{"id":"https://openalex.org/W2998043395","doi":"https://doi.org/10.1038/s41598-019-56824-x","title":"Characterization of IL-10-producing neutrophils in cattle infected with Ostertagia ostertagi","display_name":"Characterization of IL-10-producing neutrophils in cattle infected with Ostertagia ostertagi","publication_year":2019,"publication_date":"2019-12-30","ids":{"openalex":"https://openalex.org/W2998043395","doi":"https://doi.org/10.1038/s41598-019-56824-x","mag":"2998043395","pmid":"https://pubmed.ncbi.nlm.nih.gov/31889109","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6937330"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-019-56824-x","doi":"https://doi.org/10.1038/s41598-019-56824-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-56824-x","pdf_url":"https://www.nature.com/articles/s41598-019-56824-x.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-019-56824-x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Lei Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lei Li","raw_affiliation_strings":["Department of Avian and Animal Sciences, University of Maryland, College Park, MD, 20742, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Avian and Animal Sciences, University of Maryland, College Park, MD, 20742, USA","institution_ids":["https://openalex.org/I66946132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070094506","display_name":"Hongbin Si","orcid":"https://orcid.org/0000-0002-0416-6150","observed_orcids":["https://orcid.org/0000-0002-0416-6150","https://orcid.org/0009-0000-4508-6264"]},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongbin Si","raw_affiliation_strings":["Department of Avian and Animal Sciences, University of Maryland, College Park, MD, 20742, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Avian and Animal Sciences, University of Maryland, College Park, MD, 20742, USA","institution_ids":["https://openalex.org/I66946132"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shu-Wei Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shu-Wei Wu","raw_affiliation_strings":["Department of Avian and Animal Sciences, University of Maryland, College Park, MD, 20742, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Avian and Animal Sciences, University of Maryland, College Park, MD, 20742, USA","institution_ids":["https://openalex.org/I66946132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059107762","display_name":"Jonatan Mendez","orcid":"https://orcid.org/0000-0003-1408-9686","observed_orcids":["https://orcid.org/0000-0003-1408-9686"]},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonatan Orangel Mendez","raw_affiliation_strings":["Department of Avian and Animal Sciences, University of Maryland, College Park, MD, 20742, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Avian and Animal Sciences, University of Maryland, College Park, MD, 20742, USA","institution_ids":["https://openalex.org/I66946132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007656010","display_name":"Dante S. Zarlenga","orcid":"https://orcid.org/0000-0002-8845-1724","observed_orcids":["https://orcid.org/0000-0002-8845-1724"]},"institutions":[{"id":"https://openalex.org/I1312222531","display_name":"Agricultural Research Service","ror":"https://ror.org/02d2m2044","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I1336096307","display_name":"United States Department of Agriculture","ror":"https://ror.org/01na82s61","country_code":"US","type":"government","lineage":["https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I4210125976","display_name":"Beltsville Agricultural Research Center","ror":"https://ror.org/03b08sh51","country_code":"US","type":"facility","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210125976","https://openalex.org/I4210138094"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dante Zarlenga","raw_affiliation_strings":["Animal Parasitic Diseases Laboratory, USDA/ARS, Beltsville, MD, 20705, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Animal Parasitic Diseases Laboratory, USDA/ARS, Beltsville, MD, 20705, USA","institution_ids":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210125976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021827662","display_name":"Wenbin Tuo","orcid":"https://orcid.org/0000-0002-3764-8981","observed_orcids":["https://orcid.org/0000-0002-3764-8981"]},"institutions":[{"id":"https://openalex.org/I1312222531","display_name":"Agricultural Research Service","ror":"https://ror.org/02d2m2044","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I1336096307","display_name":"United States Department of Agriculture","ror":"https://ror.org/01na82s61","country_code":"US","type":"government","lineage":["https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I4210125976","display_name":"Beltsville Agricultural Research Center","ror":"https://ror.org/03b08sh51","country_code":"US","type":"facility","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210125976","https://openalex.org/I4210138094"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wenbin Tuo","raw_affiliation_strings":["Animal Parasitic Diseases Laboratory, USDA/ARS, Beltsville, MD, 20705, USA. wenbin.tuo@ars.usda.gov","Animal Parasitic Diseases Laboratory, USDA/ARS, Beltsville, MD, 