{"id":"https://openalex.org/W2998144673","doi":"https://doi.org/10.1016/j.redox.2019.101407","title":"Neuronal vulnerability to fetal hypoxia-reoxygenation injury and motor deficit development relies on regional brain tetrahydrobiopterin levels","display_name":"Neuronal vulnerability to fetal hypoxia-reoxygenation injury and motor deficit development relies on regional brain tetrahydrobiopterin levels","publication_year":2019,"publication_date":"2019-12-12","ids":{"openalex":"https://openalex.org/W2998144673","doi":"https://doi.org/10.1016/j.redox.2019.101407","mag":"2998144673","pmid":"https://pubmed.ncbi.nlm.nih.gov/31926630","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6928344"},"language":"en","primary_location":{"id":"doi:10.1016/j.redox.2019.101407","doi":"https://doi.org/10.1016/j.redox.2019.101407","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.redox.2019.101407","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2213231719311978/pdf","source":{"id":"https://openalex.org/S2764928002","display_name":"Redox Biology","issn_l":"2213-2317","issn":["2213-2317"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2213231719311978/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001723877","display_name":"Jeannette M. Vasquez-Vivar","orcid":"https://orcid.org/0000-0002-4225-7520","observed_orcids":["https://orcid.org/0000-0002-4225-7520"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeannette Vasquez-Vivar","raw_affiliation_strings":["Department of Biophysics and Redox Biology Program, Medical College of Wisconsin, Milwaukee, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biophysics and Redox Biology Program, Medical College of Wisconsin, Milwaukee, WI, USA","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037027452","display_name":"Zhongjie Shi","orcid":"https://orcid.org/0000-0002-1912-229X","observed_orcids":["https://orcid.org/0000-0002-1912-229X"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhongjie Shi","raw_affiliation_strings":["Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040649127","display_name":"Jeong\u2010Won Jeong","orcid":"https://orcid.org/0000-0003-4498-0939","observed_orcids":["https://orcid.org/0000-0003-4498-0939"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeong-Won Jeong","raw_affiliation_strings":["Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA; Department of Neurology, Wayne State University School of Medicine, Detroit, MI, USA","Department of Neurology, Wayne State University School of Medicine, Detroit, MI, USA","Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA; Department of Neurology, Wayne State University School of Medicine, Detroit, MI, USA","institution_ids":["https://openalex.org/I185443292"]},{"raw_affiliation_string":"Department of Neurology, Wayne State University School of Medicine, Detroit, MI, USA","institution_ids":["https://openalex.org/I185443292"]},{"raw_affiliation_string":"Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102329403","display_name":"Kehuan Luo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kehuan Luo","raw_affiliation_strings":["Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082181309","display_name":"Amit Sharma","orcid":"https://orcid.org/0000-0002-8109-1690","observed_orcids":["https://orcid.org/0000-0002-8109-1690"]},"institutions":[{"id":"https://openalex.org/I4210130818","display_name":"Children's Hospital of Michigan","ror":"https://ror.org/0429x9p85","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800326109","https://openalex.org/I4210130818"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amit Sharma","raw_affiliation_strings":["Neonatology Division, Children's Hospital of Michigan, Detroit, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neonatology Division, Children's Hospital of Michigan, Detroit, MI, USA","institution_ids":["https://openalex.org/I4210130818"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041929771","display_name":"Karthikeyan Thirugnanam","orcid":"https://orcid.org/0000-0003-2832-2581","observed_orcids":["https://orcid.org/0000-0003-2832-2581"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karthikeyan Thirugnanam","raw_affiliation_strings":["Department of Biophysics and Redox Biology Program, Medical College of Wisconsin, Milwaukee, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biophysics and Redox Biology Program, Medical College of Wisconsin, Milwaukee, WI, USA","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040519455","display_name":"Sidhartha Tan","orcid":"https://orcid.org/0000-0003-2382-729X","observed_orcids":["https://orcid.org/0000-0003-2382-729X"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I4210130818","display_name":"Children's Hospital of Michigan","ror":"https://ror.org/0429x9p85","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800326109","https://openalex.org/I4210130818"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sidhartha Tan","raw_affiliation_strings":["Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA; Neonatology Division, Children's Hospital of Michigan, Detroit, MI, USA. Electronic address: sidhartha.tan@wayne.edu","Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA","Neonatology Division, Children's Hospital of Michigan, Detroit, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA; Neonatology Division, Children's Hospital of Michigan, Detroit, MI, USA. Electronic address: