{"id":"https://openalex.org/W2998505342","doi":"https://doi.org/10.1126/sciadv.aax5576","title":"PRSS contributes to cetuximab resistance in colorectal cancer","display_name":"PRSS contributes to cetuximab resistance in colorectal cancer","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W2998505342","doi":"https://doi.org/10.1126/sciadv.aax5576","mag":"2998505342","pmid":"https://pubmed.ncbi.nlm.nih.gov/31911942","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6938705"},"language":"en","primary_location":{"id":"doi:10.1126/sciadv.aax5576","doi":"https://doi.org/10.1126/sciadv.aax5576","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.aax5576","pdf_url":null,"source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1126/sciadv.aax5576","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017833906","display_name":"Zhao-Li Tan","orcid":"https://orcid.org/0000-0001-7600-2350","observed_orcids":["https://orcid.org/0000-0001-7600-2350"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhaoli Tan","raw_affiliation_strings":["Beijing Institute of Biotechnology, 20 Dongdajie, Beijing, China","Department of Gastrointestinal Oncology, the Fifth Medical Center, General Hospital of PLA, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0001-7600-2350","affiliations":[{"raw_affiliation_string":"Beijing Institute of Biotechnology, 20 Dongdajie, Beijing, China","institution_ids":[]},{"raw_affiliation_string":"Department of Gastrointestinal Oncology, the Fifth Medical Center, General Hospital of PLA, Beijing, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101758511","display_name":"Lihua Gao","orcid":"https://orcid.org/0000-0003-3653-8702","observed_orcids":["https://orcid.org/0000-0003-3653-8702"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lihua Gao","raw_affiliation_strings":["Beijing Institute of Biotechnology, 20 Dongdajie, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0003-3653-8702","affiliations":[{"raw_affiliation_string":"Beijing Institute of Biotechnology, 20 Dongdajie, Beijing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100322986","display_name":"Yan Wang","orcid":"https://orcid.org/0000-0003-4862-3912","observed_orcids":["https://orcid.org/0000-0003-4862-3912"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yan Wang","raw_affiliation_strings":["Beijing Institute of Biotechnology, 20 Dongdajie, Beijing, China","Department of Gastrointestinal Oncology, the Fifth Medical Center, General Hospital of PLA, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0003-4862-3912","affiliations":[{"raw_affiliation_string":"Beijing Institute of Biotechnology, 20 Dongdajie, Beijing, China","institution_ids":[]},{"raw_affiliation_string":"Department of Gastrointestinal Oncology, the Fifth Medical Center, General Hospital of PLA, Beijing, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027633075","display_name":"Huihui Yin","orcid":"https://orcid.org/0000-0002-1300-9966","observed_orcids":["https://orcid.org/0000-0002-1300-9966"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huihui Yin","raw_affiliation_strings":["Beijing Institute of Biotechnology, 20 Dongdajie, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0002-1300-9966","affiliations":[{"raw_affiliation_string":"Beijing Institute of Biotechnology, 20 Dongdajie, Beijing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101558342","display_name":"Y. Xi","orcid":"https://orcid.org/0000-0002-4971-494X","observed_orcids":["https://orcid.org/0000-0002-4971-494X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yongyi Xi","raw_affiliation_strings":["Beijing Institute of Biotechnology, 20 Dongdajie, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0002-4971-494X","affiliations":[{"raw_affiliation_string":"Beijing Institute of Biotechnology, 20 Dongdajie, Beijing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101496013","display_name":"Xiaojie Wu","orcid":"https://orcid.org/0000-0001-7307-5503","observed_orcids":["https://orcid.org/0000-0001-7307-5503"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaojie Wu","raw_affiliation_strings":["Beijing Institute of Biotechnology, 20 Dongdajie, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0001-7307-5503","affiliations":[{"raw_affiliation_string":"Beijing Institute of Biotechnology, 20 Dongdajie, Beijing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yong Shao","orcid":"https://orcid.org/0000-0001-6591-8072","observed_orcids":["https://orcid.org/0000-0001-6591-8072"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yong Shao","raw_affiliation_strings":["Beijing Institute of Biotechnology, 20 Dongdajie, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0001-6591-8072","affiliations":[{"raw_affiliation_string":"Beijing Institute of Biotechnology, 20 