{"id":"https://openalex.org/W2998072139","doi":"https://doi.org/10.1038/s41598-019-56173-9","title":"Small molecule allosteric uncoupling of microtubule depolymerase activity from motility in human Kinesin-5 during mitotic spindle assembly","display_name":"Small molecule allosteric uncoupling of microtubule depolymerase activity from motility in human Kinesin-5 during mitotic spindle assembly","publication_year":2019,"publication_date":"2019-12-27","ids":{"openalex":"https://openalex.org/W2998072139","doi":"https://doi.org/10.1038/s41598-019-56173-9","mag":"2998072139","pmid":"https://pubmed.ncbi.nlm.nih.gov/31882607"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-019-56173-9","doi":"https://doi.org/10.1038/s41598-019-56173-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-56173-9","pdf_url":"https://www.nature.com/articles/s41598-019-56173-9.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-019-56173-9.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041588894","display_name":"Catherine D. Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine D. Kim","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, LSU School of Medicine & Health Sciences Center, 1901 Perdido Street, New Orleans, LA, 70112, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, LSU School of Medicine & Health Sciences Center, 1901 Perdido Street, New Orleans, LA, 70112, USA","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083270105","display_name":"Elizabeth D. Kim","orcid":"https://orcid.org/0000-0002-6240-484X","observed_orcids":["https://orcid.org/0000-0002-6240-484X"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth D. Kim","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, LSU School of Medicine & Health Sciences Center, 1901 Perdido Street, New Orleans, LA, 70112, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, LSU School of Medicine & Health Sciences Center, 1901 Perdido Street, New Orleans, LA, 70112, USA","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102017391","display_name":"Liqiong Liu","orcid":"https://orcid.org/0009-0006-9814-7626","observed_orcids":["https://orcid.org/0009-0006-9814-7626"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liqiong Liu","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, LSU School of Medicine & Health Sciences Center, 1901 Perdido Street, New Orleans, LA, 70112, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, LSU School of Medicine & Health Sciences Center, 1901 Perdido Street, New Orleans, LA, 70112, USA","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020405092","display_name":"Rebecca S. Buckley","orcid":"https://orcid.org/0000-0001-7908-0389","observed_orcids":["https://orcid.org/0000-0001-7908-0389"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca S. Buckley","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, LSU School of Medicine & Health Sciences Center, 1901 Perdido Street, New Orleans, LA, 70112, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, LSU School of Medicine & Health Sciences Center, 1901 Perdido Street, New Orleans, LA, 70112, USA","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070459086","display_name":"Sreeja Parameswaran","orcid":"https://orcid.org/0009-0002-3631-3669","observed_orcids":["https://orcid.org/0009-0002-3631-3669"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sreeja Parameswaran","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, LSU School of Medicine & Health Sciences Center, 1901 Perdido Street, New Orleans, LA, 70112, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, LSU School of Medicine & Health Sciences Center, 1901 Perdido Street, New Orleans, LA, 70112, USA","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100333099","display_name":"Sunyoung Kim","orcid":"https://orcid.org/0000-0002-1736-9088","observed_orcids":["https://orcid.org/0000-0002-1736-9088"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sunyoung Kim","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, LSU School of Medicine & Health Sciences Center, 1901 Perdido Street, New Orleans, LA, 70112, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, LSU School of Medicine & Health Sciences Center, 1901 Perdido Street, New Orleans, LA, 70112, USA","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084217207","display_name":"Edward J. Wojcik","orcid":"https://orcid.org/0000-0002-3023-0312","observed_orcids":["https://orcid.org/0000-0002-3023-0312"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Edward J. Wojcik","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, LSU School of Medicine & Health Sciences Center, 1901 Perdido Street, New Orleans, LA, 70112, USA. ewojci@lsuhsc.edu","Department of Biochemistry and Molecular Biology, LSU School of Medicine & Health Sciences Center, 1901 Perdido Street, New Orleans, LA, 70112, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, LSU School of Medicine & Health Sciences Center, 1901 Perdido Street, New Orleans, LA, 70112, USA. ewojci@lsuhsc.edu","institution_ids":["https://openalex.org/I75420490"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, LSU School of Medicine & Health Sciences Center, 1901 Perdido Street, New Orleans, LA, 