{"id":"https://openalex.org/W2998274131","doi":"https://doi.org/10.33594/000000190","title":"Inflammatory Serine Proteases Play a Critical Role in the Early Pathogenesis of Diabetic Cardiomyopathy","display_name":"Inflammatory Serine Proteases Play a Critical Role in the Early Pathogenesis of Diabetic Cardiomyopathy","publication_year":2019,"publication_date":"2019-12-12","ids":{"openalex":"https://openalex.org/W2998274131","doi":"https://doi.org/10.33594/000000190","mag":"2998274131","pmid":"https://pubmed.ncbi.nlm.nih.gov/31829530","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6956403"},"language":"en","primary_location":{"id":"doi:10.33594/000000190","doi":"https://doi.org/10.33594/000000190","is_oa":true,"landing_page_url":"https://doi.org/10.33594/000000190","pdf_url":"https://articles.cellphysiolbiochem.com/Articles/000190/PDF/000190.pdf","source":{"id":"https://openalex.org/S161399637","display_name":"Cellular Physiology and Biochemistry","issn_l":"1015-8987","issn":["1015-8987","1421-9778"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Physiology and Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://articles.cellphysiolbiochem.com/Articles/000190/PDF/000190.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041867835","display_name":"Mikhail A. Kolpakov","orcid":"https://orcid.org/0000-0001-6448-2094","observed_orcids":["https://orcid.org/0000-0001-6448-2094"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mikhail A. Kolpakov","raw_affiliation_strings":["Cardiovascular Research Center and Department of Physiology, Temple University School of Medicine, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Center and Department of Physiology, Temple University School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023375088","display_name":"Kunal Sikder","orcid":"https://orcid.org/0000-0002-4235-0936","observed_orcids":["https://orcid.org/0000-0002-4235-0936"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kunal Sikder","raw_affiliation_strings":["Center for Translational Medicine, Thomas Jefferson University, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Medicine, Thomas Jefferson University, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045140204","display_name":"Amrita Sarkar","orcid":"https://orcid.org/0000-0002-5828-9682","observed_orcids":["https://orcid.org/0000-0002-5828-9682"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amrita Sarkar","raw_affiliation_strings":["Department of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042543795","display_name":"Shaswati Chaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shaswati Chaki","raw_affiliation_strings":["Center for Translational Medicine, Thomas Jefferson University, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Medicine, Thomas Jefferson University, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102113281","display_name":"Sanket K. Shukla","orcid":"https://orcid.org/0000-0002-9260-2548","observed_orcids":["https://orcid.org/0000-0002-9260-2548"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanket K. Shukla","raw_affiliation_strings":["Center for Translational Medicine, Thomas Jefferson University, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Medicine, Thomas Jefferson University, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055715202","display_name":"Xinji Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinji Guo","raw_affiliation_strings":["Cardiovascular Research Center and Department of Physiology, Temple University School of Medicine, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Center and Department of Physiology, Temple University School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022029357","display_name":"Qi Zhao","orcid":"https://orcid.org/0000-0002-5079-1803","observed_orcids":["https://orcid.org/0000-0002-5079-1803"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhao Qi","raw_affiliation_strings":["Cardiovascular Research Center and Department of Physiology, Temple University School of Medicine, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Center and Department of Physiology, Temple University School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068471171","display_name":"Carlos E. Barbery","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlos Barbery","raw_affiliation_strings":["Center for Translational Medicine, Thomas Jefferson University, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Medicine, Thomas Jefferson University, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051015751","display_name":"Abdelkarim Sabri","orcid":"https://orcid.org/0000-0003-0553-790X","observed_orcids":["https://orcid.org/0000-0003-0553-790X"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abdelkarim Sabri","raw_affiliation_strings":["Cardiovascular Research Center and Department of Physiology, Temple University School of Medicine, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Center and Department of Physiology, Temple University School of Medicine, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082964755","display_name":"Khadija Rafiq","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Khadija Rafiq","raw_affiliation_strings":["Center for Translational Medicine, Thomas Jefferson University, Philadelphia, PA, USA, khadija.rafiq@jefferson.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Medicine, Thomas Jefferson University, Philadelphia, PA, USA, khadija.rafiq@jefferson.edu","institution_ids":["https://openalex.org/I149251103"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5082964755"],"corresponding_institution_ids":["https://openalex.org/I149251103"],"apc_list":{"value":1785,"currency":"EUR","value_usd":1925},"apc_paid":{"value":1785,"currency":"EUR","value_usd":1925},"fwci":1.2647,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.82872661,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"53","issue":"6","first_page":"982","last_page":"998"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9351000189781189,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9351000189781189,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.02850000001490116,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-cardiomyopathy","display_name":"diabetic cardiomyopathy","score":1.0},{"id":"https://openalex.org/keywords/dipeptidyl-peptidase-i","display_name":"dipeptidyl peptidase I","score":0.996999979019165},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9760000109672546},{"id":"https://openalex.org/keywords/cardiac-inflammation","display_name":"cardiac inflammation","score":0.7480000257492065},{"id":"https://openalex.org/keywords/myocyte-apoptosis","display_name":"myocyte apoptosis","score":0.8330000042915344},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.984000027179718},{"id":"https://openalex.org/keywords/cardiac-remodeling","display_name":"cardiac remodeling","score":0.8949999809265137},{"id":"https://openalex.org/keywords/neutrophil-infiltration","display_name":"neutrophil infiltration","score":0.8600000143051147},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9879999756813049},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9419999718666077}],"concepts":[{"id":"https://openalex.org/C2776553924","wikidata":"https://www.wikidata.org/wiki/Q5270132","display_name":"Diabetic cardiomyopathy","level":4,"score":0.6709056496620178},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5955826044082642},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5467277765274048},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5167528986930847},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5139421820640564},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.5050297379493713},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48975491523742676},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.47828659415245056},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.4575809836387634},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.4502033591270447},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.417896568775177},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.38048040866851807},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3694663643836975},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31157252192497253},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.2511543035507202},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.250774621963501},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.14413896203041077},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020789","descriptor_name":"Cathepsin C","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020789","descriptor_name":"Cathepsin C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057057","descriptor_name":"Serine Proteases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058065","descriptor_name":"Diabetic Cardiomyopathies","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D058065","descriptor_name":"Diabetic