{"id":"https://openalex.org/W2998025834","doi":"https://doi.org/10.1016/j.cgh.2019.12.014","title":"Systematic Review and External Validation of Prediction Models Based on Symptoms and Biomarkers for Identifying Endoscopic Activity in Crohn's Disease","display_name":"Systematic Review and External Validation of Prediction Models Based on Symptoms and Biomarkers for Identifying Endoscopic Activity in Crohn's Disease","publication_year":2019,"publication_date":"2019-12-24","ids":{"openalex":"https://openalex.org/W2998025834","doi":"https://doi.org/10.1016/j.cgh.2019.12.014","mag":"2998025834","pmid":"https://pubmed.ncbi.nlm.nih.gov/31881273"},"language":"en","primary_location":{"id":"doi:10.1016/j.cgh.2019.12.014","doi":"https://doi.org/10.1016/j.cgh.2019.12.014","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cgh.2019.12.014","pdf_url":null,"source":{"id":"https://openalex.org/S6642600","display_name":"Clinical Gastroenterology and Hepatology","issn_l":"1542-3565","issn":["1542-3565","1542-7714"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Gastroenterology and Hepatology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://orbi.uliege.be/bitstream/2268/247535/1/2_Systematic%20review%20and%20external%20validation%20of%20prediction%20models%20based%20on%20symptoms%20and%20biomarkers...Crohn%20s%20disease_ClinGastroenterolHepatol_PrePA.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074151326","display_name":"Eelco Christiaan Brand","orcid":"https://orcid.org/0000-0002-5195-0562","observed_orcids":["https://orcid.org/0000-0002-5195-0562"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Eelco C. Brand","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Utrecht, The Netherlands; Center for Translational Immunology, Utrecht, The Netherlands","Center for Translational Immunology, Utrecht, The Netherlands","Department of Gastroenterology and Hepatology, Utrecht, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-5195-0562","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Utrecht, The Netherlands; Center for Translational Immunology, Utrecht, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"Center for Translational Immunology, Utrecht, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076661327","display_name":"Sjoerd Geert Elias","orcid":"https://orcid.org/0000-0003-3903-4024","observed_orcids":["https://orcid.org/0000-0003-3903-4024"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sjoerd G. Elias","raw_affiliation_strings":["Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353","https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037821832","display_name":"Itta M. Minderhoud","orcid":"https://orcid.org/0000-0002-7424-1873","observed_orcids":["https://orcid.org/0000-0002-7424-1873"]},"institutions":[{"id":"https://openalex.org/I4210147058","display_name":"Tergooi","ror":"https://ror.org/045nawc23","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210147058"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Itta M. Minderhoud","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Tergooi Hospitals, Blaricum/Hilversum, The Netherland"],"raw_orcid":"https://orcid.org/0000-0002-7424-1873","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Tergooi Hospitals, Blaricum/Hilversum, The Netherland","institution_ids":["https://openalex.org/I4210147058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089175268","display_name":"Julius J. van der Veen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Julius J. van der Veen","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103548181","display_name":"Filip J. Baert","orcid":"https://orcid.org/0009-0003-4370-6708","observed_orcids":["https://orcid.org/0009-0003-4370-6708"]},"institutions":[{"id":"https://openalex.org/I4210144110","display_name":"AZ Delta","ror":"https://ror.org/04b0her22","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210144110"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Filip J. Baert","raw_affiliation_strings":["Department of Gastroenterology, AZ Delta, Roeselare, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, AZ Delta, Roeselare, Belgium","institution_ids":["https://openalex.org/I4210144110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009680823","display_name":"David Laharie","orcid":"https://orcid.org/0000-0002-4753-6676","observed_orcids":["https://orcid.org/0000-0002-4753-6676"]},"institutions":[{"id":"https://openalex.org/I3018323443","display_name":"Centre Hospitalier Universitaire de Bordeaux","ror":"https://ror.org/01hq89f96","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"David Laharie","raw_affiliation_strings":["Service d'H\u00e9pato-gastroent\u00e9rologie et Oncologie Digestive, H\u00f4pital Haut-L\u00e9v\u00eaque, Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d'H\u00e9pato-gastroent\u00e9rologie et Oncologie Digestive, H\u00f4pital Haut-L\u00e9v\u00eaque, Bordeaux, France","institution_ids":["https://openalex.org/I3018323443"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021791508","display_name":"Peter J. Bossuyt","orcid":"https://orcid.org/0000-0003-4027-7365","observed_orcids":["https://orcid.org/0000-0003-4027-7365"]},"institutions":[{"id":"https://openalex.org/I4210135614","display_name":"Imelda