70112, USA","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5084217207"],"corresponding_institution_ids":["https://openalex.org/I121820613","https://openalex.org/I75420490"],"apc_list":{"value":1790,"currency":"USD","value_usd":1790},"apc_paid":{"value":1790,"currency":"USD","value_usd":1790},"fwci":0.9969,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.72091237,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"9","issue":"1","first_page":"19900","last_page":"19900"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kinesin-5","display_name":"kinesin-5","score":0.9779999852180481},{"id":"https://openalex.org/keywords/eg5","display_name":"Eg5","score":0.9940000176429749},{"id":"https://openalex.org/keywords/allosteric-inhibition","display_name":"allosteric inhibition","score":0.7730000019073486},{"id":"https://openalex.org/keywords/monastrol","display_name":"monastrol","score":0.9929999709129333},{"id":"https://openalex.org/keywords/s-trityl-l-cysteine","display_name":"S-trityl-L-cysteine","score":0.996999979019165},{"id":"https://openalex.org/keywords/mitotic-spindle-assembly","display_name":"mitotic spindle assembly","score":0.9810000061988831},{"id":"https://openalex.org/keywords/monopolar-spindle","display_name":"monopolar spindle","score":0.7099999785423279},{"id":"https://openalex.org/keywords/microtubule-dynamics","display_name":"microtubule dynamics","score":0.9779999852180481},{"id":"https://openalex.org/keywords/spindle-density","display_name":"spindle density","score":0.6740000247955322},{"id":"https://openalex.org/keywords/anticancer-drug-candidates","display_name":"anticancer drug candidates","score":0.6679999828338623}],"concepts":[{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.9192439913749695},{"id":"https://openalex.org/C59006786","wikidata":"https://www.wikidata.org/wiki/Q15319390","display_name":"Kinesin","level":3,"score":0.8602856397628784},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.7732451558113098},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7057927250862122},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.6852681636810303},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.6048692464828491},{"id":"https://openalex.org/C47432576","wikidata":"https://www.wikidata.org/wiki/Q918594","display_name":"Spindle apparatus","level":4,"score":0.5581983327865601},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5507635474205017},{"id":"https://openalex.org/C93126451","wikidata":"https://www.wikidata.org/wiki/Q2383767","display_name":"Motor protein","level":3,"score":0.512196958065033},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.41186538338661194},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2229151427745819},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12175363302230835},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.11643218994140625},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.09100520610809326}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008941","descriptor_name":"Spindle Apparatus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008941","descriptor_name":"Spindle Apparatus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008941","descriptor_name":"Spindle Apparatus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016547","descriptor_name":"Kinesins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016547","descriptor_name":"Kinesins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016547","descriptor_name":"Kinesins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41598-019-56173-9","doi":"https://doi.org/10.1038/s41598-019-56173-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-56173-9","pdf_url":"https://www.nature.com/articles/s41598-019-56173-9.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmid:31882607","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31882607","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6934681","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6934681","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:7ae172d8b93d4e1da1c3a67a531293ed","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/7ae172d8b93d4e1da1c3a67a531293ed","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-019-56173-9","doi":"https://doi.org/10.1038/s41598-019-56173-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-56173-9","pdf_url":"https://www.nature.com/articles/s41598-019-56173-9.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.428600013256073}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.44999998807907104}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1774034284","display_name":null,"funder_award_id":"R01-GM097350","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5061531652","display_name":null,"funder_award_id":"GM097350","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5846430868","display_name":"Chemistry and energy transduction in kinesin motor proteins","funder_award_id":"5r01gm097350-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7404178643","display_name":null,"funder_award_id":"GM097350","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G9000263648","display_name":null,"funder_award_id":"GM097350","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320308380","display_name":"Yale University","ror":"https://ror.org/03v76x132"},{"id":"https://openalex.org/F4320309500","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94"},{"id":"https://openalex.org/F4320309622","display_name":"Harvard University","ror":"https://ror.org/03vek6s52"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2998072139.pdf","grobid_xml":"https://content.openalex.org/works/W2998072139.