611","display_name":"Lo\u0131\u0308c Dupr\u00e9","orcid":"https://orcid.org/0000-0002-7278-6503","observed_orcids":["https://orcid.org/0000-0002-7278-6503"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210113758","display_name":"Centre de Physiopathologie de Toulouse-Purpan","ror":"https://ror.org/02c1tv516","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I134560555","https://openalex.org/I154526488","https://openalex.org/I4210088668","https://openalex.org/I4210096427","https://openalex.org/I4210113758","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4210142115","display_name":"Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases","ror":"https://ror.org/03hgkg910","country_code":"AT","type":"facility","lineage":["https://openalex.org/I2799334681","https://openalex.org/I4210142115"]}],"countries":["AT","FR"],"is_corresponding":true,"raw_author_name":"Lo\u00efc Dupr\u00e9","raw_affiliation_strings":["CNRS, UMR 5282, Toulouse, France","INSERM, UMR1043, Center for Pathophysiology of Toulouse Purpan, Toulouse, France","Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria","Toulouse III Paul-Sabatier University, Toulouse, France","INSERM, UMR043, Center for Pathophysiology of Toulouse Purpan, Toulouse, France"],"raw_orcid":"https://orcid.org/0000-0002-7278-6503","affiliations":[{"raw_affiliation_string":"CNRS, UMR 5282, Toulouse, France","institution_ids":["https://openalex.org/I1294671590"]},{"raw_affiliation_string":"INSERM, UMR1043, Center for Pathophysiology of Toulouse Purpan, Toulouse, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210113758"]},{"raw_affiliation_string":"Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria","institution_ids":["https://openalex.org/I4210142115"]},{"raw_affiliation_string":"Toulouse III Paul-Sabatier University, Toulouse, France","institution_ids":["https://openalex.org/I134560555"]},{"raw_affiliation_string":"INSERM, UMR043, Center for Pathophysiology of Toulouse Purpan, Toulouse, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210113758"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5042010611"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I134560555","https://openalex.org/I154526488","https://openalex.org/I4210113758","https://openalex.org/I4210142115"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9038000106811523,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9038000106811523,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.04809999838471413,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.01640000008046627,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunological-synapse","display_name":"immunological synapse","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cytotoxic-lymphocytes","display_name":"cytotoxic lymphocytes","score":0.7889999747276306},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.7260000109672546},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9739999771118164},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.9599999785423279},{"id":"https://openalex.org/keywords/morphological-profiling","display_name":"morphological profiling","score":0.8410000205039978},{"id":"https://openalex.org/keywords/immunodeficiency","display_name":"immunodeficiency","score":0.8370000123977661},{"id":"https://openalex.org/keywords/lymphocyte-activation","display_name":"lymphocyte activation","score":0.7400000095367432},{"id":"https://openalex.org/keywords/individual-heterogeneity","display_name":"individual heterogeneity","score":0.8270000219345093},{"id":"https://openalex.org/keywords/high-content-imaging","display_name":"high-content imaging","score":0.8730000257492065}],"concepts":[{"id":"https://openalex.org/C9756297","wikidata":"https://www.wikidata.org/wiki/Q126223","display_name":"Immunological synapse","level":5,"score":0.9002834558486938},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.7321575880050659},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6511582136154175},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5531137585639954},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.5169345736503601},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4907897412776947},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4643557071685791},{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.4428374469280243},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42108309268951416},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3997011184692383},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3259497284889221},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2859867513179779},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2514339089393616},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.180855393409729},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1590328812599182},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11778202652931213}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2020.01.17.910091","doi":"https://doi.org/10.1101/2020.01.17.910091","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.01.17.910091","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/01/17/2020.01.17.910091.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2020.01.17.910091","doi":"https://doi.org/10.1101/2020.01.17.910091","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.01.17.910091","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/01/17/2020.01.17.910091.