{"id":"https://openalex.org/W2998459192","doi":"https://doi.org/10.18008/1816-5095-2019-4-508-514","title":"Structural and Functional Criteria of Neuroprotection Effectiveness after Anti-VEGF Therapy in Patients with Neovascular Age-Related Macular Degeneration","display_name":"Structural and Functional Criteria of Neuroprotection Effectiveness after Anti-VEGF Therapy in Patients with Neovascular Age-Related Macular Degeneration","publication_year":2019,"publication_date":"2019-12-27","ids":{"openalex":"https://openalex.org/W2998459192","doi":"https://doi.org/10.18008/1816-5095-2019-4-508-514","mag":"2998459192"},"language":"en","primary_location":{"id":"doi:10.18008/1816-5095-2019-4-508-514","doi":"https://doi.org/10.18008/1816-5095-2019-4-508-514","is_oa":true,"landing_page_url":"https://doi.org/10.18008/1816-5095-2019-4-508-514","pdf_url":"https://www.ophthalmojournal.com/opht/article/download/1085/654","source":{"id":"https://openalex.org/S4210233720","display_name":"Ophthalmology in Russia","issn_l":"1816-5095","issn":["1816-5095","2500-0845"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310312650","host_organization_name":"Ophthalmology Publishing Group","host_organization_lineage":["https://openalex.org/P4310312650"],"host_organization_lineage_names":["Ophthalmology Publishing Group"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ophthalmology in Russia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.ophthalmojournal.com/opht/article/download/1085/654","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041336269","display_name":"N.S. Zhajvoronok","orcid":"https://orcid.org/0000-0001-5515-4099","observed_orcids":["https://orcid.org/0000-0001-5515-4099"]},"institutions":[{"id":"https://openalex.org/I4210148519","display_name":"Intersectoral Research and Technology Complex Eye Microsurgery","ror":"https://ror.org/04w68cb80","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210148519"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"N. S. Zhajvoronok","raw_affiliation_strings":["Khabarovsk branch of the S. Fyodorov Eye Microsurgery Federal State Institution"],"raw_orcid":"https://orcid.org/0000-0001-5515-4099","affiliations":[{"raw_affiliation_string":"Khabarovsk branch of the S. Fyodorov Eye Microsurgery Federal State Institution","institution_ids":["https://openalex.org/I4210148519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083801607","display_name":"Victor V. Egorov","orcid":"https://orcid.org/0000-0002-9888-7353","observed_orcids":["https://orcid.org/0000-0002-9888-7353"]},"institutions":[{"id":"https://openalex.org/I4210148519","display_name":"Intersectoral Research and Technology Complex Eye Microsurgery","ror":"https://ror.org/04w68cb80","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210148519"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"V. V. Egorov","raw_affiliation_strings":["Khabarovsk branch of the S. Fyodorov Eye Microsurgery Federal State Institution,\r\nPostgraduate Institute for Public Health Workers"],"raw_orcid":"https://orcid.org/0000-0002-9888-7353","affiliations":[{"raw_affiliation_string":"Khabarovsk branch of the S. Fyodorov Eye Microsurgery Federal State Institution,\r\nPostgraduate Institute for Public Health Workers","institution_ids":["https://openalex.org/I4210148519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008578994","display_name":"Galina P. Smoliakova","orcid":"https://orcid.org/0000-0002-6943-5518","observed_orcids":["https://orcid.org/0000-0002-6943-5518"]},"institutions":[{"id":"https://openalex.org/I4210148519","display_name":"Intersectoral Research and Technology Complex Eye Microsurgery","ror":"https://ror.org/04w68cb80","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210148519"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"G. P. Smoliakova","raw_affiliation_strings":["Khabarovsk branch o of the S. Fyodorov Eye Microsurgery Federal State Institution,\r\nPostgraduate Institute for Public Health