{"id":"https://openalex.org/W2998348290","doi":"https://doi.org/10.1001/jamanetworkopen.2019.16777","title":"Association of Periconception Paternal Body Mass Index With Persistent Changes in DNA Methylation of Offspring in Childhood","display_name":"Association of Periconception Paternal Body Mass Index With Persistent Changes in DNA Methylation of Offspring in Childhood","publication_year":2019,"publication_date":"2019-12-27","ids":{"openalex":"https://openalex.org/W2998348290","doi":"https://doi.org/10.1001/jamanetworkopen.2019.16777","mag":"2998348290","pmid":"https://pubmed.ncbi.nlm.nih.gov/31880793","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6991200"},"language":"en","primary_location":{"id":"doi:10.1001/jamanetworkopen.2019.16777","doi":"https://doi.org/10.1001/jamanetworkopen.2019.16777","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamanetworkopen.2019.16777","pdf_url":"https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2757997/noor_2019_oi_190636.pdf","source":{"id":"https://openalex.org/S4210217848","display_name":"JAMA Network Open","issn_l":"2574-3805","issn":["2574-3805"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Network Open","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2757997/noor_2019_oi_190636.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112371275","display_name":"Nudrat Noor","orcid":"https://orcid.org/0000-0003-0400-7835","observed_orcids":["https://orcid.org/0000-0003-0400-7835"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nudrat Noor","raw_affiliation_strings":["Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts","Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074833807","display_name":"Andr\u00e9s C\u00e1rdenas","orcid":"https://orcid.org/0000-0003-2284-3298","observed_orcids":["https://orcid.org/0000-0003-2284-3298","https://orcid.org/0000-0003-1927-6042"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210111543","display_name":"Harvard Pilgrim Health Care","ror":"https://ror.org/01zxdeg39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210111543"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andres Cardenas","raw_affiliation_strings":["Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts","Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210111543"]},{"raw_affiliation_string":"Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030667666","display_name":"Sheryl L. Rifas\u2010Shiman","orcid":"https://orcid.org/0000-0003-0033-920X","observed_orcids":["https://orcid.org/0000-0003-0033-920X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210111543","display_name":"Harvard Pilgrim Health Care","ror":"https://ror.org/01zxdeg39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210111543"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sheryl L. Rifas-Shiman","raw_affiliation_strings":["Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210111543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100357495","display_name":"Hui Pan","orcid":"https://orcid.org/0000-0001-5748-7217","observed_orcids":["https://orcid.org/0000-0001-5748-7217","https://orcid.org/0000-0002-7206-5423"]},"institutions":[{"id":"https://openalex.org/I1293231726","display_name":"Joslin Diabetes Center","ror":"https://ror.org/0280a3n32","country_code":"US","type":"facility","lineage":["https://openalex.org/I1293231726"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hui Pan","raw_affiliation_strings":["Research Division, Joslin Diabetes Center, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Division, Joslin Diabetes Center, Boston, Massachusetts","institution_ids":["https://openalex.org/I1293231726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089465175","display_name":"Jonathan M. Dreyfuss","orcid":"https://orcid.org/0000-0001-7242-3991","observed_orcids":["https://orcid.org/0000-0001-7242-3991"]},"institutions":[{"id":"https://openalex.org/I1293231726","display_name":"Joslin Diabetes Center","ror":"https://ror.org/0280a3n32","country_code":"US","type":"facility","lineage":["https://openalex.org/I1293231726"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan M. Dreyfuss","raw_affiliation_strings":["Research Division, Joslin Diabetes Center, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Division, Joslin Diabetes Center, Boston, Massachusetts","institution_ids":["https://openalex.org/I1293231726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077350027","display_name":"Emily Oken","orcid":"https://orcid.org/0000-0003-2513-3339","observed_orcids":["https://orcid.org/0000-0003-2513-3339"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210111543","display_name":"Harvard Pilgrim Health Care","ror":"https://ror.org/01zxdeg39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210111543"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Oken","raw_affiliation_strings":["Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts","Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210111543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054864150","display_name":"Marie\u2010France Hivert","orcid":"https://orcid.org/0000-0001-7752-2585","observed_orcids":["https://orcid.org/0000-0001-7752-2585"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210111543","display_name":"Harvard Pilgrim Health