20705, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Animal Parasitic Diseases Laboratory, USDA/ARS, Beltsville, MD, 20705, USA. wenbin.tuo@ars.usda.gov","institution_ids":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210125976"]},{"raw_affiliation_string":"Animal Parasitic Diseases Laboratory, USDA/ARS, Beltsville, MD, 20705, USA","institution_ids":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210125976"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044827559","display_name":"Zhengguo Xiao","orcid":"https://orcid.org/0000-0002-3359-6491","observed_orcids":["https://orcid.org/0000-0002-3359-6491"]},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zhengguo Xiao","raw_affiliation_strings":["Department of Avian and Animal Sciences, University of Maryland, College Park, MD, 20742, USA. xiao0028@umd.edu","Department of Avian and Animal Sciences, University of Maryland, College Park, MD, 20742, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Avian and Animal Sciences, University of Maryland, College Park, MD, 20742, USA. xiao0028@umd.edu","institution_ids":["https://openalex.org/I66946132"]},{"raw_affiliation_string":"Department of Avian and Animal Sciences, University of Maryland, College Park, MD, 20742, USA","institution_ids":["https://openalex.org/I66946132"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5021827662","https://openalex.org/A5044827559"],"corresponding_institution_ids":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210125976","https://openalex.org/I66946132"],"apc_list":{"value":1790,"currency":"USD","value_usd":1790},"apc_paid":{"value":1790,"currency":"USD","value_usd":1790},"fwci":2.6344,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.88434257,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"9","issue":"1","first_page":"20292","last_page":"20292"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11074","display_name":"Helminth infection and control","score":0.9023000001907349,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11074","display_name":"Helminth infection and control","score":0.9023000001907349,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.03720000013709068,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12322","display_name":"Animal health and immunology","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9580000042915344},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.9890000224113464},{"id":"https://openalex.org/keywords/ostertagia-ostertagi","display_name":"Ostertagia ostertagi","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cattle","display_name":"cattle","score":0.6650000214576721},{"id":"https://openalex.org/keywords/gastrointestinal-nematode-infection","display_name":"gastrointestinal nematode infection","score":0.7820000052452087},{"id":"https://openalex.org/keywords/mhc-class-ii-expression","display_name":"MHC class II expression","score":0.8019999861717224},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.9539999961853027},{"id":"https://openalex.org/keywords/cd4-t-cell-activation","display_name":"CD4+ T cell activation","score":0.9380000233650208},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.6420000195503235},{"id":"https://openalex.org/keywords/host-parasite-interactions","display_name":"host-parasite interactions","score":0.609000027179718},{"id":"https://openalex.org/keywords/spleen","display_name":"spleen","score":0.5040000081062317},{"id":"https://openalex.org/keywords/abomasal-lymph-nodes","display_name":"abomasal lymph nodes","score":0.6470000147819519},{"id":"https://openalex.org/keywords/immune-priming","display_name":"immune priming","score":0.48500001430511475}],"concepts":[{"id":"https://openalex.org/C2779904531","wikidata":"https://www.wikidata.org/wiki/Q901112","display_name":"Ostertagia ostertagi","level":3,"score":0.8194116353988647},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7221658825874329},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.6180242300033569},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5934686660766602},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5920006036758423},{"id":"https://openalex.org/C2778814158","wikidata":"https://www.wikidata.org/wiki/Q959350","display_name":"MHC class II","level":4,"score":0.4662054777145386},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.44827601313591003},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.43523871898651123},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.43475142121315},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4234263598918915},{"id":"https://openalex.org/C165901193","wikidata":"https://www.wikidata.org/wiki/Q3129936","display_name":"Helminths","level":2,"score":0.07255598902702332}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000949","descriptor_name":"Histocompatibility Antigens Class II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000949","descriptor_name":"Histocompatibility Antigens Class II","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006790","descriptor_name":"Host-Parasite Interactions","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008221","descriptor_name":"Lymphoid