{"id":"https://openalex.org/W2998705129","doi":"https://doi.org/10.1016/j.trecan.2019.11.009","title":"Metabolic Fitness and Plasticity in Cancer Progression","display_name":"Metabolic Fitness and Plasticity in Cancer Progression","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W2998705129","doi":"https://doi.org/10.1016/j.trecan.2019.11.009","mag":"2998705129","pmid":"https://pubmed.ncbi.nlm.nih.gov/31952781"},"language":"en","primary_location":{"id":"doi:10.1016/j.trecan.2019.11.009","doi":"https://doi.org/10.1016/j.trecan.2019.11.009","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.trecan.2019.11.009","pdf_url":null,"source":{"id":"https://openalex.org/S2765069123","display_name":"Trends in cancer","issn_l":"2405-8025","issn":["2405-8025","2405-8033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Cancer","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043617404","display_name":"Shawn McGuirk","orcid":"https://orcid.org/0000-0002-7183-7962","observed_orcids":["https://orcid.org/0000-0002-7183-7962"]},"institutions":[{"id":"https://openalex.org/I4405260784","display_name":"Institut du cancer Rosalind & Morris Goodman","ror":"https://ror.org/0494tzz73","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4405260784","https://openalex.org/I5023651"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Shawn McGuirk","raw_affiliation_strings":["Department of Biochemistry, Rosalind and Morris Goodman Cancer Centre, McGill University, Montreal, QC H3G 1Y6, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Rosalind and Morris Goodman Cancer Centre, McGill University, Montreal, QC H3G 1Y6, Canada","institution_ids":["https://openalex.org/I4405260784","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086117748","display_name":"Yannick Audet-Delage","orcid":"https://orcid.org/0000-0002-8467-6168","observed_orcids":["https://orcid.org/0000-0002-8467-6168"]},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]},{"id":"https://openalex.org/I4401200393","display_name":"Ottawa Institute of Systems Biology","ror":"https://ror.org/047xz1e88","country_code":null,"type":"facility","lineage":["https://openalex.org/I153718931","https://openalex.org/I4401200393"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Yannick Audet-Delage","raw_affiliation_strings":["Department of Biochemistry, Microbiology, and Immunology and Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON K1H 8M5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Microbiology, and Immunology and Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON K1H 8M5, Canada","institution_ids":["https://openalex.org/I153718931","https://openalex.org/I4401200393"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048843465","display_name":"Julie St\u2010Pierre","orcid":"https://orcid.org/0000-0002-2815-7099","observed_orcids":["https://orcid.org/0000-0002-2815-7099"]},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]},{"id":"https://openalex.org/I4401200393","display_name":"Ottawa Institute of Systems Biology","ror":"https://ror.org/047xz1e88","country_code":null,"type":"facility","lineage":["https://openalex.org/I153718931","https://openalex.org/I4401200393"]},{"id":"https://openalex.org/I4405260784","display_name":"Institut du cancer Rosalind & Morris Goodman","ror":"https://ror.org/0494tzz73","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4405260784","https://openalex.org/I5023651"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Julie St-Pierre","raw_affiliation_strings":["Department of Biochemistry, Rosalind and Morris Goodman Cancer Centre, McGill University, Montreal, QC H3G 1Y6, Canada; Department of Biochemistry, Microbiology, and Immunology and Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON K1H 8M5, Canada. Electronic address: julie.st-pierre@uottawa.ca","Department of Biochemistry, Microbiology, and Immunology and Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON K1H 8M5, Canada","Department of Biochemistry, Rosalind and Morris Goodman Cancer Centre, McGill University, Montreal, QC H3G 1Y6, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Rosalind and Morris Goodman Cancer Centre, McGill University, Montreal, QC H3G 1Y6, Canada; Department of Biochemistry, Microbiology, and Immunology and Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON K1H 8M5, Canada. Electronic address: julie.st-pierre@uottawa.ca","institution_ids":["https://openalex.org/I153718931","https://openalex.org/I4401200393","https://openalex.org/I4405260784","https://openalex.org/I5023651"]},{"raw_affiliation_string":"Department of Biochemistry, Microbiology, and Immunology and Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON K1H 8M5, Canada","institution_ids":["https://openalex.org/I153718931","https://openalex.org/I4401200393"]},{"raw_affiliation_string":"Department of Biochemistry, Rosalind and Morris Goodman Cancer Centre, McGill University, Montreal, QC H3G 1Y6, Canada","institution_ids":["https://openalex.org/I4405260784","https://openalex.org/I5023651"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5048843465"],"corresponding_institution_ids":["https://openalex.org/I153718931","https://openalex.org/I4401200393","https://openalex.org/I4405260784","https://openalex.org/I5023651"],"apc_list":{"value":4000,"currency":"USD","value_usd":4000},"apc_paid":null,"fwci":2.4768,"has_fulltext":false,"cited_by_count":133,"citation_normalized_percentile":{"value":0.93654822,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"6","issue":"1","first_page":"49","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.9399999976158142},{"id":"https://openalex.org/keywords/metabolic-plasticity","display_name":"metabolic