Care","ror":"https://ror.org/01zxdeg39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210111543"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marie-France Hivert","raw_affiliation_strings":["Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210111543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072915455","display_name":"Tamarra M James-Todd","orcid":"https://orcid.org/0000-0003-3589-5169","observed_orcids":["https://orcid.org/0000-0003-3589-5169"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tamarra James-Todd","raw_affiliation_strings":["Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts","Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046421306","display_name":"Mary\u2010Elizabeth Patti","orcid":"https://orcid.org/0000-0002-8163-3429","observed_orcids":["https://orcid.org/0000-0002-8163-3429"]},"institutions":[{"id":"https://openalex.org/I1293231726","display_name":"Joslin Diabetes Center","ror":"https://ror.org/0280a3n32","country_code":"US","type":"facility","lineage":["https://openalex.org/I1293231726"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary-Elizabeth Patti","raw_affiliation_strings":["Department of Medicine, Harvard Medical School, Boston, Massachusetts","Research Division, Joslin Diabetes Center, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Research Division, Joslin Diabetes Center, Boston, Massachusetts","institution_ids":["https://openalex.org/I1293231726"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047948839","display_name":"ELVIRA M. ISGANAITIS","orcid":"https://orcid.org/0000-0003-3477-0305","observed_orcids":["https://orcid.org/0000-0003-3477-0305"]},"institutions":[{"id":"https://openalex.org/I1293231726","display_name":"Joslin Diabetes Center","ror":"https://ror.org/0280a3n32","country_code":"US","type":"facility","lineage":["https://openalex.org/I1293231726"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Elvira Isganaitis","raw_affiliation_strings":["Department of Pediatrics, Harvard Medical School, Boston, Massachusetts","Research Division, Joslin Diabetes Center, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Research Division, Joslin Diabetes Center, Boston, Massachusetts","institution_ids":["https://openalex.org/I1293231726"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5047948839"],"corresponding_institution_ids":["https://openalex.org/I1293231726","https://openalex.org/I136199984"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":6.4838,"has_fulltext":true,"cited_by_count":69,"citation_normalized_percentile":{"value":0.97233156,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"2","issue":"12","first_page":"e1916777","last_page":"e1916777"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.5273000001907349,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.5273000001907349,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.4546000063419342,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paternal-obesity","display_name":"paternal obesity","score":0.9350000023841858},{"id":"https://openalex.org/keywords/paternal-body-mass-index","display_name":"paternal body mass index","score":0.9269999861717224},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8859999775886536},{"id":"https://openalex.org/keywords/umbilical-cord-blood","display_name":"umbilical cord blood","score":0.7099999785423279},{"id":"https://openalex.org/keywords/childhood-obesity","display_name":"childhood obesity","score":0.5590000152587891},{"id":"https://openalex.org/keywords/birth-weight","display_name":"birth weight","score":0.7480000257492065},{"id":"https://openalex.org/keywords/maternal-pre-pregnancy-bmi","display_name":"maternal pre-pregnancy BMI","score":0.7210000157356262},{"id":"https://openalex.org/keywords/epigenetic-inheritance","display_name":"epigenetic inheritance","score":0.5569999814033508},{"id":"https://openalex.org/keywords/project-viva","display_name":"Project Viva","score":0.5789999961853027},{"id":"https://openalex.org/keywords/tfap2c","display_name":"TFAP2C","score":0.6759999990463257},{"id":"https://openalex.org/keywords/bmp-7","display_name":"BMP-7","score":0.9750000238418579},{"id":"https://openalex.org/keywords/newborns","display_name":"neonates","score":0.3269999921321869},{"id":"https://openalex.org/keywords/toddlers","display_name":"toddlers","score":0.4519999921321869},{"id":"https://openalex.org/keywords/elementary-school-students","display_name":"elementary school students","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.8949302434921265},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7404451370239258},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.5981237888336182},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.5624553561210632},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.5121712684631348},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.48431864380836487},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4706529676914215},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4481734335422516},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4311717748641968},{"id":"https://openalex.org/C2777382242","wikidata":"https://www.wikidata.org/wiki/Q6017816","display_name":"Index (typography)","level":2,"score":0.42336490750312805},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3335757255554199},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.24057137966156006},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.23211446404457092},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.19263574481010437},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15955626964569092},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.15362343192100525},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1101977527141571},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.10011780261993408},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001724","descriptor_name":"Birth Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011297","descriptor_name":"Prenatal Exposure Delayed Effects","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018812","descriptor_name":"Paternal Exposure","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D063766","descriptor_name":"Pediatric Obesity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1001/jamanetworkopen.2019.16777","doi":"https://doi.org/10.1001/jamanetworkopen.2019.16777","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamanetworkopen.2019.16777","pdf_url":"https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2757997/noor_2019_oi_190636.pdf","source":{"id":"https://openalex.org/S4210217848","display_name":"JAMA Network Open","issn_l":"2574-3805","issn":["2574-3805"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Network Open","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6991200","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6991200","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Netw Open","raw_type":"Text"},{"id":"pmid:31880793","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31880793","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA network open","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1001/jamanetworkopen.2019.16777","doi":"https://doi.org/10.1001/jamanetworkopen.2019.16777","is_oa":true,"landing_page_url":"https://doi.org/10.1001/jamanetworkopen.2019.16777","pdf_url":"https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2757997/noor_2019_oi_190636.pdf","source":{"id":"https://openalex.org/S4210217848","display_name":"JAMA Network Open","issn_l":"2574-3805","issn":["2574-3805"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Network Open","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2948425520","display_name":"Common and distinct early environmental influences on cardiometabolic and respiratory health:  Mechanisms and methods","funder_award_id":"UH3OD023286","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2982121942","display_name":"The Harvard Clinical and Translational Science Center","funder_award_id":"UL1TR002541","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4769690452","display_name":"Harvard Chan School NIEHS Center for Environmental Health","funder_award_id":"P30ES000002","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G5804536747","display_name":"Impact of Metabolic Health in Type 2 Diabetes on Sperm Epigenetic Marks in Humans: A Novel Intergenerational Mechanism for Metabolic Disease Risk Transmission","funder_award_id":"R21HD091974","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G6069333029","display_name":"Novel Epigenomic Biomarkers of Prenatal Risk Factors, and Childhood Obesity","funder_award_id":"R01NR013945","funder_id":"https://openalex.org/F4320337353","funder_display_name":"National Institute of Nursing Research"},{"id":"https://openalex.org/G6710017717","display_name":"Training Program in Environmental Epidemiology","funder_award_id":"T32ES007069","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G6799151368","display_name":"Early Life DNA Methylation and Childhood Allergic Disease","funder_award_id":"R01HL111108","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7677968875","display_name":"Paternal Contributions to Metabolic Disease in Offspring:  Environment, Epigenetics, and Sperm","funder_award_id":"R01DK106193","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000868266","display_name":"Diabetes Research Center","funder_award_id":"P30DK036836","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000900676","display_name":"Prenatal environmental determinants of health in young adulthood: a lifecourse approach","funder_award_id":"R01HD034568","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337353","display_name":"National Institute of Nursing Research","ror":"https://ror.org/01y3zfr79"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2998348290.pdf","grobid_xml":"https://content.openalex.org/works/W2998348290.