{"id":"https://openalex.org/W2998568585","doi":null,"title":"The Somatic Genetics of Human Melanoma","display_name":"The Somatic Genetics of Human Melanoma","publication_year":2018,"publication_date":"2018-04-10","ids":{"openalex":"https://openalex.org/W2998568585","mag":"2998568585"},"language":"en","primary_location":{"id":"pmh:oai:dash.harvard.edu:1/41129208","doi":null,"is_oa":false,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:41129208","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis or Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049998336","display_name":"Eran Hodis","orcid":"https://orcid.org/0000-0002-5651-4268","observed_orcids":["https://orcid.org/0000-0002-5651-4268"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Eran Hodis","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5651-4268","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5049998336"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9146000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9146000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.04600000008940697,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9340000152587891},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.8420000076293945},{"id":"https://openalex.org/keywords/melanoma-pathogenesis","display_name":"melanoma pathogenesis","score":0.8740000128746033},{"id":"https://openalex.org/keywords/melanocytes","display_name":"melanocytes","score":0.6449999809265137},{"id":"https://openalex.org/keywords/prex2","display_name":"PREX2","score":0.8349999785423279},{"id":"https://openalex.org/keywords/tert-promoter-mutation","display_name":"TERT promoter mutation","score":0.9879999756813049},{"id":"https://openalex.org/keywords/tert","display_name":"telomerase reverse transcriptase","score":0.421999990940094},{"id":"https://openalex.org/keywords/crispr-cas9-genome-editing","display_name":"CRISPR/Cas9 genome editing","score":0.7839999794960022},{"id":"https://openalex.org/keywords/melanocyte-transformation","display_name":"melanocyte transformation","score":0.609000027179718},{"id":"https://openalex.org/keywords/metastatic-melanoma","display_name":"metastatic melanoma","score":0.7910000085830688},{"id":"https://openalex.org/keywords/cancer-genomics","display_name":"cancer genomics","score":0.37599998712539673}],"concepts":[{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.6679369211196899},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5531842708587646},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.49668413400650024},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49094536900520325},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4236312806606293},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35750532150268555},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1331627070903778}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dash.harvard.edu:1/41129208","doi":null,"is_oa":false,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:41129208","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis or Dissertation"},{"id":"mag:2998568585","doi":null,"is_oa":false,"landing_page_url":"https://dash.harvard.edu/handle/1/41129208","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7099431109","https://openalex.org/W2162066233","https://openalex.org/W2000645703","https://openalex.org/W1528010436","https://openalex.org/W2149793889","https://openalex.org/W2782190494","https://openalex.org/W2294698383","https://openalex.org/W2058781266","https://openalex.org/W2596390636","https://openalex.org/W4206974333"],"abstract_inverted_index":{"How":[0],"do":[1,263],"you":[2,264],"make":[3,265],"a":[4,12,23,84,266],"melanoma?":[5],"Which":[6],"mutations":[7,96,162,185,222,237],"of":[8,19,47,63,74,86,89,94,110,114,117,123,130,138,142,151,159,167,186,190,207,210,220,225,228,235,249],"the":[9,17,20,30,45,64,87,92,111,121,139,146,157,164,182,205,229,259],"genome":[10,80,208,231],"turn":[11],"normal":[13],"melanocyte":[14],"residing":[15],"at":[16],"base":[18],"epidermis":[21],"into":[22,36,44,97,181],"malignant":[24],"cancer?":[25],"And":[26],"what":[27],"commonalities":[28],"unite":[29],"myriad":[31],"genetic":[32,65,221],"paths":[33],"to":[34,72,101,156,214,246,254,258],"melanoma":[35,40,77,90,104,129,187,194,230,236,251],"broad":[37],"requirements":[38],"for":[39],"pathogenesis?\\nThe":[41],"research":[42],"herein,":[43],"pathogenesis":[46,88,252],"melanoma,":[48],"has":[49,244],"been":[50],"enabled":[51,83],"by":[52,188],"two":[53],"new":[54],"technologies.":[55],"Next-generation":[56],"sequencing":[57],"first":[58],"allowed":[59],"an":[60,136,239],"unbiased":[61],"ascertainment":[62],"changes":[66],"in":[67,163,238],"patient-derived":[68],"human":[69,99,212,250],"melanomas,":[70,144],"leading":[71],"discovery":[73],"several":[75],"mutated":[76,147],"genes.":[78],"CRISPR/Cas9":[79],"editing":[81,209],"then":[82],"retracing":[85],"through":[91],"introduction":[93],"precise":[95],"primary":[98,211],"melanocytes":[100,213],"create":[102],"metastatic":[103],"cells.\\nChapter":[105],"1":[106],"reviews":[107],"current":[108],"knowledge":[109],"somatic":[112,183],"genetics":[113],"all":[115],"types":[116],"melanocytic":[118],"neoplasia,":[119],"though":[120],"rest":[122],"this":[124,242],"thesis":[125,243],"focuses":[126,172],"exclusively":[127],"on":[128,174],"hair-bearing":[131],"skin.":[132],"Chapter":[133,170,177,202],"2":[134],"presents":[135],"analysis":[137,189],"whole-genome":[140,153],"sequences":[141,154],"twenty-five":[143],"highlighting":[145],"gene":[148],"PREX2.":[149],"Analysis":[150],"these":[152],"led":[155],"identification":[158],"highly":[160],"recurrent":[161],"promoter":[165],"sequence":[166],"TERT,":[168],"and":[169,223,232,253],"3":[171],"entirely":[173],"those":[175],"mutations.":[176],"4":[178],"next":[179],"delves":[180],"coding":[184],"over":[191],"one":[192],"hundred":[193],"exome":[195],"sequences,":[196],"defining":[197],"common":[198],"mutation":[199],"patterns.":[200],"Finally,":[201],"5":[203],"introduces":[204],"use":[206],"establish":[215],"causal":[216],"relationships":[217],"between":[218],"sets":[219],"phenotypes":[224],"malignancy.\\nThrough":[226],"characterization":[227],"subsequent":[233],"study":[234],"experimental":[240],"model,":[241],"endeavored":[245],"further":[247],"understanding":[248],"put":[255],"forward":[256],"answers":[257],"basic":[260],"question,":[261],"\u201cHow":[262],"melanoma?\u201d":[267]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2020-01-10T00:00:00"}