Hospital","ror":"https://ror.org/037s71n47","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210135614"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Peter Bossuyt","raw_affiliation_strings":["Inflammatory Bowel Disease Clinic, Imelda General Hospital, Bonheiden, Belgium"],"raw_orcid":"https://orcid.org/0000-0003-4027-7365","affiliations":[{"raw_affiliation_string":"Inflammatory Bowel Disease Clinic, Imelda General Hospital, Bonheiden, Belgium","institution_ids":["https://openalex.org/I4210135614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070441072","display_name":"Yoram Bouhnik","orcid":"https://orcid.org/0000-0002-5787-4943","observed_orcids":["https://orcid.org/0000-0002-5787-4943"]},"institutions":[{"id":"https://openalex.org/I2799502834","display_name":"H\u00f4pital Beaujon","ror":"https://ror.org/03jyzk483","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I2799502834","https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4387154366","display_name":"Universit\u00e9 Paris Diderot","ror":"https://ror.org/02n7qrg46","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387154366"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Yoram Bouhnik","raw_affiliation_strings":["Department of Gastroenterology, Beaujon Hospital, Assistance publique - H\u00f4pitaux de Paris (APHP), Paris Diderot University, Clichy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Beaujon Hospital, Assistance publique - H\u00f4pitaux de Paris (APHP), Paris Diderot University, Clichy, France","institution_ids":["https://openalex.org/I2799502834","https://openalex.org/I4210097159","https://openalex.org/I4387154366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068930601","display_name":"Anthony Buisson","orcid":"https://orcid.org/0000-0002-6347-409X","observed_orcids":["https://orcid.org/0000-0002-6347-409X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anthony Buisson","raw_affiliation_strings":["Department of Gastroenterology, Estaing University Hospital, Clermont-Ferrand, France"],"raw_orcid":"https://orcid.org/0000-0002-6347-409X","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Estaing University Hospital, Clermont-Ferrand, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007991769","display_name":"Guy L.Y. Lambrecht","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131339","display_name":"Damiaan Dicht bij het leven","ror":"https://ror.org/03w1sg385","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210131339"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Guy Lambrecht","raw_affiliation_strings":["Department of Gastroenterology, Algemeen Ziekenhuis (AZ), Damiaan, Oostende, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Algemeen Ziekenhuis (AZ), Damiaan, Oostende, Belgium","institution_ids":["https://openalex.org/I4210131339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065356435","display_name":"Edouard J. Louis","orcid":"https://orcid.org/0000-0002-1287-7075","observed_orcids":["https://orcid.org/0000-0002-1287-7075"]},"institutions":[{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Edouard Louis","raw_affiliation_strings":["Department of Gastroenterology, Li\u00e8ge University Hospital Centre Hospitalier Universitaire (CHU), Li\u00e8ge, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Li\u00e8ge University Hospital Centre Hospitalier Universitaire (CHU), Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I4210134544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046232245","display_name":"Benjamin Pariente","orcid":"https://orcid.org/0000-0003-1442-0244","observed_orcids":["https://orcid.org/0000-0003-1442-0244","https://orcid.org/0000-0002-1136-0699"]},"institutions":[{"id":"https://openalex.org/I4210155195","display_name":"H\u00f4pital Claude Huriez","ror":"https://ror.org/05cpv3t46","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406","https://openalex.org/I4210155195"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Benjamin Pariente","raw_affiliation_strings":["Department of Gastroenterology, Huriez Hospital, Lille 2 University, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Huriez Hospital, Lille 2 University, Lille, France","institution_ids":["https://openalex.org/I4210155195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028518564","display_name":"Marieke J. Pierik","orcid":"https://orcid.org/0000-0001-6981-6516","observed_orcids":["https://orcid.org/0000-0001-6981-6516"]},"institutions":[{"id":"https://openalex.org/I2800191616","display_name":"Maastricht University Medical Centre","ror":"https://ror.org/02d9ce178","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2800191616"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marieke J. Pierik","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Maastricht University Medical Center, Maastricht, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0001-6981-6516","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Maastricht University Medical Center, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I2800191616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087316268","display_name":"C. Janneke