Workers"],"raw_orcid":"https://orcid.org/0000-0002-6943-5518","affiliations":[{"raw_affiliation_string":"Khabarovsk branch o of the S. Fyodorov Eye Microsurgery Federal State Institution,\r\nPostgraduate Institute for Public Health Workers","institution_ids":["https://openalex.org/I4210148519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027190982","display_name":"L.P. Danilova","orcid":"https://orcid.org/0000-0003-0665-1755","observed_orcids":["https://orcid.org/0000-0003-0665-1755"]},"institutions":[{"id":"https://openalex.org/I4210148519","display_name":"Intersectoral Research and Technology Complex Eye Microsurgery","ror":"https://ror.org/04w68cb80","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210148519"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"L. P. Danilova","raw_affiliation_strings":["Khabarovsk branch of the S. Fyodorov Eye Microsurgery Federal State Institution,\r\nPostgraduate Institute for Public Health Workers"],"raw_orcid":"https://orcid.org/0000-0003-0665-1755","affiliations":[{"raw_affiliation_string":"Khabarovsk branch of the S. Fyodorov Eye Microsurgery Federal State Institution,\r\nPostgraduate Institute for Public Health Workers","institution_ids":["https://openalex.org/I4210148519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007387236","display_name":"L.P. Emanova","orcid":"https://orcid.org/0000-0002-1813-4213","observed_orcids":["https://orcid.org/0000-0002-1813-4213"]},"institutions":[{"id":"https://openalex.org/I4210148519","display_name":"Intersectoral Research and Technology Complex Eye Microsurgery","ror":"https://ror.org/04w68cb80","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210148519"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"L. P. Emanova","raw_affiliation_strings":["Khabarovsk branch of the S. Fyodorov Eye Microsurgery Federal State Institution"],"raw_orcid":"https://orcid.org/0000-0002-1813-4213","affiliations":[{"raw_affiliation_string":"Khabarovsk branch of the S. Fyodorov Eye Microsurgery Federal State Institution","institution_ids":["https://openalex.org/I4210148519"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046374233","display_name":"D.\u0410. Povalyaeva","orcid":"https://orcid.org/0000-0001-5944-486X","observed_orcids":["https://orcid.org/0000-0001-5944-486X"]},"institutions":[{"id":"https://openalex.org/I4210148519","display_name":"Intersectoral Research and Technology Complex Eye Microsurgery","ror":"https://ror.org/04w68cb80","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210148519"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"D. A. Povalyaeva","raw_affiliation_strings":["Khabarovsk branch of the S. Fyodorov Eye Microsurgery Federal State Institution"],"raw_orcid":"https://orcid.org/0000-0001-5944-486X","affiliations":[{"raw_affiliation_string":"Khabarovsk branch of the S. Fyodorov Eye Microsurgery Federal State Institution","institution_ids":["https://openalex.org/I4210148519"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210148519"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.2090096,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"16","issue":"4","first_page":"508","last_page":"514"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neovascular-age-related-macular-degeneration","display_name":"neovascular age-related macular degeneration","score":0.9990000128746033},{"id":"https://openalex.org/keywords/aflibercept","display_name":"aflibercept","score":0.9449999928474426},{"id":"https://openalex.org/keywords/meldonium","display_name":"meldonium","score":0.9800000190734863},{"id":"https://openalex.org/keywords/ranibizumab","display_name":"ranibizumab","score":0.8619999885559082},{"id":"https://openalex.org/keywords/anti-vegf-therapy","display_name":"anti-VEGF therapy","score":0.9049999713897705},{"id":"https://openalex.org/keywords/tachyphylaxis","display_name":"tachyphylaxis","score":0.8100000023841858},{"id":"https://openalex.org/keywords/visual-acuity","display_name":"visual acuity","score":0.753000020980835},{"id":"https://openalex.org/keywords/retinal-pigment-epithelium","display_name":"retinal