{"id":"https://openalex.org/W2999036336","doi":"https://doi.org/10.1530/joe-19-0438","title":"Loss of Cyp11c1 causes delayed spermatogenesis due to the absence of 11-ketotestosterone","display_name":"Loss of Cyp11c1 causes delayed spermatogenesis due to the absence of 11-ketotestosterone","publication_year":2020,"publication_date":"2020-01-07","ids":{"openalex":"https://openalex.org/W2999036336","doi":"https://doi.org/10.1530/joe-19-0438","mag":"2999036336","pmid":"https://pubmed.ncbi.nlm.nih.gov/31910154"},"language":"en","primary_location":{"id":"doi:10.1530/joe-19-0438","doi":"https://doi.org/10.1530/joe-19-0438","is_oa":false,"landing_page_url":"https://doi.org/10.1530/joe-19-0438","pdf_url":null,"source":{"id":"https://openalex.org/S34842069","display_name":"Journal of Endocrinology","issn_l":"0022-0795","issn":["0022-0795","1479-6805"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079414341","display_name":"Qiaoyuan Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142108993","display_name":"Southwest University","ror":"https://ror.org/01kj4z117","country_code":"CN","type":"education","lineage":["https://openalex.org/I142108993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiaoyuan Zheng","raw_affiliation_strings":["1Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing, China","institution_ids":["https://openalex.org/I142108993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040635711","display_name":"Hesheng Xiao","orcid":"https://orcid.org/0000-0002-8773-7421","observed_orcids":["https://orcid.org/0000-0002-8773-7421"]},"institutions":[{"id":"https://openalex.org/I142108993","display_name":"Southwest University","ror":"https://ror.org/01kj4z117","country_code":"CN","type":"education","lineage":["https://openalex.org/I142108993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hesheng Xiao","raw_affiliation_strings":["1Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing, China","institution_ids":["https://openalex.org/I142108993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068258465","display_name":"Hongjuan Shi","orcid":"https://orcid.org/0000-0002-0744-4013","observed_orcids":["https://orcid.org/0000-0002-0744-4013"]},"institutions":[{"id":"https://openalex.org/I142108993","display_name":"Southwest University","ror":"https://ror.org/01kj4z117","country_code":"CN","type":"education","lineage":["https://openalex.org/I142108993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongjuan Shi","raw_affiliation_strings":["1Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing, China","institution_ids":["https://openalex.org/I142108993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025076538","display_name":"Tingru Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142108993","display_name":"Southwest University","ror":"https://ror.org/01kj4z117","country_code":"CN","type":"education","lineage":["https://openalex.org/I142108993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tingru Wang","raw_affiliation_strings":["1Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing, China","institution_ids":["https://openalex.org/I142108993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041811714","display_name":"Lina Sun","orcid":"https://orcid.org/0000-0002-6082-9473","observed_orcids":["https://orcid.org/0000-0002-6082-9473"]},"institutions":[{"id":"https://openalex.org/I142108993","display_name":"Southwest University","ror":"https://ror.org/01kj4z117","country_code":"CN","type":"education","lineage":["https://openalex.org/I142108993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lina Sun","raw_affiliation_strings":["1Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing, China","institution_ids":["https://openalex.org/I142108993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024761740","display_name":"Wenjing Tao","orcid":"https://orcid.org/0000-0002-2622-3486","observed_orcids":["https://orcid.org/0000-0002-2622-3486"]},"institutions":[{"id":"https://openalex.org/I142108993","display_name":"Southwest University","ror":"https://ror.org/01kj4z117","country_code":"CN","type":"education","lineage":["https://openalex.org/I142108993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenjing Tao","raw_affiliation_strings":["1Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing, China","institution_ids":["https://openalex.org/I142108993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013691786","display_name":"Thomas D. Kocher","orcid":"https://orcid.org/0000-0002-7547-0133","observed_orcids":["https://orcid.org/0000-0002-7547-0133"]},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas D Kocher","raw_affiliation_strings":["2Department of Biology, University of Maryland, College Park, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Biology, University of Maryland, College