{"id":"https://openalex.org/W2997830134","doi":"https://doi.org/10.1126/scitranslmed.aax6629","title":"Physiological consequences of transient hyperleptinemia during discrete developmental periods on body weight in mice","display_name":"Physiological consequences of transient hyperleptinemia during discrete developmental periods on body weight in mice","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W2997830134","doi":"https://doi.org/10.1126/scitranslmed.aax6629","mag":"2997830134","pmid":"https://pubmed.ncbi.nlm.nih.gov/31894105","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7427106"},"language":"en","primary_location":{"id":"doi:10.1126/scitranslmed.aax6629","doi":"https://doi.org/10.1126/scitranslmed.aax6629","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scitranslmed.aax6629","pdf_url":null,"source":{"id":"https://openalex.org/S24207032","display_name":"Science Translational Medicine","issn_l":"1946-6234","issn":["1946-6234","1946-6242"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Translational Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7427106","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062020495","display_name":"Alicja A. Skowronski","orcid":"https://orcid.org/0000-0003-4648-8593","observed_orcids":["https://orcid.org/0000-0003-4648-8593"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alicja A. Skowronski","raw_affiliation_strings":["Division of Molecular Genetics, Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA"],"raw_orcid":"https://orcid.org/0000-0003-4648-8593","affiliations":[{"raw_affiliation_string":"Division of Molecular Genetics, Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058342195","display_name":"Charles A. LeDuc","orcid":"https://orcid.org/0000-0002-2073-5050","observed_orcids":["https://orcid.org/0000-0002-2073-5050"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles A. LeDuc","raw_affiliation_strings":["Division of Molecular Genetics, Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA","Naomi Berrie Diabetes Center, Columbia University Irving Medical Center, New York, NY 10032, USA"],"raw_orcid":"https://orcid.org/0000-0002-2073-5050","affiliations":[{"raw_affiliation_string":"Division of Molecular Genetics, Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"Naomi Berrie Diabetes Center, Columbia University Irving Medical Center, New York, NY 10032, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088977046","display_name":"Kylie S. Foo","orcid":"https://orcid.org/0000-0002-4040-5761","observed_orcids":["https://orcid.org/0000-0002-4040-5761"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kylie S. Foo","raw_affiliation_strings":["Division of Molecular Genetics, Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA"],"raw_orcid":"https://orcid.org/0000-0002-4040-5761","affiliations":[{"raw_affiliation_string":"Division of Molecular Genetics, Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003144111","display_name":"Yossef Goffer","orcid":"https://orcid.org/0000-0002-3144-9527","observed_orcids":["https://orcid.org/0000-0002-3144-9527"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yossef Goffer","raw_affiliation_strings":["Division of Molecular Genetics, Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA"],"raw_orcid":"https://orcid.org/0000-0002-3144-9527","affiliations":[{"raw_affiliation_string":"Division of Molecular Genetics, Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073663720","display_name":"Lisa Cole Burnett","orcid":"https://orcid.org/0000-0001-8958-3828","observed_orcids":["https://orcid.org/0000-0001-8958-3828"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa C. Burnett","raw_affiliation_strings":["Division of Molecular Genetics, Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA"],"raw_orcid":"https://orcid.org/0000-0001-8958-3828","affiliations":[{"raw_affiliation_string":"Division of Molecular Genetics, Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086997649","display_name":"Dieter M. Egli","orcid":"https://orcid.org/0000-0002-0812-6412","observed_orcids":["https://orcid.org/0000-0002-0812-6412","https://orcid.org/0000-0002-5876-2409"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dieter Egli","raw_affiliation_strings":["Department of Obstetrics and Gynecology, and Columbia Stem Cell Initiative, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA","Division of Molecular Genetics, Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA","Naomi Berrie Diabetes Center, Columbia University Irving Medical Center, New York, NY 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, and Columbia Stem Cell Initiative, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]},{"raw_affiliation_string":"Division of Molecular Genetics, Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"Naomi Berrie Diabetes Center, Columbia University Irving Medical Center, New York, NY 10032, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005825467","display_name":"Rudolph L. Leibel","orcid":"https://orcid.org/0000-0002-6062-7222","observed_orcids":["https://orcid.org/0000-0002-6062-7222"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rudolph L. Leibel","raw_affiliation_strings":["Division of Molecular Genetics, Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA","Naomi Berrie Diabetes Center, Columbia University Irving Medical Center, New