van der Woude","orcid":"https://orcid.org/0000-0003-3875-6957","observed_orcids":["https://orcid.org/0000-0003-3875-6957"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"C. Janneke van der Woude","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057899912","display_name":"Geert D\u2019Haens","orcid":"https://orcid.org/0000-0003-2784-4046","observed_orcids":["https://orcid.org/0000-0003-2784-4046"]},"institutions":[{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Geert R.A. M. D\u2019Haens","raw_affiliation_strings":["Department of Gastroenterology, Amsterdam University Medical Centers (UMC), University of Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Amsterdam University Medical Centers (UMC), University of Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210151833","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019474609","display_name":"S\u00e9verine Vermeire","orcid":"https://orcid.org/0000-0001-9942-3019","observed_orcids":["https://orcid.org/0000-0001-9942-3019"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"S\u00e9verine Vermeire","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I2800231306"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011860225","display_name":"Bas Oldenburg","orcid":"https://orcid.org/0000-0002-3962-6831","observed_orcids":["https://orcid.org/0000-0002-3962-6831"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Bas Oldenburg","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Utrecht, The Netherlands. Electronic address: b.oldenburg@umcutrecht.nl","Department of Gastroenterology and Hepatology, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Utrecht, The Netherlands. Electronic address: b.oldenburg@umcutrecht.nl","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":17,"corresponding_author_ids":["https://openalex.org/A5011860225"],"corresponding_institution_ids":["https://openalex.org/I193662353","https://openalex.org/I3018483916"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.3999,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.35064142,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"18","issue":"8","first_page":"1704","last_page":"1718"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13569","display_name":"Microscopic Colitis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.9649999737739563},{"id":"https://openalex.org/keywords/endoscopic-disease-activity","display_name":"endoscopic activity","score":0.875},{"id":"https://openalex.org/keywords/endoscopic-mucosal-healing","display_name":"endoscopic healing","score":0.890999972820282},{"id":"https://openalex.org/keywords/predictive-model","display_name":"prediction model","score":0.8159999847412109},{"id":"https://openalex.org/keywords/external-validation","display_name":"external validation","score":0.7379999756813049},{"id":"https://openalex.org/keywords/fecal-calprotectin","display_name":"fecal calprotectin","score":0.9129999876022339},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":1.0},{"id":"https://openalex.org/keywords/crohn-s-disease-activity-index","display_name":"CDAI","score":0.6769999861717224},{"id":"https://openalex.org/keywords/infliximab","display_name":"infliximab","score":0.6959999799728394},{"id":"https://openalex.org/keywords/ileocolonoscopy","display_name":"ileocolonoscopy","score":0.7799999713897705},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.5139999985694885},{"id":"https://openalex.org/keywords/symptoms","display_name":"clinical symptoms","score":0.6629999876022339},{"id":"https://openalex.org/keywords/model-accuracy-comparison","display_name":"model accuracy comparison","score":0.3959999978542328}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9007512927055359},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.6563419103622437},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6264786124229431},{"id":"https://openalex.org/C2777138892","wikidata":"https://www.wikidata.org/wiki/Q415264","display_name":"Infliximab","level":3,"score":0.6176072359085083},{"id":"https://openalex.org/C2779280984","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn's disease","level":3,"score":0.6018666625022888},{"id":"https://openalex.org/C2778292693","wikidata":"https://www.wikidata.org/wiki/Q22328664","display_name":"Calprotectin","level":4,"score":0.5975314974784851},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4933835566043854},{"id":"https://openalex.org/C2779008522","wikidata":"https://www.wikidata.org/wiki/Q3651030","display_name":"Faecal calprotectin","level":5,"score":0.4558415114879608},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.44792884588241577},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.4393216669559479},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.3684259057044983},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.363007128238678}],"mesh":[{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003113","descriptor_name":"Colonoscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039841","descriptor_name":"Leukocyte L1 