plasticity","score":0.953000009059906},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.7760000228881836},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7110000252723694},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.824999988079071},{"id":"https://openalex.org/keywords/metabolic-coupling","display_name":"metabolic coupling","score":0.515999972820282},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.6930000185966492},{"id":"https://openalex.org/keywords/metabolic-intervention","display_name":"metabolic intervention","score":0.6359999775886536},{"id":"https://openalex.org/keywords/biosynthesis","display_name":"biosynthesis","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.634066104888916},{"id":"https://openalex.org/C2780124434","wikidata":"https://www.wikidata.org/wiki/Q12357464","display_name":"AMPK","level":4,"score":0.6051304340362549},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5757657289505005},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5734339356422424},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5419507622718811},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.536631166934967},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5183644890785217},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.5130599737167358},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.5000901222229004},{"id":"https://openalex.org/C2777949483","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"Mechanistic target of rapamycin","level":4,"score":0.48109835386276245},{"id":"https://openalex.org/C2779081379","wikidata":"https://www.wikidata.org/wiki/Q7852677","display_name":"Tumor hypoxia","level":3,"score":0.45237645506858826},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3454931378364563},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26232239603996277},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.24054181575775146},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.2398078739643097},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.21721151471138},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20746862888336182},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.16203346848487854},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.15403494238853455},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.13352122902870178},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.11203768849372864},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000066670","descriptor_name":"Cell Plasticity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000066670","descriptor_name":"Cell Plasticity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000066670","descriptor_name":"Cell Plasticity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000071248","descriptor_name":"Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000071248","descriptor_name":"Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000071248","descriptor_name":"Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000072258","descriptor_name":"Tumor Hypoxia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000072258","descriptor_name":"Tumor Hypoxia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000072258","descriptor_name":"Tumor Hypoxia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000078622","descriptor_name":"Nutrients","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000078622","descriptor_name":"Nutrients","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000078622","descriptor_name":"Nutrients","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002952","descriptor_name":"Citric Acid Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002952","descriptor_name":"Citric Acid Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002952","descriptor_name":"Citric Acid Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009360","descriptor_name":"Neoplastic Cells, Circulating","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009360","descriptor_name":"Neoplastic Cells, Circulating","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009360","descriptor_name":"Neoplastic Cells, Circulating","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009360","descriptor_name":"Neoplastic Cells, Circulating","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009360","descriptor_name":"Neoplastic Cells, Circulating","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009360","descriptor_name":"Neoplastic Cells, Circulating","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010085","descriptor_name":"Oxidative Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010085","descriptor_name":"Oxidative Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010085","descriptor_name":"Oxidative Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051793","descriptor_name":"Hypoxia-Inducible Factor 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051793","descriptor_name":"Hypoxia-Inducible Factor 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051793","descriptor_name":"Hypoxia-Inducible Factor 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.trecan.2019.11.009","doi":"https://doi.org/10.1016/j.trecan.2019.11.009","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.trecan.2019.11.009","pdf_url":null,"source":{"id":"https://openalex.org/S2765069123","display_name":"Trends in cancer","issn_l":"2405-8025","issn":["2405-8025","2405-8033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Cancer","raw_type":"journal-article"},{"id":"pmid:31952781","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31952781","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"sustainable_development_goals_aurora":[{"display_name":"Affordable