Park, Maryland, USA","institution_ids":["https://openalex.org/I66946132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101784123","display_name":"Minghui Li","orcid":"https://orcid.org/0000-0002-0880-2783","observed_orcids":["https://orcid.org/0000-0002-0880-2783"]},"institutions":[{"id":"https://openalex.org/I142108993","display_name":"Southwest University","ror":"https://ror.org/01kj4z117","country_code":"CN","type":"education","lineage":["https://openalex.org/I142108993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Minghui Li","raw_affiliation_strings":["1Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing, China","institution_ids":["https://openalex.org/I142108993"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017777601","display_name":"Deshou Wang","orcid":"https://orcid.org/0000-0002-4967-524X","observed_orcids":["https://orcid.org/0000-0002-4967-524X"]},"institutions":[{"id":"https://openalex.org/I142108993","display_name":"Southwest University","ror":"https://ror.org/01kj4z117","country_code":"CN","type":"education","lineage":["https://openalex.org/I142108993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Deshou Wang","raw_affiliation_strings":["1Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing, China","institution_ids":["https://openalex.org/I142108993"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.7089,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.9610249,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"244","issue":"3","first_page":"487","last_page":"499"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11505","display_name":"Reproductive biology and impacts on aquatic species","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11505","display_name":"Reproductive biology and impacts on aquatic species","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/11beta-hydroxylase","display_name":"11\u03b2-hydroxylase","score":0.9900000095367432},{"id":"https://openalex.org/keywords/11-ketotestosterone","display_name":"11-ketotestosterone","score":0.996999979019165},{"id":"https://openalex.org/keywords/spermatogenesis","display_name":"spermatogenesis","score":0.9010000228881836},{"id":"https://openalex.org/keywords/tilapia","display_name":"tilapia","score":0.6600000262260437},{"id":"https://openalex.org/keywords/leydig-cells","display_name":"Leydig cells","score":0.9319999814033508},{"id":"https://openalex.org/keywords/interrenal-cells","display_name":"interrenal cells","score":0.9290000200271606},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.8119999766349792},{"id":"https://openalex.org/keywords/androgens","display_name":"androgens","score":0.7749999761581421},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.9240000247955322},{"id":"https://openalex.org/keywords/testicular-development","display_name":"testicular development","score":0.9079999923706055},{"id":"https://openalex.org/keywords/crispr-cas9-mutants","display_name":"CRISPR/Cas9 mutants","score":0.7620000243186951},{"id":"https://openalex.org/keywords/efferent-ducts","display_name":"efferent ducts","score":0.6930000185966492}],"concepts":[{"id":"https://openalex.org/C123765429","wikidata":"https://www.wikidata.org/wiki/Q36961","display_name":"Spermatogenesis","level":2,"score":0.880847156047821},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8397530913352966},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8385807871818542},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6678787469863892},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.6116653680801392},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.6099585294723511},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.2328696846961975},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14006906747817993}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013091","descriptor_name":"Spermatogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013252","descriptor_name":"Steroid 11-beta-Hydroxylase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013252","descriptor_name":"Steroid 11-beta-Hydroxylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D023681","descriptor_name":"Cichlids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D023681","descriptor_name":"Cichlids","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D023681","descriptor_name":"Cichlids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055786","descriptor_name":"Gene Knockout Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1530/joe-19-0438","doi":"https://doi.org/10.1530/joe-19-0438","is_oa":false,"landing_page_url":"https://doi.org/10.1530/joe-19-0438","pdf_url":null,"source":{"id":"https://openalex.org/S34842069","display_name":"Journal of