Cardiomyopathies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.33594/000000190","doi":"https://doi.org/10.33594/000000190","is_oa":true,"landing_page_url":"https://doi.org/10.33594/000000190","pdf_url":"https://articles.cellphysiolbiochem.com/Articles/000190/PDF/000190.pdf","source":{"id":"https://openalex.org/S161399637","display_name":"Cellular Physiology and Biochemistry","issn_l":"1015-8987","issn":["1015-8987","1421-9778"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Physiology and Biochemistry","raw_type":"journal-article"},{"id":"pmid:31829530","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31829530","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6956403","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6956403","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cell Physiol Biochem","raw_type":"Text"},{"id":"pmh:oai:jdc.jefferson.edu:transmedfp-1065","doi":null,"is_oa":true,"landing_page_url":"https://jdc.jefferson.edu/transmedfp/64","pdf_url":null,"source":{"id":"https://openalex.org/S4210178181","display_name":"The Medicine Forum","issn_l":"2325-2863","issn":["2325-2863"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Center for Translational Medicine Faculty Papers","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:1f253c886c4b4193b941b3ec8fb6fdd4","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1f253c886c4b4193b941b3ec8fb6fdd4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cellular Physiology and Biochemistry, Vol 53, Iss 6, Pp 982-998 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.33594/000000190","doi":"https://doi.org/10.33594/000000190","is_oa":true,"landing_page_url":"https://doi.org/10.33594/000000190","pdf_url":"https://articles.cellphysiolbiochem.com/Articles/000190/PDF/000190.pdf","source":{"id":"https://openalex.org/S161399637","display_name":"Cellular Physiology and Biochemistry","issn_l":"1015-8987","issn":["1015-8987","1421-9778"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Physiology and Biochemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9907000064849854}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2473496358","display_name":"Vevo 2100 ultrasound scanner","funder_award_id":"1s10od010408-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3061533474","display_name":"Infammatory Proteases and Proteases and Diabetic Cardiomyopathy","funder_award_id":"R01HL111278","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5654135384","display_name":"Inflammatory serine proteases and cardiac repair post myocardial infarction","funder_award_id":"R01HL128446","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5735127536","display_name":"Targeting Cbl for Cardiac Repair Post-Myocardial Infarction","funder_award_id":"R01HL145177","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6539319638","display_name":"Protein activated Receptor-4 in Cardiac Rupture after Myocardial Infarction","funder_award_id":"R01HL139889","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2998274131.pdf","grobid_xml":"https://content.openalex.org/works/W2998274131.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W582046237","https://openalex.org/W1512100404","https://openalex.org/W1535326074","https://openalex.org/W1602072441","https://openalex.org/W1670524885","https://openalex.org/W1980633899","https://openalex.org/W1995408153","https://openalex.org/W1998923348","https://openalex.org/W2019227795","https://openalex.org/W2035780068","https://openalex.org/W2039952205","https://openalex.org/W2042152938","https://openalex.org/W2043260389","https://openalex.org/W2052289997","https://openalex.org/W2053071530","https://openalex.org/W2065465687","https://openalex.org/W2067485115","https://openalex.org/W2074523098","https://openalex.org/W2074842903","https://openalex.org/W2076261981","https://openalex.org/W2084024115","https://openalex.org/W2108061252","https://openalex.org/W2118080345","https://openalex.org/W2119957365","https://openalex.org/W2127321192","https://openalex.org/W2127516841","https://openalex.org/W2128062438","https://openalex.org/W2132250523","https://openalex.org/W2132426379","https://openalex.org/W2137522692","https://openalex.org/W2138572815","https://openalex.org/W2140335269","https://openalex.org/W2145444893","https://openalex.org/W2154306328","https://openalex.org/W2155572920","https://openalex.org/W2161189203","https://openalex.org/W2164531685","https://openalex.org/W2170872843","https://openalex.org/W2289832887","https://openalex.org/W2411586275","https://openalex.org/W2581121492","https://openalex.org/W2596947530","https://openalex.org/W2601633584","https://openalex.org/W2605871826","https://openalex.org/W2610218706","https://openalex.org/W2624048203","https://openalex.org/W2745105509","https://openalex.org/W2807893746","https://openalex.org/W2889568240","https://openalex.org/W2895563103","https://openalex.org/W2928098613","https://openalex.org/W2930690443","https://openalex.org/W2945022937","https://openalex.org/W2959803243","https://openalex.org/W2977739228","https://openalex.org/W2981923436","https://openalex.org/W4242443609","https://openalex.org/W4245099632"],"related_works":["https://openalex.org/W202091398","https://openalex.org/W2624284676","https://openalex.org/W2893352733","https://openalex.org/W2906132666","https://openalex.org/W2083237611","https://openalex.org/W4389023525","https://openalex.org/W2025110661","https://openalex.org/W7613878","https://openalex.org/W4387166565","https://openalex.org/W2558690825"],"abstract_inverted_index":{"BACKGROUND/AIMS:":[0],"Diabetic":[1],"cardiomyopathy":[2],"(DCM)":[3],"is":[4,38,271],"characterized":[5],"by":[6,119,149,158,224,230],"structural":[7],"and":[8,81,97,103,123,132,139,153,161,177,202,239,280,289],"functional":[9],"alterations":[10],"that":[11,33,255,277,285,296],"can":[12],"lead":[13,256],"to":[14,21,36,208,257,275,291,299],"heart":[15,148],"failure.":[16],"Several":[17],"mechanisms":[18],"are":[19],"known":[20],"be":[22],"involved":[23,74],"in":[24,75,181,219,250,262],"the":[25,30,48,56,76,166,182,252,258,265,272,283,292],"pathogenesis":[26,259],"of":[27,50,58,67,78,108,115,136,197,233,248,260,267],"DCM,":[28],"however,":[29],"molecular":[31],"mechanism":[32],"links":[34],"inflammation":[35,284],"DCM":[37,261],"incompletely":[39],"understood.":[40],"To":[41,264],"learn":[42],"about":[43],"this":[44,270],"mechanism,":[45],"we":[46],"investigated":[47],"role":[49,247],"inflammatory":[51,140,221],"serine":[52],"proteases":[53],"(ISPs)":[54],"during":[55],"development":[57],"DCM.":[59,300],"METHODS:":[60],"Eight":[61],"weeks":[62],"old":[63],"mice":[64,85,215],"with":[65,89,174],"deletion":[66],"dipeptidyl":[68],"peptidase":[69],"I":[70],"(DPPI),":[71],"an":[72],"enzyme":[73,129],"maturation":[77],"major":[79],"ISPs,":[80,138,198],"wild":[82],"type":[83,109],"(WT)":[84],"controls":[86],"were":[87],"injected":[88],"streptozotocin":[90],"(50":[91],"mg/kg":[92],"for":[93],"5":[94],"days":[95],"intraperitoneally)":[96],"studied":[98],"after":[99,106],"4,":[100],"8,":[101],"16,":[102],"20":[104],"week":[105],"induction":[107,226],"1":[110],"diabetes":[111,116,225],"mellitus":[112],"(T1DM).":[113],"Induction":[114],"was":[117,143,156,205,228],"followed":[118],"echocardiographic":[120],"measurements,":[121],"glycemic":[122],"hemoglobulin":[124],"A1c":[125],"profiling,":[126],"immunoblot,":[127],"qPCR,":[128],"activity":[130],"assays,":[131],"immunohistochemistry":[133],"(IHC)":[134],"analysis":[135],"DPPI,":[137],"markers.":[141],"Fibrosis":[142],"determined":[144,157],"from":[145,186],"left":[146,183],"ventricular":[147],"Serius":[150],"Red":[151],"staining":[152],"qPCR.":[154],"Apoptosis":[155],"TUNEL":[159],"assay":[160],"immunoblot":[162],"analysis.":[163],"RESULTS:":[164],"In":[165,189,212],"diabetic":[167,190,209],"WT":[168,210],"mice,":[169,193],"DPPI":[170,178,278],"expression":[171,279],"increased":[172],"along":[173],"ISP":[175],"activation,":[176],"accumulated":[179],"abundantly":[180],"ventricle":[184],"mainly":[185],"infiltrating":[187],"neutrophils.":[188],"DPPI-knockout":[191],"(DPPI-KO)":[192],"significantly":[194],"decreased":[195,231],"activation":[196,281],"myocyte":[199,287],"apoptosis,":[200],"fibrosis,":[201],"cardiac":[203,294],"function":[204],"improved":[206],"compared":[207],"mice.":[211],"addition,":[213],"DPPI-KO":[214],"showed":[216],"a":[217,245],"decrease":[218],"overall":[220],"status":[222],"mediated":[223],"which":[227],"manifested":[229],"production":[232],"pro-inflammatory":[234],"cytokines":[235],"like":[236],"TNF-\u03b1,":[237],"IL-1\u03b2":[238],"IL-6.":[240],"CONCLUSION:":[241],"This":[242],"study":[243,274],"elucidates":[244],"novel":[246],"ISPs":[249],"potentiating":[251],"immunological":[253],"responses":[254],"T1DM.":[263],"best":[266],"our":[268],"knowledge,":[269],"first":[273],"report":[276],"promotes":[282],"enhances":[286],"apoptosis":[288],"contributes":[290],"adverse":[293],"remodeling":[295],"subsequently":[297],"leads":[298]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-01-10T00:00:00"}
