{"id":"https://openalex.org/W2998474530","doi":"https://doi.org/10.1186/s12885-019-6455-x","title":"An analysis about heterogeneity among cancers based on the DNA methylation patterns","display_name":"An analysis about heterogeneity among cancers based on the DNA methylation patterns","publication_year":2019,"publication_date":"2019-12-01","ids":{"openalex":"https://openalex.org/W2998474530","doi":"https://doi.org/10.1186/s12885-019-6455-x","mag":"2998474530","pmid":"https://pubmed.ncbi.nlm.nih.gov/31888612","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6937830"},"language":"en","primary_location":{"id":"doi:10.1186/s12885-019-6455-x","doi":"https://doi.org/10.1186/s12885-019-6455-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-019-6455-x","pdf_url":"https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-019-6455-x","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-019-6455-x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100392463","display_name":"Yang Liu","orcid":"https://orcid.org/0000-0001-5767-360X","observed_orcids":["https://orcid.org/0000-0001-5767-360X"]},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Liu","raw_affiliation_strings":["School of Life Science and Technology, Computational Biology Research Center, Harbin Institute of Technology, Harbin, 150001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, Computational Biology Research Center, Harbin Institute of Technology, Harbin, 150001, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082437921","display_name":"Yue Gu","orcid":"https://orcid.org/0000-0002-3852-9319","observed_orcids":["https://orcid.org/0000-0002-3852-9319","https://orcid.org/0009-0004-1292-3440"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Gu","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062486470","display_name":"Mu Su","orcid":"https://orcid.org/0000-0002-3923-1303","observed_orcids":["https://orcid.org/0000-0002-3923-1303"]},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mu Su","raw_affiliation_strings":["School of Life Science and Technology, Computational Biology Research Center, Harbin Institute of Technology, Harbin, 150001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, Computational Biology Research Center, Harbin Institute of Technology, Harbin, 150001, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101912980","display_name":"Hui Liu","orcid":"https://orcid.org/0000-0001-9549-2615","observed_orcids":["https://orcid.org/0000-0001-9549-2615"]},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Liu","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102000994","display_name":"Shumei Zhang","orcid":"https://orcid.org/0000-0002-7983-8492","observed_orcids":["https://orcid.org/0000-0002-7983-8492"]},"institutions":[{"id":"https://openalex.org/I47689461","display_name":"Northeast Forestry University","ror":"https://ror.org/02yxnh564","country_code":"CN","type":"education","lineage":["https://openalex.org/I47689461"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shumei Zhang","raw_affiliation_strings":["College of Information and Computer Engineering, Northeast Forestry University, Harbin, 150040, China. zhangshumei@nefu.edu.cn","College of Information and Computer Engineering, Northeast Forestry University, Harbin, 150040, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Information and Computer Engineering, Northeast Forestry University, Harbin, 150040, China. zhangshumei@nefu.edu.cn","institution_ids":["https://openalex.org/I47689461"]},{"raw_affiliation_string":"College of Information and Computer Engineering, Northeast Forestry University, Harbin, 150040, China","institution_ids":["https://openalex.org/I47689461"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100456264","display_name":"Yan Zhang","orcid":"https://orcid.org/0000-0002-5307-2484","observed_orcids":["https://orcid.org/0000-0002-5307-2484"]},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yan Zhang","raw_affiliation_strings":["School of Life Science and Technology, Computational Biology Research Center, Harbin Institute of Technology, Harbin, 150001, China. zhangtyo@hit.edu.cn","School of Life Science and Technology, Computational Biology Research Center, Harbin Institute of Technology, Harbin, 150001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology, Computational Biology Research Center, Harbin Institute of Technology, Harbin, 150001, China. zhangtyo@hit.edu.cn","institution_ids":["https://openalex.org/I204983213"]},{"raw_affiliation_string":"School of Life Science and Technology, Computational Biology Research Center, Harbin Institute of Technology, Harbin, 