{"id":"https://openalex.org/W2998055004","doi":null,"title":"[ADHERENCE TO ORAL ANTI-CANCER DRUGS IN HEMATO-ONCOLOGY].","display_name":"[ADHERENCE TO ORAL ANTI-CANCER DRUGS IN HEMATO-ONCOLOGY].","publication_year":2017,"publication_date":"2017-04-01","ids":{"openalex":"https://openalex.org/W2998055004","mag":"2998055004","pmid":"https://pubmed.ncbi.nlm.nih.gov/28551924"},"language":"en","primary_location":{"id":"pmid:28551924","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28551924","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Harefuah","raw_type":"Case Reports"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Sarit Ashkenazi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800389475","display_name":"Rabin Medical Center","ror":"https://ror.org/01vjtf564","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800389475","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Sarit Ashkenazi","raw_affiliation_strings":["Hematology Institute, Beilinson Hospital, Rabin Medical Center, Petach Tikva, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Institute, Beilinson Hospital, Rabin Medical Center, Petach Tikva, Israel","institution_ids":["https://openalex.org/I2800389475"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023480958","display_name":"Juliet Dreyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800389475","display_name":"Rabin Medical Center","ror":"https://ror.org/01vjtf564","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800389475","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Juliet Dreyer","raw_affiliation_strings":["Nursing, Davidoff Cancer Center, Beilinson Hospital, Rabin Medical Center, Petach Tikva, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nursing, Davidoff Cancer Center, Beilinson Hospital, Rabin Medical Center, Petach Tikva, Israel","institution_ids":["https://openalex.org/I2800389475"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086557065","display_name":"Pia Raanani","orcid":"https://orcid.org/0000-0001-9973-639X","observed_orcids":["https://orcid.org/0000-0001-9973-639X"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2800389475","display_name":"Rabin Medical Center","ror":"https://ror.org/01vjtf564","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800389475","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Pia Raanani","raw_affiliation_strings":["Hematology Institute, Beilinson Hospital, Rabin Medical Center, Petach Tikva, Israel","Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Institute, Beilinson Hospital, Rabin Medical Center, Petach Tikva, Israel","institution_ids":["https://openalex.org/I2800389475"]},{"raw_affiliation_string":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046708642","display_name":"Avi Leader","orcid":"https://orcid.org/0000-0003-2245-345X","observed_orcids":["https://orcid.org/0000-0003-2245-345X"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2800389475","display_name":"Rabin Medical Center","ror":"https://ror.org/01vjtf564","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800389475","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Avi Leader","raw_affiliation_strings":["Hematology Institute, Beilinson Hospital, Rabin Medical Center, Petach Tikva, Israel","Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Institute, Beilinson Hospital, Rabin Medical Center, Petach Tikva, Israel","institution_ids":["https://openalex.org/I2800389475"]},{"raw_affiliation_string":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2957,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.67238494,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"156","issue":"4","first_page":"254","last_page":"258"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11620","display_name":"Medication Adherence and Compliance","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2714","display_name":"Family Practice"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11620","display_name":"Medication Adherence and Compliance","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2714","display_name":"Family Practice"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13970","display_name":"Pharmacy and Medical Practices","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/3611","display_name":"Pharmacy"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10178","display_name":"Cancer survivorship and care","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.8349999785423279},{"id":"https://openalex.org/keywords/noncompliance","display_name":"non-compliance","score":0.7960000038146973},{"id":"https://openalex.org/keywords/oral-anticancer-drugs","display_name":"oral anticancer drugs","score":0.9789999723434448},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.7960000038146973},{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.9950000047683716},{"id":"https://openalex.org/keywords/imatinib","display_name":"imatinib","score":0.9789999723434448},{"id":"https://openalex.org/keywords/dasatinib","display_name":"dasatinib","score":1.0},{"id":"https://openalex.org/keywords/electronic-medication-monitoring","display_name":"electronic medication monitoring","score":0.6850000023841858},{"id":"https://openalex.org/keywords/adherence-interventions","display_name":"adherence