Antigen Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":11,"locations":[{"id":"doi:10.1016/j.cgh.2019.12.014","doi":"https://doi.org/10.1016/j.cgh.2019.12.014","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cgh.2019.12.014","pdf_url":null,"source":{"id":"https://openalex.org/S6642600","display_name":"Clinical Gastroenterology and Hepatology","issn_l":"1542-3565","issn":["1542-3565","1542-7714"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Gastroenterology and Hepatology","raw_type":"journal-article"},{"id":"pmid:31881273","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31881273","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association","raw_type":"Journal Article"},{"id":"pmh:oai:cris.maastrichtuniversity.nl:openaire_cris_publications/1e0ab01f-64af-445a-8957-53645d20714f","doi":null,"is_oa":false,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/1e0ab01f-64af-445a-8957-53645d20714f","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:orbi.ulg.ac.be:2268/247535","doi":null,"is_oa":true,"landing_page_url":"https://orbi.uliege.be/handle/2268/247535","pdf_url":"https://orbi.uliege.be/bitstream/2268/247535/1/2_Systematic%20review%20and%20external%20validation%20of%20prediction%20models%20based%20on%20symptoms%20and%20biomarkers...Crohn%20s%20disease_ClinGastroenterolHepatol_PrePA.pdf","source":{"id":"https://openalex.org/S4306401300","display_name":"ORBi (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical Gastroenterology and Hepatology (2020)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/037d2be9-445b-4c3b-a0a2-6b99c6f745ca","doi":null,"is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/037d2be9-445b-4c3b-a0a2-6b99c6f745ca","pdf_url":"https://pure.amsterdamumc.nl/files/157734050/Systematic-review-and-external-validation-of-prediction-models-based-on-symptoms-and-biomarkers-for-identifying-endoscop.pdf","source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dutch Initiative on Crohn and Colitis 2020, 'Systematic Review and External Validation of Prediction Models Based on Symptoms and Biomarkers for Identifying Endoscopic Activity in Crohn's Disease', Clinical gastroenterology and hepatology, vol. 18, no. 8, pp. 1704-1718. https://doi.org/10.1016/j.cgh.2019.12.014","raw_type":"info:eu-repo/semantics/review"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/56cbca38-1135-4841-98a0-04da210c0b95","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/systematic-review-and-external-validation-of-prediction-models-based-on-symptoms-and-biomarkers-for-identifying-endoscopic-activity-in-crohns-disease(56cbca38-1135-4841-98a0-04da210c0b95).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical gastroenterology and hepatology, 18(8), 1704 - 1718. W.B. Saunders Ltd","raw_type":"info:eu-repo/semantics/other"},{"id":"pmh:eur:oai:pure.eur.nl:publications/f0729834-47d2-4c44-88bb-06e785064061","doi":null,"is_oa":false,"landing_page_url":"https://pure.eur.nl/en/publications/f0729834-47d2-4c44-88bb-06e785064061","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical Gastroenterology and Hepatology, 18(8), 1704 - 1718. W.B. Saunders","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dspace.library.uu.nl:1874/439191","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/439191","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/648950","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31881273","pdf_url":null,"source":{"id":"https://openalex.org/S7407055369","display_name":"Lirias","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical Gastroenterology And Hepatology, vol. 18 (8), (1704-1718)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.eur.nl:openaire_cris_publications/f0729834-47d2-4c44-88bb-06e785064061","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1765/127986","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brand, EC, Elias, SG, Minderhoud, IM, van der Veen, JJ, Baert, FJ, Laharie, D, Bossuyt, P, Bouhnik, Y, Buisson, A, Lambrecht, G, Louis, E, Pariente, B, Pierik, MJ, van der Woude, C J, D'Haens, GRAM, Vermeire, S & Oldenburg, B 2020, 'Systematic Review and External Validation of Prediction Models Based on Symptoms and Biomarkers for Identifying Endoscopic Activity in Crohn's Disease', Clinical Gastroenterology and Hepatology, vol. 18, no. 8, pp. 1704-1718. https://doi.org/10.1016/j.cgh.2019.12.014","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:um:oai:cris.maastrichtuniversity.nl:publications/1e0ab01f-64af-445a-8957-53645d20714f","doi":null,"is_oa":false,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/1e0ab01f-64af-445a-8957-53645d20714f","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical gastroenterology and hepatology, 18(8), 1704 - 1718. Elsevier Science","raw_type":"info:eu-repo/semantics/other"}],"best_oa_location":{"id":"pmh:oai:orbi.ulg.ac.be:2268/247535","doi":null,"is_oa":true,"landing_page_url":"https://orbi.uliege.be/handle/2268/247535","pdf_url":"https://orbi.uliege.be/bitstream/2268/247535/1/2_Systematic%20review%20and%20external%20validation%20of%20prediction%20models%20based%20on%20symptoms%20and%20biomarkers...Crohn%20s%20disease_ClinGastroenterolHepatol_PrePA.pdf","source":{"id":"https://openalex.org/S4306401300","display_name":"ORBi (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical Gastroenterology and Hepatology (2020)","raw_type":"http://purl.org/coar/resource_type/c_6501"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"},{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320307776","display_name":"Merck","ror":"https://ror.org/02891sr49"},{"id":"https://openalex.org/F4320307779","display_name":"Roche","ror":"https://ror.org/00by1q217"},{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"},{"id":"https://openalex.org/F4320308573","display_name":"Gilead Sciences","ror":"https://ror.org/056546b03"},{"id":"https://openalex.org/F4320308604","display_name":"Biogen","ror":"https://ror.org/02jqkb192"},{"id":"https://openalex.org/F4320309086","display_name":"Celgene","ror":"https://ror.org/0527yg379"},{"id":"https://openalex.org/F4320309117","display_name":"AbbVie","ror":"https://ror.org/02g5p4n58"},{"id":"https://openalex.org/F4320309470","display_name":"Meso Scale Diagnostics","ror":"https://ror.org/05jgy0m16"},{"id":"https://openalex.org/F4320310465","display_name":"Takeda Pharmaceutical Company","ror":"https://ror.org/04hjbmv12"},{"id":"https://openalex.org/F4320312286","display_name":"Ablynx","ror":"https://ror.org/05s030550"},{"id":"https://openalex.org/F4320317099","display_name":"Hospira","ror":null},{"id":"https://openalex.org/F4320318316","display_name":"Celltrion","ror":"https://ror.org/05k84m754"},{"id":"https://openalex.org/F4320322546","display_name":"Shire","ror":"https://ror.org/02hb3t423"},{"id":"https://openalex.org/F4320322992","display_name":"Ferring Pharmaceuticals","ror":"https://ror.org/031zfq432"},{"id":"https://openalex.org/F4320323906","display_name":"Vifor Pharma","ror":"https://ror.org/0185z7g17"},{"id":"https://openalex.org/F4320328455","display_name":"Ipsen","ror":"https://ror.org/00d801g55"},{"id":"https://openalex.org/F4320332137","display_name":"Norgine","ror":"https://ror.org/02vt89g81"},{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"},{"id":"https://openalex.org/F4320332195","display_name":"Samsung","ror":"https://ror.org/04w3jy968"},{"id":"https://openalex.org/F4320332585","display_name":"Allergan","ror":"https://ror.org/00wthd003"},{"id":"https://openalex.org/F4320333100","display_name":"Sandoz","ror":null},{"id":"https://openalex.org/F4320337601","display_name":"Janssen Pharmaceuticals","ror":"https://ror.org/03qd7mz70"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2998025834.pdf","grobid_xml":"https://content.openalex.org/works/W2998025834.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W154377515","https://openalex.org/W1547861381","https://openalex.org/W1609762315","https://openalex.org/W1752248076","https://openalex.org/W1976388664","https://openalex.org/W1997241682","https://openalex.org/W1999413206","https://openalex.org/W2019982728","https://openalex.org/W2021504343","https://openalex.org/W2022661087","https://openalex.org/W2026437676","https://openalex.org/W2034008046","https://openalex.org/W2034892783","https://openalex.org/W2043211155","https://openalex.org/W2055213169","https://openalex.org/W2066063421","https://openalex.org/W2071339121","https://openalex.org/W2071662837","https://openalex.org/W2075354786","https://openalex.org/W2077663753","https://openalex.org/W2078271269","https://openalex.org/W2087212501","https://openalex.org/W2092895549","https://openalex.org/W2105857910","https://openalex.org/W2115098571","https://openalex.org/W2118502261","https://openalex.org/W2121569640","https://openalex.org/W2123571431","https://openalex.org/W2146668705","https://openalex.org/W2151389232","https://openalex.org/W2159013446","https://openalex.org/W2170950246","https://openalex.org/W2171484002","https://openalex.org/W2172206840","https://openalex.org/W2173095346","https://openalex.org/W2208369196","https://openalex.org/W2234088349","https://openalex.org/W2304776681","https://openalex.org/W2318487091","https://openalex.org/W2341848334","https://openalex.org/W2394902529","https://openalex.org/W2406496009","https://openalex.org/W2548168877","https://openalex.org/W2550880436","https://openalex.org/W2559772049","https://openalex.org/W2559806380","https://openalex.org/W2566199716","https://openalex.org/W2582743722","https://openalex.org/W2712755743","https://openalex.org/W2781482422","https://openalex.org/W2793624926","https://openalex.org/W2800798497","https://openalex.org/W2804399971","https://openalex.org/W2826641198","https://openalex.org/W2907638671","https://openalex.org/W2913038517","https://openalex.org/W2915065916","https://openalex.org/W2927788980","https://openalex.org/W2943973817","https://openalex.org/W2944263044","https://openalex.org/W2956087440","https://openalex.org/W2984121388","https://openalex.org/W3149527659","https://openalex.org/W4235207944","https://openalex.org/W4249929154"],"related_works":["https://openalex.org/W2913219883","https://openalex.org/W2394902529","https://openalex.org/W2793624926","https://openalex.org/W4387132027","https://openalex.org/W4384926282","https://openalex.org/W2586662385","https://openalex.org/W7125239442","https://openalex.org/W4406704989","https://openalex.org/W2146428250","https://openalex.org/W2944254023"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-01-10T00:00:00"}