Endocrinology","issn_l":"0022-0795","issn":["0022-0795","1479-6805"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology","raw_type":"journal-article"},{"id":"pmid:31910154","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31910154","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W49408494","https://openalex.org/W291504039","https://openalex.org/W820225944","https://openalex.org/W1544169104","https://openalex.org/W1546185806","https://openalex.org/W1980505379","https://openalex.org/W1983570177","https://openalex.org/W1987170579","https://openalex.org/W1997825005","https://openalex.org/W1998863971","https://openalex.org/W2004469122","https://openalex.org/W2005195078","https://openalex.org/W2013805728","https://openalex.org/W2014834979","https://openalex.org/W2016073581","https://openalex.org/W2021509750","https://openalex.org/W2027256955","https://openalex.org/W2029552542","https://openalex.org/W2033527028","https://openalex.org/W2036307999","https://openalex.org/W2036818994","https://openalex.org/W2041487236","https://openalex.org/W2045374451","https://openalex.org/W2046104690","https://openalex.org/W2048033000","https://openalex.org/W2066196799","https://openalex.org/W2070385857","https://openalex.org/W2072579007","https://openalex.org/W2073744473","https://openalex.org/W2077644837","https://openalex.org/W2080377138","https://openalex.org/W2081785484","https://openalex.org/W2085994088","https://openalex.org/W2097464871","https://openalex.org/W2098057944","https://openalex.org/W2098496251","https://openalex.org/W2102023039","https://openalex.org/W2102996805","https://openalex.org/W2107277218","https://openalex.org/W2108764695","https://openalex.org/W2113140808","https://openalex.org/W2119038501","https://openalex.org/W2129411930","https://openalex.org/W2135411748","https://openalex.org/W2136249457","https://openalex.org/W2138806965","https://openalex.org/W2142157054","https://openalex.org/W2147452643","https://openalex.org/W2159110353","https://openalex.org/W2168054595","https://openalex.org/W2173990490","https://openalex.org/W2183044194","https://openalex.org/W2553603417","https://openalex.org/W2583180641","https://openalex.org/W2586174650","https://openalex.org/W2593992817","https://openalex.org/W2737896631","https://openalex.org/W2771129185","https://openalex.org/W2889674915","https://openalex.org/W2953039206","https://openalex.org/W4250389880"],"related_works":["https://openalex.org/W3013089541","https://openalex.org/W3078662031","https://openalex.org/W2041114367","https://openalex.org/W2985610908","https://openalex.org/W1580091282","https://openalex.org/W4414168569","https://openalex.org/W7140137527","https://openalex.org/W2138806965","https://openalex.org/W7096961417","https://openalex.org/W7162528586"],"abstract_inverted_index":{"The":[0],"impacts":[1],"of":[2,25,69,77,83,114,121,143,167],"androgens":[3],"and":[4,27,32,48,61,86,88,132,164],"glucocorticoids":[5],"on":[6],"spermatogenesis":[7,92,108],"have":[8],"intrigued":[9],"scientists":[10],"for":[11,157,161],"decades.":[12],"11\u03b2-hydroxylase,":[13],"encoded":[14],"by":[15,73,97],"cyp11c1,":[16],"is":[17,155,170],"the":[18,23,29,38,57,162,171],"key":[19],"enzyme":[20],"involved":[21],"in":[22,34,56,91,136,175],"synthesis":[24],"11-ketotestosterone":[26,99,169],"cortisol,":[28],"major":[30],"androgen":[31,174],"glucocorticoid":[33],"fish,":[35],"respectively.":[36],"In":[37,118],"present":[39],"study,":[40],"a":[41,80,89,128,140],"Cyp11c1":[42,52,122],"antibody":[43],"was":[44,53,71,146],"produced.":[45,147],"Western":[46],"blot":[47],"immunohistochemistry":[49],"showed":[50],"that":[51,153],"predominantly":[54],"expressed":[55],"testicular":[58,158],"Leydig":[59],"cells":[60],"head":[62],"kidney":[63],"interrenal":[64],"cells.":[65],"A":[66],"mutant":[67],"line":[68],"cyp11c1":[70,78,154],"established":[72],"CRISPR/Cas9.":[74],"Homozygous":[75],"mutation":[76],"caused":[79],"sharp":[81],"decrease":[82],"serum":[84],"cortisol":[85,104],"11-ketotestosterone,":[87],"delay":[90],"which":[93],"could":[94],"be":[95],"rescued":[96],"exogenous":[98],"or":[100],"testosterone,":[101],"but":[102],"not":[103],"treatment.":[105],"Intriguingly,":[106],"this":[107],"restored":[109],"spontaneously,":[110],"indicating":[111],"compensatory":[112],"effects":[113],"other":[115],"androgenic":[116],"steroids.":[117],"addition,":[119],"loss":[120],"led":[123],"to":[124],"undersized":[125],"testes":[126],"with":[127],"smaller":[129],"efferent":[130],"duct":[131],"disordered":[133],"spermatogenic":[134],"cysts":[135],"adult":[137],"males.":[138],"However,":[139],"small":[141],"amount":[142],"viable":[144],"sperm":[145],"Taken":[148],"together,":[149],"our":[150],"results":[151],"demonstrate":[152],"important":[156],"development,":[159],"especially":[160],"initiation":[163],"proper":[165],"progression":[166],"spermatogenesis.":[168],"most":[172],"efficient":[173],"tilapia.":[176]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-01-23T00:00:00"}