Dongdajie, Beijing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075756138","display_name":"Weiyi Qiu","orcid":"https://orcid.org/0000-0001-9039-8363","observed_orcids":["https://orcid.org/0000-0001-9039-8363"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Weiyi Qiu","raw_affiliation_strings":["Beijing Institute of Biotechnology, 20 Dongdajie, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0001-9039-8363","affiliations":[{"raw_affiliation_string":"Beijing Institute of Biotechnology, 20 Dongdajie, Beijing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101979071","display_name":"Peng Du","orcid":"https://orcid.org/0000-0001-6626-6627","observed_orcids":["https://orcid.org/0000-0001-6626-6627","https://orcid.org/0000-0002-7658-233X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peng Du","raw_affiliation_strings":["Beijing Institute of Biotechnology, 20 Dongdajie, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0001-6626-6627","affiliations":[{"raw_affiliation_string":"Beijing Institute of Biotechnology, 20 Dongdajie, Beijing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018425961","display_name":"Wenlong Shen","orcid":"https://orcid.org/0000-0002-2293-5590","observed_orcids":["https://orcid.org/0000-0002-2293-5590"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wenlong Shen","raw_affiliation_strings":["Beijing Institute of Biotechnology, 20 Dongdajie, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0002-2293-5590","affiliations":[{"raw_affiliation_string":"Beijing Institute of Biotechnology, 20 Dongdajie, Beijing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100726024","display_name":"Ling Lin Fu","orcid":"https://orcid.org/0000-0002-5918-3978","observed_orcids":["https://orcid.org/0000-0002-5918-3978"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ling Fu","raw_affiliation_strings":["Beijing Institute of Biotechnology, 20 Dongdajie, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0002-5918-3978","affiliations":[{"raw_affiliation_string":"Beijing Institute of Biotechnology, 20 Dongdajie, Beijing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101843755","display_name":"Ru Jia","orcid":"https://orcid.org/0000-0002-4064-8333","observed_orcids":["https://orcid.org/0000-0002-4064-8333"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ru Jia","raw_affiliation_strings":["Department of Gastrointestinal Oncology, the Fifth Medical Center, General Hospital of PLA, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0002-4064-8333","affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Oncology, the Fifth Medical Center, General Hospital of PLA, Beijing, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103203337","display_name":"Chuanhua Zhao","orcid":"https://orcid.org/0000-0001-7698-9618","observed_orcids":["https://orcid.org/0000-0001-7698-9618"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chuanhua Zhao","raw_affiliation_strings":["Department of Gastrointestinal Oncology, the Fifth Medical Center, General Hospital of PLA, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0001-7698-9618","affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Oncology, the Fifth Medical Center, General Hospital of PLA, Beijing, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100356821","display_name":"Yun Zhang","orcid":"https://orcid.org/0009-0003-7055-2206","observed_orcids":["https://orcid.org/0009-0003-7055-2206","https://orcid.org/0000-0002-7477-5314"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yun Zhang","raw_affiliation_strings":["Department of Gastrointestinal Oncology, the Fifth Medical Center, General Hospital of PLA, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0002-7477-5314","affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Oncology, the Fifth Medical Center, General Hospital of PLA, Beijing, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056714525","display_name":"Zhihu Zhao","orcid":"https://orcid.org/0000-0001-7081-8914","observed_orcids":["https://orcid.org/0000-0001-7081-8914"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhihu Zhao","raw_affiliation_strings":["Beijing Institute of Biotechnology, 20 Dongdajie, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0001-7081-8914","affiliations":[{"raw_affiliation_string":"Beijing Institute of Biotechnology, 20 Dongdajie, Beijing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100650628","display_name":"Zhiwei Sun","orcid":"https://orcid.org/0000-0003-0552-5116","observed_orcids":["https://orcid.org/0000-0003-0552-5116"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhiwei Sun","raw_affiliation_strings":["Beijing Institute of Biotechnology, 20 Dongdajie, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0003-0552-5116","affiliations":[{"raw_affiliation_string":"Beijing