York, NY 10032, USA"],"raw_orcid":"https://orcid.org/0000-0002-6062-7222","affiliations":[{"raw_affiliation_string":"Division of Molecular Genetics, Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"Naomi Berrie Diabetes Center, Columbia University Irving Medical Center, New York, NY 10032, USA","institution_ids":["https://openalex.org/I2799503643"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5005825467"],"corresponding_institution_ids":["https://openalex.org/I2799503643"],"apc_list":null,"apc_paid":null,"fwci":1.9245,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.83008496,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"12","issue":"524","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.9380000233650208},{"id":"https://openalex.org/keywords/hyperleptinemia","display_name":"hyperleptinemia","score":0.9620000123977661},{"id":"https://openalex.org/keywords/developmental-timing","display_name":"developmental timing","score":0.5569999814033508},{"id":"https://openalex.org/keywords/body-weight","display_name":"body weight","score":0.6309999823570251},{"id":"https://openalex.org/keywords/adiposity","display_name":"adiposity","score":0.8759999871253967},{"id":"https://openalex.org/keywords/diet-induced-obesity","display_name":"diet-induced obesity","score":0.8130000233650208},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.9860000014305115},{"id":"https://openalex.org/keywords/postpartum-period","display_name":"postpartum period","score":0.7540000081062317},{"id":"https://openalex.org/keywords/adolescence","display_name":"adolescence","score":0.7590000033378601},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.5519999861717224},{"id":"https://openalex.org/keywords/obesity-susceptibility","display_name":"obesity susceptibility","score":0.7210000157356262},{"id":"https://openalex.org/keywords/body-weight-set-point","display_name":"body weight set point","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.5343540906906128},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5113784670829773},{"id":"https://openalex.org/C2780799671","wikidata":"https://www.wikidata.org/wiki/Q17087362","display_name":"Transient (computer programming)","level":2,"score":0.4870915412902832},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.4827353358268738},{"id":"https://openalex.org/C2780320433","wikidata":"https://www.wikidata.org/wiki/Q3403879","display_name":"Weight gain","level":3,"score":0.4775567650794983},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.4566880464553833},{"id":"https://openalex.org/C2781291010","wikidata":"https://www.wikidata.org/wiki/Q178580","display_name":"Period (music)","level":2,"score":0.4329474866390228},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4160494804382324},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39982926845550537},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.06148359179496765},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004318","descriptor_name":"Doxycycline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1126/scitranslmed.aax6629","doi":"https://doi.org/10.1126/scitranslmed.aax6629","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scitranslmed.aax6629","pdf_url":null,"source":{"id":"https://openalex.org/S24207032","display_name":"Science Translational Medicine","issn_l":"1946-6234","issn":["1946-6234","1946-6242"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Translational Medicine","raw_type":"journal-article"},{"id":"pmid:31894105","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31894105","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science translational medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7427106","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7427106","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Sci Transl Med","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7427106","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7427106","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Sci Transl Med","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3364976376","display_name":"The Rewarding  Value of Sugar in the Absence of Sweet Taste","funder_award_id":"F30DK108564","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3771701322","display_name":"The molecular genetic analysis of human obesity","funder_award_id":"R01DK052431","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6781921799","display_name":null,"funder_award_id":"DK P3026685-36","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000867824","display_name":"New York Obesity Research Center","funder_award_id":"P30DK026687","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000914557","display_name":"Postdoctoral Training in Arteriosclerosis