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4494642681","display_name":null,"funder_award_id":"C15092BS","funder_id":"https://openalex.org/F4320321003","funder_display_name":"Vienna Science and Technology Fund"},{"id":"https://openalex.org/G5235636548","display_name":"Systems precision medicine of inborn errors of the immune system (PrecisePID)","funder_award_id":"LS16-060","funder_id":"https://openalex.org/F4320321003","funder_display_name":"Vienna Science and Technology Fund"},{"id":"https://openalex.org/G590242461","display_name":null,"funder_award_id":"C15092BS","funder_id":"https://openalex.org/F4320320893","funder_display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale"},{"id":"https://openalex.org/G6091999327","display_name":null,"funder_award_id":"WWTF-LS16-060","funder_id":"https://openalex.org/F4320321003","funder_display_name":"Vienna Science and Technology Fund"}],"funders":[{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320321003","display_name":"Vienna Science and Technology Fund","ror":"https://ror.org/01f9mc681"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2999059804.pdf","grobid_xml":"https://content.openalex.org/works/W2999059804.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W355948156","https://openalex.org/W1509855903","https://openalex.org/W1555165588","https://openalex.org/W1562441478","https://openalex.org/W1692656962","https://openalex.org/W1731383134","https://openalex.org/W1753012612","https://openalex.org/W1841423094","https://openalex.org/W1970386645","https://openalex.org/W1970568241","https://openalex.org/W1984072908","https://openalex.org/W2014118715","https://openalex.org/W2033107431","https://openalex.org/W2037871133","https://openalex.org/W2044688242","https://openalex.org/W2054622570","https://openalex.org/W2056736540","https://openalex.org/W2061873245","https://openalex.org/W2063372301","https://openalex.org/W2071738215","https://openalex.org/W2075871987","https://openalex.org/W2075882071","https://openalex.org/W2096234619","https://openalex.org/W2097841259","https://openalex.org/W2103015997","https://openalex.org/W2104036010","https://openalex.org/W2109655591","https://openalex.org/W2113221184","https://openalex.org/W2124260943","https://openalex.org/W2129249398","https://openalex.org/W2129391478","https://openalex.org/W2140099246","https://openalex.org/W2148488002","https://openalex.org/W2158792709","https://openalex.org/W2167836339","https://openalex.org/W2193492990","https://openalex.org/W2211797036","https://openalex.org/W2485815614","https://openalex.org/W2498631646","https://openalex.org/W2528460956","https://openalex.org/W2534647638","https://openalex.org/W2580641909","https://openalex.org/W2596519089","https://openalex.org/W2611974609","https://openalex.org/W2668309208","https://openalex.org/W2754927378","https://openalex.org/W2767728771","https://openalex.org/W2772186909","https://openalex.org/W2782425490","https://openalex.org/W2784975031","https://openalex.org/W2791004613","https://openalex.org/W2792537129","https://openalex.org/W2793768725","https://openalex.org/W2796060558","https://openalex.org/W2796393045","https://openalex.org/W2801391537","https://openalex.org/W2811106513","https://openalex.org/W2889326414","https://openalex.org/W2890381028","https://openalex.org/W2900851168","https://openalex.org/W2905273157","https://openalex.org/W2911964244","https://openalex.org/W2949812970","https://openalex.org/W2971686199","https://openalex.org/W2980236851","https://openalex.org/W2983963516","https://openalex.org/W2986624514"],"related_works":["https://openalex.org/W3182990044","https://openalex.org/W7011285527","https://openalex.org/W2945075983","https://openalex.org/W3174382978","https://openalex.org/W632639065","https://openalex.org/W2092297709","https://openalex.org/W6910783988","https://openalex.org/W2008471079","https://openalex.org/W2286169945","https://openalex.org/W1584598484"],"abstract_inverted_index":{"Abstract":[0],"The":[1,19],"detection":[2],"and":[3,8,27,38,90,135,145],"neutralization":[4],"of":[5,47,51,65,82,129],"infected":[6],"cells":[7,113],"tumors":[9],"by":[10,79],"cytotoxic":[11,30,53],"lymphocytes":[12],"is":[13],"a":[14,124,133],"vital":[15],"immune":[16],"defense":[17],"mechanism.":[18],"immunological":[20,49,75,104],"synapse":[21,50,76,105],"orchestrates":[22],"the":[23,28,44,48,127],"target":[24],"recognition":[25],"process":[26],"subsequent":[29],"activity.":[31],"Here,":[32],"we":[33],"present":[34],"an":[35,61,80],"integrated":[36],"experimental":[37,144],"computational":[39],"strategy":[40],"to":[41,138],"systematically":[42],"characterize":[43],"morphological":[45,67,99,130],"properties":[46],"human":[52],"lymphocytes.":[54,92],"Our":[55,120],"approach":[56,137],"combines":[57],"high-content":[58],"imaging":[59],"with":[60,72],"unbiased,":[62],"data-driven":[63],"identification":[64],"high-resolution":[66],"profiles.":[68],"Such":[69],"profiling":[70,131],"discriminates":[71],"high":[73],"accuracy":[74],"perturbations":[77],"induced":[78],"array":[81],"actin":[83],"drugs":[84],"in":[85,97,107,143],"both":[86],"model":[87],"cell":[88],"lines":[89],"primary":[91],"It":[93],"reveals":[94],"inter-individual":[95],"heterogeneity":[96],"lymphocyte":[98,140],"traits.":[100],"Furthermore,":[101],"it":[102],"uncovers":[103],"alterations":[106],"functionally":[108],"defective":[109],"CD8":[110],"+":[111],"T":[112],"from":[114],"immunodeficient":[115],"patients":[116],"carrying":[117],"ARPC1B":[118],"mutations.":[119],"study":[121],"thus":[122],"provides":[123],"foundation":[125],"for":[126],"application":[128],"as":[132],"powerful":[134],"scalable":[136],"monitor":[139],"activation":[141],"status":[142],"disease":[146],"settings.":[147]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-01-23T00:00:00"}