150001, China","institution_ids":["https://openalex.org/I204983213"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100456264","https://openalex.org/A5102000994"],"corresponding_institution_ids":["https://openalex.org/I204983213","https://openalex.org/I47689461"],"apc_list":{"value":2390,"currency":"USD","value_usd":2390},"apc_paid":{"value":2390,"currency":"USD","value_usd":2390},"fwci":1.164,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.75819415,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"19","issue":"1","first_page":"1259","last_page":"1259"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9210000038146973},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.8370000123977661},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7929999828338623},{"id":"https://openalex.org/keywords/promoter-methylation","display_name":"promoter methylation","score":0.8309999704360962},{"id":"https://openalex.org/keywords/differentially-methylated-genes","display_name":"differentially methylated genes","score":0.8019999861717224},{"id":"https://openalex.org/keywords/gene-interaction-networks","display_name":"gene interaction networks","score":0.8090000152587891},{"id":"https://openalex.org/keywords/kegg-pathway-enrichment","display_name":"KEGG pathway enrichment","score":0.8889999985694885},{"id":"https://openalex.org/keywords/survival-analysis","display_name":"survival analysis","score":0.6159999966621399},{"id":"https://openalex.org/keywords/cancer-specific-biomarkers","display_name":"cancer-specific biomarkers","score":0.4410000145435333}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.7944434881210327},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7899155616760254},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.5858362317085266},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.577189564704895},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5264925360679626},{"id":"https://openalex.org/C2780140570","wikidata":"https://www.wikidata.org/wiki/Q3545481","display_name":"Surgical oncology","level":2,"score":0.4870806038379669},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4335862994194031},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.42238807678222656},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.4200451672077179},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.4109605848789215},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3883058428764343},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3880370259284973},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35838180780410767},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2614644169807434},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.23452749848365784},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2215072214603424},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.15018868446350098}],"mesh":[{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12885-019-6455-x","doi":"https://doi.org/10.1186/s12885-019-6455-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-019-6455-x","pdf_url":"https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-019-6455-x","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},{"id":"doi:10.21203/rs.2.11636/v1","doi":"https://doi.org/10.21203/rs.2.11636/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.2.11636/v1","pdf_url":"https://www.researchsquare.com/article/rs-2485/v1.pdf?c=1631840377000","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmid:31888612","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31888612","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6937830","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6937830/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:9c85f0d31ac04f85a48ed8eb76f69478","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/9c85f0d31ac04f85a48ed8eb76f69478","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Cancer, Vol 19, Iss 1, Pp 1-15 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12885-019-6455-x","doi":"https://doi.org/10.1186/s12885-019-6455-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-019-6455-x","pdf_url":"https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-019-6455-x","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5726222144","display_name":null,"funder_award_id":"grant number 61972116","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8171665353","display_name":null,"funder_award_id":"61972116","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2998474530.pdf","grobid_xml":"https://content.openalex.org/works/W2998474530.