{"id":"https://openalex.org/W2998069424","doi":"https://doi.org/10.1038/s41578-019-0156-6","title":"Materials for oral delivery of proteins and peptides","display_name":"Materials for oral delivery of proteins and peptides","publication_year":2019,"publication_date":"2019-12-24","ids":{"openalex":"https://openalex.org/W2998069424","doi":"https://doi.org/10.1038/s41578-019-0156-6","mag":"2998069424"},"language":"en","primary_location":{"id":"doi:10.1038/s41578-019-0156-6","doi":"https://doi.org/10.1038/s41578-019-0156-6","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41578-019-0156-6","pdf_url":null,"source":{"id":"https://openalex.org/S2764917516","display_name":"Nature Reviews Materials","issn_l":"2058-8437","issn":["2058-8437"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-1","ki-jl-1","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Materials","raw_type":"journal-article"},"volume":null,"type":"book-review","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071268394","display_name":"Tyler D. Brown","orcid":"https://orcid.org/0000-0003-1752-2174","observed_orcids":["https://orcid.org/0000-0003-1752-2174"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I44142251","display_name":"Wyss Institute for Biologically Inspired Engineering","ror":"https://ror.org/008cfmj78","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tyler D. Brown","raw_affiliation_strings":["John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, USA","Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, USA","John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA","Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA"],"raw_orcid":"https://orcid.org/0000-0003-1752-2174","affiliations":[{"raw_affiliation_string":"John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I44142251"]},{"raw_affiliation_string":"John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010666650","display_name":"Kathryn A. Whitehead","orcid":"https://orcid.org/0000-0002-0100-7824","observed_orcids":["https://orcid.org/0000-0002-0100-7824"]},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathryn A. Whitehead","raw_affiliation_strings":["Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, USA","Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, USA","Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA","Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA"],"raw_orcid":"https://orcid.org/0000-0002-0100-7824","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, USA","institution_ids":["https://openalex.org/I74973139"]},{"raw_affiliation_string":"Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, USA","institution_ids":["https://openalex.org/I74973139"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I74973139"]},{"raw_affiliation_string":"Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I74973139"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087180621","display_name":"Samir Mitragotri","orcid":"https://orcid.org/0000-0002-2459-8305","observed_orcids":["https://orcid.org/0000-0002-2459-8305"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I44142251","display_name":"Wyss Institute for Biologically Inspired Engineering","ror":"https://ror.org/008cfmj78","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samir Mitragotri","raw_affiliation_strings":["John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, USA","Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, USA","John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA","Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA"],"raw_orcid":"https://orcid.org/0000-0002-2459-8305","affiliations":[{"raw_affiliation_string":"John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I44142251"]},{"raw_affiliation_string":"John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":522,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"2","first_page":"127","last_page":"148"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10411","display_name":"Proteins in Food Systems","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oral-protein-delivery","display_name":"oral protein delivery","score":0.9549999833106995},{"id":"https://openalex.org/keywords/oral-peptide-delivery","display_name":"oral peptide delivery","score":0.8009999990463257},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.7630000114440918},{"id":"https://openalex.org/keywords/therapeutic-proteins","display_name":"therapeutic proteins","score":0.6690000295639038},{"id":"https://openalex.org/keywords/drug-delivery-materials","display_name":"drug delivery materials","score":0.5830000042915344},{"id":"https://openalex.org/keywords/translational-research","display_name":"translational research","score":0.5450000166893005}],"concepts":[{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.6516757607460022},{"id":"https://openalex.org/C3019315460","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral route","level":2,"score":0.6354113221168518},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5508501529693604},{"id":"https://openalex.org/C2983812674","wikidata":"https://www.wikidata.org/wiki/Q134808","display_name":"Delivery system","level":2,"score":0.5167574286460876},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.5119069814682007},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.44186657667160034},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.41880857944488525},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.347733736038208},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.10607296228408813}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1038/s41578-019-0156-6","doi":"https://doi.org/10.1038/s41578-019-0156-6","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41578-019-0156-6","pdf_url":null,"source":{"id":"https://openalex.org/S2764917516","display_name":"Nature