{"id":"https://openalex.org/W2998099994","doi":"https://doi.org/10.3390/ijms21010130","title":"TLQP-21, A VGF-Derived Peptide Endowed of Endocrine and Extraendocrine Properties: Focus on In Vitro Calcium Signaling","display_name":"TLQP-21, A VGF-Derived Peptide Endowed of Endocrine and Extraendocrine Properties: Focus on In Vitro Calcium Signaling","publication_year":2019,"publication_date":"2019-12-24","ids":{"openalex":"https://openalex.org/W2998099994","doi":"https://doi.org/10.3390/ijms21010130","mag":"2998099994","pmid":"https://pubmed.ncbi.nlm.nih.gov/31878142","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6982260"},"language":"en","primary_location":{"id":"doi:10.3390/ijms21010130","doi":"https://doi.org/10.3390/ijms21010130","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms21010130","pdf_url":"https://www.mdpi.com/1422-0067/21/1/130/pdf?version=1577181733","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/21/1/130/pdf?version=1577181733","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076609343","display_name":"Elena Bresciani","orcid":"https://orcid.org/0000-0002-8247-276X","observed_orcids":["https://orcid.org/0000-0002-8247-276X"]},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Elena Bresciani","raw_affiliation_strings":["School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy"],"raw_orcid":"https://orcid.org/0000-0002-8247-276X","affiliations":[{"raw_affiliation_string":"School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy","institution_ids":["https://openalex.org/I66752286"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054899915","display_name":"Roberta Possenti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberta Possenti","raw_affiliation_strings":["Department of Systems Medicine, University of Roma Tor Vergata, 00133 Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Medicine, University of Roma Tor Vergata, 00133 Roma, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031711272","display_name":"Silvia Coco","orcid":"https://orcid.org/0000-0002-3883-9472","observed_orcids":["https://orcid.org/0000-0002-3883-9472"]},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvia Coco","raw_affiliation_strings":["School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy"],"raw_orcid":"https://orcid.org/0000-0002-3883-9472","affiliations":[{"raw_affiliation_string":"School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy","institution_ids":["https://openalex.org/I66752286"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076976446","display_name":"Laura Rizzi","orcid":"https://orcid.org/0000-0002-3709-6574","observed_orcids":["https://orcid.org/0000-0002-3709-6574"]},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Laura Rizzi","raw_affiliation_strings":["School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy"],"raw_orcid":"https://orcid.org/0000-0002-3709-6574","affiliations":[{"raw_affiliation_string":"School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy","institution_ids":["https://openalex.org/I66752286"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049252544","display_name":"Ramona Meanti","orcid":"https://orcid.org/0000-0002-9734-1025","observed_orcids":["https://orcid.org/0000-0002-9734-1025"]},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ramona Meanti","raw_affiliation_strings":["School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy","institution_ids":["https://openalex.org/I66752286"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012769425","display_name":"Laura Molteni","orcid":"https://orcid.org/0000-0003-0510-9083","observed_orcids":["https://orcid.org/0000-0003-0510-9083"]},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Laura Molteni","raw_affiliation_strings":["School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy"],"raw_orcid":"https://orcid.org/0000-0003-0510-9083","affiliations":[{"raw_affiliation_string":"School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy","institution_ids":["https://openalex.org/I66752286"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017160244","display_name":"Vittorio Locatelli","orcid":"https://orcid.org/0000-0002-3175-6535","observed_orcids":["https://orcid.org/0000-0002-3175-6535"]},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vittorio Locatelli","raw_affiliation_strings":["School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy","institution_ids":["https://openalex.org/I66752286"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026741989","display_name":"Antonio