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1107917109","https://openalex.org/W1565966108","https://openalex.org/W1903281529","https://openalex.org/W1927355923","https://openalex.org/W1968483633","https://openalex.org/W1985444222","https://openalex.org/W1991923868","https://openalex.org/W2006219739","https://openalex.org/W2007368465","https://openalex.org/W2009720434","https://openalex.org/W2010522003","https://openalex.org/W2019507660","https://openalex.org/W2021976298","https://openalex.org/W2041686632","https://openalex.org/W2048167482","https://openalex.org/W2055237453","https://openalex.org/W2056314801","https://openalex.org/W2088285084","https://openalex.org/W2097948046","https://openalex.org/W2110017373","https://openalex.org/W2110881699","https://openalex.org/W2123032740","https://openalex.org/W2126740719","https://openalex.org/W2130430382","https://openalex.org/W2131971406","https://openalex.org/W2133465414","https://openalex.org/W2140149776","https://openalex.org/W2141410747","https://openalex.org/W2145975061","https://openalex.org/W2150162153","https://openalex.org/W2152061559","https://openalex.org/W2152656267","https://openalex.org/W2152716163","https://openalex.org/W2155142785","https://openalex.org/W2156827176","https://openalex.org/W2158207797","https://openalex.org/W2158217645","https://openalex.org/W2162624621","https://openalex.org/W2164327622","https://openalex.org/W2181647431","https://openalex.org/W2308244787","https://openalex.org/W2414449891","https://openalex.org/W2426586472","https://openalex.org/W2487261336","https://openalex.org/W2537167162","https://openalex.org/W2581467944","https://openalex.org/W2595038369","https://openalex.org/W2610657571","https://openalex.org/W2617427009","https://openalex.org/W2633757688","https://openalex.org/W2908798728","https://openalex.org/W6823576019","https://openalex.org/W7096449427"],"related_works":["https://openalex.org/W2663574681","https://openalex.org/W2048860253","https://openalex.org/W2535322499","https://openalex.org/W2048338967","https://openalex.org/W2090035678","https://openalex.org/W2912321830","https://openalex.org/W4206327682","https://openalex.org/W2778689912","https://openalex.org/W2775679882","https://openalex.org/W7053411607"],"abstract_inverted_index":{"BACKGROUND:":[0],"It":[1],"is":[2],"generally":[3],"believed":[4],"that":[5,230],"DNA":[6,85,123,264],"methylation,":[7],"as":[8,146],"one":[9],"of":[10,20,31,59,68,80,88,101,177,220,260,274],"the":[11,18,29,57,77,111,122,128,133,150,156,174,186,238,258,263],"most":[12],"important":[13,26],"epigenetic":[14,36,71,78],"modifications,":[15],"participates":[16],"in":[17,28,82,110,132,204,235],"regulation":[19],"gene":[21,116,129,189],"expression":[22],"and":[23,33,61,127,136,158,172,197,213,225,267],"plays":[24],"an":[25],"role":[27],"development":[30],"cancer,":[32,171],"there":[34,231],"exits":[35],"heterogeneity":[37,58,79,259],"among":[38],"cancers.":[39],"Therefore,":[40],"this":[41],"study":[42,244],"tried":[43],"to":[44,163,201],"screen":[45],"for":[46,50,56,64,149,169,217,250,257,270],"reliable":[47,247],"prognostic":[48,167,248],"markers":[49,117,148,168,190,216,249],"different":[51,205,251],"cancers,":[52,60,252],"providing":[53,253],"further":[54,255],"explanation":[55,256],"more":[62,268],"targets":[63,269],"clinical":[65,271],"transformation":[66],"studies":[67,273],"cancer":[69,81,90,187,221,261],"from":[70,94,141],"perspective.":[72],"METHODS:":[73],"This":[74,243],"article":[75],"discusses":[76],"detail.":[83],"Firstly,":[84],"methylation":[86,106,124,195,265],"data":[87],"seven":[89],"types":[91],"were":[92,118,144,191,199],"obtained":[93,119,140,192],"Illumina":[95],"Infinium":[96],"HumanMethylation":[97],"450":[98],"K":[99],"platform":[100],"TCGA":[102],"database.":[103],"Then,":[104],"differential":[105,194],"analysis":[107,196,228],"was":[108,222,232],"performed":[109],"promotor":[112],"region.":[113],"Secondly,":[114],"pivotal":[115],"by":[120,180,193,208],"constructing":[121],"correlation":[125],"network":[126,131],"interaction":[130],"KEGG":[134],"pathway,":[135],"317":[137],"marker":[138],"genes":[139,179],"two":[142,239],"networks":[143],"integrated":[145],"candidate":[147],"prognosis":[151],"model.":[152],"Finally,":[153],"we":[154],"used":[155],"univariate":[157],"multivariate":[159],"COX":[160],"regression":[161],"models":[162],"select":[164],"specific":[165,212],"independent":[166],"each":[170,218],"studied":[173],"risk":[175,240],"factor":[176],"these":[178],"doing":[181],"survival":[182,227,236],"analysis.":[183,210],"RESULTS:":[184],"First,":[185],"type-specific":[188],"they":[198],"found":[200],"be":[202],"involved":[203],"biological":[206],"functions":[207],"enrichment":[209],"Moreover,":[211],"common":[214],"diagnostic":[215],"type":[219],"sorted":[223],"out":[224,246],"Kaplan-Meier":[226],"showed":[229],"significant":[233],"difference":[234],"between":[237],"groups.":[241],"CONCLUSIONS:":[242],"screened":[245],"a":[254],"at":[262],"level":[266],"conversion":[272],"cancer.":[275]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-01-10T00:00:00"}