Reviews Materials","issn_l":"2058-8437","issn":["2058-8437"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-1","ki-jl-1","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Materials","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.6200000047683716}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":293,"referenced_works":["https://openalex.org/W5692000","https://openalex.org/W39672263","https://openalex.org/W165833636","https://openalex.org/W176352299","https://openalex.org/W190556238","https://openalex.org/W258855894","https://openalex.org/W274484008","https://openalex.org/W326473513","https://openalex.org/W605483014","https://openalex.org/W640261019","https://openalex.org/W1207088236","https://openalex.org/W1490299254","https://openalex.org/W1521173508","https://openalex.org/W1535579925","https://openalex.org/W1540828078","https://openalex.org/W1547433582","https://openalex.org/W1555210583","https://openalex.org/W1585404684","https://openalex.org/W1598080651","https://openalex.org/W1611441558","https://openalex.org/W1807009022","https://openalex.org/W1829747289","https://openalex.org/W1844725082","https://openalex.org/W1858567345","https://openalex.org/W1880932432","https://openalex.org/W1961169379","https://openalex.org/W1963564206","https://openalex.org/W1963901992","https://openalex.org/W1965682482","https://openalex.org/W1965884363","https://openalex.org/W1966849003","https://openalex.org/W1967017848","https://openalex.org/W1967260264","https://openalex.org/W1969205895","https://openalex.org/W1970057581","https://openalex.org/W1970272416","https://openalex.org/W1973323385","https://openalex.org/W1973696609","https://openalex.org/W1974467009","https://openalex.org/W1979749715","https://openalex.org/W1980279815","https://openalex.org/W1981330980","https://openalex.org/W1982181595","https://openalex.org/W1983386052","https://openalex.org/W1984294723","https://openalex.org/W1986477299","https://openalex.org/W1987324444","https://openalex.org/W1987625267","https://openalex.org/W1988208849","https://openalex.org/W1988644249","https://openalex.org/W1989513078","https://openalex.org/W1989654577","https://openalex.org/W1992111884","https://openalex.org/W1992759633","https://openalex.org/W1993753740","https://openalex.org/W1994294415","https://openalex.org/W1994304349","https://openalex.org/W1995013658","https://openalex.org/W1998624966","https://openalex.org/W1998938973","https://openalex.org/W2002370686","https://openalex.org/W2003097465","https://openalex.org/W2004312574","https://openalex.org/W2004470087","https://openalex.org/W2004735852","https://openalex.org/W2005700263","https://openalex.org/W2006584531","https://openalex.org/W2007539416","https://openalex.org/W2008471973","https://openalex.org/W2008561295","https://openalex.org/W2008770690","https://openalex.org/W2009942061","https://openalex.org/W2010235956","https://openalex.org/W2010365195","https://openalex.org/W2010665051","https://openalex.org/W2011189203","https://openalex.org/W2014442937","https://openalex.org/W2017529559","https://openalex.org/W2017853225","https://openalex.org/W2018445772","https://openalex.org/W2018827358","https://openalex.org/W2019495164","https://openalex.org/W2021797926","https://openalex.org/W2021930046","https://openalex.org/W2022369464","https://openalex.org/W2023755664","https://openalex.org/W2024510872","https://openalex.org/W2024903800","https://openalex.org/W2025099749","https://openalex.org/W2025678616","https://openalex.org/W2025954862","https://openalex.org/W2026558129","https://openalex.org/W2030620248","https://openalex.org/W2032195777","https://openalex.org/W2032222317","https://openalex.org/W2033439047","https://openalex.org/W2034014716","https://openalex.org/W2034858937","https://openalex.org/W2036459378","https://openalex.org/W2036573647","https://openalex.org/W2038299379","https://openalex.org/W2038323484","https://openalex.org/W2039388013","https://openalex.org/W2040309080","https://openalex.org/W2041711980","https://openalex.org/W2041977189","https://openalex.org/W2043079937","https://openalex.org/W2044210368","https://openalex.org/W2044883396","https://openalex.org/W2045978260","https://openalex.org/W2047183738","https://openalex.org/W2047419112","https://openalex.org/W2047683507","https://openalex.org/W2047796161","https://openalex.org/W2048893269","https://openalex.org/W2052157194","https://openalex.org/W2053090377","https://openalex.org/W2053236035","https://openalex.org/W2053960742","https://openalex.org/W2055037481","https://openalex.org/W2055289694","https://openalex.org/W2056169693","https://openalex.org/W2057771413","https://openalex.org/W2057883890","https://openalex.org/W2058577193","https://openalex.org/W2059465562","https://openalex.org/W2059648852","https://openalex.org/W2059865269","https://openalex.org/W2062853793","https://openalex.org/W2063276424","https://openalex.org/W2064033300","https://openalex.org/W2064458171","https://openalex.org/W2065254628","https://openalex.org/W2066222405","https://openalex.org/W2066685510","https://openalex.org/W2066709066","https://openalex.org/W2069202991","https://openalex.org/W2070517405","https://openalex.org/W2070808114","https://openalex.org/W2071087850","https://openalex.org/W2072419850","https://openalex.org/W2077179773","https://openalex.org/W2077485813","https://openalex.org/W2078015189","https://openalex.org/W2078647601","https://openalex.org/W2081006702","https://openalex.org/W2081664500","https://openalex.org/W2083198165","https://openalex.org/W2083306884","https://openalex.org/