interventions","score":0.6520000100135803},{"id":"https://openalex.org/keywords/patient-education","display_name":"patient education","score":0.7710000276565552},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.5879999995231628},{"id":"https://openalex.org/keywords/barriers-to-adherence","display_name":"barriers to adherence","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9482522010803223},{"id":"https://openalex.org/C2779536868","wikidata":"https://www.wikidata.org/wiki/Q419940","display_name":"Dasatinib","level":4,"score":0.7104111313819885},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5775004625320435},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5642574429512024},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.5432513952255249},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5192063450813293},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.48737794160842896},{"id":"https://openalex.org/C2777413986","wikidata":"https://www.wikidata.org/wiki/Q412327","display_name":"Nilotinib","level":4,"score":0.4859660863876343},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.44269484281539917},{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.4084378182888031},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35768431425094604},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3283115327358246},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.2758479118347168},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.12219220399856567},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.10941845178604126},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069439","descriptor_name":"Dasatinib","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055118","descriptor_name":"Medication Adherence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:28551924","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28551924","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Harefuah","raw_type":"Case Reports"},{"id":"mag:2998055004","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28551924","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2132696690","https://openalex.org/W1982375833","https://openalex.org/W1562209281","https://openalex.org/W2067050055","https://openalex.org/W1495547312","https://openalex.org/W1867518657","https://openalex.org/W4391032298","https://openalex.org/W2966636228","https://openalex.org/W1995705474","https://openalex.org/W2168618337"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Non-adherence":[1],"to":[2,22,42,52,60,73,120,135,222,224],"medical":[3,61],"treatment":[4,13,48,62,92,211],"is":[5,63],"prevalent":[6],"in":[7,31,46,81,103,154,164,181,207,213],"the":[8,43,66,114,175,218],"context":[9],"of":[10,20,33,58,89,97,116,118,127,167,183,191,204],"potentially":[11],"life-saving":[12],"for":[14],"diseases":[15],"such":[16],"as":[17],"cancer.":[18],"Estimates":[19],"non-adherence":[21,72,143,223],"oral":[23,53,121],"anti-cancer":[24,47,54],"therapy":[25],"range":[26],"between":[27],"27%":[28],"and":[29,95,150,170,194,210],"63%":[30],"studies":[32],"cancer":[34],"patients.":[35],"This":[36,216],"represents":[37],"a":[38,75,192],"growing":[39],"challenge,":[40],"due":[41],"paradigm":[44],"shift":[45],"from":[49],"parenteral":[50],"chemotherapy":[51],"drugs.":[55],"The":[56,107],"importance":[57],"adherence":[59,119,209],"highlighted":[64],"by":[65,100,146,174],"World":[67],"Health":[68],"Organization":[69],"which":[70,153,185],"considers":[71],"be":[74],"major":[76],"public":[77],"health":[78],"concern.":[79],"Studies":[80],"several":[82],"malignancies":[83],"have":[84,157],"shown":[85],"an":[86,101,125,128],"adverse":[87],"effect":[88],"nonadherence":[90],"on":[91,201],"response,":[93],"survival":[94],"quality":[96],"life,":[98],"accompanied":[99],"increase":[102],"health-care":[104],"related":[105],"costs.":[106],"clinical":[108],"vignette":[109],"accompanying":[110],"this":[111,214],"review":[112],"demonstrates":[113],"complexity":[115],"management":[117,166,173],"anticancer":[122],"therapy,":[123],"through":[124],"example":[126],"elderly":[129],"chronic":[130],"myeloid":[131],"leukemia":[132],"patient,":[133],"non-adherent":[134],"serial":[136],"tyrosine":[137],"kinase":[138],"inhibitors":[139],"(imatinib,":[140],"dasatinib).":[141],"Her":[142],"was":[144,186],"explained":[145],"subtle":[147],"socio-demographic,":[148],"patient-related":[149],"treatment-related":[151],"factors,":[152],"hindsight":[155],"could":[156],"already":[158],"been":[159],"identified":[160],"at":[161],"diagnosis,":[162],"resulting":[163],"preemptive":[165],"these":[168],"barriers":[169],"adherence.":[171],"Routine":[172],"hematologist,":[176],"using":[177],"education":[178],"alone":[179],"resulted":[180,206],"improvement":[182],"adherence,":[184,205],"predictably":[187],"short-lived.":[188],"Our":[189],"use":[190],"multilevel":[193],"multidisciplinary":[195],"adherence-enhancing":[196],"intervention,":[197],"incorporating":[198],"feedback":[199],"based":[200],"electronic":[202],"monitoring":[203],"improved":[208],"response":[212],"patient.":[215],"exemplifies":[217],"contemporary":[219],"evidence-based":[220],"approach":[221],"oral-anticancer":[225],"therapy.":[226]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-01-10T00:00:00"}