Institute of Biotechnology, 20 Dongdajie, Beijing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103111712","display_name":"Chen Hong-xing","orcid":"https://orcid.org/0000-0002-9873-463X","observed_orcids":["https://orcid.org/0000-0002-9873-463X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hongxing Chen","raw_affiliation_strings":["Beijing Institute of Biotechnology, 20 Dongdajie, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0002-9873-463X","affiliations":[{"raw_affiliation_string":"Beijing Institute of Biotechnology, 20 Dongdajie, Beijing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xianwen Hu","orcid":"https://orcid.org/0000-0001-6582-7920","observed_orcids":["https://orcid.org/0000-0001-6582-7920"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Xianwen Hu","raw_affiliation_strings":["Beijing Institute of Biotechnology, 20 Dongdajie, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0001-6582-7920","affiliations":[{"raw_affiliation_string":"Beijing Institute of Biotechnology, 20 Dongdajie, Beijing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100726660","display_name":"XU Jian-ming","orcid":"https://orcid.org/0000-0001-6791-9837","observed_orcids":["https://orcid.org/0000-0001-6791-9837"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jianming Xu","raw_affiliation_strings":["Department of Gastrointestinal Oncology, the Fifth Medical Center, General Hospital of PLA, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0001-6791-9837","affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Oncology, the Fifth Medical Center, General Hospital of PLA, Beijing, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101639900","display_name":"Youliang Wang","orcid":"https://orcid.org/0000-0003-1319-0344","observed_orcids":["https://orcid.org/0000-0003-1319-0344","https://orcid.org/0000-0001-8658-6564"]},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Youliang Wang","raw_affiliation_strings":["Beijing Institute of Biotechnology, 20 Dongdajie, Beijing, China","Department of Gastrointestinal Oncology, the Fifth Medical Center, General Hospital of PLA, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0003-1319-0344","affiliations":[{"raw_affiliation_string":"Beijing Institute of Biotechnology, 20 Dongdajie, Beijing, China","institution_ids":[]},{"raw_affiliation_string":"Department of Gastrointestinal Oncology, the Fifth Medical Center, General Hospital of PLA, Beijing, China","institution_ids":["https://openalex.org/I2802939634"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5017833906","https://openalex.org/A5100322986","https://openalex.org/A5100726660","https://openalex.org/A5101639900","https://openalex.org/A5101758511"],"corresponding_institution_ids":["https://openalex.org/I2802939634"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":1.9814,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.88276692,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"6","issue":"1","first_page":"eaax5576","last_page":"eaax5576"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cetuximab-resistance","display_name":"cetuximab resistance","score":0.8999999761581421},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9419999718666077},{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.8569999933242798},{"id":"https://openalex.org/keywords/spink1","display_name":"SPINK1","score":0.8980000019073486},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.7639999985694885},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.4259999990463257},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.7789999842643738},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8930000066757202},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5429999828338623}],"concepts":[{"id":"https://openalex.org/C2779998722","wikidata":"https://www.wikidata.org/wiki/Q420296","display_name":"Cetuximab","level":4,"score":0.9626158475875854},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7288421392440796},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3914584219455719},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32369422912597656},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2084101140499115}],"mesh":[{"descriptor_ui":"D000068258","descriptor_name":"Bevacizumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000068818","descriptor_name":"Cetuximab","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000068818","descriptor_name":"Cetuximab","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014359","descriptor_name":"Trypsin Inhibitor, Kazal