sidhartha.tan@wayne.edu","institution_ids":["https://openalex.org/I185443292","https://openalex.org/I4210130818"]},{"raw_affiliation_string":"Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA","institution_ids":["https://openalex.org/I185443292"]},{"raw_affiliation_string":"Neonatology Division, Children's Hospital of Michigan, Detroit, MI, USA","institution_ids":["https://openalex.org/I4210130818"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5040519455"],"corresponding_institution_ids":["https://openalex.org/I185443292","https://openalex.org/I4210130818"],"apc_list":{"value":2850,"currency":"USD","value_usd":2850},"apc_paid":{"value":2850,"currency":"USD","value_usd":2850},"fwci":3.8727,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.93608555,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"29","issue":null,"first_page":"101407","last_page":"101407"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11097","display_name":"Cerebral Palsy and Movement Disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerebral-palsy","display_name":"cerebral palsy","score":0.8180000185966492},{"id":"https://openalex.org/keywords/fetal-hypoxia-ischemia","display_name":"fetal hypoxia-ischemia","score":0.8930000066757202},{"id":"https://openalex.org/keywords/tetrahydrobiopterin","display_name":"tetrahydrobiopterin","score":0.9369999766349792},{"id":"https://openalex.org/keywords/hypertonia","display_name":"hypertonia","score":0.6150000095367432},{"id":"https://openalex.org/keywords/motor-impairment","display_name":"motor impairment","score":0.5400000214576721},{"id":"https://openalex.org/keywords/reactive-nitrogen-species","display_name":"reactive nitrogen species","score":0.8730000257492065},{"id":"https://openalex.org/keywords/sepiapterin","display_name":"sepiapterin","score":0.9169999957084656},{"id":"https://openalex.org/keywords/thalamus","display_name":"thalamus","score":0.7670000195503235},{"id":"https://openalex.org/keywords/basal-ganglia","display_name":"basal ganglia","score":0.9300000071525574},{"id":"https://openalex.org/keywords/cerebellum","display_name":"cerebellum","score":0.8259999752044678},{"id":"https://openalex.org/keywords/cortex","display_name":"cortex","score":0.5830000042915344},{"id":"https://openalex.org/keywords/placental-insufficiency","display_name":"placental insufficiency","score":0.8579999804496765},{"id":"https://openalex.org/keywords/uterine-ischemia","display_name":"uterine ischemia","score":0.953000009059906},{"id":"https://openalex.org/keywords/brain-development","display_name":"brain development","score":0.3230000138282776}],"concepts":[{"id":"https://openalex.org/C2776145790","wikidata":"https://www.wikidata.org/wiki/Q419808","display_name":"Tetrahydrobiopterin","level":4,"score":0.7820847034454346},{"id":"https://openalex.org/C2779248504","wikidata":"https://www.wikidata.org/wiki/Q574942","display_name":"Hypertonia","level":2,"score":0.7686653137207031},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.5764017701148987},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.47685372829437256},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4474329352378845},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.43427878618240356},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.4219474494457245},{"id":"https://openalex.org/C2781458332","wikidata":"https://www.wikidata.org/wiki/Q720026","display_name":"Brain damage","level":2,"score":0.4183281362056732},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4036467671394348},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36362770199775696},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.13225218653678894},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.10883501172065735},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.06003773212432861},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001708","descriptor_name":"Biopterins","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D001708","descriptor_name":"Biopterins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005311","descriptor_name":"Fetal Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020925","descriptor_name":"Hypoxia-Ischemia, Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.redox.2019.101407","doi":"https://doi.org/10.1016/j.redox.2019.101407","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.redox.2019.101407","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2213231719311978/pdf","source":{"id":"https://openalex.org/S2764928002","display_name":"Redox Biology","issn_l":"2213-2317","issn":["2213-2317"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6928344","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6928344","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox Biol","raw_type":"Text"},{"id":"pmid:31926630","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31926630","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox biology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:1376f2796b4340429b7abd991d0a8df5","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1376f2796b4340429b7abd991d0a8df5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Redox Biology, Vol 29, Iss , Pp - (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.redox.2019.101407","doi":"https://doi.org/10.1016/j.redox.2019.101407","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.redox.2019.101407","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2213231719311978/pdf","source":{"id":"https://openalex.org/S2764928002","display_name":"Redox Biology","issn_l":"2213-2317","issn":["2213-2317"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.979200005531311,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2751139691","display_name":"Tetrahydrobiopterin in Fetal Hypoxic Brain Injury","funder_award_id":"R01NS081936","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8778120514","display_name":"Non-apoptotic cell death in fetal brain injury","funder_award_id":"R56NS100088","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2998144673.pdf","grobid_xml":"https://content.openalex.org/works/W2998144673.