pigment epithelium","score":0.8600000143051147},{"id":"https://openalex.org/keywords/choroidal-neovascularization-regression","display_name":"choroidal neovascularization regression","score":0.8579999804496765},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C2778749236","wikidata":"https://www.wikidata.org/wiki/Q4689286","display_name":"Aflibercept","level":4,"score":0.9548667073249817},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9151527881622314},{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.9070452451705933},{"id":"https://openalex.org/C2781100027","wikidata":"https://www.wikidata.org/wiki/Q414270","display_name":"Ranibizumab","level":4,"score":0.8749260306358337},{"id":"https://openalex.org/C2781359195","wikidata":"https://www.wikidata.org/wiki/Q5105209","display_name":"Choroidal neovascularization","level":3,"score":0.7584091424942017},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.7513209581375122},{"id":"https://openalex.org/C2778257484","wikidata":"https://www.wikidata.org/wiki/Q555066","display_name":"Visual acuity","level":2,"score":0.6568958163261414},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.34074780344963074},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.32888972759246826},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.05030617117881775}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.18008/1816-5095-2019-4-508-514","doi":"https://doi.org/10.18008/1816-5095-2019-4-508-514","is_oa":true,"landing_page_url":"https://doi.org/10.18008/1816-5095-2019-4-508-514","pdf_url":"https://www.ophthalmojournal.com/opht/article/download/1085/654","source":{"id":"https://openalex.org/S4210233720","display_name":"Ophthalmology in Russia","issn_l":"1816-5095","issn":["1816-5095","2500-0845"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310312650","host_organization_name":"Ophthalmology Publishing Group","host_organization_lineage":["https://openalex.org/P4310312650"],"host_organization_lineage_names":["Ophthalmology Publishing Group"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ophthalmology in Russia","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:42bb32f6729240b3b442c61a63cea3ff","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/42bb32f6729240b3b442c61a63cea3ff","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Oftal\u02b9mologi\u00e2, Vol 16, Iss 4, Pp 508-514 (2019)","raw_type":"article"},{"id":"pmh:oai:oai.ophthalmology.elpub.ru:article/1085","doi":null,"is_oa":true,"landing_page_url":"https://www.ophthalmojournal.com/opht/article/view/1085","pdf_url":null,"source":{"id":"https://openalex.org/S4210233720","display_name":"Ophthalmology in Russia","issn_l":"1816-5095","issn":["1816-5095","2500-0845"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310312650","host_organization_name":"Ophthalmology Publishing Group","host_organization_lineage":["https://openalex.org/P4310312650"],"host_organization_lineage_names":["Ophthalmology Publishing Group"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Ophthalmology in Russia; \u0422\u043e\u043c 16, \u2116 4 (2019); 508-514","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.18008/1816-5095-2019-4-508-514","doi":"https://doi.org/10.18008/1816-5095-2019-4-508-514","is_oa":true,"landing_page_url":"https://doi.org/10.18008/1816-5095-2019-4-508-514","pdf_url":"https://www.ophthalmojournal.com/opht/article/download/1085/654","source":{"id":"https://openalex.org/S4210233720","display_name":"Ophthalmology in Russia","issn_l":"1816-5095","issn":["1816-5095","2500-0845"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310312650","host_organization_name":"Ophthalmology Publishing Group","host_organization_lineage":["https://openalex.org/P4310312650"],"host_organization_lineage_names":["Ophthalmology Publishing Group"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ophthalmology in