Pancreatic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064593","descriptor_name":"Heterografts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1126/sciadv.aax5576","doi":"https://doi.org/10.1126/sciadv.aax5576","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.aax5576","pdf_url":null,"source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6938705","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6938705/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6938705/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Adv","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:5901863","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6938705","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:31911942","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31911942","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science advances","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1126/sciadv.aax5576","doi":"https://doi.org/10.1126/sciadv.aax5576","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.aax5576","pdf_url":null,"source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4434569073","display_name":"\u5faa\u73af\u80bf\u7624DNA\u7684\u7a81\u53d8\u5206\u6790\u7528\u4e8e\u76d1\u6d4b\u9776\u5411EGFR\u5355\u6297\u6cbb\u7597\u665a\u671f\u7ed3\u76f4\u80a0\u764c\u7ee7\u53d1\u8010\u836f\u7684\u4ef7\u503c","funder_award_id":"81573458","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7832119773","display_name":null,"funder_award_id":"2016ZX08006002","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2998505342.pdf","grobid_xml":"https://content.openalex.org/works/W2998505342.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1235656097","https://openalex.org/W1499315980","https://openalex.org/W1975274124","https://openalex.org/W1996593169","https://openalex.org/W2005202092","https://openalex.org/W2007513598","https://openalex.org/W2015509032","https://openalex.org/W2032440188","https://openalex.org/W2037690883","https://openalex.org/W2048259842","https://openalex.org/W2057611085","https://openalex.org/W2062109911","https://openalex.org/W2086061799","https://openalex.org/W2096924438","https://openalex.org/W2097121246","https://openalex.org/W2099213341","https://openalex.org/W2119746400","https://openalex.org/W2121955371","https://openalex.org/W2131371081","https://openalex.org/W2134519717","https://openalex.org/W2137218814","https://openalex.org/W2150840254","https://openalex.org/W2154988647","https://openalex.org/W2170564629","https://openalex.org/W2287672071","https://openalex.org/W2560160922","https://openalex.org/W2606050648","https://openalex.org/W2609927476","https://openalex.org/W2889646458","https://openalex.org/W2897246241","https://openalex.org/W2902129153","https://openalex.org/W2911901974","https://openalex.org/W2913991184"],"related_works":["https://openalex.org/W2996652692","https://openalex.org/W3019785843","https://openalex.org/W3152116520","https://openalex.org/W4400308578","https://openalex.org/W2887433064","https://openalex.org/W2112910897","https://openalex.org/W4405810635","https://openalex.org/W3197260142","https://openalex.org/W3214435359","https://openalex.org/W2631413551"],"abstract_inverted_index":{"Cetuximab":[0,56],"improves":[1],"the":[2,18,37,81],"survival":[3],"of":[4,21,39,83,93],"patients":[5,85,99,110,125],"with":[6,36,60,86,100,111,126,147],"metastatic":[7],"colorectal":[8],"cancer.":[9],"The":[10,114],"main":[11],"limitation":[12],"is":[13],"primary":[14],"and":[15,90],"secondary":[16],"resistance,":[17],"underlying":[19],"mechanism":[20],"which":[22],"requires":[23],"extensive":[24],"investigation.":[25],"We":[26],"proved":[27],"that":[28,48],"PRSS":[29,49,63,78,102,104,128,144],"expression":[30,105,129],"levels":[31,79],"are":[32],"significantly":[33,131],"negatively":[34],"associated":[35],"sensitivity":[38],"cancer":[40,112],"cells":[41],"to":[42,54,122],"cetuximab.":[43],"Detailed":[44],"mechanistic":[45],"analysis":[46],"indicated":[47],"can":[50],"cleave":[51],"cetuximab,":[52],"leading":[53],"resistance.":[55],"or":[57,72],"bevacizumab":[58,73],"combined":[59],"SPINK1,":[61],"a":[62,138],"inhibitor,":[64],"inhibited":[65],"cell":[66],"growth":[67],"more":[68],"efficiently":[69],"than":[70],"cetuximab":[71,94,148],"alone":[74],"in":[75,80,98,106,145],"xenograft":[76],"models.":[77],"serum":[82],"156":[84],"mCRC":[87],"were":[88],"analyzed,":[89],"poor":[91],"efficacy":[92],"therapy":[95],"was":[96,119],"observed":[97],"aberrant":[101],"expression.":[103],"monoclonal":[107],"antibody":[108],"(mAb)-treated":[109],"from":[113],"Cancer":[115],"Genome":[116],"Atlas":[117],"database":[118],"also":[120],"evaluated":[121],"determine":[123],"whether":[124],"higher":[127],"have":[130],"reduced":[132],"progression-free":[133],"survival.":[134],"Our":[135],"work":[136],"provides":[137],"strong":[139],"scientific":[140],"rationale":[141],"for":[142],"targeting":[143],"combination":[146],"therapy.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2020-01-10T00:00:00"}