W2084630731","https://openalex.org/W2085361723","https://openalex.org/W2085387111","https://openalex.org/W2087778274","https://openalex.org/W2088382816","https://openalex.org/W2088694674","https://openalex.org/W2089594946","https://openalex.org/W2091532737","https://openalex.org/W2091908005","https://openalex.org/W2094577650","https://openalex.org/W2095266942","https://openalex.org/W2095298038","https://openalex.org/W2095552493","https://openalex.org/W2097519121","https://openalex.org/W2097603366","https://openalex.org/W2100672979","https://openalex.org/W2103011143","https://openalex.org/W2105968451","https://openalex.org/W2108042351","https://openalex.org/W2110476766","https://openalex.org/W2112331652","https://openalex.org/W2117279110","https://openalex.org/W2119784812","https://openalex.org/W2120812026","https://openalex.org/W2126694067","https://openalex.org/W2126906532","https://openalex.org/W2131469970","https://openalex.org/W2133449485","https://openalex.org/W2134625581","https://openalex.org/W2137543384","https://openalex.org/W2142010926","https://openalex.org/W2142096612","https://openalex.org/W2144644090","https://openalex.org/W2145189896","https://openalex.org/W2145870791","https://openalex.org/W2148228852","https://openalex.org/W2150374080","https://openalex.org/W2153392360","https://openalex.org/W2158038344","https://openalex.org/W2162919306","https://openalex.org/W2165182780","https://openalex.org/W2166458266","https://openalex.org/W2170641162","https://openalex.org/W2178935826","https://openalex.org/W2197456826","https://openalex.org/W2216174252","https://openalex.org/W2228716042","https://openalex.org/W2260255165","https://openalex.org/W2261104477","https://openalex.org/W2265200464","https://openalex.org/W2281837728","https://openalex.org/W2290824142","https://openalex.org/W2298343040","https://openalex.org/W2320853086","https://openalex.org/W2324661394","https://openalex.org/W2330963211","https://openalex.org/W2394545821","https://openalex.org/W2408908640","https://openalex.org/W2413938766","https://openalex.org/W2414365196","https://openalex.org/W2422625570","https://openalex.org/W2442713952","https://openalex.org/W2463479819","https://openalex.org/W2463562243","https://openalex.org/W2465854659","https://openalex.org/W2478226370","https://openalex.org/W2490281913","https://openalex.org/W2538425024","https://openalex.org/W2539107597","https://openalex.org/W2553064235","https://openalex.org/W2556998674","https://openalex.org/W2558677829","https://openalex.org/W2566202925","https://openalex.org/W2567619704","https://openalex.org/W2577478589","https://openalex.org/W2578529686","https://openalex.org/W2580018907","https://openalex.org/W2593206170","https://openalex.org/W2594508345","https://openalex.org/W2604190474","https://openalex.org/W2605203575","https://openalex.org/W2608157931","https://openalex.org/W2615117811","https://openalex.org/W2736653872","https://openalex.org/W2738491178","https://openalex.org/W2738548558","https://openalex.org/W2753692261","https://openalex.org/W2754189939","https://openalex.org/W2754233839","https://openalex.org/W2756294810","https://openalex.org/W2765425655","https://openalex.org/W2775703306","https://openalex.org/W2781350987","https://openalex.org/W2788372277","https://openalex.org/W2789991725","https://openalex.org/W2792131027","https://openalex.org/W2792969792","https://openalex.org/W2793485037","https://openalex.org/W2794370011","https://openalex.org/W2801765418","https://openalex.org/W2805646166","https://openalex.org/W2805833715","https://openalex.org/W2807594408","https://openalex.org/W2808474537","https://openalex.org/W2808747546","https://openalex.org/W2809183137","https://openalex.org/W2809484572","https://openalex.org/W2809789630","https://openalex.org/W2810098751","https://openalex.org/W2810749858","https://openalex.org/W2813742493","https://openalex.org/W2883284633","https://openalex.org/W2884848444","https://openalex.org/W2887767966","https://openalex.org/W2891265575","https://openalex.org/W2892150973","https://openalex.org/W2896249671","https://openalex.org/W2896578268","https://openalex.org/W2900887638","https://openalex.org/W2901306081","https://openalex.org/W2901440033","https://openalex.org/W2904942504","https://openalex.org/W2910866765","https://openalex.org/W2911680209","https://openalex.org/W2911904767","https://openalex.org/W2912754726","https://openalex.org/W2913582983","https://openalex.org/W2917960454","https://openalex.org/W2921161313","https://openalex.org/W2922550132","https://openalex.org/W2924479779","https://openalex.org/W2930165044","https://openalex.org/W2932460700","https://openalex.org/W2936474387","https://openalex.org/W2942084191","https://openalex.org/W2944166343","https://openalex.org/W2948622224","https://openalex.org/W2968903369","https://openalex.org/W2981882748","https://openalex.org/W2987932370","https://openalex.org/W3012487927","https://openalex.org/W3022404008","https://openalex.org/W4211185542","https://openalex.org/W4248926061"],"related_works":["https://openalex.org/W7220320492","https://openalex.org/W7142078185","https://openalex.org/W2162139246","https://openalex.org/W3083070838","https://openalex.org/W1994971111","https://openalex.org/W4413510438","https://openalex.org/W254612597","https://openalex.org/W4384297342","https://openalex.org/W2348763949","https://openalex.org/W3196702547"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":64},{"year":2025,"cited_by_count":102},{"year":2024,"cited_by_count":84},{"year":2023,"cited_by_count":84},{"year":2022,"cited_by_count":74},{"year":2021,"cited_by_count":79},{"year":2020,"cited_by_count":35}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-01-10T00:00:00"}