Tissue","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008221","descriptor_name":"Lymphoid Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008221","descriptor_name":"Lymphoid Tissue","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010028","descriptor_name":"Ostertagia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010029","descriptor_name":"Ostertagiasis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010029","descriptor_name":"Ostertagiasis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010029","descriptor_name":"Ostertagiasis","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":true},{"descriptor_ui":"D010029","descriptor_name":"Ostertagiasis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41598-019-56824-x","doi":"https://doi.org/10.1038/s41598-019-56824-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-56824-x","pdf_url":"https://www.nature.com/articles/s41598-019-56824-x.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5899579","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6937330","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6937330","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6937330","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:31889109","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31889109","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:8127bfe8523d4d628d07e87f042a6487","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/8127bfe8523d4d628d07e87f042a6487","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-019-56824-x","doi":"https://doi.org/10.1038/s41598-019-56824-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-56824-x","pdf_url":"https://www.nature.com/articles/s41598-019-56824-x.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4456116288","display_name":null,"funder_award_id":"GRANT12684386","funder_id":"https://openalex.org/F4320332299","funder_display_name":"National Institute of Food and Agriculture"},{"id":"https://openalex.org/G5206309906","display_name":null,"funder_award_id":"GRANT11885997","funder_id":"https://openalex.org/F4320306114","funder_display_name":"U.S. Department of Agriculture"},{"id":"https://openalex.org/G5526659612","display_name":null,"funder_award_id":"GRANT11885997","funder_id":"https://openalex.org/F4320332299","funder_display_name":"National Institute of Food and Agriculture"},{"id":"https://openalex.org/G6553644680","display_name":null,"funder_award_id":"GRANT12684386","funder_id":"https://openalex.org/F4320306114","funder_display_name":"U.S. Department of Agriculture"},{"id":"https://openalex.org/G8742911249","display_name":null,"funder_award_id":"11885997","funder_id":"https://openalex.org/F4320332299","funder_display_name":"National Institute of Food and Agriculture"}],"funders":[{"id":"https://openalex.org/F4320306114","display_name":"U.S. Department of Agriculture","ror":"https://ror.org/01na82s61"},{"id":"https://openalex.org/F4320332299","display_name":"National Institute of Food and Agriculture","ror":"https://ror.org/05qx3fv49"},{"id":"https://openalex.org/F4320332605","display_name":"Agricultural Research Service","ror":"https://ror.org/02d2m2044"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2998043395.pdf","grobid_xml":"https://content.openalex.org/works/W2998043395.grobid-xml"},"referenced_works_count":99,"referenced_works":["https://openalex.org/W15859992","https://openalex.org/W125106425","https://openalex.org/W187946142","https://openalex.org/W318642571","https://openalex.org/W1493811903","https://openalex.org/W1547450219","https://openalex.org/W1591426856","https://openalex.org/W1593256488","https://openalex.org/W1880663945","https://openalex.org/W1940802809","https://openalex.org/W1965207971","https://openalex.org/W1965209950","https://openalex.org/W1966799741","https://openalex.org/W1968217509","https://openalex.org/W1970771177","https://openalex.org/W1974142498","https://openalex.org/W1974918642","https://openalex.org/W1979243353","https://openalex.org/W1982691990","https://openalex.org/W1983269394","https://openalex.org/W1983805572","https://openalex.org/W1989206630","https://openalex.org/W1990066995","https://openalex.org/W1993410470","https://openalex.org/W1994208003","https://openalex.org/W1996794676","https://openalex.org/W2001328992","https://openalex.org/W2001710332","https://openalex.org/W2003386935","https://openalex.org/W2004037340","https://openalex.org/W2007932330","https://openalex.org/W2010029728","https://openalex.org/W2011310819","https://openalex.org/W2016862474","https://openalex.org/W2020373191","https://openalex.org/W2020527944","https://openalex.org/W2023491212","https://openalex.org/W2023751929","https://openalex.org/W2026110882","https://openalex.org/W2027830774","https://openalex.org/W2032227357","https://openalex.org/W2034866848","https://openalex.org/W2036474409","https://openalex.org/W2036597538","https://openalex.org/W2038659816","https://openalex.org/W2039025802","https://openalex.org/W2041266914","https://openalex.org/W2051449873","https://openalex.org/W2053691846","https://openalex.org/W2062187636","https://openalex.org/W2062429797","https://openalex.org/W2072211198","https://openalex.org/W2074038874","https://openalex.org/W2078532650","https://openalex.org/W2080462805","https://openalex.org/W2082937218