Torsello","orcid":"https://orcid.org/0000-0003-4557-676X","observed_orcids":["https://orcid.org/0000-0003-4557-676X"]},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Torsello","raw_affiliation_strings":["School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy","institution_ids":["https://openalex.org/I66752286"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5076609343"],"corresponding_institution_ids":["https://openalex.org/I66752286"],"apc_list":{"value":1800,"currency":"CHF","value_usd":1824},"apc_paid":{"value":1800,"currency":"CHF","value_usd":1824},"fwci":0.153,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.09461235,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"21","issue":"1","first_page":"130","last_page":"130"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.7432000041007996,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.7432000041007996,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.23669999837875366,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tlqp-21","display_name":"TLQP-21","score":1.0},{"id":"https://openalex.org/keywords/complement-c3a","display_name":"complement C3a","score":0.718999981880188},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.8159999847412109},{"id":"https://openalex.org/keywords/er-calcium-release","display_name":"endoplasmic reticulum calcium release","score":0.9150000214576721},{"id":"https://openalex.org/keywords/trpc-channels","display_name":"TRPC channels","score":0.9300000071525574},{"id":"https://openalex.org/keywords/neuropeptide-receptors","display_name":"neuropeptide receptors","score":0.5569999814033508}],"concepts":[{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.5936267375946045},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.587917685508728},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.546695351600647},{"id":"https://openalex.org/C162740809","wikidata":"https://www.wikidata.org/wiki/Q15334560","display_name":"STIM1","level":3,"score":0.4662700295448303},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4635343551635742},{"id":"https://openalex.org/C201571599","wikidata":"https://www.wikidata.org/wiki/Q5018840","display_name":"Calcium signaling","level":3,"score":0.44299885630607605},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38118404150009155},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38089972734451294},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.38004642724990845},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3592572510242462},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.33649158477783203},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.32882171869277954},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000071736","descriptor_name":"Stromal Interaction Molecules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D050051","descriptor_name":"Transient Receptor Potential Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.3390/ijms21010130","doi":"https://doi.org/10.3390/ijms21010130","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms21010130","pdf_url":"https://www.mdpi.com/1422-0067/21/1/130/pdf?version=1577181733","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5954160","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6982260","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:31878142","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31878142","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6982260","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6982260/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmh:oai:boa.unimib.it:10281/259529","doi":null,"is_oa":true,"landing_page_url":"https://www.mdpi.com/1422-0067/21/1/130","pdf_url":null,"source":{"id":"https://openalex.org/S4306401259","display_name":"BOA (University of Milano-Bicocca)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66752286","host_organization_name":"University of Milano-Bicocca","host_organization_lineage":["https://openalex.org/I66752286"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:c82035ceaeec49fa85534feb7d3f33a7","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/c82035ceaeec49fa85534feb7d3f33a7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 21, Iss 1, p 130 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms21010130","doi":"https://doi.org/10.3390/ijms21010130","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms21010130","pdf_url":"https://www.mdpi.com/1422-0067/21/1/130/pdf?version=1577181733","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321610","display_name":"Universit\u00e0 degli Studi di Milano-Bicocca","ror":"https://ror.org/01ynf4891"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2998099994.pdf","grobid_xml":"https://content.openalex.org/works/W2998099994.grobid-xml"},"referenced_works_count":81,"referenced_works":["https://openalex.org/W21331039","https://openalex.org/W23640957","https://openalex.org/W1491001981","https://openalex.org/W1517074681","https://openalex.org/W1734831379","https://openalex.org/W1945571160","https://openalex.org/W1946281621","https://openalex.org/W1966614678","https://openalex.org/W1967205770","https://openalex.org/W1967896645","https://openalex.org/W1968913752","https://openalex.org/W1974742583","https://openalex.org/W1974837024","https://openalex.org/W1980404566","https://openalex.org/W1982363787","https://openalex.org/W1984743586","https://openalex.org/W1989642979","https://openalex.org/W1993