Research","funder_award_id":"T32HL007343","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W1499803297","https://openalex.org/W1507312044","https://openalex.org/W1511961767","https://openalex.org/W1693408209","https://openalex.org/W1866517486","https://openalex.org/W1887831276","https://openalex.org/W1964819028","https://openalex.org/W1966428464","https://openalex.org/W1968786994","https://openalex.org/W1969587440","https://openalex.org/W1971754084","https://openalex.org/W1972116648","https://openalex.org/W1972275518","https://openalex.org/W1974031039","https://openalex.org/W1981468083","https://openalex.org/W1982267895","https://openalex.org/W1985780260","https://openalex.org/W1987476260","https://openalex.org/W1987922392","https://openalex.org/W1991148887","https://openalex.org/W2004583907","https://openalex.org/W2006190738","https://openalex.org/W2006844115","https://openalex.org/W2007711534","https://openalex.org/W2013799006","https://openalex.org/W2015455880","https://openalex.org/W2018870528","https://openalex.org/W2022707231","https://openalex.org/W2022964472","https://openalex.org/W2028861833","https://openalex.org/W2035036680","https://openalex.org/W2042478221","https://openalex.org/W2048033775","https://openalex.org/W2052790535","https://openalex.org/W2062316965","https://openalex.org/W2062906649","https://openalex.org/W2070233031","https://openalex.org/W2081738005","https://openalex.org/W2081777956","https://openalex.org/W2082571287","https://openalex.org/W2083321610","https://openalex.org/W2084991422","https://openalex.org/W2085975528","https://openalex.org/W2089779965","https://openalex.org/W2090130376","https://openalex.org/W2090491403","https://openalex.org/W2095656037","https://openalex.org/W2097660065","https://openalex.org/W2099605002","https://openalex.org/W2107832644","https://openalex.org/W2109167669","https://openalex.org/W2118500158","https://openalex.org/W2125121504","https://openalex.org/W2127709546","https://openalex.org/W2128313606","https://openalex.org/W2128643576","https://openalex.org/W2131385402","https://openalex.org/W2131530831","https://openalex.org/W2134900335","https://openalex.org/W2142379941","https://openalex.org/W2147712103","https://openalex.org/W2149565430","https://openalex.org/W2154696002","https://openalex.org/W2155027151","https://openalex.org/W2160542669","https://openalex.org/W2166897446","https://openalex.org/W2171465385","https://openalex.org/W2172288854","https://openalex.org/W2276852211","https://openalex.org/W2518692192","https://openalex.org/W2561325798","https://openalex.org/W2574634442","https://openalex.org/W2802623263","https://openalex.org/W2808947308","https://openalex.org/W2895006350","https://openalex.org/W2954492537"],"related_works":["https://openalex.org/W2741542763","https://openalex.org/W2048033775","https://openalex.org/W4255718894","https://openalex.org/W7099644892","https://openalex.org/W2090130376","https://openalex.org/W2084991422","https://openalex.org/W2203405655","https://openalex.org/W1974838371","https://openalex.org/W2410327319","https://openalex.org/W2037208683"],"abstract_inverted_index":{"Leptin":[0],"plays":[1],"a":[2,39,73,229],"role":[3],"in":[4,38,76,154,197,246],"central":[5],"nervous":[6],"system":[7],"developmental":[8,231],"programs":[9],"and":[10,21,32,49,57,69,120,136,169,194],"intercurrent":[11],"physiological":[12,91,102],"processes":[13],"related":[14],"to":[15,29,53,60,110,116,128,131,138,173,190,199,204,220,228,233],"body":[16,40,162],"fat":[17,195],"regulation.":[18],"The":[19],"timing":[20],"neuromolecular":[22],"mechanisms":[23],"for":[24,243],"these":[25,224],"effects":[26,66,103,225],"are":[27,58],"relevant":[28],"the":[30,90,121],"prevention":[31],"treatment":[33],"of":[34,93,104,185,215],"obesity.":[35],"Factors":[36],"implicated":[37],"weight":[41,140,163,175,193,244],"\"set":[42],"point\"":[43],"including":[44],"dietary":[45],"fat,":[46],"circulating":[47,186],"leptin,":[48],"other":[50],"adipokines":[51],"tend":[52],"covary":[54],"with":[55],"adiposity":[56,68,135],"difficult":[59],"disarticulate":[61],"experimentally.":[62],"To":[63],"dissociate":[64],"leptin":[65,78,105,166,187,211],"from":[67,180,188],"diet,":[70],"we":[71,88],"created":[72],"transgenic":[74],"mouse":[75],"which":[77],"expression":[79],"is":[80],"regulated":[81],"by":[82],"doxycycline":[83],"exposure.":[84],"Using":[85],"this":[86],"system,":[87],"investigated":[89],"consequences":[92],"developmentally-timed":[94],"transient":[95,183,209,216],"hyperleptinemia":[96,153],"on":[97,133,141],"subsequent":[98],"adiposity.":[99],"We":[100,148],"evaluated":[101],"elevation":[106,184],"during":[107],"adulthood":[108],"(9":[109],"29":[111],"weeks":[112,118],"old),":[113,119],"\"adolescence\"":[114],"(3":[115],"8":[117],"immediate":[122],"postnatal":[123],"period":[124],"[postnatal":[125],"days":[126],"0":[127],"22":[129],"(P0":[130,232],"P22)]":[132],"long-term":[134],"susceptibility":[137,203,219],"gain":[139,176,196],"high-fat":[142],"diet":[143],"(HFD)":[144],"fed":[145],"ad":[146],"libitum.":[147],"found":[149],"that":[150],"inducing":[151],"chronic":[152],"adult":[155],"or":[156],"\"adolescent\"":[157],"mice":[158],"did":[159,177],"not":[160,178],"alter":[161],"when":[164],"excess":[165],"was":[167],"discontinued,":[168],"upon":[170],"later":[171,218],"exposure":[172],"HFD,":[174,200],"differ":[179],"controls.":[181],"However,":[182],"P0":[189],"P22":[191],"increased":[192],"response":[198],"indicating":[201],"greater":[202],"obesity":[205],"as":[206],"adults.":[207],"Thus,":[208],"plasma":[210],"elevations-mimicking":[212],"one":[213],"aspect":[214],"adiposity-increased":[217],"diet-induced":[221],"obesity,":[222],"although":[223],"were":[226],"restricted":[227],"critical":[230],"P22)":[234],"time":[235],"window.":[236],"These":[237],"findings":[238],"may":[239],"have":[240],"clinical":[241],"implications":[242],"management":[245],"infancy.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-01-10T00:00:00"}