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W134873815","https://openalex.org/W168435911","https://openalex.org/W1492143208","https://openalex.org/W1507819507","https://openalex.org/W1540070193","https://openalex.org/W1584476685","https://openalex.org/W1966553673","https://openalex.org/W1984678540","https://openalex.org/W1985701763","https://openalex.org/W1988678729","https://openalex.org/W1988887329","https://openalex.org/W1996396451","https://openalex.org/W2004059254","https://openalex.org/W2007557610","https://openalex.org/W2014636427","https://openalex.org/W2017760953","https://openalex.org/W2019912010","https://openalex.org/W2021756912","https://openalex.org/W2029178312","https://openalex.org/W2031137786","https://openalex.org/W2033334357","https://openalex.org/W2034119823","https://openalex.org/W2035472375","https://openalex.org/W2037415133","https://openalex.org/W2043410014","https://openalex.org/W2046320664","https://openalex.org/W2046546361","https://openalex.org/W2048253734","https://openalex.org/W2052132055","https://openalex.org/W2052261649","https://openalex.org/W2055611040","https://openalex.org/W2056605370","https://openalex.org/W2057523896","https://openalex.org/W2072540184","https://openalex.org/W2072656825","https://openalex.org/W2073300793","https://openalex.org/W2073764400","https://openalex.org/W2081963355","https://openalex.org/W2082335806","https://openalex.org/W2092502645","https://openalex.org/W2099540110","https://openalex.org/W2103138603","https://openalex.org/W2107913178","https://openalex.org/W2108376231","https://openalex.org/W2111827360","https://openalex.org/W2122111428","https://openalex.org/W2127754605","https://openalex.org/W2128653554","https://openalex.org/W2133003941","https://openalex.org/W2150888812","https://openalex.org/W2157556274","https://openalex.org/W2167279371","https://openalex.org/W2253382748","https://openalex.org/W2312822969","https://openalex.org/W2345583633","https://openalex.org/W2507815021","https://openalex.org/W2767139098","https://openalex.org/W2805515834","https://openalex.org/W2811082648","https://openalex.org/W2891078642","https://openalex.org/W2954466294","https://openalex.org/W4234257879"],"related_works":["https://openalex.org/W2594034871","https://openalex.org/W2064422190","https://openalex.org/W2028375545","https://openalex.org/W1974345291","https://openalex.org/W2996393376","https://openalex.org/W2017522528","https://openalex.org/W2792289411","https://openalex.org/W2041499140","https://openalex.org/W2001636354","https://openalex.org/W1987849283"],"abstract_inverted_index":{"Human":[0],"Kinesin-5":[1,121],"(Eg5)":[2],"has":[3],"a":[4,78,153,179],"large":[5],"number":[6],"of":[7,18,39,44,70,120,133,142,148,170,186,194],"known":[8],"allosteric":[9,54,146],"inhibitors":[10,17,74,119],"that":[11,35,105,117],"disrupt":[12],"its":[13,162],"mitotic":[14,173,196],"function.":[15,31,155],"Small-molecule":[16],"Eg5":[19,36,62,80,176],"are":[20,89],"candidate":[21],"anti-cancer":[22],"agents":[23],"and":[24,47,59,100,115,189],"important":[25],"probes":[26],"for":[27],"understanding":[28],"the":[29,98,111,130,134,140,168,171,184,192,195],"cellular":[30],"Here":[32],"we":[33],"show":[34],"is":[37],"capable":[38],"more":[40],"than":[41],"one":[42],"type":[43],"microtubule":[45,81,101,112],"interaction,":[46],"these":[48,71],"activities":[49],"can":[50,107],"be":[51,108,125],"controlled":[52],"by":[53],"agents.":[55],"While":[56],"both":[57],"monastrol":[58],"S-trityl-L-cysteine":[60],"inhibit":[61],"motility,":[63,149],"our":[64],"data":[65],"reveal":[66],"an":[67],"unexpected":[68],"ability":[69],"loop5":[72,87],"targeting":[73],"to":[75,91,139,161],"differentially":[76],"control":[77],"novel":[79],"depolymerizing":[82,131],"activity.":[83],"Remarkably,":[84],"small":[85],"molecule":[86],"effectors":[88],"able":[90],"independently":[92],"modulate":[93],"discrete":[94],"functional":[95],"interactions":[96],"between":[97],"motor":[99,135],"track.":[102],"We":[103,156],"establish":[104],"motility":[106],"uncoupled":[109],"from":[110],"depolymerase":[113],"activity":[114,132],"argue":[116],"loop5-targeting":[118],"should":[122],"not":[123,137],"all":[124],"considered":[126],"functionally":[127],"synonymous.":[128],"Also,":[129],"does":[136],"contribute":[138],"genesis":[141],"monopolar":[143],"spindles":[144],"during":[145],"inhibition":[147],"but":[150],"instead":[151],"reveals":[152],"new":[154],"propose":[157],"that,":[158],"in":[159,165,167,182],"addition":[160],"canonical":[163],"role":[164,181],"participating":[166],"construction":[169],"three-dimensional":[172],"spindle":[174],"structure,":[175],"also":[177],"plays":[178],"distinct":[180],"regulating":[183],"dynamics":[185],"individual":[187],"microtubules,":[188],"thereby":[190],"impacts":[191],"density":[193],"spindle.":[197]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}