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1187536559","https://openalex.org/W1587143425","https://openalex.org/W1596198528","https://openalex.org/W1600167813","https://openalex.org/W1821797507","https://openalex.org/W1965448789","https://openalex.org/W1966484189","https://openalex.org/W1966509583","https://openalex.org/W1981525131","https://openalex.org/W1991187107","https://openalex.org/W2000553262","https://openalex.org/W2005075378","https://openalex.org/W2009368068","https://openalex.org/W2022144980","https://openalex.org/W2044794679","https://openalex.org/W2073122969","https://openalex.org/W2095937701","https://openalex.org/W2096601431","https://openalex.org/W2101675838","https://openalex.org/W2114949397","https://openalex.org/W2115947337","https://openalex.org/W2118017182","https://openalex.org/W2123363267","https://openalex.org/W2125620273","https://openalex.org/W2129206964","https://openalex.org/W2130597092","https://openalex.org/W2137291580","https://openalex.org/W2148228932","https://openalex.org/W2151372165","https://openalex.org/W2166236051","https://openalex.org/W2168708557","https://openalex.org/W2170654934","https://openalex.org/W2191849231","https://openalex.org/W2203634181","https://openalex.org/W2287198619","https://openalex.org/W2345953938","https://openalex.org/W2347038054","https://openalex.org/W2472142542","https://openalex.org/W2513716578","https://openalex.org/W2559221635","https://openalex.org/W2570847399","https://openalex.org/W2790722904","https://openalex.org/W2790846406","https://openalex.org/W2791411224","https://openalex.org/W2793434823","https://openalex.org/W2800074119","https://openalex.org/W4238384604"],"related_works":["https://openalex.org/W3110089189","https://openalex.org/W4386098217","https://openalex.org/W3057270625","https://openalex.org/W3203243408","https://openalex.org/W2125620273","https://openalex.org/W6902282665","https://openalex.org/W6958647255","https://openalex.org/W4295756783","https://openalex.org/W2613971698","https://openalex.org/W2605491015"],"abstract_inverted_index":{"Importance:":[0],"While":[1],"prenatal":[2],"nutrition":[3],"and":[4,15,56,59,64,74,79,90,105,123,137,166,178,197,219,241,311,340,380,391,405],"maternal":[5,55,163,170,221,301],"obesity":[6,22],"are":[7],"recognized":[8],"as":[9],"important":[10],"contributors":[11],"to":[12,51,65,102,108,148,169,235,258],"epigenetic":[13,69],"changes":[14],"childhood":[16,406],"obesity,":[17],"the":[18,24,60,113,130,352,356],"role":[19],"of":[20,26,62,68,88,115,204,300,355],"paternal":[21,38,57,121,156,214,269,297,324,396],"in":[23,49,126,129,188,316,323,351,410],"epigenome":[25,61],"offspring":[27,107,127,189,264],"has":[28],"not":[29],"been":[30],"well":[31],"studied.":[32],"Objectives:":[33],"To":[34],"test":[35],"whether":[36],"periconception":[37,157,213],"body":[39],"mass":[40],"index":[41],"(BMI)":[42],"is":[43,83],"associated":[44,261,295,346,365,399],"with":[45,117,262,268,296,319,347,366,381,400],"DNA":[46,124,185,288,401],"methylation":[47,125,186,289,348,359],"patterns":[48,187],"newborns,":[50],"examine":[52,66],"associations":[53,159],"between":[54,309],"BMI":[58,122,165,171,215,223,230,244,253,270,298,302,325,344,383,397,407],"offspring,":[63],"persistence":[67],"marks":[70],"at":[71,133,138,192,290,307,332,336,349,360,386],"ages":[72,337],"3":[73,135,195,338,388],"7":[75,140,199,341],"years.":[76,141,200,342,389],"Design,":[77],"Setting,":[78],"Participants:":[80],"Project":[81],"Viva":[82],"a":[84],"prebirth":[85],"cohort":[86],"study":[87,111],"mothers":[89,98],"children":[91],"including":[92],"2128":[93],"live":[94],"births":[95],"that":[96],"enrolled":[97],"from":[99,145],"April":[100],"1999":[101],"July":[103,146],"2002":[104],"followed":[106],"adolescence.":[109],"This":[110],"analyzed":[112,144],"subset":[114],"participants":[116],"available":[118],"data":[119],"on":[120],"blood":[128,190,287,318],"newborn":[131],"period,":[132],"age":[134,139,194,198,387],"years,":[136,196],"Data":[142],"were":[143,160,208],"2017":[147],"October":[149],"2019.":[150],"Exposures:":[151],"The":[152,180,210],"primary":[153,181],"exposure":[154],"was":[155,183,216,224,260,294,345,363,398],"BMI;":[158],"adjusted":[161],"for":[162],"prepregnancy":[164,222],"stratified":[167],"according":[168],"above":[172],"or":[173,233,256],"below":[174],"25.":[175],"Main":[176],"Outcomes":[177],"Measures:":[179],"outcome":[182],"genome-wide":[184],"collected":[191],"birth,":[193],"Results:":[201],"A":[202],"total":[203],"429":[205],"father-mother-infant":[206],"triads":[207],"included.":[209],"mean":[211,220],"(SD)":[212],"26.4":[217],"(4.0)":[218],"24.5":[225],"(5.2);":[226],"268":[227],"fathers":[228],"had":[229,243],"greater":[231,254],"than":[232,246,255,272],"equal":[234,257],"25":[236,247,259,273],"(mean":[237,248,274],"[SD],":[238,249],"28.5":[239],"[3.3])":[240],"161":[242],"less":[245,271],"22.8":[250],"[1.8]).":[251],"Paternal":[252,343],"increased":[263],"birth":[265,369,403],"weight":[266,370],"compared":[267],"[SD]":[275],"z":[276,384,408],"score,":[277],"0.38":[278],"[0.91]":[279],"vs":[280],"0.11":[281],"[0.96];":[282],"P":[283,377],"=":[284,327,372,375,378],".004).":[285],"Cord":[286],"9":[291],"CpG":[292],"sites":[293],"independent":[299],"(q":[303],"<":[304],".05).":[305],"Methylation":[306],"cg04763273,":[308],"TFAP2C":[310],"BMP7,":[312],"decreased":[313],"by":[314],"5%":[315],"cord":[317],"every":[320],"1-unit":[321],"increase":[322],"(P":[326],"3.13":[328],"\u00d7":[329],"10-8);":[330],"hypomethylation":[331],"this":[333,361,394],"site":[334,362],"persisted":[335],"years":[339],"cg01029450":[350],"promoter":[353],"region":[354],"ARFGAP3":[357],"gene;":[358],"also":[364],"lower":[367],"infant":[368],"(\u03b2":[371],"-0.0003;":[373],"SD":[374],"0.0001;":[376],".03)":[379],"higher":[382],"score":[385,409],"Conclusions":[390],"Relevance:":[392],"In":[393],"study,":[395],"methylation,":[402],"weight,":[404],"offspring.":[411]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-01-10T00:00:00"}