609137","https://openalex.org/W1999527871","https://openalex.org/W2000147383","https://openalex.org/W2000598734","https://openalex.org/W2001058095","https://openalex.org/W2001578694","https://openalex.org/W2003982930","https://openalex.org/W2009222237","https://openalex.org/W2009821042","https://openalex.org/W2014557719","https://openalex.org/W2019911667","https://openalex.org/W2021584629","https://openalex.org/W2023024494","https://openalex.org/W2037839118","https://openalex.org/W2038626246","https://openalex.org/W2049472317","https://openalex.org/W2052651819","https://openalex.org/W2059476202","https://openalex.org/W2063106692","https://openalex.org/W2064397103","https://openalex.org/W2067342827","https://openalex.org/W2070240681","https://openalex.org/W2073678037","https://openalex.org/W2078555192","https://openalex.org/W2079539712","https://openalex.org/W2082914392","https://openalex.org/W2086102609","https://openalex.org/W2087511526","https://openalex.org/W2091002427","https://openalex.org/W2092751013","https://openalex.org/W2099027573","https://openalex.org/W2102107904","https://openalex.org/W2102554343","https://openalex.org/W2102977671","https://openalex.org/W2106451215","https://openalex.org/W2110445591","https://openalex.org/W2123156974","https://openalex.org/W2126878361","https://openalex.org/W2134070809","https://openalex.org/W2134495693","https://openalex.org/W2139223838","https://openalex.org/W2148501562","https://openalex.org/W2155696186","https://openalex.org/W2167827899","https://openalex.org/W2488988553","https://openalex.org/W2545964391","https://openalex.org/W2546209918","https://openalex.org/W2602971647","https://openalex.org/W2614566686","https://openalex.org/W2621239131","https://openalex.org/W2753008210","https://openalex.org/W2789369470","https://openalex.org/W2809384620","https://openalex.org/W2900644715","https://openalex.org/W2901782699","https://openalex.org/W2903164637","https://openalex.org/W2908621307","https://openalex.org/W2953703975","https://openalex.org/W2970444380","https://openalex.org/W2972134410","https://openalex.org/W2973297931","https://openalex.org/W6640622971","https://openalex.org/W6672489148","https://openalex.org/W6752612076"],"related_works":["https://openalex.org/W2730187928","https://openalex.org/W1993609137","https://openalex.org/W2903164637","https://openalex.org/W2614566686","https://openalex.org/W7062779641","https://openalex.org/W2001578694","https://openalex.org/W2793021933","https://openalex.org/W2059476202","https://openalex.org/W3164994586","https://openalex.org/W2021584629"],"abstract_inverted_index":{"VGF":[0],"gene":[1],"encodes":[2],"for":[3,69,168],"a":[4,46,59,150],"neuropeptide":[5],"precursor":[6,41],"of":[7,48,61,101,141,159,195],"68":[8],"kDa":[9],"composed":[10],"by":[11,96,187],"615":[12],"(human)":[13],"and":[14,35,53,73,116,162,183,197],"617":[15],"(rat,":[16],"mice)":[17],"residues,":[18],"expressed":[19],"prevalently":[20],"in":[21,29,36,51,90,172,200],"the":[22,30,86,112,139,146,156,165,173,180],"central":[23],"nervous":[24,32],"system":[25,33],"(CNS),":[26],"but":[27],"also":[28],"peripheral":[31],"(PNS)":[34],"various":[37],"endocrine":[38,72,182],"cells.":[39],"This":[40,104],"undergoes":[42],"proteolytic":[43],"cleavage,":[44],"generating":[45],"family":[47],"peptides":[49],"different":[50,91,201],"length":[52],"biological":[54],"activity.":[55],"Among":[56],"them,":[57],"TLQP-21,":[58,188],"peptide":[60],"21":[62],"amino":[63],"acids,":[64],"has":[65,82],"been":[66,83],"widely":[67],"investigated":[68],"its":[70,94,193,198],"relevant":[71],"extraendocrine":[74,184],"activities.":[75],"The":[76,120],"complement":[77,78],"C3a":[79],"receptor-1":[80],"(C3aR1)":[81],"suggested":[84],"as":[85],"TLQP-21":[87,97],"receptor":[88,131],"and,":[89],"cell":[92],"lines,":[93],"activation":[95,140],"induces":[98],"an":[99],"increase":[100,171],"intracellular":[102],"Ca2+.":[103],"effect":[105],"relies":[106],"both":[107],"on":[108,123,192],"Ca2+":[109,118,137,160,170],"release":[110],"from":[111],"endoplasmic":[113],"reticulum":[114],"(ER)":[115],"extracellular":[117],"entry.":[119],"latter":[121],"depends":[122],"stromal":[124],"interaction":[125,128],"molecules":[126],"(STIM)-Orai1":[127],"or":[129],"transient":[130],"potential":[132,199],"channel":[133],"(TRPC)":[134],"involvement.":[135],"After":[136],"entry,":[138],"outward":[142],"K+-Ca2+-dependent":[143],"currents,":[144,148],"mainly":[145],"KCa3.1":[147],"provides":[149],"membrane":[151],"polarizing":[152],"influence":[153],"which":[154],"offset":[155],"depolarizing":[157],"action":[158,196],"elevation":[161],"indirectly":[163],"maintains":[164],"driving":[166],"force":[167],"optimal":[169],"cytosol.":[174],"In":[175],"this":[176],"review,":[177],"we":[178],"address":[179],"main":[181],"actions":[185],"displayed":[186],"highlighting":[189],"recent":[190],"findings":[191],"mechanism":[194],"pathological":[202],"conditions.":[203]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-01-10T00:00:00"}