","https://openalex.org/W2086871484","https://openalex.org/W2087428144","https://openalex.org/W2089333681","https://openalex.org/W2089385363","https://openalex.org/W2090922043","https://openalex.org/W2094957782","https://openalex.org/W2113107507","https://openalex.org/W2119168502","https://openalex.org/W2123448870","https://openalex.org/W2124904564","https://openalex.org/W2140368744","https://openalex.org/W2140473547","https://openalex.org/W2140909488","https://openalex.org/W2142495846","https://openalex.org/W2148420646","https://openalex.org/W2152864702","https://openalex.org/W2154646372","https://openalex.org/W2160117150","https://openalex.org/W2160527024","https://openalex.org/W2166210236","https://openalex.org/W2166864086","https://openalex.org/W2169195750","https://openalex.org/W2295956362","https://openalex.org/W2324198342","https://openalex.org/W2324918089","https://openalex.org/W2334060217","https://openalex.org/W2362101403","https://openalex.org/W2401898117","https://openalex.org/W2528492033","https://openalex.org/W2566439988","https://openalex.org/W2578607799","https://openalex.org/W2583496887","https://openalex.org/W2677983758","https://openalex.org/W2763796455","https://openalex.org/W2794125535","https://openalex.org/W2885360757","https://openalex.org/W2897255155","https://openalex.org/W2903473991","https://openalex.org/W2971859264","https://openalex.org/W2983216927","https://openalex.org/W4251039585","https://openalex.org/W4300633276","https://openalex.org/W4313331172"],"related_works":["https://openalex.org/W2087428144","https://openalex.org/W3170380387","https://openalex.org/W2093511940","https://openalex.org/W2324198342","https://openalex.org/W2020725350","https://openalex.org/W3134656240","https://openalex.org/W2059582853","https://openalex.org/W1593256488","https://openalex.org/W2047616239","https://openalex.org/W4313381240"],"abstract_inverted_index":{"IL-10":[0,71,128,153,196,263,280],"is":[1,47,256,264],"a":[2,29,162],"master":[3],"regulator":[4],"of":[5,20,56,89,115,142,179,205,212,219,253],"immune":[6,21,77,235,292],"responses,":[7],"but":[8],"its":[9],"cellular":[10],"source":[11],"and":[12,51,94,121,126,154,228,239,278,286,294],"function":[13,204],"in":[14,34,40,92,95,118,136,158,161,171,216,267,271],"cattle":[15,172],"during":[16],"the":[17,35,74,87,100,116,119,202,217,233,251,257],"initial":[18,64],"phase":[19],"priming":[22],"have":[23],"not":[24],"been":[25],"well":[26],"established.":[27],"Despite":[28],"massive":[30],"B":[31,68,105],"cell":[32,193,269],"response":[33],"abomasal":[36],"draining":[37],"lymph":[38],"nodes":[39],"Ostertagia":[41],"ostertagi":[42],"(OO)-infected":[43],"cattle,":[44],"protective":[45,76],"immunity":[46],"slow":[48],"to":[49,113,149,190,231,250,259,289],"develop,":[50],"partial":[52],"protection":[53],"requires":[54],"years":[55],"repeated":[57],"exposure.":[58],"In":[59,109,139],"addressing":[60],"this":[61],"problem,":[62],"our":[63,80,254],"hypothesis":[65],"was":[66],"that":[67,72,83,131,146,223,261,276],"cells":[69,91,106,160,188,215],"produce":[70],"downregulates":[73],"host":[75,291],"response.":[78,236],"However,":[79],"results":[81],"showed":[82],"neutrophils":[84,117,132,144,169,181,277],"made":[85],"up":[86],"majority":[88],"IL-10-producing":[90,104],"circulation":[93],"secondary":[96],"lymphoid":[97],"tissues,":[98],"particularly":[99],"spleen":[101,122],"(80%).":[102],"Conversely,":[103],"were":[107,127,241],"rare.":[108],"addition,":[110],"approximately":[111],"10%":[112],"20%":[114],"blood":[120],"expressed":[123],"MHC":[124,155],"II":[125,156],"negative,":[129],"suggesting":[130,222],"could":[133],"also":[134],"participate":[135],"antigen":[137],"presentation.":[138],"vitro":[140],"investigation":[141],"bovine":[143,234],"revealed":[145],"exposure":[147],"thereof":[148],"OO":[150,176,207,224],"extract":[151,208],"increased":[152],"expression":[157],"these":[159],"dose-dependent":[163],"manner,":[164],"consistent":[165],"with":[166,182,198],"IL-10+/MHC":[167],"II+":[168],"detected":[170],"shortly":[173],"after":[174],"experimental":[175],"infection.":[177],"Co-culture":[178],"untreated":[180],"anti-CD3":[183],"antibody":[184],"(Ab)-stimulated":[185],"CD4+":[186,213],"T":[187,192,214,244,268],"led":[189],"enhanced":[191,201],"activation;":[194],"also,":[195],"depletion":[197],"neutralizing":[199],"Ab":[200],"stimulatory":[203],"neutrophils.":[206],"depressed":[209],"neutrophil":[210,246],"stimulation":[211],"presence":[218],"IL-10-neutralizing":[220],"Ab,":[221],"utilizes":[225],"both":[226],"IL-10-dependent":[227],"independent":[229],"mechanisms":[230],"manipulate":[232],"Finally,":[237],"contact":[238],"viability":[240],"required":[242],"for":[243],"cell-stimulatory":[245],"function.":[247],"This":[248],"report,":[249],"best":[252],"knowledge,":[255],"first":[258],"demonstrate":[260],"neutrophil-derived":[262,279],"directly":[265],"involved":[266],"regulation":[270],"cattle.":[272],"Our":[273],"data":[274],"suggest":[275],"are":[281],"co-opted":[282],"by":[283],"nematode":[284],"parasites":[285],"other":[287],"pathogens":[288],"attenuate":[290],"responses":[293],"facilitate":[295],"pathogen":[296],"survival.":[297]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-01-10T00:00:00"}