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1581978537","https://openalex.org/W1968689753","https://openalex.org/W1984103180","https://openalex.org/W1984776205","https://openalex.org/W2000513364","https://openalex.org/W2002175191","https://openalex.org/W2018649598","https://openalex.org/W2026425756","https://openalex.org/W2041124764","https://openalex.org/W2045721183","https://openalex.org/W2051459142","https://openalex.org/W2064188898","https://openalex.org/W2075453410","https://openalex.org/W2085893897","https://openalex.org/W2092689006","https://openalex.org/W2094245818","https://openalex.org/W2098951649","https://openalex.org/W2101979195","https://openalex.org/W2134547814","https://openalex.org/W2135122869","https://openalex.org/W2135821537","https://openalex.org/W2136441437","https://openalex.org/W2148096041","https://openalex.org/W2152793449","https://openalex.org/W2162755743","https://openalex.org/W2164127547","https://openalex.org/W2424459626","https://openalex.org/W2743249620","https://openalex.org/W2759349072","https://openalex.org/W2763527823","https://openalex.org/W2789284810","https://openalex.org/W2911607717","https://openalex.org/W2948248182"],"related_works":["https://openalex.org/W2743249620","https://openalex.org/W2134547814","https://openalex.org/W2041124764","https://openalex.org/W2136892850","https://openalex.org/W2135821537","https://openalex.org/W2045721183","https://openalex.org/W7100222766","https://openalex.org/W2042383455","https://openalex.org/W2044137193","https://openalex.org/W1984103180"],"abstract_inverted_index":{"Hypertonia":[0],"is":[1,265,271],"pathognomonic":[2],"of":[3,20,29,60,78,114,160,176,196,232],"cerebral":[4],"palsy":[5],"(CP),":[6],"often":[7],"caused":[8],"by":[9],"brain":[10,32,62,128,166,188,234],"injury":[11,33],"before":[12],"birth.":[13],"To":[14],"understand":[15],"the":[16,54,58,61,112,153,161,181,207,218,229,233],"early":[17,30],"driving":[18],"events":[19],"hypertonia,":[21],"we":[22],"utilized":[23],"magnetic":[24],"resonance":[25],"imaging":[26],"(MRI)":[27],"assessment":[28],"critical":[31,272],"in":[34,53,57,70,140,152,165,180,217,228],"rabbit":[35,96],"fetuses":[36],"(79%":[37],"term)":[38],"that":[39,173,260,278],"will":[40],"predict":[41],"hypertonia":[42,241,255],"after":[43,132,252],"birth":[44],"following":[45],"antenatal":[46],"hypoxia-ischemia.":[47],"We":[48,171,258],"examined":[49],"if":[50],"individual":[51,121],"variations":[52],"tetrahydrobiopterin":[55,162,178,223,263],"cofactor":[56],"parts":[59,231],"controlling":[63],"motor":[64,74,87,276],"function":[65],"could":[66],"indicate":[67],"a":[68,107,141,174,192,261],"role":[69],"specific":[71],"damage":[72],"to":[73,118,200,248],"regions":[75,129,167],"and":[76,102,157,186,224,242,256,270],"disruption":[77],"circuit":[79],"integration":[80],"as":[81,149],"an":[82],"underlying":[83],"mechanism":[84],"for":[85,210,273],"acquiring":[86],"disorders,":[88],"which":[89,120],"has":[90],"not":[91,191,236],"been":[92],"considered":[93],"before.":[94],"The":[95,202,282],"model":[97],"mimicked":[98],"acute":[99],"placental":[100],"insufficiency":[101],"used":[103,117,148],"uterine":[104],"ischemia":[105],"at":[106],"premature":[108],"gestation.":[109],"MRI":[110,239],"during":[111],"time":[113],"hypoxia-ischemia":[115,133,253,269],"was":[116,205,215],"differentiate":[119],"fetal":[122,268],"brains":[123],"would":[124],"become":[125],"hypertonic.":[126],"Four":[127],"collected":[130],"immediately":[131,251],"or":[134],"48":[135,221],"h":[136],"later":[137],"were":[138,147,168,235],"analyzed":[139],"blinded":[142],"fashion.":[143],"Age-matched":[144],"sham-operated":[145],"animals":[146],"controls.":[150],"Changes":[151],"reactive":[154,212,287],"nitrogen":[155,213,288],"species":[156,214],"gene":[158,225],"expression":[159,226],"biosynthetic":[163],"enzymes":[164],"also":[169],"studied.":[170],"found":[172,216],"combination":[175],"low":[177,194],"content":[179],"cortex,":[182],"basal":[183],"ganglia,":[184],"cerebellum,":[185],"thalamus":[187],"regions,":[189],"but":[190],"unique":[193],"threshold":[195],"tetrahydrobiopterin,":[197],"contributed":[198],"etiologically":[199],"hypertonia.":[201,281],"biggest":[203],"contribution":[204],"from":[206],"thalamus.":[208],"Evidence":[209],"increased":[211],"cortex.":[219],"By":[220],"h,":[222],"levels":[227],"different":[230,237],"between":[238],"stratified":[240],"non-hypertonia":[243],"groups.":[244],"Sepiapterin":[245],"treatment":[246],"given":[247],"pregnant":[249],"dams":[250],"ameliorated":[254],"death.":[257],"conclude":[259],"developmental":[262],"variation":[264],"necessary":[266],"with":[267],"disrupting":[274],"normal":[275],"circuits":[277],"develop":[279],"into":[280],"possible":[283],"mechanistic":[284],"pathway":[285],"involves":[286],"species.":[289]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-01-10T00:00:00"}