and clean energy","id":"https://metadata.un.org/sdg/7","score":0.4699999988079071}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5331425910","display_name":null,"funder_award_id":"TFF-PPG-242122","funder_id":"https://openalex.org/F4320316526","funder_display_name":"Fondation du cancer du sein du Qu\u00e9bec"},{"id":"https://openalex.org/G6196091481","display_name":null,"funder_award_id":"PJT-244105","funder_id":"https://openalex.org/F4320316526","funder_display_name":"Fondation du cancer du sein du Qu\u00e9bec"}],"funders":[{"id":"https://openalex.org/F4320316526","display_name":"Fondation du cancer du sein du Qu\u00e9bec","ror":"https://ror.org/00dfyw498"},{"id":"https://openalex.org/F4320322597","display_name":"Terry Fox Research Institute","ror":"https://ror.org/05vd00053"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334618","display_name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","ror":"https://ror.org/02eqrsj93"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":111,"referenced_works":["https://openalex.org/W1553978925","https://openalex.org/W1868543250","https://openalex.org/W1892036645","https://openalex.org/W1906566368","https://openalex.org/W1929533080","https://openalex.org/W1932780354","https://openalex.org/W1964324925","https://openalex.org/W1979843175","https://openalex.org/W2014349355","https://openalex.org/W2019019085","https://openalex.org/W2036168963","https://openalex.org/W2042619042","https://openalex.org/W2046178144","https://openalex.org/W2048364483","https://openalex.org/W2052048865","https://openalex.org/W2060469376","https://openalex.org/W2092152920","https://openalex.org/W2100039832","https://openalex.org/W2116516144","https://openalex.org/W2152647938","https://openalex.org/W2155593866","https://openalex.org/W2156519214","https://openalex.org/W2158240289","https://openalex.org/W2183107372","https://openalex.org/W2234115940","https://openalex.org/W2253135181","https://openalex.org/W2270865385","https://openalex.org/W2294143173","https://openalex.org/W2299260311","https://openalex.org/W2310326452","https://openalex.org/W2342466981","https://openalex.org/W2345381093","https://openalex.org/W2395626624","https://openalex.org/W2470644820","https://openalex.org/W2488631284","https://openalex.org/W2507530438","https://openalex.org/W2513105811","https://openalex.org/W2519004842","https://openalex.org/W2519232588","https://openalex.org/W2552872119","https://openalex.org/W2556180876","https://openalex.org/W2560396365","https://openalex.org/W2562133517","https://openalex.org/W2573765262","https://openalex.org/W2586382778","https://openalex.org/W2586407709","https://openalex.org/W2588245864","https://openalex.org/W2588583440","https://openalex.org/W2593200173","https://openalex.org/W2593816418","https://openalex.org/W2605757478","https://openalex.org/W2605979451","https://openalex.org/W2611090362","https://openalex.org/W2611848952","https://openalex.org/W2619354999","https://openalex.org/W2736018139","https://openalex.org/W2738571701","https://openalex.org/W2739510344","https://openalex.org/W2747758951","https://openalex.org/W2755975022","https://openalex.org/W2760817956","https://openalex.org/W2761245997","https://openalex.org/W2763979809","https://openalex.org/W2767281692","https://openalex.org/W2780201866","https://openalex.org/W2785337517","https://openalex.org/W2785559034","https://openalex.org/W2785624388","https://openalex.org/W2789786349","https://openalex.org/W2791549657","https://openalex.org/W2793135703","https://openalex.org/W2793902970","https://openalex.org/W2797261189","https://openalex.org/W2798231099","https://openalex.org/W2800247717","https://openalex.org/W2800385116","https://openalex.org/W2801309958","https://openalex.org/W2808347790","https://openalex.org/W2808391024","https://openalex.org/W2808976292","https://openalex.org/W2809388839","https://openalex.org/W2810293702","https://openalex.org/W2866743330","https://openalex.org/W2885086490","https://openalex.org/W2885803994","https://openalex.org/W2885885985","https://openalex.org/W2890026694","https://openalex.org/W2891551984","https://openalex.org/W2891587993","https://openalex.org/W2898994124","https://openalex.org/W2899130161","https://openalex.org/W2901242178","https://openalex.org/W2905431641","https://openalex.org/W2906067435","https://openalex.org/W2911281137","https://openalex.org/W2911915561","https://openalex.org/W2913095286","https://openalex.org/W2913214687","https://openalex.org/W2917068792","https://openalex.org/W2917237457","https://openalex.org/W2923083564","https://openalex.org/W2924844902","https://openalex.org/W2954805572","https://openalex.org/W2960921967","https://openalex.org/W2964871068","https://openalex.org/W2969593942","https://openalex.org/W2969711625","https://openalex.org/W2971544885","https://openalex.org/W2972936715","https://openalex.org/W2973847049","https://openalex.org/W2975852908"],"related_works":["https://openalex.org/W2063062622","https://openalex.org/W2294221646","https://openalex.org/W4312201105","https://openalex.org/W2985479685","https://openalex.org/W4361826906","https://openalex.org/W2286673285","https://openalex.org/W4312209854","https://openalex.org/W4213197580","https://openalex.org/W4309048070","https://openalex.org/W4387745385"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":19},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":21},{"year":2023,"cited_by_count":20},{"year":2022,"cited_by_count":25},{"year":2021,"cited_by_count":20},{"year":2020,"cited_by_count":12}],"updated_date":"2026-10-09T09:14:12.587421","created_date":"2025-10-10T00:00:00"}