Russia","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2998459192.pdf","grobid_xml":"https://content.openalex.org/works/W2998459192.grobid-xml"},"referenced_works_count":9,"referenced_works":["https://openalex.org/W1601092960","https://openalex.org/W1979285901","https://openalex.org/W2093044616","https://openalex.org/W2095852956","https://openalex.org/W2112911107","https://openalex.org/W2126467871","https://openalex.org/W2154711032","https://openalex.org/W2486491482","https://openalex.org/W3129066690"],"related_works":["https://openalex.org/W2912568837","https://openalex.org/W4364379415","https://openalex.org/W2522975619","https://openalex.org/W2737121038","https://openalex.org/W2902873452","https://openalex.org/W2560083233","https://openalex.org/W4392709029","https://openalex.org/W3177213420","https://openalex.org/W2463477672","https://openalex.org/W4390658124"],"abstract_inverted_index":{"Purpose":[0],".":[1,250],"Estimate":[2],"of":[3,6,9,15,28,31,55,62,70,83,120,128,131,162,176,179,183,194,205,222,230,233,237,243,247],"clinical":[4],"efficacy":[5],"combined":[7],"use":[8,258],"aflibercept":[10,135,170,271],"and":[11,24,88,152,160,240,277,287],"meldonium":[12,180,206,259],"at":[13],"tachyphylaxis":[14],"neovascular":[16],"age-related":[17],"macular":[18,84],"degeneration":[19],"(nAMD)":[20],"to":[21,41,58,115,212,217,257,268],"ranibizumab.":[22],"Patients":[23,75,193],"methods.":[25],"Comparative":[26],"analysis":[27],"treatment":[29,130,262],"results":[30,252],"nAMD":[32,56],"in":[33,207,219,227,260,263,282],"25":[34],"eyes":[35],"(25":[36],"patients)":[37],"aged":[38],"from":[39,99],"52":[40],"79":[42],"years":[43,112],"was":[44,53,124],"carried":[45],"out.":[46],"Main":[47],"criterion":[48],"for":[49,110,126,139,190,273],"the":[50,166,195,208,213,234,238,279],"patients":[51,105,133,144,264],"inclusion":[52],"presence":[54],"resistant":[57,267],"intravitreal":[59],"injections":[60,175],"(IVI)":[61],"VEGF":[63],"inhibitor":[64],"ranibizumab":[65,109],"with":[66,76,86,108,265,270],"visual":[67,158,225,275],"acuity":[68,159],"values":[69],"not":[71,199],"less":[72],"than":[73],"0.1.":[74],"different":[77],"ophthalmologic":[78],"pathology,":[79],"accompanied":[80],"by":[81,155],"development":[82],"edema,":[85],"glaucoma":[87],"after":[89],"any":[90],"eye":[91],"operations,":[92],"performed":[93],"during":[94],"study":[95],"period,":[96],"were":[97,106,145,172],"excluded":[98],"study.":[100],"Before":[101],"using":[102],"aflibercept,":[103],"all":[104],"treated":[107],"1.5\u20132":[111],"(from":[113],"5":[114,187],"7":[116],"injections).":[117],"The":[118,143,203],"lack":[119],"persistent":[121],"positive":[122],"result":[123],"cause":[125],"change":[127],"course":[129,261],"this":[132],"on":[134],"(3":[136],"monthly":[137],"injections)":[138],"enhance":[140],"anti-vasoproliferative":[141],"effect.":[142],"divided":[146],"into":[147],"two":[148],"groups":[149],"\u2014":[150],"main":[151,167,209],"comparison,":[153],"comparable":[154],"sex,":[156],"age,":[157],"type":[161],"choroidal":[163],"neovascularization.":[164,248],"In":[165],"group,":[168,210,215],"3":[169],"IVI":[171,272],"supplemented":[173],"parabulbar":[174],"0.5":[177],"ml":[178],"(with":[181],"concentration":[182],"500":[184],"mg":[185],"/":[186],"ml)":[188],"daily":[189],"10":[191],"days.":[192],"comparison":[196,214],"group":[197],"did":[198],"receive":[200],"meldonium.":[201],"Results.":[202],"supplement":[204],"relative":[211],"led":[216],"increase":[218,274],"1.5":[220],"times":[221,229],"best":[223],"corrected":[224],"acuity,":[226],"1.2":[228],"b-wave":[231],"amplitude":[232],"electroretinogram,":[235],"preservation":[236],"neuro-":[239],"pigment":[241,285],"epithelium":[242,286],"retina,":[244,284],"complete":[245],"regression":[246],"Conclusion":[249],"Findings":[251],"evidence":[253],"about":[254],"clinically":[255],"advisable":[256],"nAMD,":[266],"ranibizumab,":[269],"functions":[276],"stabilize":[278],"degenerative":[280],"changes":[281],"neurosensory":[283],"choriocapillary":[288],"layer.":[289]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-01-10T00:00:00"}